milrinone has been researched along with Hypoplastic Left Heart Syndrome in 10 studies
Hypoplastic Left Heart Syndrome: A condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardiac chambers (HEART ATRIUM; HEART VENTRICLE), the AORTA, the AORTIC VALVE, and the MITRAL VALVE. Severe symptoms appear in early infancy when DUCTUS ARTERIOSUS closes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is a paucity of information reported regarding the use of milrinone in patients with hypoplastic left heart syndrome prior to the Norwood procedure." | 8.31 | Milrinone for treatment of elevated lactate in the pre-operative newborn with hypoplastic left heart syndrome. ( Aljiffry, A; Aronoff, E; Basu, M; Beshish, AG; Chauhan, D; Maher, KO; Shashidharan, S; Zinyandu, T, 2023) |
| "We performed a blinded, randomized pharmacokinetic study of milrinone in 16 neonates with hypoplastic left heart undergoing stage I reconstruction to determine the impact of cardiopulmonary bypass and modified ultrafiltration on drug disposition and to define the drug exposure during a continuous IV infusion of drug postoperatively." | 6.72 | Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction. ( Adamson, PC; Barrett, JS; Burnham, N; Davis, LA; Gaynor, JW; Greeley, WJ; Hoffman, TM; Mondick, JT; Nicolson, SC; Spray, TL; Wernovsky, G; Zuppa, AF, 2006) |
| "There is a paucity of information reported regarding the use of milrinone in patients with hypoplastic left heart syndrome prior to the Norwood procedure." | 4.31 | Milrinone for treatment of elevated lactate in the pre-operative newborn with hypoplastic left heart syndrome. ( Aljiffry, A; Aronoff, E; Basu, M; Beshish, AG; Chauhan, D; Maher, KO; Shashidharan, S; Zinyandu, T, 2023) |
| "We performed a blinded, randomized pharmacokinetic study of milrinone in 16 neonates with hypoplastic left heart undergoing stage I reconstruction to determine the impact of cardiopulmonary bypass and modified ultrafiltration on drug disposition and to define the drug exposure during a continuous IV infusion of drug postoperatively." | 2.72 | Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction. ( Adamson, PC; Barrett, JS; Burnham, N; Davis, LA; Gaynor, JW; Greeley, WJ; Hoffman, TM; Mondick, JT; Nicolson, SC; Spray, TL; Wernovsky, G; Zuppa, AF, 2006) |
| "Sixty patients had hypoplastic left heart syndrome." | 2.42 | Prevention of early sudden circulatory collapse after the Norwood operation. ( Adatia, IT; Ashburn, DA; Burkhart, HM; De Oliveira, NC; Holtby, HM; Khalid, F; Van Arsdell, GS; Williams, WG, 2004) |
| "Of 26 subjects (47 encounters), 20 had hypoplastic left heart syndrome (77%)." | 1.72 | Relation of Right Atrial Strain to Mortality in Infants With Single Right Ventricles. ( Colquitt, JL; Liu, A; Loar, RW; McFarland, CA; Minich, LL; Ou, Z; Pignatelli, RH; Wilkinson, JC, 2022) |
| "Tachyarrhythmias are common after the Norwood stage I palliation." | 1.40 | Tachyarrhythmias after the Norwood procedure: relationship and effect of vasoactive agents. ( Collins, KK; da Cruz, EM; Jaggers, J; Kaufman, J; McCanta, AC; McFerson, MC; Pan, Z, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Colquitt, JL | 1 |
| McFarland, CA | 1 |
| Loar, RW | 1 |
| Liu, A | 1 |
| Pignatelli, RH | 1 |
| Ou, Z | 1 |
| Minich, LL | 1 |
| Wilkinson, JC | 1 |
| Beshish, AG | 1 |
| Aljiffry, A | 1 |
| Aronoff, E | 1 |
| Chauhan, D | 1 |
| Zinyandu, T | 1 |
| Basu, M | 1 |
| Shashidharan, S | 1 |
| Maher, KO | 1 |
| Kanazawa, T | 1 |
| Shimizu, K | 1 |
| Iwasaki, T | 1 |
| Baba, K | 1 |
| Otsuki, S | 1 |
| Kotani, Y | 1 |
| Kasahara, S | 1 |
| Morimatsu, H | 1 |
| Jones, PM | 1 |
| Perumal, G | 1 |
| Marathe, SP | 1 |
| Schlapbach, LJ | 1 |
| Morwood, J | 1 |
| Venugopal, P | 1 |
| Alphonso, N | 1 |
| McFerson, MC | 1 |
| McCanta, AC | 1 |
| Pan, Z | 1 |
| Collins, KK | 1 |
| Jaggers, J | 1 |
| da Cruz, EM | 1 |
| Kaufman, J | 1 |
| Mills, KI | 1 |
| Kaza, AK | 1 |
| Walsh, BK | 1 |
| Bond, HC | 1 |
| Ford, M | 1 |
| Wypij, D | 1 |
| Thiagarajan, RR | 1 |
| Almodovar, MC | 1 |
| Quinonez, LG | 1 |
| Baird, CW | 1 |
| Emani, SE | 1 |
| Pigula, FA | 1 |
| DiNardo, JA | 1 |
| Kheir, JN | 1 |
| De Oliveira, NC | 1 |
| Ashburn, DA | 1 |
| Khalid, F | 1 |
| Burkhart, HM | 1 |
| Adatia, IT | 1 |
| Holtby, HM | 1 |
| Williams, WG | 1 |
| Van Arsdell, GS | 1 |
| Zuppa, AF | 1 |
| Nicolson, SC | 1 |
| Adamson, PC | 1 |
| Wernovsky, G | 1 |
| Mondick, JT | 1 |
| Burnham, N | 1 |
| Hoffman, TM | 1 |
| Gaynor, JW | 1 |
| Davis, LA | 1 |
| Greeley, WJ | 1 |
| Spray, TL | 1 |
| Barrett, JS | 1 |
| Reinoso-Barbero, F | 1 |
| Garcia-Fernandez, FJ | 1 |
| Díez-Labajo, A | 1 |
| del Cerro, MJ | 1 |
| Cordovilla, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)[NCT02184169] | 27 participants (Actual) | Interventional | 2012-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A calculated estimate of cardiac index/systemic blood flow based on the Fick principle. (NCT02184169)
Timeframe: While mechanically ventilated, up to 14 days
| Intervention | L/min/m2 (Mean) |
|---|---|
| Hypoplastic Left Heart Syndrome | 1.3 |
| Transposition of the Great Arteries | 2.2 |
Oxygen consumption is the mass of oxygen gas consumed per minute, measured as the difference between oxygen mass inspired versus exhaled per minute. (NCT02184169)
Timeframe: While mechanically ventilated, up to 14 days
| Intervention | mL oxygen/min/m^2 (Mean) |
|---|---|
| HLHS | 72 |
| TGA With/Without VSD | 102 |
1 review available for milrinone and Hypoplastic Left Heart Syndrome
| Article | Year |
|---|---|
Prevention of early sudden circulatory collapse after the Norwood operation.
Topics: Adrenergic alpha-Antagonists; Biomarkers; Cardiopulmonary Bypass; Cardiotonic Agents; Case Managemen | 2004 |
1 trial available for milrinone and Hypoplastic Left Heart Syndrome
| Article | Year |
|---|---|
Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction.
Topics: Cardiopulmonary Bypass; Humans; Hypoplastic Left Heart Syndrome; Infant; Infant, Newborn; Milrinone; | 2006 |
8 other studies available for milrinone and Hypoplastic Left Heart Syndrome
| Article | Year |
|---|---|
Relation of Right Atrial Strain to Mortality in Infants With Single Right Ventricles.
Topics: Echocardiography; Heart Ventricles; Humans; Hypoplastic Left Heart Syndrome; Infant; Milrinone; Pros | 2022 |
Milrinone for treatment of elevated lactate in the pre-operative newborn with hypoplastic left heart syndrome.
Topics: Humans; Hypoplastic Left Heart Syndrome; Infant, Newborn; Lactates; Milrinone; Norwood Procedures; R | 2023 |
Perioperative Milrinone Infusion Improves One-Year Survival After the Norwood-Sano Procedure.
Topics: Child; Humans; Hypoplastic Left Heart Syndrome; Milrinone; Norwood Procedures; Retrospective Studies | 2021 |
In Reference to "Perioperative Milrinone Infusion Improves One-Year Survival After the Norwood-Sano Procedure".
Topics: Humans; Hypoplastic Left Heart Syndrome; Milrinone; Norwood Procedures | 2021 |
Postoperative catecholamine resistance following fetal methamphetamine exposure.
Topics: Amphetamine-Related Disorders; Cardiotonic Agents; Central Nervous System Stimulants; Dopamine; Drug | 2019 |
Tachyarrhythmias after the Norwood procedure: relationship and effect of vasoactive agents.
Topics: Colorado; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Heart Ra | 2014 |
Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation.
Topics: Blalock-Taussig Procedure; Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxygenation; Femal | 2016 |
Postoperative use of milrinone for Norwood procedure.
Topics: Cardiotonic Agents; Female; Hemodynamics; Humans; Hypoplastic Left Heart Syndrome; Infant, Newborn; | 1996 |