milrinone has been researched along with Heart Disease, Ischemic in 29 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Postoperatively, the patient had persistent sinus tachycardia that was initially unsuccessfully treated with metoprolol." | 7.70 | Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998) |
| "Cilostazol (Pletal), a quinolinone derivative with a cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitory activity, was recently approved by the Food and Drug Administration for treatment of symptoms of intermittent claudication (IC)." | 7.70 | Inhibition of adenosine uptake and augmentation of ischemia-induced increase of interstitial adenosine by cilostazol, an agent to treat intermittent claudication. ( Cone, J; Fong, M; Kambayashi, J; Liu, Y; Wang, S; Yoshitake, M, 2000) |
| " Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat." | 7.68 | Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993) |
| "Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography." | 5.29 | Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts. ( Blazincic, B; Klaus, W; Rump, AF, 1993) |
| "Serum levels of creatine phosphokinase (CPK), the MB isoenzyme of creatine kinase (CK-MB), occurrence of myocardial ischemia or infarction, and mean duration of using inotropic agents were significantly lower in the milrinone group (p < 0." | 5.14 | Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: A randomized controlled trial. ( Darehzereshki, A; Dianat, S; Eghtesadi-Araghi, P; Ghazinoor, M; Goodarzynejad, H; Jebeli, M; Mandegar, MH; Mohammadzadeh, R; Rasouli, MR, 2010) |
| " 1) Milrinone decreased incidence of myocardial ischemia and myocardial infarction (15." | 4.93 | Effect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials. ( Cheng, X; Huang, L; Jiang, X; Wu, Q; Wu, Y; You, Z, 2016) |
| "We report a 23-month old girl who presented with bilateral epiphora who underwent bilateral lacrimal probing and syringing, during which a cocaine adrenaline solution was used." | 3.81 | Myocardial ischaemia following cocaine and adrenaline exposure in a child during an ophthalmological procedure. ( McGovern, E; McMahon, CJ; Moylett, E, 2015) |
| "To evaluate: 1) the effects of dobutamine (DOB) on left ventricular function in early (48-72 h) and late (14 days) phases of a post-MI canine model, compared to ISTA, and 2) the efficacy of DOB in chronic left ventricular dysfunction (6 months post-MI) in dogs pre-treated or not with a beta-blocker, compared with ISTA and milrinone (MIL)." | 3.74 | Sympathomimetic inefficiency in restoring contractility in the acute or chronic beta-blocker-treated ischaemic heart: comparison with a new agent. ( Borsini, F; Carminati, P; Gagnol, JP; Loi, FM; Mattera, GG; Vanoli, E, 2008) |
| " Postoperatively, the patient had persistent sinus tachycardia that was initially unsuccessfully treated with metoprolol." | 3.70 | Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998) |
| "Cilostazol (Pletal), a quinolinone derivative with a cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitory activity, was recently approved by the Food and Drug Administration for treatment of symptoms of intermittent claudication (IC)." | 3.70 | Inhibition of adenosine uptake and augmentation of ischemia-induced increase of interstitial adenosine by cilostazol, an agent to treat intermittent claudication. ( Cone, J; Fong, M; Kambayashi, J; Liu, Y; Wang, S; Yoshitake, M, 2000) |
| " Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat." | 3.68 | Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993) |
| "Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography." | 1.29 | Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts. ( Blazincic, B; Klaus, W; Rump, AF, 1993) |
| "Milrinone was then administered to group 3 (n = 7); group 4 (n = 8) served as ischemically injured controls." | 1.29 | Ischemia-dependent efficacy of phosphodiesterase inhibition. ( Burns, PG; Caldarone, CA; Gaudette, GR; Krukenkamp, IB; Levitsky, S; Misare, BD, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (41.38) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 7 (24.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Axelsson, B | 2 |
| Johansson, G | 2 |
| Abrahamsson, P | 1 |
| Gupta, A | 2 |
| Tydén, H | 2 |
| Wouters, P | 2 |
| Haney, M | 2 |
| Hadadzadeh, M | 1 |
| Hosseini, SH | 1 |
| Mostafavi Pour Manshadi, SM | 1 |
| Naderi, N | 1 |
| Emami Meybodi, M | 1 |
| McGovern, E | 1 |
| Moylett, E | 1 |
| McMahon, CJ | 1 |
| You, Z | 1 |
| Huang, L | 1 |
| Cheng, X | 1 |
| Wu, Q | 1 |
| Jiang, X | 1 |
| Wu, Y | 1 |
| Häggmark, S | 1 |
| Svenmarker, S | 1 |
| Mattera, GG | 1 |
| Vanoli, E | 1 |
| Gagnol, JP | 1 |
| Loi, FM | 1 |
| Borsini, F | 1 |
| Carminati, P | 1 |
| Hein, M | 1 |
| Roehl, AB | 1 |
| Baumert, JH | 1 |
| Scherer, K | 1 |
| Steendijk, P | 1 |
| Rossaint, R | 1 |
| Yamaguchi, A | 1 |
| Tanaka, M | 1 |
| Naito, K | 1 |
| Kimura, C | 1 |
| Kobinata, T | 1 |
| Okamura, H | 1 |
| Ino, T | 1 |
| Adachi, H | 1 |
| Jebeli, M | 1 |
| Ghazinoor, M | 1 |
| Mandegar, MH | 1 |
| Rasouli, MR | 1 |
| Eghtesadi-Araghi, P | 1 |
| Goodarzynejad, H | 1 |
| Mohammadzadeh, R | 1 |
| Darehzereshki, A | 1 |
| Dianat, S | 1 |
| Kato, M | 1 |
| Hirayama, A | 1 |
| Möllhoff, T | 1 |
| Schmidt, C | 1 |
| Van Aken, H | 1 |
| Berendes, E | 1 |
| Buerkle, H | 1 |
| Marmann, P | 1 |
| Reinbold, T | 1 |
| Prenger-Berninghoff, R | 1 |
| Tjan, TD | 1 |
| Scheld, HH | 1 |
| Deng, MC | 1 |
| Kim, JH | 1 |
| Ham, BM | 1 |
| Kim, YL | 1 |
| Bahk, JH | 1 |
| Ryu, HG | 1 |
| Jeon, YS | 1 |
| Kim, KB | 1 |
| De Luca, L | 1 |
| Proietti, P | 1 |
| Palombaro, GL | 1 |
| Battagliese, A | 1 |
| Celotto, A | 1 |
| Bucciarelli Ducci, C | 1 |
| Fedele, F | 1 |
| Sablotzki, A | 1 |
| Starzmann, W | 1 |
| Scheubel, R | 1 |
| Grond, S | 1 |
| Czeslick, EG | 1 |
| Use, T | 1 |
| Makita, T | 1 |
| Ureshino, H | 1 |
| Cho, S | 1 |
| Yoshitomi, O | 1 |
| Akiyama, D | 1 |
| Oshibuchi, M | 1 |
| Hara, T | 1 |
| Sumikawa, K | 1 |
| Pridjian, AK | 2 |
| Frohlich, ED | 1 |
| VanMeter, CH | 2 |
| McFadden, PM | 2 |
| Ochsner, JL | 2 |
| Rump, AF | 2 |
| Acar, D | 1 |
| Klaus, W | 2 |
| Jones, RB | 1 |
| Frodsham, G | 1 |
| Dickinson, K | 1 |
| Foster, GA | 1 |
| Blazincic, B | 1 |
| Caldarone, CA | 1 |
| Krukenkamp, IB | 1 |
| Burns, PG | 1 |
| Misare, BD | 1 |
| Gaudette, GR | 1 |
| Levitsky, S | 1 |
| Zhang, YI | 1 |
| Ritchie, RH | 2 |
| Horowitz, JD | 2 |
| Ishisu, R | 1 |
| Abe, Y | 1 |
| Onishi, K | 1 |
| Ueda, Y | 1 |
| Sekioka, K | 1 |
| Nakano, T | 1 |
| Chung, KC | 1 |
| Touchard, CL | 1 |
| Ishikawa, M | 1 |
| Koga, K | 1 |
| Fujiki, H | 1 |
| Mori, T | 1 |
| Yabuuchi, Y | 1 |
| Alhashemi, JA | 1 |
| Hooper, J | 1 |
| Hii, JT | 1 |
| Liu, Y | 1 |
| Fong, M | 1 |
| Cone, J | 1 |
| Wang, S | 1 |
| Yoshitake, M | 1 |
| Kambayashi, J | 1 |
| Carceles, MD | 1 |
| Aleixandre, F | 1 |
| Fuente, T | 1 |
| López-Vidal, J | 1 |
| Laorden, ML | 1 |
| Van de Water, A | 1 |
| Xhonneux, R | 1 |
| Reneman, RS | 1 |
| Janssen, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute and Chronic Protective Effects of Peri-interventional Administration of Levosimendan in ST Elevation Myocardial Infarctions[NCT03022877] | 0 participants (Actual) | Interventional | 2017-06-30 | Withdrawn (stopped due to Rationale obsolete) | |||
| 2- Inhaled Milrinone Prevents the Increase in Pulmonary Artery Pressure After CPB[NCT00819377] | Phase 2 | 124 participants (Anticipated) | Interventional | 2009-02-28 | Completed | ||
| Study of the Efficacy and Safety of Cilostazol in the Prevention of Ischemic Vascular Events in Diabetic Patients With Symptomatic Peripheral Artery Disease.[NCT02983214] | Phase 4 | 826 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for milrinone and Heart Disease, Ischemic
| Article | Year |
|---|---|
Effect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials.
Topics: Cardiotonic Agents; Coronary Artery Bypass; Humans; Intensive Care Units; Length of Stay; Milrinone; | 2016 |
[Combination therapy; dobutamine and milrinone].
Topics: Cardiomyopathy, Dilated; Cardiotonic Agents; Dobutamine; Drug Therapy, Combination; Heart Failure; H | 2011 |
New positive inotropic agents in the treatment of left ventricular dysfunction.
Topics: Cardiotonic Agents; Diastole; Heart Failure; Humans; Hydrazones; Milrinone; Myocardial Ischemia; Pho | 2004 |
6 trials available for milrinone and Heart Disease, Ischemic
| Article | Year |
|---|---|
Effect of milrinone on short term outcome of patients with myocardial dysfunction undergoing off-pump coronary artery bypass graft: a randomized clinical trial.
Topics: Aged; Cardiotonic Agents; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle | 2013 |
Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: A randomized controlled trial.
Topics: Aged; Cardiotonic Agents; Coronary Artery Bypass; Creatine Kinase; Creatine Kinase, MB Form; Drug Ad | 2010 |
Myocardial ischaemia in patients with impaired left ventricular function undergoing coronary artery bypass grafting--milrinone versus nifedipin.
Topics: Aged; Anesthesia, General; Calcium Channel Blockers; Coronary Artery Bypass; Coronary Disease; Creat | 2002 |
Prophylactic milrinone during OPCAB of posterior vessels: implication in angina patients taking beta-blockers.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Aged; Angina Pectoris; Cardiotonic | 2003 |
Selective pulmonary vasodilation with inhaled aerosolized milrinone in heart transplant candidates.
Topics: Adult; Aerosols; Blood Volume; Cardiomyopathy, Dilated; Extravascular Lung Water; Heart Transplantat | 2005 |
Postextrasystolic potentiation in patients with ischaemic heart disease: influence of inotropic agents.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiac Complexes, Premature; Cardiotonic Agents; Female; | 1995 |
20 other studies available for milrinone and Heart Disease, Ischemic
| Article | Year |
|---|---|
Milrinone and levosimendan during porcine myocardial ischemia -- no effects on calcium overload and metabolism.
Topics: Animals; Calcium; Calcium Radioisotopes; Cardiotonic Agents; Drug Evaluation, Preclinical; Energy Me | 2013 |
Myocardial ischaemia following cocaine and adrenaline exposure in a child during an ophthalmological procedure.
Topics: Administration, Topical; Anesthetics, Local; Cardiovascular Agents; Cocaine; Diagnostic Techniques, | 2015 |
Effects of Combined Milrinone and Levosimendan Treatment on Systolic and Diastolic Function During Postischemic Myocardial Dysfunction in a Porcine Model.
Topics: Animals; Cardiotonic Agents; Diastole; Disease Models, Animal; Drug Therapy, Combination; Hydrazones | 2016 |
Sympathomimetic inefficiency in restoring contractility in the acute or chronic beta-blocker-treated ischaemic heart: comparison with a new agent.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Dobutamine; Dogs | 2008 |
Anti-ischemic effects of inotropic agents in experimental right ventricular infarction.
Topics: Animals; Blood Gas Analysis; Cardiotonic Agents; Dobutamine; Female; Heart Ventricles; Hemodynamics; | 2009 |
The efficacy of intravenous milrinone in left ventricular restoration.
Topics: Aged; Cardiac Surgical Procedures; Cardiomyopathies; Cardiopulmonary Bypass; Cardiotonic Agents; Com | 2009 |
Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine.
Topics: Anesthesia; Animals; Cardiotonic Agents; Female; Male; Milrinone; Myocardial Contraction; Myocardial | 2006 |
Pharmacologic support with high-energy phosphate preservation in the postischemic neonatal heart.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Animals, Newborn; Cardiotonic Agents; Cyclic A | 1995 |
A quantitative comparison of functional and anti-ischaemic effects of the phosphodiesterase-inhibitors, amrinone, milrinone and levosimendan in rabbit isolated hearts.
Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Electric Stimulation; Heart; Heart Rate | 1994 |
Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressu | 1993 |
Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts.
Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Fluorescence; Hemodynamics; Histocytoch | 1993 |
Ischemia-dependent efficacy of phosphodiesterase inhibition.
Topics: Animals; Cardiotonic Agents; Female; Male; Milrinone; Myocardial Contraction; Myocardial Ischemia; M | 1994 |
Changes in calcium transient and left ventricular function during positive inotropic stimulation and myocardial ischemia in indo-1-loaded beating guinea pig heart.
Topics: Animals; Calcium; Cardiotonic Agents; Digoxin; Fluorescent Dyes; Guinea Pigs; Indoles; Male; Milrino | 1996 |
Repletion of high energy phosphates in the postischemic neonatal heart.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cardiac Output; Cardiotonic Agents; Cyclic AMP; D | 1996 |
Comparative study of toborinone (OPC-18790) and milrinone on energy metabolism in microembolized guinea pig hearts.
Topics: Animals; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Heart; Male; Milrinone; Myocardial Isch | 1997 |
Treatment of milrinone-associated tachycardia with beta-blockers.
Topics: Adrenergic beta-Antagonists; Aged; Anesthesia, Epidural; Anesthesia, General; Anti-Arrhythmia Agents | 1998 |
Relationship between myocardial milrinone content and its acute hemodynamic and electrophysiologic effects.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Hemodynamics; Humans; Male; Middle Aged; Milrinon | 1998 |
Inhibition of adenosine uptake and augmentation of ischemia-induced increase of interstitial adenosine by cilostazol, an agent to treat intermittent claudication.
Topics: Adenosine; Animals; Blood Pressure; Cilostazol; Dose-Response Relationship, Drug; Heart Rate; Humans | 2000 |
Combined phosphodiesterase inhibition and beta-blockade in the GI104313, decreases ischemia-induced arrhythmias in the rat.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Hemodynamics; Ma | 2001 |
Cardiac and hemodynamic effects of intravenous R80122, a new phosphodiesterase III inhibitor, in a canine model of myocardial ischemia and heart failure.
Topics: Animals; Blood Pressure; Cardiac Output, Low; Dogs; Female; Heart Rate; Hemodynamics; Imidazoles; In | 1992 |