Page last updated: 2024-10-31

milrinone and Cardiovascular Stroke

milrinone has been researched along with Cardiovascular Stroke in 37 studies

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to compare the hemodynamic and clinical effects of milrinone, a vasodilating and positive inotropic agent, with those of dobutamine in patients with congestive heart failure (CHF) following acute myocardial infarction (AMI)."9.08Comparative efficacy of short-term intravenous infusions of milrinone and dobutamine in acute congestive heart failure following acute myocardial infarction. Milrinone-Dobutamine Study Group. ( Berk, MR; DeMaria, AN; DeWood, MA; Karlsberg, RP; Lasher, KP, 1996)
"The authors examined whether milrinone and levosimendan could exert cardiac postconditioning effects in rats under normoglycemia and hyperglycemia, and whether the effects could be mediated by mitochondrial permeability transition pore (mPTP)."7.78Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts. ( Cho, S; Hara, T; Higashijima, U; Maekawa, T; Matsumoto, S; Sumikawa, K; Tosaka, S, 2012)
"This study compared the effects of simendan, a calcium sensitizer, with those of milrinone and enalapril on survival of rats with healed myocardial infarction."7.71Improved survival with simendan after experimental myocardial infarction in rats. ( Haikala, H; Kaheinen, P; Levijoki, J; Pollesello, P, 2001)
"Chronic milrinone therapy after acute myocardial infarction improves cardiac hemodynamic indexes and attenuates progressive left ventricular dilation."7.68Effects of milrinone on left ventricular remodeling after acute myocardial infarction. ( Brown, EJ; Halpern, J; Jain, P; Langenback, EG; Lillis, O; Mannisi, JA; Raeder, E, 1991)
"The effects of milrinone and pimobendan upon the initiation of programmed ventricular stimulation-induced ventricular tachycardia (VT) and the incidence of lethal ischemic ventricular arrhythmias were assessed in conscious dogs with recent anterior myocardial infarctions."7.67Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction. ( Driscoll, EM; Frye, JW; Kitzen, JM; Lucchesi, BR; Lynch, JJ; Uprichard, AC, 1989)
"The long-term survival of rats with healed myocardial infarction and congestive heart failure treated with milrinone, enalapril and the combination of milrinone plus enalapril, was documented."7.67Beneficial effects of milrinone and enalapril on long-term survival of rats with healed myocardial infarction. ( Emmert, SE; Heyse, JF; Ludden, CT; Stabilito, II; Sweet, CS, 1988)
"The present study was designed to evaluate the regional vascular profile of milrinone in the setting of experimental heart failure."7.67[Central and regional vascular hemodynamics of milrinone in experimental heart failure: comparison with captopril and dobutamine]. ( Drexler, H; Faude, F; Freudenberg, N; Just, H; Winterer, H; Wollschläger, H, 1987)
"The combination therapy with M + E produces a minimal change in hemodynamics and appears safe as an adjunctive therapy to PCI in AMI patients."6.79Safety of combination therapy with milrinone and esmolol for heart protection during percutaneous coronary intervention in acute myocardial infarction. ( Chan, KH; Chan, MY; Fujise, K; Huang, MH; Lee, CH; Low, AF; Lui, CY; Nguyen, V; Poh, KK; Sia, W; Tan, HC; Tang, LQ; Tay, EL; Xu, X, 2014)
"The milrinone plasma level was significantly greater in group III than in the other groups (group I, 0 ng/mL; group II, 1."5.40Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction. ( Al Kindi, H; Nepotchatykh, O; Paul, A; Prakash, S; Schwertani, A; Shum-Tim, D; You, Z, 2014)
"Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography."5.29Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts. ( Blazincic, B; Klaus, W; Rump, AF, 1993)
"Milrinone is a phosphodiesterase inhibitor which combines vasodilating effects with inotropic effects."5.28Beneficial hemodynamic effects of two weeks' milrinone treatment in conscious rats with heart failure. ( Debets, JJ; Schoemaker, RG; Smits, JF; Struyker-Boudier, HA, 1990)
"Treatment with milrinone (2."5.28Beneficial hemodynamic effects of milrinone and enalapril in conscious rats with healed myocardial infarction. ( DeFelice, A; Frering, R; Harris, A; Horan, P, 1989)
"Serum levels of creatine phosphokinase (CPK), the MB isoenzyme of creatine kinase (CK-MB), occurrence of myocardial ischemia or infarction, and mean duration of using inotropic agents were significantly lower in the milrinone group (p < 0."5.14Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: A randomized controlled trial. ( Darehzereshki, A; Dianat, S; Eghtesadi-Araghi, P; Ghazinoor, M; Goodarzynejad, H; Jebeli, M; Mandegar, MH; Mohammadzadeh, R; Rasouli, MR, 2010)
"The purpose of this study was to compare the hemodynamic and clinical effects of milrinone, a vasodilating and positive inotropic agent, with those of dobutamine in patients with congestive heart failure (CHF) following acute myocardial infarction (AMI)."5.08Comparative efficacy of short-term intravenous infusions of milrinone and dobutamine in acute congestive heart failure following acute myocardial infarction. Milrinone-Dobutamine Study Group. ( Berk, MR; DeMaria, AN; DeWood, MA; Karlsberg, RP; Lasher, KP, 1996)
" 1) Milrinone decreased incidence of myocardial ischemia and myocardial infarction (15."4.93Effect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials. ( Cheng, X; Huang, L; Jiang, X; Wu, Q; Wu, Y; You, Z, 2016)
" Parenteral sympathomimetic agents, usually dobutamine, and phosphodiesterase inhibitors, usually milrinone, are used for the management of exacerbations of chronic systolic heart failure."4.82Role of nonglycosidic inotropic agents: indications, ethics, and limitations. ( Chatterjee, K; De Marco, T, 2003)
"The authors examined whether milrinone and levosimendan could exert cardiac postconditioning effects in rats under normoglycemia and hyperglycemia, and whether the effects could be mediated by mitochondrial permeability transition pore (mPTP)."3.78Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts. ( Cho, S; Hara, T; Higashijima, U; Maekawa, T; Matsumoto, S; Sumikawa, K; Tosaka, S, 2012)
"To evaluate: 1) the effects of dobutamine (DOB) on left ventricular function in early (48-72 h) and late (14 days) phases of a post-MI canine model, compared to ISTA, and 2) the efficacy of DOB in chronic left ventricular dysfunction (6 months post-MI) in dogs pre-treated or not with a beta-blocker, compared with ISTA and milrinone (MIL)."3.74Sympathomimetic inefficiency in restoring contractility in the acute or chronic beta-blocker-treated ischaemic heart: comparison with a new agent. ( Borsini, F; Carminati, P; Gagnol, JP; Loi, FM; Mattera, GG; Vanoli, E, 2008)
"This study compared the effects of simendan, a calcium sensitizer, with those of milrinone and enalapril on survival of rats with healed myocardial infarction."3.71Improved survival with simendan after experimental myocardial infarction in rats. ( Haikala, H; Kaheinen, P; Levijoki, J; Pollesello, P, 2001)
"Chronic milrinone therapy after acute myocardial infarction improves cardiac hemodynamic indexes and attenuates progressive left ventricular dilation."3.68Effects of milrinone on left ventricular remodeling after acute myocardial infarction. ( Brown, EJ; Halpern, J; Jain, P; Langenback, EG; Lillis, O; Mannisi, JA; Raeder, E, 1991)
"The effects of milrinone and pimobendan upon the initiation of programmed ventricular stimulation-induced ventricular tachycardia (VT) and the incidence of lethal ischemic ventricular arrhythmias were assessed in conscious dogs with recent anterior myocardial infarctions."3.67Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction. ( Driscoll, EM; Frye, JW; Kitzen, JM; Lucchesi, BR; Lynch, JJ; Uprichard, AC, 1989)
"The long-term survival of rats with healed myocardial infarction and congestive heart failure treated with milrinone, enalapril and the combination of milrinone plus enalapril, was documented."3.67Beneficial effects of milrinone and enalapril on long-term survival of rats with healed myocardial infarction. ( Emmert, SE; Heyse, JF; Ludden, CT; Stabilito, II; Sweet, CS, 1988)
"The present study was designed to evaluate the regional vascular profile of milrinone in the setting of experimental heart failure."3.67[Central and regional vascular hemodynamics of milrinone in experimental heart failure: comparison with captopril and dobutamine]. ( Drexler, H; Faude, F; Freudenberg, N; Just, H; Winterer, H; Wollschläger, H, 1987)
"The combination therapy with M + E produces a minimal change in hemodynamics and appears safe as an adjunctive therapy to PCI in AMI patients."2.79Safety of combination therapy with milrinone and esmolol for heart protection during percutaneous coronary intervention in acute myocardial infarction. ( Chan, KH; Chan, MY; Fujise, K; Huang, MH; Lee, CH; Low, AF; Lui, CY; Nguyen, V; Poh, KK; Sia, W; Tan, HC; Tang, LQ; Tay, EL; Xu, X, 2014)
"The milrinone plasma level was significantly greater in group III than in the other groups (group I, 0 ng/mL; group II, 1."1.40Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction. ( Al Kindi, H; Nepotchatykh, O; Paul, A; Prakash, S; Schwertani, A; Shum-Tim, D; You, Z, 2014)
"Olprinone was also examined with an intracoronary cotreatment with a PKA inhibitor (H89), a PKC inhibitor (GF109203X), an extracellular signal-regulated kinase kinase (MEK) inhibitor (PD98059), or a p38 MAPK inhibitor (SB203580) throughout the preischemic period."1.31Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase. ( Asakura, M; Asanuma, H; Fukushima, T; Hori, M; Kitakaze, M; Kuzuya, T; Liao, Y; Mori, H; Node, K; Ogai, A; Ogita, H; Papst, PJ; Sakata, Y; Sanada, S; Shinozaki, Y; Takashima, S; Terada, N; Yamada, J, 2001)
"Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography."1.29Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts. ( Blazincic, B; Klaus, W; Rump, AF, 1993)
"Milrinone is a phosphodiesterase inhibitor which combines vasodilating effects with inotropic effects."1.28Beneficial hemodynamic effects of two weeks' milrinone treatment in conscious rats with heart failure. ( Debets, JJ; Schoemaker, RG; Smits, JF; Struyker-Boudier, HA, 1990)
"Treatment with milrinone (2."1.28Beneficial hemodynamic effects of milrinone and enalapril in conscious rats with healed myocardial infarction. ( DeFelice, A; Frering, R; Harris, A; Horan, P, 1989)
"Enalaprilat was tested in a similar design with the infusion phase (70 micrograms/kg, total dose) separated by oral enalapril (Enal), 1 mg/kg/day."1.27Acute and subacute hemodynamic effects of enalaprilat, milrinone and combination therapy in rats with chronic left ventricular dysfunction. ( Emmert, SE; Stabilito, II; Sweet, CS, 1987)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19908 (21.62)18.7374
1990's10 (27.03)18.2507
2000's6 (16.22)29.6817
2010's10 (27.03)24.3611
2020's3 (8.11)2.80

Authors

AuthorsStudies
Jung, RG2
Di Santo, P2
Mathew, R2
Abdel-Razek, O2
Parlow, S2
Simard, T2
Marbach, JA1
Gillmore, T1
Mao, B1
Bernick, J1
Theriault-Lauzier, P1
Fu, A2
Lau, L1
Motazedian, P2
Russo, JJ1
Labinaz, M1
Hibbert, B2
Prosperi-Porta, G1
Hutson, J1
Malhotra, N1
Ramirez, FD1
Froeschl, M1
Torregroza, C1
Maas, K1
Feige, K1
Raupach, A2
Stroethoff, M1
Heinen, A2
Hollmann, MW2
Huhn, R2
Behmenburg, F1
Trefz, L1
Dorsch, M1
Ströthoff, M1
Mathes, A1
Berger, MM1
Lee, TM1
Lin, SZ1
Chang, NC1
Poh, KK1
Xu, X1
Chan, MY1
Lee, CH1
Tay, EL1
Low, AF1
Chan, KH1
Sia, W1
Tang, LQ1
Tan, HC1
Lui, CY1
Nguyen, V1
Fujise, K1
Huang, MH1
Al Kindi, H1
Paul, A1
You, Z2
Nepotchatykh, O1
Schwertani, A1
Prakash, S1
Shum-Tim, D1
Tang, X1
Liu, P1
Li, R1
Jing, Q1
Lv, J1
Liu, L1
Liu, Y1
Novaes, RD1
Gonçalves, RV1
Huang, L1
Cheng, X1
Wu, Q1
Jiang, X1
Wu, Y1
Mattera, GG1
Vanoli, E1
Gagnol, JP1
Loi, FM1
Borsini, F1
Carminati, P1
Hein, M1
Roehl, AB1
Baumert, JH1
Scherer, K1
Steendijk, P1
Rossaint, R1
Jebeli, M1
Ghazinoor, M1
Mandegar, MH1
Rasouli, MR1
Eghtesadi-Araghi, P1
Goodarzynejad, H1
Mohammadzadeh, R1
Darehzereshki, A1
Dianat, S1
Matsumoto, S1
Cho, S1
Tosaka, S1
Higashijima, U1
Maekawa, T1
Hara, T1
Sumikawa, K1
Chatterjee, K1
De Marco, T1
Palmaers, T1
Albrecht, S1
Heuser, F1
Leuthold, C1
Schuettler, J1
Schmitz, B1
Alonso Francia, C1
Calvo Cebollero, I1
Diarte de Miguel, JA1
Gomollón García, JP1
Placer Peralta, LJ1
Rump, AF1
Blazincic, B1
Klaus, W1
Jain, P2
Hughes, M1
Korlipara, G1
Lillis, O2
Dervan, JP1
Cohn, PF1
Karlsberg, RP1
DeWood, MA1
DeMaria, AN1
Berk, MR1
Lasher, KP1
Levijoki, J1
Pollesello, P1
Kaheinen, P1
Haikala, H1
Sanada, S1
Kitakaze, M1
Papst, PJ1
Asanuma, H1
Node, K1
Takashima, S1
Asakura, M1
Ogita, H1
Liao, Y1
Sakata, Y1
Ogai, A1
Fukushima, T1
Yamada, J1
Shinozaki, Y1
Kuzuya, T1
Mori, H1
Terada, N1
Hori, M1
Pagani, ED1
Buchholz, RA1
Silver, PJ1
Feneck, RO1
Trolese-Mongheal, Y1
Barthelemy, J1
Paire, M1
Duchene-Marullaz, P1
Brown, EJ1
Langenback, EG1
Raeder, E1
Halpern, J1
Mannisi, JA1
Schoemaker, RG2
Smits, JF2
Debets, JJ1
Struyker-Boudier, HA1
Lynch, JJ1
Uprichard, AC1
Frye, JW1
Driscoll, EM1
Kitzen, JM1
Lucchesi, BR1
DeFelice, A1
Harris, A1
Frering, R1
Horan, P1
Vleeming, W1
van der Wouw, PA1
van Rooij, HH1
Wemer, J1
Porsius, AJ1
Sweet, CS2
Ludden, CT1
Stabilito, II2
Emmert, SE2
Heyse, JF1
Drexler, H2
Faude, F2
Winterer, H1
Wollschläger, H1
Freudenberg, N1
Just, H2
Campbell, CA1
Reddy, BR1
Alker, KJ1
Wynne, J1
Kloner, RA1
Höing, S1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Milrinone Versus Dobutamine in a Heterogeneous Population of Critically Ill Patients[NCT03207165]Phase 4192 participants (Actual)Interventional2017-08-30Completed
Concomitant Milrinone and Esmolol Treatment in Patients With Acute Myocardial Infarction[NCT02098629]Phase 1/Phase 20 participants (Actual)Interventional2015-05-31Withdrawn (stopped due to Difficulty in enrollment)
Acute and Chronic Protective Effects of Peri-interventional Administration of Levosimendan in ST Elevation Myocardial Infarctions[NCT03022877]0 participants (Actual)Interventional2017-06-30Withdrawn (stopped due to Rationale obsolete)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for milrinone and Cardiovascular Stroke

ArticleYear
Milrinone for the Treatment of Acute Heart Failure After Acute Myocardial Infarction: A Systematic Review and Meta-Analysis.
    Basic & clinical pharmacology & toxicology, 2015, Volume: 117, Issue:3

    Topics: Cardiotonic Agents; Heart Failure; Humans; Milrinone; Myocardial Infarction

2015
Effect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials.
    Drug design, development and therapy, 2016, Volume: 10

    Topics: Cardiotonic Agents; Coronary Artery Bypass; Humans; Intensive Care Units; Length of Stay; Milrinone;

2016
Role of nonglycosidic inotropic agents: indications, ethics, and limitations.
    The Medical clinics of North America, 2003, Volume: 87, Issue:2

    Topics: Adrenergic beta-Antagonists; Cardiac Glycosides; Cardiotonic Agents; Dobutamine; Ethics, Clinical; H

2003
[Therapeutic options in cardiogenic shock].
    Revista espanola de cardiologia, 1995, Volume: 48, Issue:9

    Topics: Amrinone; Angioplasty, Balloon, Coronary; Assisted Circulation; Cardiotonic Agents; Coronary Artery

1995

Trials

6 trials available for milrinone and Cardiovascular Stroke

ArticleYear
Implications of Myocardial Infarction on Management and Outcome in Cardiogenic Shock.
    Journal of the American Heart Association, 2021, 11-02, Volume: 10, Issue:21

    Topics: Dobutamine; Heart Arrest; Humans; Milrinone; Myocardial Infarction; Percutaneous Coronary Interventi

2021
No sex-based difference in cardiogenic shock: A post-hoc analysis of the DOREMI trial.
    Journal of cardiology, 2022, Volume: 80, Issue:4

    Topics: Dobutamine; Female; Heart Arrest; Humans; Male; Milrinone; Myocardial Infarction; Shock, Cardiogenic

2022
Safety of combination therapy with milrinone and esmolol for heart protection during percutaneous coronary intervention in acute myocardial infarction.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:5

    Topics: Blood Pressure; Drug Therapy, Combination; Electrocardiography; Heart Rate; Humans; Infusions, Intra

2014
Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: A randomized controlled trial.
    Cardiology journal, 2010, Volume: 17, Issue:1

    Topics: Aged; Cardiotonic Agents; Coronary Artery Bypass; Creatine Kinase; Creatine Kinase, MB Form; Drug Ad

2010
Comparative efficacy of short-term intravenous infusions of milrinone and dobutamine in acute congestive heart failure following acute myocardial infarction. Milrinone-Dobutamine Study Group.
    Clinical cardiology, 1996, Volume: 19, Issue:1

    Topics: Acute Disease; Aged; Cardiotonic Agents; Dobutamine; Echocardiography; Electrocardiography, Ambulato

1996
Intravenous milrinone following cardiac surgery: II. Influence of baseline hemodynamics and patient factors on therapeutic response. The European Milrinone Multicentre Trial Group.
    Journal of cardiothoracic and vascular anesthesia, 1992, Volume: 6, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Blood Pressure; Cardiac Output; Cardiac Surgica

1992

Other Studies

27 other studies available for milrinone and Cardiovascular Stroke

ArticleYear
Combination of the Phosphodiesterase Inhibitors Sildenafil and Milrinone Induces Cardioprotection With Various Conditioning Strategies.
    Journal of cardiovascular pharmacology, 2020, Volume: 76, Issue:6

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hemody

2020
Milrinone-Induced Postconditioning Requires Activation of Mitochondrial Ca
    Journal of cardiothoracic and vascular anesthesia, 2018, Volume: 32, Issue:5

    Topics: Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Large-Conductance Calcium-Activated P

2018
Differential effect of phosphodiesterase-3 inhibitors on sympathetic hyperinnervation in healed rat infarcts.
    Circulation journal : official journal of the Japanese Circulation Society, 2014, Volume: 78, Issue:2

    Topics: Animals; Cilostazol; Heart; Male; Milrinone; Myocardial Infarction; Phosphodiesterase 3 Inhibitors;

2014
Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction.
    The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:5

    Topics: Animals; Blood Pressure; Cardiotonic Agents; Cell Adhesion Molecules; Chemistry, Pharmaceutical; Chr

2014
Discussion.
    The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:5

    Topics: Animals; Cardiotonic Agents; Female; Heart Failure; Milrinone; Myocardial Infarction

2014
Methodological Perspectives from 'Milrinone for the Treatment of Acute Heart Failure After Acute Myocardial Infarction: A Systematic Review and Meta-analysis'.
    Basic & clinical pharmacology & toxicology, 2015, Volume: 117, Issue:6

    Topics: Cardiotonic Agents; Heart Failure; Humans; Milrinone; Myocardial Infarction

2015
Sympathomimetic inefficiency in restoring contractility in the acute or chronic beta-blocker-treated ischaemic heart: comparison with a new agent.
    European journal of heart failure, 2008, Volume: 10, Issue:10

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Dobutamine; Dogs

2008
Anti-ischemic effects of inotropic agents in experimental right ventricular infarction.
    Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:7

    Topics: Animals; Blood Gas Analysis; Cardiotonic Agents; Dobutamine; Female; Heart Ventricles; Hemodynamics;

2009
Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts.
    Cardiovascular diabetology, 2012, Jan-12, Volume: 11

    Topics: Animals; Blood Glucose; Disease Models, Animal; Hemodynamics; Hydrazones; Hyperglycemia; Male; Milri

2012
Milrinone combined with vasopressin improves cardiac index after cardiopulmonary resuscitation in a pig model of myocardial infarction.
    Anesthesiology, 2007, Volume: 106, Issue:1

    Topics: Animals; Blood Pressure; Cardiopulmonary Resuscitation; Coronary Circulation; Disease Models, Animal

2007
Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:12

    Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Fluorescence; Hemodynamics; Histocytoch

1993
The effects of chronic oral milrinone therapy on early postinfarction left ventricular remodeling.
    American heart journal, 1993, Volume: 126, Issue:3 Pt 1

    Topics: Administration, Oral; Analysis of Variance; Animals; Cardiotonic Agents; Disease Models, Animal; Dru

1993
Improved survival with simendan after experimental myocardial infarction in rats.
    European journal of pharmacology, 2001, May-11, Volume: 419, Issue:2-3

    Topics: Animals; Antihypertensive Agents; Cardiotonic Agents; Enalapril; Hydrazones; Male; Milrinone; Myocar

2001
Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase.
    Circulation, 2001, Aug-07, Volume: 104, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Flow Velocity; Bucladesine; Calcium-Calmodulin-D

2001
Cardiovascular cyclic nucleotide phosphodiesterases and their role in regulating cardiovascular function.
    Basic research in cardiology, 1992, Volume: 87 Suppl 1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Heart Failure; Humans;

1992
Arrhythmogenic potencies of amrinone and milrinone in unanesthetized dogs with myocardial infarct.
    General pharmacology, 1992, Volume: 23, Issue:1

    Topics: Amrinone; Analysis of Variance; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Dogs; Heart Rate;

1992
Effects of milrinone on left ventricular remodeling after acute myocardial infarction.
    Circulation, 1991, Volume: 84, Issue:2

    Topics: Animals; Female; Heart; Heart Ventricles; Hemodynamics; Milrinone; Myocardial Infarction; Myocardium

1991
Systolic time intervals as indicators for cardiac function in rat models for heart failure.
    European heart journal, 1990, Volume: 11 Suppl I

    Topics: Age Factors; Animals; Blood Flow Velocity; Captopril; Cardiac Output; Cardiotonic Agents; Dobutamine

1990
Beneficial hemodynamic effects of two weeks' milrinone treatment in conscious rats with heart failure.
    European journal of pharmacology, 1990, Jul-17, Volume: 182, Issue:3

    Topics: Animals; Blood Pressure; Cardiac Output; Coronary Vessels; Heart Failure; Hemodynamics; Male; Milrin

1990
Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction.
    Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Vessels; Dogs; Electric Stimulation; Ele

1989
Beneficial hemodynamic effects of milrinone and enalapril in conscious rats with healed myocardial infarction.
    European journal of pharmacology, 1989, Aug-22, Volume: 167, Issue:2

    Topics: Administration, Oral; Animals; Blood Pressure; Enalapril; Heart Rate; Hemodynamics; Male; Milrinone;

1989
In vitro method for measurement of cardiac performance and responses to inotropic drugs after experimentally induced myocardial infarction in the rat.
    Journal of pharmacological methods, 1989, Volume: 21, Issue:2

    Topics: Animals; Cardiotonic Agents; Coronary Circulation; Dobutamine; Heart; In Vitro Techniques; Male; Mil

1989
Beneficial effects of milrinone and enalapril on long-term survival of rats with healed myocardial infarction.
    European journal of pharmacology, 1988, Feb-16, Volume: 147, Issue:1

    Topics: Animals; Body Weight; Cardiomegaly; Cardiotonic Agents; Electrocardiography; Enalapril; Heart Failur

1988
Acute and subacute hemodynamic effects of enalaprilat, milrinone and combination therapy in rats with chronic left ventricular dysfunction.
    Clinical and experimental hypertension. Part A, Theory and practice, 1987, Volume: 9, Issue:2-3

    Topics: Animals; Antihypertensive Agents; Drug Therapy, Combination; Enalapril; Enalaprilat; Heart Failure;

1987
[Central and regional vascular hemodynamics of milrinone in experimental heart failure: comparison with captopril and dobutamine].
    Zeitschrift fur Kardiologie, 1987, Volume: 76, Issue:8

    Topics: Animals; Captopril; Dobutamine; Heart Failure; Hemodynamics; Male; Milrinone; Muscles; Myocardial In

1987
Effect of milrinone on acute myocardial infarct size.
    The American journal of cardiology, 1987, Aug-01, Volume: 60, Issue:4

    Topics: Animals; Cardiotonic Agents; Dogs; Hemodynamics; Milrinone; Myocardial Contraction; Myocardial Infar

1987
Blood flow distribution within skeletal muscle during exercise in the presence of chronic heart failure: effect of milrinone.
    Circulation, 1987, Volume: 76, Issue:6

    Topics: Animals; Heart Failure; Hemodynamics; Male; Milrinone; Muscles; Myocardial Infarction; Physical Exer

1987