milrinone has been researched along with Cardiac Output, Low in 61 studies
Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare levosimendan with milrinone to prevent low cardiac output syndrome in patients undergoing tetralogy of Fallot correction." | 9.51 | [Levosimendan for preventing low output syndrome in pediatric patients with correction of tetralogy of Fallot]. ( Dosta-Herrera, JJ; Gutiérrez-Riveroll, KI; Mejía Picazo, HJ, 2022) |
| " Allometrically scaled body weight, AKI stages, and maturation function were identified as significant predictors of milrinone clearance." | 9.30 | Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. ( Alten, J; Cooper, DS; Gao, Z; Gist, KM; Goldstein, SL; Mizuno, T; Vinks, AA; Wempe, MF, 2019) |
| "There is insufficient evidence of the effectiveness of prophylactic milrinone in preventing death or low cardiac output syndrome in children undergoing surgery for congenital heart disease, compared to placebo." | 8.91 | Prophylactic milrinone for the prevention of low cardiac output syndrome and mortality in children undergoing surgery for congenital heart disease. ( Burkhardt, BE; Rücker, G; Stiller, B, 2015) |
| "In patients with acute postoperative heart failure, before receiving milrinone, renal blood flow was lower (-33%, p < ." | 7.96 | Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery. ( Bragadottir, G; Lannemyr, L; Redfors, B; Ricksten, SE, 2020) |
| "To describe a case of milrinone-associated tachycardia that was successfully treated with two beta-blockers." | 7.70 | Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998) |
| "To compare levosimendan with milrinone to prevent low cardiac output syndrome in patients undergoing tetralogy of Fallot correction." | 5.51 | [Levosimendan for preventing low output syndrome in pediatric patients with correction of tetralogy of Fallot]. ( Dosta-Herrera, JJ; Gutiérrez-Riveroll, KI; Mejía Picazo, HJ, 2022) |
| " Allometrically scaled body weight, AKI stages, and maturation function were identified as significant predictors of milrinone clearance." | 5.30 | Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. ( Alten, J; Cooper, DS; Gao, Z; Gist, KM; Goldstein, SL; Mizuno, T; Vinks, AA; Wempe, MF, 2019) |
| "Milrinone is a drug frequently used for hemodynamic support in children during critical illness." | 5.05 | The effect of milrinone on hemodynamic and gas exchange parameters in children. ( Dorsey, V; Flores, S; Loomba, RS; Villarreal, EG, 2020) |
| "There is insufficient evidence of the effectiveness of prophylactic milrinone in preventing death or low cardiac output syndrome in children undergoing surgery for congenital heart disease, compared to placebo." | 4.91 | Prophylactic milrinone for the prevention of low cardiac output syndrome and mortality in children undergoing surgery for congenital heart disease. ( Burkhardt, BE; Rücker, G; Stiller, B, 2015) |
| "In patients with acute postoperative heart failure, before receiving milrinone, renal blood flow was lower (-33%, p < ." | 3.96 | Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery. ( Bragadottir, G; Lannemyr, L; Redfors, B; Ricksten, SE, 2020) |
| "To describe a case of milrinone-associated tachycardia that was successfully treated with two beta-blockers." | 3.70 | Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998) |
| "To prevent low cardiac output syndrome, prophylactic administration of milrinone after cardiopulmonary bypass is commonly used in small children." | 2.77 | Levosimendan versus milrinone in neonates and infants after corrective open-heart surgery: a pilot study. ( Freynschlag, R; Gombotz, H; Hofer, A; Lechner, E; Leitner-Peneder, G; Mair, R; Rehak, P; Weinzettel, R, 2012) |
| "Iloprost was administered during weaning from cardiopulmonary bypass (CPB)." | 2.73 | Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: a prospective, randomized-controlled trial. ( Autschbach, R; Buhre, W; de Waal, EE; Flier, S; Metzelder, S; Rex, S; Rossaint, R; Schaelte, G, 2008) |
| "We used population pharmacokinetic modeling to develop an optimal dosing regimen for milrinone." | 2.72 | Pilot study of milrinone for low systemic blood flow in very preterm infants. ( Evans, N; Kluckow, M; McLachlan, AJ; Osborn, D; Paradisis, M, 2006) |
| "The hemodynamic, mixed venous oxygen saturation, oxygen extraction ratios, arterial lactate concentrations, and postoperative insulin infusion rates were serially documented for the first 48 hours after the diagnosis." | 2.72 | Levosimendan or milrinone in the type 2 diabetic patient with low ejection fraction undergoing elective coronary artery surgery. ( Al-Shawaf, E; Ayed, A; Dehrab, N; Radomir, B; Tarazi, R; Vislocky, I, 2006) |
| "Milrinone was associated with a higher incidence of sinus bradycardia (D = 2%, M = 13%; p < 0." | 2.70 | Comparison of the hemodynamic effects of milrinone with dobutamine in patients after cardiac surgery. ( Feneck, RO; Oduro-Dominah, A; Sherry, KM; Withington, PS, 2001) |
| "Milrinone was intravenously administered in three stages: a) baseline stage, in which patients had a stable hemodynamic status, ventilation and gas exchange, hemostasis, and body temperature; b) loading stage, in which a 50 microgram/kg intravenous loading dose of milrinone was administered over 15 mins; and c) infusion stage, in which milrinone was continuously infused at 0." | 2.68 | Milrinone: systemic and pulmonary hemodynamic effects in neonates after cardiac surgery. ( Atz, AM; Burke, RP; Chang, AC; Wernovsky, G; Wessel, DL, 1995) |
| "Milrinone is a phosphodiesterase F-III inhibitor with positive inotropic and vasodilating activities." | 2.68 | Multicenter, double-blind study of intravenous milrinone for patients with acute heart failure in Japan. Japan Intravenous Milrinone Investigators. ( Hayakawa, H; Katoh, K; Momomura, S; Seino, Y; Takano, T, 1996) |
| " Patients were allocated to each dosage group sequentially, not randomly." | 2.67 | Intravenous milrinone following cardiac surgery: I. Effects of bolus infusion followed by variable dose maintenance infusion. The European Milrinone Multicentre Trial Group. ( Feneck, RO, 1992) |
| " Three dosage regimens were investigated sequentially." | 2.67 | Milrinone in the treatment of low output states following cardiac surgery. ( Sherry, KM; Skoyles, J; Wright, EM, 1992) |
| " Patients were allocated to each dosage group sequentially, not randomly." | 2.67 | Effects of variable dose milrinone in patients with low cardiac output after cardiac surgery. European Multicenter Trial Group. ( Feneck, RO, 1991) |
| "Postoperative low cardiac output syndrome has been shown to have both a central and a peripheral vascular involvement." | 2.53 | Inodilators in the Management of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery. ( Bautista-Hernandez, V; Ferrer-Barba, A; Gonzalez-Rivera, I, 2016) |
| "In non-hyperdynamic septic shock, CI, SVI, and DO₂ significantly increased while SVRI significantly decreased after milrinone when compared to placebo." | 2.47 | The role of milrinone in children with cardiovascular compromise: review of the literature. ( Abdul-Khaliq, H; Brown, K; Gortner, L; Meyer, S, 2011) |
| "Management of patients with low cardiac output syndromes is difficult." | 2.44 | Nesiritide compared with milrinone for cardiac surgery. ( Blais, DM, 2007) |
| "Milrinone has been shown to be effective in the treatment of acute low output syndrome, and a loading bolus infusion of 50 micrograms kg-1 over 10 min causes an increase in cardiac index and a fall in pulmonary capillary wedge pressure." | 2.38 | Overview of the effects of intravenous milrinone in acute heart failure following surgery. ( Copp, MV; Feneck, RO; Hill, AJ, 1992) |
| "Nine (18%) developed low cardiac output syndrome." | 1.62 | Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery. ( Campbell, K; Gist, KM; Karimpour-Fard, A; Korst, A; Miyamoto, SD; Nakano, SJ; Stauffer, BL; Sucharov, CC; Wempe, MF; Zhou, W, 2021) |
| "The PBPK drug-disease model for milrinone in paediatric patients with and without LCOS after open heart surgery highlights that age, disease and surgery differently impact the pharmacokinetics of milrinone, and that current milrinone dosing for LCOS is suboptimal to maintain the therapeutic target range across the entire paediatric age range." | 1.40 | Evaluation and optimisation of current milrinone prescribing for the treatment and prevention of low cardiac output syndrome in paediatric patients after open heart surgery using a physiology-based pharmacokinetic drug-disease model. ( Vogt, W, 2014) |
| " The availability of drug and dosing information for prescribing was stated to be insufficient by 40% of participants, while 88% would appreciate clinical practice guidelines." | 1.37 | Treatment for paediatric low cardiac output syndrome: results from the European EuLoCOS-Paed survey. ( Läer, S; Vogt, W, 2011) |
| " Beta-blocker dosages were titrated, and three patients achieved the target beta-blocker dosage established for stage A-C heart failure." | 1.34 | Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone. ( Earl, GL; Fitzpatrick, JM; Narula, J; Verbos-Kazanas, MA, 2007) |
| "Milrinone was tolerated well: three patients developed tachycardia greater than 125 beat min-1, one patient developed atrial fibrillation and one patient had a short run of atrial bigemini." | 1.28 | Clinical and haemodynamic effects of milrinone in the treatment of low cardiac output after cardiac surgery. ( Sherry, KM; Wright, EM, 1991) |
| "Milrinone was administered as a bolus of 50 micrograms/kg/min over 10 minutes followed by a continuous infusion for at least 12 hours." | 1.28 | [Hemodynamic effects of milrinone in the treatment of cardiac insufficiency after heart surgery with extracorporeal circulation]. ( Caillard, B; Lançon, JP; Le Bloch, Y; Leblanc-Beaufils, C; Obadia, JF; Pillet, M, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (31.15) | 18.2507 |
| 2000's | 21 (34.43) | 29.6817 |
| 2010's | 14 (22.95) | 24.3611 |
| 2020's | 7 (11.48) | 2.80 |
| Authors | Studies |
|---|---|
| Gutiérrez-Riveroll, KI | 1 |
| Mejía Picazo, HJ | 1 |
| Dosta-Herrera, JJ | 1 |
| Taylor, K | 1 |
| Pehora, C | 1 |
| Faraoni, D | 1 |
| Ferri, S | 1 |
| Colantonio, D | 1 |
| Laussen, P | 1 |
| Schwartz, S | 1 |
| Parshuram, C | 1 |
| Loomba, RS | 1 |
| Dorsey, V | 1 |
| Villarreal, EG | 1 |
| Flores, S | 1 |
| Lannemyr, L | 1 |
| Bragadottir, G | 1 |
| Redfors, B | 1 |
| Ricksten, SE | 1 |
| Seilitz, J | 1 |
| Grafver, I | 1 |
| Kiszakiewicz, L | 1 |
| Oikonomakis, I | 1 |
| Jansson, K | 1 |
| Axelsson, B | 1 |
| Nilsson, KF | 1 |
| Gist, KM | 2 |
| Korst, A | 1 |
| Nakano, SJ | 1 |
| Stauffer, BL | 1 |
| Karimpour-Fard, A | 1 |
| Zhou, W | 1 |
| Campbell, K | 1 |
| Wempe, MF | 2 |
| Sucharov, CC | 1 |
| Miyamoto, SD | 1 |
| DiNardo, JA | 1 |
| Nasr, VG | 1 |
| Grocott, HP | 1 |
| Cavigelli-Brunner, A | 1 |
| Hug, MI | 1 |
| Dave, H | 1 |
| Baenziger, O | 1 |
| Buerki, C | 1 |
| Bettex, D | 1 |
| Cannizzaro, V | 1 |
| Balmer, C | 1 |
| Schindler, E | 1 |
| Yamamoto, T | 2 |
| Mizuno, T | 1 |
| Gao, Z | 1 |
| Alten, J | 1 |
| Cooper, DS | 1 |
| Goldstein, SL | 1 |
| Vinks, AA | 1 |
| Mathew, R | 1 |
| Visintini, SM | 1 |
| Ramirez, FD | 1 |
| DiSanto, P | 1 |
| Simard, T | 1 |
| Labinaz, M | 1 |
| Hibbert, BM | 1 |
| Vogt, W | 4 |
| Burkhardt, BE | 1 |
| Rücker, G | 1 |
| Stiller, B | 1 |
| Ferrer-Barba, A | 1 |
| Gonzalez-Rivera, I | 1 |
| Bautista-Hernandez, V | 1 |
| von Scheidt, W | 1 |
| Pauschinger, M | 1 |
| Ertl, G | 1 |
| Paradisis, M | 2 |
| Evans, N | 2 |
| Kluckow, M | 2 |
| Osborn, D | 2 |
| Meyer, S | 1 |
| Gortner, L | 1 |
| Brown, K | 1 |
| Abdul-Khaliq, H | 1 |
| Läer, S | 3 |
| Lechner, E | 1 |
| Hofer, A | 1 |
| Leitner-Peneder, G | 1 |
| Freynschlag, R | 1 |
| Mair, R | 1 |
| Weinzettel, R | 1 |
| Rehak, P | 1 |
| Gombotz, H | 1 |
| Hoffman, TM | 2 |
| Wernovsky, G | 4 |
| Atz, AM | 3 |
| Kulik, TJ | 2 |
| Nelson, DP | 2 |
| Chang, AC | 3 |
| Bailey, JM | 2 |
| Akbary, A | 2 |
| Kocsis, JF | 2 |
| Kaczmarek, R | 1 |
| Spray, TL | 2 |
| Wessel, DL | 4 |
| Ravishankar, C | 1 |
| Tabbutt, S | 1 |
| Osborn, DA | 1 |
| Barrington, KJ | 1 |
| Dempsey, EM | 1 |
| McLachlan, AJ | 1 |
| Al-Shawaf, E | 1 |
| Ayed, A | 1 |
| Vislocky, I | 1 |
| Radomir, B | 1 |
| Dehrab, N | 1 |
| Tarazi, R | 1 |
| Cripe, LH | 1 |
| Barber, BJ | 1 |
| Spicer, RL | 1 |
| Wong, BL | 1 |
| Weidner, N | 1 |
| Benson, DW | 1 |
| Markham, LW | 1 |
| Stocker, CF | 1 |
| Shekerdemian, LS | 1 |
| Nørgaard, MA | 1 |
| Brizard, CP | 1 |
| Mynard, JP | 1 |
| Horton, SB | 1 |
| Penny, DJ | 1 |
| Seri, I | 1 |
| Brackbill, ML | 1 |
| Stam, MD | 1 |
| Schuller-Williams, RV | 1 |
| Dhavle, AA | 1 |
| Blais, DM | 1 |
| Earl, GL | 1 |
| Verbos-Kazanas, MA | 1 |
| Fitzpatrick, JM | 1 |
| Narula, J | 1 |
| Heringlake, M | 1 |
| Wernerus, M | 1 |
| Grünefeld, J | 1 |
| Klaus, S | 1 |
| Heinze, H | 1 |
| Bechtel, M | 1 |
| Bahlmann, L | 1 |
| Poeling, J | 1 |
| Schön, J | 1 |
| Schofield, RS | 1 |
| Pierce, GL | 1 |
| Nichols, WW | 1 |
| Klodell, CT | 1 |
| Aranda, JM | 1 |
| Pauly, DF | 1 |
| Hill, JA | 1 |
| Braith, RW | 1 |
| Simkova, V | 1 |
| Radermacher, P | 1 |
| Barth, E | 1 |
| Rex, S | 1 |
| Schaelte, G | 1 |
| Metzelder, S | 1 |
| Flier, S | 1 |
| de Waal, EE | 1 |
| Autschbach, R | 1 |
| Rossaint, R | 1 |
| Buhre, W | 1 |
| Zimmermann, W | 1 |
| Scholz, H | 1 |
| Schumacher, C | 1 |
| Wenzlaff, H | 1 |
| Haverich, A | 1 |
| Burke, RP | 1 |
| Konstam, MA | 1 |
| Cody, RJ | 1 |
| Das, PA | 1 |
| Skoyles, JR | 1 |
| Sherry, KM | 4 |
| Peacock, JE | 1 |
| Fox, PA | 1 |
| Woolfrey, SG | 1 |
| Jaggers, J | 1 |
| Fullerton, DA | 1 |
| Campbell, DN | 1 |
| Andrea, B | 1 |
| Jones, SD | 1 |
| Brown, JM | 1 |
| Wolfel, EE | 1 |
| Lindenfeld, J | 1 |
| Grover, FL | 1 |
| Bristow, MR | 1 |
| Seino, Y | 1 |
| Momomura, S | 1 |
| Takano, T | 1 |
| Hayakawa, H | 1 |
| Katoh, K | 1 |
| Alhashemi, JA | 1 |
| Hooper, J | 1 |
| Bellomo, R | 1 |
| Cole, L | 1 |
| Ronco, C | 1 |
| Tanigawa, T | 1 |
| Yano, M | 1 |
| Kohno, M | 1 |
| Hisaoka, T | 1 |
| Ono, K | 1 |
| Ueyama, T | 1 |
| Kobayashi, S | 1 |
| Hisamatsu, Y | 1 |
| Ohkusa, T | 1 |
| Matsuzaki, M | 1 |
| Feneck, RO | 4 |
| Withington, PS | 1 |
| Oduro-Dominah, A | 1 |
| Van de Water, A | 1 |
| Xhonneux, R | 1 |
| Reneman, RS | 1 |
| Janssen, PA | 1 |
| Boldt, J | 1 |
| Knothe, C | 1 |
| Hempelmann, G | 1 |
| Löllgen, H | 1 |
| Fahrenkrog, U | 1 |
| Wright, EM | 2 |
| Skoyles, J | 1 |
| George, M | 1 |
| Lehot, JJ | 1 |
| Estanove, S | 1 |
| Copp, MV | 1 |
| Hill, AJ | 1 |
| Lançon, JP | 1 |
| Caillard, B | 1 |
| Obadia, JF | 1 |
| Pillet, M | 1 |
| Leblanc-Beaufils, C | 1 |
| Le Bloch, Y | 1 |
| Arnold, JM | 1 |
| Ribeiro, JP | 1 |
| Colucci, WS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)[NCT02405195] | 28 participants (Actual) | Observational | 2011-10-31 | Completed | |||
| Impact of CArdiopulmonary Bypass Flow on Renal Blood Flow, Function and OXygenation[NCT02549066] | 18 participants (Actual) | Interventional | 2016-01-31 | Completed | |||
| Hemodynamic Effects of Dopamine Versus Norepinephrine Under General Anesthesia in Infant With Congenital Heart Disease[NCT04536194] | Phase 3 | 60 participants (Actual) | Interventional | 2020-10-10 | Completed | ||
| USE OF ACUTE KIDNEY INJURY BIOMARKERS TO PREDICT IMPAIRED MILRINONE PHARMACOKINETICS IN CHILDREN FOLLOWING CARDIAC SURGERY[NCT01966237] | 92 participants (Actual) | Observational | 2013-09-30 | Completed | |||
| Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants[NCT04413097] | 140 participants (Anticipated) | Interventional | 2021-11-17 | Recruiting | |||
| STeroids to REduce Systemic Inflammation After Infant Heart Surgery (STRESS)[NCT03229538] | Phase 3 | 1,263 participants (Actual) | Interventional | 2017-10-18 | Completed | ||
| Phase 2 Prospective, Randomized, Double-Blind Pilot Study on Cardiac Output Following Corrective Open Heart Surgery in Children Less Than One Year: Use of Levosimendan Versus Milrinone.[NCT00549107] | Phase 2 | 40 participants (Anticipated) | Interventional | 2007-09-30 | Recruiting | ||
| Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass[NCT00934843] | 77 participants (Actual) | Interventional | 2007-03-31 | Completed | |||
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation[NCT02519335] | Phase 1 | 12 participants (Actual) | Interventional | 2014-09-30 | Terminated (stopped due to PI no longer at this facility) | ||
| 2- Inhaled Milrinone Prevents the Increase in Pulmonary Artery Pressure After CPB[NCT00819377] | Phase 2 | 124 participants (Anticipated) | Interventional | 2009-02-28 | Completed | ||
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery[NCT04997291] | Phase 1 | 12 participants (Anticipated) | Interventional | 2021-04-09 | Recruiting | ||
| Phase 3 Study of Adrenaline and Milrinone in Patients With Myocardial Dysfunction[NCT00446017] | Phase 3 | 60 participants | Interventional | 2003-06-30 | Completed | ||
| Platelet and Tissue cAMP: Novel Biomarkers of Milrinone Efficacy in Children[NCT02728128] | 53 participants (Actual) | Observational | 2016-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
GFR measured by renal extraction of 51Cr-EDTA (NCT02405195)
Timeframe: 6 hours
| Intervention | ml per minute per 1.73 m2 body surface (Mean) | |||
|---|---|---|---|---|
| Before CPB | CPB 30 minutes | CPB 60 minutes | Post CPB (30 - 60 minutes) | |
| CardioPulmonaryBypass | 67 | 68 | 70 | 67 |
Renal blood flow measured with PAH clearance (NCT02405195)
Timeframe: 6 hours
| Intervention | ml per minute per 1.73 m2 body surface (Mean) | |||
|---|---|---|---|---|
| Pre CPB | CPB 30 minutes | CPB 60 minutes | Post CPB (30 - 60 minutes) | |
| CardioPulmonaryBypass | 554 | 524 | 564 | 558 |
Renal oxygen extraction, defined as renal oxygen consumption divided by renal oxygen delivery (NCT02405195)
Timeframe: 6 hours
| Intervention | fraction (Mean) | |||
|---|---|---|---|---|
| Pre CPB | CPB 30 minutes | CPB 60 minutes | Post CPB (30 - 60 minutes) | |
| CardioPulmonaryBypass | 0.09 | 0.12 | 0.13 | 0.16 |
Calculated as discharge date minus surgery date. (NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 18 |
| Placebo Arm | 29 |
(NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 237 |
| Placebo Arm | 264 |
The 7 highest global ranking categories range from 91 (postoperative length of hospital stay > 90 days) to 97 (operative mortality). (NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 103 |
| Placebo Arm | 122 |
(NCT03229538)
Timeframe: up to 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 12 |
| Placebo Arm | 17 |
(NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 31 |
| Placebo Arm | 24 |
"Based upon the STS-CHSD registry defined cardiac dysfunction resulting in low cardiac output complication variable." (NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 31 |
| Placebo Arm | 37 |
(NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 41 |
| Placebo Arm | 51 |
The inotropic score was calculated by the equation using drug dosages in micrograms/kg/min, (dopamine+dobutamine) + (milrinonex10) + (epinephrinex100) and recorded hourly upon arrival to the ICUthrough 36 hours postoperatively. The highest score during this timeframe was recorded. This score converts dosages of commonly used inotropic medications into a score. The higher the score the more inotropic medications required. The minimum score would be zero indicating no inotropic medications were used. There is no maximum score. (NCT00934843)
Timeframe: over the first 36 hours after surgery
| Intervention | Scores on a scale (Mean) |
|---|---|
| MP Single Dose | 14.4 |
| MP Two Dose | 15.0 |
Number of participants who died of any cause between 36 hours and 30 days following cardiac surgery (NCT00934843)
Timeframe: at 36 hours and 30 days
| Intervention | participants (Number) |
|---|---|
| MP Single Dose | 1 |
| MP Two Dose | 0 |
The presence of low cardiac output syndrome (LCOS) was defined by the same definition used in the PRIMACORP study (Hoffman TM.et.al. Circulation 2003 107:996-1002). Specifically, if there were clinical signs and symptoms of low cardiac output (e.g., tachycardia, oliguria, cold extremities, cardiac arrest, etc.) which required one or more of the following interventions: mechanical circulatory support, the escalation of existing pharmacological circulatory support to >100% over baseline, or the initiation of new pharmacological circulatory support. (NCT00934843)
Timeframe: 36 hours
| Intervention | participants (Number) |
|---|---|
| MP Single Dose | 17 |
| MP Two Dose | 15 |
Total urine output in mL over the first 36 hours after cardiac surgery (NCT00934843)
Timeframe: over 36 hours
| Intervention | mL (Mean) |
|---|---|
| MP Single Dose | 498 |
| MP Two Dose | 453 |
Total amount of all fluids in and out during the first 36 hours postoperatively in mL. (NCT00934843)
Timeframe: over 36 hours
| Intervention | mL (Mean) | |
|---|---|---|
| Total Fluid in at 36 hr | Total Fluid out at 36 hr | |
| MP Single Dose | 575 | 600 |
| MP Two Dose | 586 | 558 |
13 reviews available for milrinone and Cardiac Output, Low
| Article | Year |
|---|---|
The effect of milrinone on hemodynamic and gas exchange parameters in children.
Topics: Blood Gas Analysis; Cardiac Output, Low; Cardiotonic Agents; Child; Critical Illness; Hemodynamics; | 2020 |
Efficacy of milrinone and dobutamine in low cardiac output states: Systematic review and meta-analysis.
Topics: Cardiac Output, Low; Cardiotonic Agents; Dobutamine; Humans; Length of Stay; Milrinone; Randomized C | 2019 |
Prophylactic milrinone for the prevention of low cardiac output syndrome and mortality in children undergoing surgery for congenital heart disease.
Topics: Cardiac Output, Low; Cardiotonic Agents; Dobutamine; Heart Defects, Congenital; Humans; Hydrazones; | 2015 |
Inodilators in the Management of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery.
Topics: Animals; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Child; Humans; Hydraz | 2016 |
Long-term intravenous inotropes in low-output terminal heart failure?
Topics: Administration, Intravenous; Cardiac Output; Cardiac Output, Low; Cardiotonic Agents; Chi-Square Dis | 2016 |
The role of milrinone in children with cardiovascular compromise: review of the literature.
Topics: Administration, Inhalation; Adolescent; Cardiac Output, Low; Cardiotonic Agents; Child; Child, Presc | 2011 |
Critical care in cardiovascular medicine.
Topics: Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Child; Critical Care; Dye Dilu | 2003 |
Diagnosis and treatment of preterm transitional circulatory compromise.
Topics: Adrenal Cortex Hormones; Blood Circulation; Blood Pressure; Cardiac Output, Low; Dobutamine; Dopamin | 2005 |
Nesiritide compared with milrinone for cardiac surgery.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cardiac Output, Low; Cyclic Nucleotide Phosphodiesterases, Type | 2007 |
Hemodynamic support and the role of dopamine.
Topics: Acute Kidney Injury; Cardiac Output, Low; Cardiotonic Agents; Critical Care; Dobutamine; Dopamine; E | 1998 |
[Treatment with phosphodiesterase inhibitors: Pro].
Topics: Cardiac Output, Low; Enoximone; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones | 1992 |
[Treatment with phosphodiesterase inhibitors: Contra].
Topics: Cardiac Output, Low; Enoximone; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones | 1992 |
Overview of the effects of intravenous milrinone in acute heart failure following surgery.
Topics: Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedures; Humans; Infusions, Intravenous; Mi | 1992 |
20 trials available for milrinone and Cardiac Output, Low
| Article | Year |
|---|---|
[Levosimendan for preventing low output syndrome in pediatric patients with correction of tetralogy of Fallot].
Topics: Cardiac Output, Low; Cardiotonic Agents; Child; Humans; Hydrazones; Longitudinal Studies; Milrinone; | 2022 |
Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone.
Topics: Adolescent; Cardiac Output, Low; Cardiopulmonary Bypass; Cardiotonic Agents; Child; Child, Preschool | 2018 |
Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery.
Topics: Acute Kidney Injury; Aging; Body Weight; Cardiac Output, Low; Cardiac Surgical Procedures; Dose-Resp | 2019 |
Randomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants.
Topics: Blood Pressure; Cardiac Output, Low; Double-Blind Method; Echocardiography; Female; Heart Rate; Huma | 2009 |
Levosimendan versus milrinone in neonates and infants after corrective open-heart surgery: a pilot study.
Topics: Analysis of Variance; Body Surface Area; Cardiac Output; Cardiac Output, Low; Cardiopulmonary Bypass | 2012 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Pilot study of milrinone for low systemic blood flow in very preterm infants.
Topics: Cardiac Output, Low; Cerebral Hemorrhage; Dose-Response Relationship, Drug; Female; Hemodynamics; Hu | 2006 |
Levosimendan or milrinone in the type 2 diabetic patient with low ejection fraction undergoing elective coronary artery surgery.
Topics: Adult; Aged; Blood Pressure; Cardiac Output, Low; Cardiopulmonary Bypass; Coronary Artery Bypass; Di | 2006 |
Perioperative nesiritide versus milrinone in high-risk coronary artery bypass graft patients.
Topics: Adult; Aged; Aged, 80 and over; Cardiac Output, Low; Cardiotonic Agents; Coronary Artery Bypass; Fem | 2007 |
The metabolic and renal effects of adrenaline and milrinone in patients with myocardial dysfunction after coronary artery bypass grafting.
Topics: Aged; Alpha-Globulins; Bicarbonates; Blood Glucose; Cardiac Output, Low; Cardiomyopathies; Coronary | 2007 |
Arterial-wave reflections are increased in heart failure patients with a left-ventricular assist device.
Topics: Adult; Aorta; Blood Pressure; Brachial Artery; Cardiac Output, Low; Cardiotonic Agents; Dobutamine; | 2007 |
Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: a prospective, randomized-controlled trial.
Topics: Administration, Inhalation; Aged; Cardiac Output, Low; Cardiopulmonary Bypass; Catheterization, Swan | 2008 |
Milrinone: systemic and pulmonary hemodynamic effects in neonates after cardiac surgery.
Topics: Cardiac Output, Low; Cardiotonic Agents; Heart Defects, Congenital; Hemodynamics; Humans; Infant, Ne | 1995 |
Multicenter, double-blind study of intravenous milrinone for patients with acute heart failure in Japan. Japan Intravenous Milrinone Investigators.
Topics: Acute Disease; Aged; Cardiac Output, Low; Double-Blind Method; Drug Administration Schedule; Female; | 1996 |
Comparison of the hemodynamic effects of milrinone with dobutamine in patients after cardiac surgery.
Topics: Adrenergic beta-Agonists; Blood Gas Analysis; Cardiac Output, Low; Cardiac Surgical Procedures; Dobu | 2001 |
Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study. Prophylactic Intravenous Use of Milrinone After Cardiac Operation in Pediatrics.
Topics: Cardiac Output, Low; Cardiopulmonary Bypass; Cardiotonic Agents; Child, Preschool; Double-Blind Meth | 2002 |
Intravenous milrinone following cardiac surgery: I. Effects of bolus infusion followed by variable dose maintenance infusion. The European Milrinone Multicentre Trial Group.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Cardiac Output | 1992 |
Milrinone in the treatment of low output states following cardiac surgery.
Topics: Adult; Aged; Cardiac Output, Low; Cardiac Surgical Procedures; Female; Hemodynamics; Humans; Male; M | 1992 |
Haemodynamic and biological effects of intravenous milrinone in patients with a low cardiac output syndrome following cardiac surgery: multicentre study.
Topics: Adult; Cardiac Output, Low; Cardiac Surgical Procedures; Hemodynamics; Humans; Infusions, Intravenou | 1992 |
Effects of variable dose milrinone in patients with low cardiac output after cardiac surgery. European Multicenter Trial Group.
Topics: Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Drug Evaluatio | 1991 |
28 other studies available for milrinone and Cardiac Output, Low
| Article | Year |
|---|---|
Milrinone therapeutic drug monitoring to reduce low cardiac output syndrome in pediatric patients.
Topics: Cardiac Output; Cardiac Output, Low; Cardiopulmonary Bypass; Cardiotonic Agents; Child; Drug Monitor | 2023 |
Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery.
Topics: Aged; Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Fema | 2020 |
Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery.
Topics: Aged; Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Fema | 2020 |
Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery.
Topics: Aged; Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Fema | 2020 |
Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery.
Topics: Aged; Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Fema | 2020 |
A Randomized Porcine Study in Low Cardiac Output of Vasoactive and Inotropic Drug Effects on the Gastrointestinal Tract.
Topics: Animals; Cardiac Output, Low; Disease Models, Animal; Female; Gastrointestinal Tract; Male; Milrinon | 2021 |
Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery.
Topics: Adenosine Monophosphate; Cardiac Output, Low; Cardiotonic Agents; Child; Heart Defects, Congenital; | 2021 |
Milrinone Administration and Pediatric Cardiac Surgery: Beloved but Sadly Misunderstood.
Topics: Cardiac Output, Low; Cardiac Surgical Procedures; Child; Humans; Milrinone | 2021 |
Updating the Update: The Final Word on Milrinone and Mortality After Cardiac Surgery?
Topics: Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Humans; Milrinone | 2017 |
New Drugs for Old Problems: Which Inotropes for Critically Ill Children?
Topics: Cardiac Output, Low; Child; Critical Illness; Dobutamine; Double-Blind Method; Humans; Milrinone; Pi | 2018 |
Evaluation and optimisation of current milrinone prescribing for the treatment and prevention of low cardiac output syndrome in paediatric patients after open heart surgery using a physiology-based pharmacokinetic drug-disease model.
Topics: Adolescent; Adult; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Child; Chil | 2014 |
Drug use patterns for the prevention of paediatric low cardiac output syndrome in Europe.
Topics: Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Child; Europe; Health Care Sur | 2011 |
Prevention for pediatric low cardiac output syndrome: results from the European survey EuLoCOS-Paed.
Topics: Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Child, Preschool; Dobutamine; | 2011 |
Treatment for paediatric low cardiac output syndrome: results from the European EuLoCOS-Paed survey.
Topics: Algorithms; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Child; Dobutamine; | 2011 |
Cardiovascular support in the preterm: treatments in search of indications.
Topics: Animals; Cardiac Output, Low; Catecholamines; Clinical Trials as Topic; Dose-Response Relationship, | 2006 |
Testing new drugs for heart failure in children.
Topics: Adolescent; Cardiac Output, Low; Cardiotonic Agents; Catecholamines; Child; Child, Preschool; Humans | 2006 |
Outpatient continuous inotrope infusion as an adjunct to heart failure therapy in Duchenne muscular dystrophy.
Topics: Adolescent; Cardiac Output, Low; Cardiotonic Agents; Disease Progression; Dobutamine; Dose-Response | 2006 |
Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass.
Topics: Age Factors; Animals; Cardiac Output; Cardiac Output, Low; Cardiopulmonary Bypass; Cardiotonic Agent | 2007 |
Cardiovascular support in the preterm: treatments in search of indications.
Topics: Cardiac Output, Low; Cardiotonic Agents; Cardiovascular System; Dopamine; Female; Humans; Hypotensio | 2007 |
Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone.
Topics: Adrenergic beta-Antagonists; Aged; Arrhythmias, Cardiac; Blood Pressure; Carbazoles; Cardiac Output, | 2007 |
Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use?
Topics: Cardiac Output, Low; Cardiotonic Agents; Energy Metabolism; Humans; Milrinone; Phosphodiesterase 3 I | 2007 |
Effects of saterinone and its enantiomers R(+)-saterinone and S(-)-saterinone on the phosphodiesterase isoenzymes from ventricular tissue of failing human hearts and porcine hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Animals; Cardiac Output, Low; Cardiomyopathy, Dilated; Cardioton | 1994 |
Short-term use of intravenous milrinone for heart failure.
Topics: Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Cardiac Output, Low; Cardiotonic Agents; Diast | 1995 |
Disposition of milrinone in patients after cardiac surgery.
Topics: Adult; Aged; Aged, 80 and over; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiopulmonary By | 1994 |
Cardiac allograft failure: successful use of biventricular assist device.
Topics: Adult; Cardiac Output, Low; Cardiotonic Agents; Combined Modality Therapy; Graft Rejection; Heart Tr | 1995 |
Treatment of milrinone-associated tachycardia with beta-blockers.
Topics: Adrenergic beta-Antagonists; Aged; Anesthesia, Epidural; Anesthesia, General; Anti-Arrhythmia Agents | 1998 |
Mechanism of preserved positive lusitropy by cAMP-dependent drugs in heart failure.
Topics: Animals; Calcium-Transporting ATPases; Cardiac Output, Low; Cardiotonic Agents; Cyclic AMP; Dobutami | 2000 |
Cardiac and hemodynamic effects of intravenous R80122, a new phosphodiesterase III inhibitor, in a canine model of myocardial ischemia and heart failure.
Topics: Animals; Blood Pressure; Cardiac Output, Low; Dogs; Female; Heart Rate; Hemodynamics; Imidazoles; In | 1992 |
Clinical and haemodynamic effects of milrinone in the treatment of low cardiac output after cardiac surgery.
Topics: Adult; Aged; Cardiac Output, Low; Cardiac Surgical Procedures; Female; Hemodynamics; Humans; Infusio | 1991 |
[Hemodynamic effects of milrinone in the treatment of cardiac insufficiency after heart surgery with extracorporeal circulation].
Topics: Aged; Blood Gas Analysis; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Extr | 1991 |
Muscle blood flow during forearm exercise in patients with severe heart failure.
Topics: Adult; Aged; Cardiac Output, Low; Chronic Disease; Exercise; Female; Forearm; Hemodynamics; Humans; | 1990 |