milrinone and Cardiac Diseases studies

Research Excerpts

Excerpt	Relevance	Reference
"Milrinone and isoprenaline both significantly increases action potential triangulation during hypothermia, and thereby the risk of ventricular arrhythmias."	8.31	Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. ( Burton, F; Dietrichs, ES; Ghasemi, M; Selli, AL; Smith, G; Watters, T, 2023)
" The aim of this study was to retrospectively evaluate the effect of inhaled milrinone versus inhaled iloprost in patients with persistent pulmonary hypertension following discontinuation of CPB."	7.85	A retrospective comparison of inhaled milrinone and iloprost in post-bypass pulmonary hypertension. ( Antoniou, T; Leontiadis, E; Perreas, K; Rellia, P; Thanopoulos, A; Theodoraki, K; Zarkalis, D, 2017)
"Milrinone is a phosphodiesterase type III inhibitor with positive inotropic and vasodilatory effects."	5.31	Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis. ( Ewald, G; Mindel, G; Saab, G; Vijayan, A, 2002)
"Milrinone and isoprenaline both significantly increases action potential triangulation during hypothermia, and thereby the risk of ventricular arrhythmias."	4.31	Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. ( Burton, F; Dietrichs, ES; Ghasemi, M; Selli, AL; Smith, G; Watters, T, 2023)
" The aim of this study was to retrospectively evaluate the effect of inhaled milrinone versus inhaled iloprost in patients with persistent pulmonary hypertension following discontinuation of CPB."	3.85	A retrospective comparison of inhaled milrinone and iloprost in post-bypass pulmonary hypertension. ( Antoniou, T; Leontiadis, E; Perreas, K; Rellia, P; Thanopoulos, A; Theodoraki, K; Zarkalis, D, 2017)
"Milrinone administered through inhalation is an emerging method aimed at specifically reducing pulmonary hypertension without affecting systemic pressures."	3.80	A specific and sensitive HPLC-MS/MS micromethod for milrinone plasma levels determination after inhalation in cardiac patients. ( Denault, AY; Gavra, P; Litalien, C; Nguyen, AQ; Theoret, Y; Varin, F, 2014)
"Milrinone was administered intravenously in successive doses of 25, 50, and 75 micrograms/kg."	2.66	Milrinone in the treatment of chronic cardiac failure: a controlled trial. ( Andrews, V; Janicki, JS; Likoff, MJ; Rocci, ML; Weber, KT; Wilson, H, 1985)
"Milrinone is an inotrope widely used for treatment of cardiac failure."	2.53	Milrinone for cardiac dysfunction in critically ill adult patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. ( Bekema, HJ; Gluud, C; Keus, F; Koster, G; van der Horst, IC; Wetterslev, J, 2016)
"Milrinone does not increase the incidence of sudden death in Doberman Pinschers."	2.38	The efficacy and safety of milrinone for treating heart failure in dogs. ( Kittleson, MD, 1991)
"Long-term survival after cardiac arrest (CA) due to shock-refractory ventricular fibrillation (VF) is low."	1.42	Milrinone and esmolol decrease cardiac damage after resuscitation from prolonged cardiac arrest. ( Lennmyr, F; Martijn, C; Semenas, E; Wiklund, L; Zoerner, F, 2015)
"Milrinone was continuously infused at a rate of 0."	1.35	Correlation between plasma milrinone concentration and renal function in patients with cardiac disease. ( Fujino, Y; Hasei, M; Mashimo, T; Nishimura, M; Uchiyama, A, 2008)
"Milrinone treatment produced a moderate tachycardia and changes in M-mode parameters indicating an increase in contractility, in particular, a decrease in end-systolic volume, an increase in ejection fraction and an increase in the rate of circumferential fiber shortening."	1.33	Effect of milrinone on echocardiographic parameters after single dose in Beagle dogs and relationship with drug-induced cardiotoxicity. ( Bonnet, P; Gautier, M; Hanton, G; Herbet, A, 2005)
"Milrinone is a phosphodiesterase type III inhibitor with positive inotropic and vasodilatory effects."	1.31	Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis. ( Ewald, G; Mindel, G; Saab, G; Vijayan, A, 2002)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (13.33)	18.7374
1990's	2 (13.33)	18.2507
2000's	4 (26.67)	29.6817
2010's	6 (40.00)	24.3611
2020's	1 (6.67)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Levosimendan Administration in High Risk Cardiac Surgery Patients With Pulmonary Hypertension[NCT04599816]		45 participants (Actual)	Interventional	2020-10-17	Completed
Comparison of Intravenous Levosimendan and Inhalational Milrinone in High Risk Cardiac Patients With Pulmonary Hypertension[NCT04718350]		40 participants (Anticipated)	Interventional	2021-01-27	Recruiting
The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery.[NCT01969071]	Phase 4	140 participants (Actual)	Interventional	2009-07-31	Completed
Preoperative Infusion of Levosimendan in High Risk Cardiac Surgery Patients: A Retrospective Study[NCT04635293]		100 participants (Actual)	Interventional	2012-01-01	Completed
Prophylactic Administration of Levosimendan in Patients With Impaired Left Ventricular Function Undergoing Coronary Surgery[NCT01318460]	Phase 4	32 participants (Actual)	Interventional	2011-03-31	Completed
[NCT00695929]		50 participants (Anticipated)	Interventional	2008-07-31	Completed
Effects of Levosimendan Pretreatment in Patients With Low Ejection Fraction (40 % or Less) Undergoing CABG: a Randomised, Double Blind, Multicenter Trial[NCT02184819]	Phase 3	335 participants (Actual)	Interventional	2013-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Milrinone for cardiac dysfunction in critically ill adult patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive care medicine, 2016, Volume: 42, Issue:9 Topics: Adult; Critical Illness; Heart Diseases; Humans; Milrinone; Phosphodiesterase 3 Inhibitors; Randomiz	2016
[Effects of phosphodiesterase inhibitors on diastolic function]. Archives des maladies du coeur et des vaisseaux, 1993, Volume: 86 Spec No 2 Topics: Diastole; Enoximone; Heart Diseases; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones	1993
The efficacy and safety of milrinone for treating heart failure in dogs. The Veterinary clinics of North America. Small animal practice, 1991, Volume: 21, Issue:5 Topics: Animals; Cardiotonic Agents; Dog Diseases; Dogs; Heart Diseases; Humans; Milrinone; Pyridones	1991

Article	Year
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Adrenergic beta-Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Age	2007
Milrinone in the treatment of chronic cardiac failure: a controlled trial. American heart journal, 1985, Volume: 110, Issue:5 Topics: Administration, Oral; Aged; Atrial Fibrillation; Cardiomyopathy, Dilated; Chronic Disease; Clinical	1985

Article	Year
Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. Scandinavian journal of trauma, resuscitation and emergency medicine, 2023, Oct-25, Volume: 31, Issue:1 Topics: Cardiotonic Agents; Heart Diseases; Humans; Hydrazones; Hypothermia; Isoproterenol; Milrinone; Myocy	2023
A retrospective comparison of inhaled milrinone and iloprost in post-bypass pulmonary hypertension. Heart and vessels, 2017, Volume: 32, Issue:12 Topics: Administration, Inhalation; Aged; Aged, 80 and over; Arterial Pressure; Cardiopulmonary Bypass; Dose	2017
A retrospective comparison of inhaled milrinone and iloprost in post-bypass pulmonary hypertension. Heart and vessels, 2017, Volume: 32, Issue:12 Topics: Administration, Inhalation; Aged; Aged, 80 and over; Arterial Pressure; Cardiopulmonary Bypass; Dose	2017
A retrospective comparison of inhaled milrinone and iloprost in post-bypass pulmonary hypertension. Heart and vessels, 2017, Volume: 32, Issue:12 Topics: Administration, Inhalation; Aged; Aged, 80 and over; Arterial Pressure; Cardiopulmonary Bypass; Dose	2017
A retrospective comparison of inhaled milrinone and iloprost in post-bypass pulmonary hypertension. Heart and vessels, 2017, Volume: 32, Issue:12 Topics: Administration, Inhalation; Aged; Aged, 80 and over; Arterial Pressure; Cardiopulmonary Bypass; Dose	2017
A specific and sensitive HPLC-MS/MS micromethod for milrinone plasma levels determination after inhalation in cardiac patients. Therapeutic drug monitoring, 2014, Volume: 36, Issue:5 Topics: Administration, Inhalation; Cardiopulmonary Bypass; Chemical Fractionation; Chromatography, High Pre	2014
Milrinone and esmolol decrease cardiac damage after resuscitation from prolonged cardiac arrest. Acta anaesthesiologica Scandinavica, 2015, Volume: 59, Issue:4 Topics: Acid-Base Equilibrium; Adrenergic beta-Antagonists; Animals; Cardiopulmonary Resuscitation; Cardioto	2015
An electrocardiographic, molecular and biochemical approach to explore the cardioprotective effect of vasopressin and milrinone against phosphide toxicity in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2015, Volume: 80 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aluminum Compounds; Animals; Apoptosis; Biomarkers; C	2015
Sex-specific associations between cerebrovascular blood pressure autoregulation and cardiopulmonary injury in neonatal encephalopathy and therapeutic hypothermia. Pediatric research, 2017, Volume: 81, Issue:5 Topics: Administration, Inhalation; Arterial Pressure; Biomarkers; Brain Diseases; Cerebrovascular Circulati	2017
Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 40, Issue:2 Topics: Acute Kidney Injury; Adrenergic beta-Agonists; Amyloidosis; Cardiotonic Agents; Dobutamine; Drug Adm	2002
Effect of milrinone on echocardiographic parameters after single dose in Beagle dogs and relationship with drug-induced cardiotoxicity. Toxicology letters, 2005, Feb-15, Volume: 155, Issue:2 Topics: Administration, Oral; Animals; Coronary Circulation; Dogs; Echocardiography; Heart Atria; Heart Dise	2005
Correlation between plasma milrinone concentration and renal function in patients with cardiac disease. Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Cardiotonic Agents; Creatinine; Female; Heart Diseases; Humans; Infu	2008
Reduced positive inotropic effects in diseased human ventricular myocardium. Cardiovascular research, 1986, Volume: 20, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Calcium; Dobutamine; Dopamine; Dose-Response Relationship,	1986

milrinone and Cardiac Diseases

Research Excerpts

Research

Studies (15)

Authors

Clinical Trials (7)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Selli, AL	1
Ghasemi, M	1
Watters, T	1
Burton, F	1
Smith, G	1
Dietrichs, ES	1
Theodoraki, K	1
Thanopoulos, A	1
Rellia, P	1
Leontiadis, E	1
Zarkalis, D	1
Perreas, K	1
Antoniou, T	1
Gavra, P	1
Nguyen, AQ	1
Theoret, Y	1
Litalien, C	1
Denault, AY	1
Varin, F	1
Zoerner, F	1
Lennmyr, F	1
Wiklund, L	1
Martijn, C	1
Semenas, E	1
Jafari, A	1
Baghaei, A	1
Solgi, R	1
Baeeri, M	1
Chamanara, M	1
Hassani, S	1
Gholami, M	1
Ostad, SN	1
Sharifzadeh, M	1
Abdollahi, M	1
Koster, G	1
Bekema, HJ	1
Wetterslev, J	1
Gluud, C	1
Keus, F	1
van der Horst, IC	1
Chavez-Valdez, R	1
O'Connor, M	1
Perin, J	1
Reyes, M	1
Armstrong, J	1
Parkinson, C	1
Gilmore, M	1
Jennings, J	1
Northington, FJ	1
Lee, JK	1
Saab, G	1
Mindel, G	1
Ewald, G	1
Vijayan, A	1
Hanton, G	1
Gautier, M	1
Bonnet, P	1
Herbet, A	1
De Hert, SG	1
Lorsomradee, S	1
Cromheecke, S	1
Van der Linden, PJ	1
Hasei, M	1
Uchiyama, A	1
Nishimura, M	1
Mashimo, T	1
Fujino, Y	1
Arbogast, R	1
Kittleson, MD	1
Brown, L	1
Lorenz, B	1
Erdmann, E	1
Likoff, MJ	1
Weber, KT	1
Andrews, V	1
Janicki, JS	1
Wilson, H	1
Rocci, ML	1