Page last updated: 2024-10-31

milrinone and Arrhythmias, Cardiac

milrinone has been researched along with Arrhythmias, Cardiac in 28 studies

Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.

Research Excerpts

ExcerptRelevanceReference
"The altered pharmacokinetics of milrinone in renal impairment could result in an increased risk of cardiac arrhythmias."8.31Renal Dysfunction and Arrhythmia Association in Patients Receiving Milrinone After Cardiac Surgery. ( Henderson, JB; Kram, SJ; Levy, JH; Valkovec, AM, 2023)
"The purpose of this study was to determine whether a low-dose β-blocker, in combination with milrinone, improves cardiac function in acute decompensated heart failure (ADHF) with tachycardia."7.78Low-dose β-blocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternans in patients with acute decompensated heart failure. ( Doi, M; Fukuta, S; Kobayashi, S; Matsuzaki, M; Murakami, W; Nao, T; Okamura, T; Okuda, S; Susa, T; Tanaka, T; Wada, Y; Yamada, J; Yano, M, 2012)
" The aim of this study was to compare the effects of several inotropic drugs on survival and the occurrence of arrhythmias in the treatment of amitriptyline poisoning."7.69Effects of epinephrine, norepinephrine, magnesium sulfate, and milrinone on survival and the occurrence of arrhythmias in amitriptyline poisoning in the rat. ( Abrahamsson, J; Knudsen, K, 1994)
" Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat."7.68Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993)
"The effects of milrinone and pimobendan upon the initiation of programmed ventricular stimulation-induced ventricular tachycardia (VT) and the incidence of lethal ischemic ventricular arrhythmias were assessed in conscious dogs with recent anterior myocardial infarctions."7.67Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction. ( Driscoll, EM; Frye, JW; Kitzen, JM; Lucchesi, BR; Lynch, JJ; Uprichard, AC, 1989)
"To determine whether oral milrinone therapy has an effect on complex ventricular arrhythmias in patients with severe congestive heart failure and, if so, whether a change in the severity of complex ventricular arrhythmias after 1 week of milrinone therapy is associated with a change in the mode or frequency of cardiac mortality, a retrospective analysis was performed to determine the frequency of ventricular tachycardia and the density of ventricular couplets on 24-hour ambulatory electrocardiographic recordings performed before and 1 week after initiation of oral milrinone therapy in 74 consecutive patients with New York Heart Association functional class III or IV congestive heart failure."7.67Effects of milrinone on complex ventricular arrhythmias in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Antman, EM; Baim, DS; Colucci, WS; Friedman, PL; Gauthier, DF; Ludmer, PL; Rocco, MB, 1987)
"Milrinone is a potent non-catecholamine, non-glycoside inotropic agent that can improve hemodynamic performance and functional capacity in patients with severe congestive heart failure."7.67Milrinone in congestive heart failure: observations on ambulatory ventricular arrhythmias. ( Cody, RJ; Holmes, JR; Kligfield, P; Kubo, SH, 1985)
"Milrinone-associated cardiomyopathy and arrhythmia can occur in patients with cerebral vasospasm."5.48Milrinone-Associated Cardiomyopathy and Arrhythmia in Cerebral Vasospasm. ( Aoun, SG; Davies, MT; El Ahmadieh, TY; Kafka, B; White, JA; Wu, EM, 2018)
"The overall arrhythmia incidence was 50%, most commonly monomorphic ventricular tachycardia (n = 85, 12%), junctional ectopic tachycardia (n = 69, 10%), accelerated junctional rhythm (n = 58, 8%), and atrial tachyarrhythmias (including atrial fibrillation, atrial flutter, and ectopic or chaotic atrial tachycardia, n = 58, 8%)."5.37Relation of milrinone after surgery for congenital heart disease to significant postoperative tachyarrhythmias. ( Borgman, KY; Fish, FA; Kannankeril, PJ; Owen, J; Smith, AH, 2011)
"Levosimendan has a more beneficial profile than milrinone regarding the development of ventricular arrhythmias during and after regional myocardial ischemia."5.33Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs. ( Papp, JG; Pollesello, P; Varró, AF; Végh, AS, 2006)
"We monitored ventricular arrhythmias during a 24-hour baseline and 48-hour milrinone infusion period in 12 patients with chronic heart failure."5.27Occurrence of ventricular arrhythmias in patients receiving acute and chronic infusions of milrinone. ( Anderson, JL; Askins, JC; Gilbert, EM; Lutz, JR; Menlove, RL, 1986)
"Controlled and uncontrolled hemodynamic and clinical studies have noted that the long-term treatment of patients with chronic heart failure with phosphodiesterase (PDE) inhibitors, such as amrinone, milrinone, enoximone and imazodan, may accelerate progression of the underlying disease and provoke serious ventricular arrhythmias."5.06Effect of phosphodiesterase inhibitors on survival of patients with chronic congestive heart failure. ( Packer, M, 1989)
"The altered pharmacokinetics of milrinone in renal impairment could result in an increased risk of cardiac arrhythmias."4.31Renal Dysfunction and Arrhythmia Association in Patients Receiving Milrinone After Cardiac Surgery. ( Henderson, JB; Kram, SJ; Levy, JH; Valkovec, AM, 2023)
"The purpose of this study was to determine whether a low-dose β-blocker, in combination with milrinone, improves cardiac function in acute decompensated heart failure (ADHF) with tachycardia."3.78Low-dose β-blocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternans in patients with acute decompensated heart failure. ( Doi, M; Fukuta, S; Kobayashi, S; Matsuzaki, M; Murakami, W; Nao, T; Okamura, T; Okuda, S; Susa, T; Tanaka, T; Wada, Y; Yamada, J; Yano, M, 2012)
" The aim of this study was to compare the effects of several inotropic drugs on survival and the occurrence of arrhythmias in the treatment of amitriptyline poisoning."3.69Effects of epinephrine, norepinephrine, magnesium sulfate, and milrinone on survival and the occurrence of arrhythmias in amitriptyline poisoning in the rat. ( Abrahamsson, J; Knudsen, K, 1994)
" Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat."3.68Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993)
"The effects of milrinone and pimobendan upon the initiation of programmed ventricular stimulation-induced ventricular tachycardia (VT) and the incidence of lethal ischemic ventricular arrhythmias were assessed in conscious dogs with recent anterior myocardial infarctions."3.67Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction. ( Driscoll, EM; Frye, JW; Kitzen, JM; Lucchesi, BR; Lynch, JJ; Uprichard, AC, 1989)
"To determine whether oral milrinone therapy has an effect on complex ventricular arrhythmias in patients with severe congestive heart failure and, if so, whether a change in the severity of complex ventricular arrhythmias after 1 week of milrinone therapy is associated with a change in the mode or frequency of cardiac mortality, a retrospective analysis was performed to determine the frequency of ventricular tachycardia and the density of ventricular couplets on 24-hour ambulatory electrocardiographic recordings performed before and 1 week after initiation of oral milrinone therapy in 74 consecutive patients with New York Heart Association functional class III or IV congestive heart failure."3.67Effects of milrinone on complex ventricular arrhythmias in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Antman, EM; Baim, DS; Colucci, WS; Friedman, PL; Gauthier, DF; Ludmer, PL; Rocco, MB, 1987)
"Milrinone is a potent non-catecholamine, non-glycoside inotropic agent that can improve hemodynamic performance and functional capacity in patients with severe congestive heart failure."3.67Milrinone in congestive heart failure: observations on ambulatory ventricular arrhythmias. ( Cody, RJ; Holmes, JR; Kligfield, P; Kubo, SH, 1985)
" Patients were allocated to each dosage group sequentially, not randomly."2.67Intravenous milrinone following cardiac surgery: I. Effects of bolus infusion followed by variable dose maintenance infusion. The European Milrinone Multicentre Trial Group. ( Feneck, RO, 1992)
"Milrinone-associated cardiomyopathy and arrhythmia can occur in patients with cerebral vasospasm."1.48Milrinone-Associated Cardiomyopathy and Arrhythmia in Cerebral Vasospasm. ( Aoun, SG; Davies, MT; El Ahmadieh, TY; Kafka, B; White, JA; Wu, EM, 2018)
"The overall arrhythmia incidence was 50%, most commonly monomorphic ventricular tachycardia (n = 85, 12%), junctional ectopic tachycardia (n = 69, 10%), accelerated junctional rhythm (n = 58, 8%), and atrial tachyarrhythmias (including atrial fibrillation, atrial flutter, and ectopic or chaotic atrial tachycardia, n = 58, 8%)."1.37Relation of milrinone after surgery for congenital heart disease to significant postoperative tachyarrhythmias. ( Borgman, KY; Fish, FA; Kannankeril, PJ; Owen, J; Smith, AH, 2011)
" Beta-blocker dosages were titrated, and three patients achieved the target beta-blocker dosage established for stage A-C heart failure."1.34Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone. ( Earl, GL; Fitzpatrick, JM; Narula, J; Verbos-Kazanas, MA, 2007)
"Levosimendan has a more beneficial profile than milrinone regarding the development of ventricular arrhythmias during and after regional myocardial ischemia."1.33Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs. ( Papp, JG; Pollesello, P; Varró, AF; Végh, AS, 2006)
"Significant proarrhythmia is uncommon, but can occur."1.28Electrophysiology of phosphodiesterase inhibitors. ( Goldstein, RA; Naccarelli, GV, 1989)
"Milrinone is a newly developed analogue of amrinone possessing potent positive inotropic action."1.27The effects of milrinone on conduction, reflection, and automaticity in canine Purkinje fibers. ( Antzelevitch, C; Davidenko, JM, 1984)
"We monitored ventricular arrhythmias during a 24-hour baseline and 48-hour milrinone infusion period in 12 patients with chronic heart failure."1.27Occurrence of ventricular arrhythmias in patients receiving acute and chronic infusions of milrinone. ( Anderson, JL; Askins, JC; Gilbert, EM; Lutz, JR; Menlove, RL, 1986)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19909 (32.14)18.7374
1990's7 (25.00)18.2507
2000's5 (17.86)29.6817
2010's5 (17.86)24.3611
2020's2 (7.14)2.80

Authors

AuthorsStudies
Jung, RG1
Di Santo, P1
Mathew, R1
Simard, T1
Parlow, S1
Weng, W1
Abdel-Razek, O1
Malhotra, N1
Cheung, M1
Hutson, JH1
Marbach, JA1
Motazedian, P1
Thibert, MJ1
Fernando, SM1
Nery, PB1
Nair, GM1
Russo, JJ1
Hibbert, B1
Ramirez, FD1
Valkovec, AM1
Kram, SJ1
Henderson, JB1
Levy, JH1
Wu, EM1
El Ahmadieh, TY1
Kafka, B1
Davies, MT1
Aoun, SG1
White, JA1
Ushio, M1
Egi, M1
Wakabayashi, J1
Nishimura, T1
Miyatake, Y1
Obata, N1
Mizobuchi, S1
Smith, AH1
Owen, J1
Borgman, KY1
Fish, FA1
Kannankeril, PJ1
Kobayashi, S1
Susa, T1
Tanaka, T1
Murakami, W1
Fukuta, S1
Okuda, S1
Doi, M1
Wada, Y1
Nao, T1
Yamada, J1
Okamura, T1
Yano, M1
Matsuzaki, M1
Yasumura, Y1
Cremers, B1
Scheler, M1
Maack, C1
Wendler, O1
Schäfers, HJ1
Südkamp, M1
Böhm, M1
Bekhit, AA1
Baraka, AM1
Papp, JG1
Pollesello, P1
Varró, AF1
Végh, AS1
Earl, GL1
Verbos-Kazanas, MA1
Fitzpatrick, JM1
Narula, J1
Davidenko, JM1
Antzelevitch, C1
Konstam, MA1
Cody, RJ2
Knudsen, K1
Abrahamsson, J1
Jones, RB1
Frodsham, G1
Dickinson, K1
Foster, GA1
Shubert, J1
Mancano, MA1
Pina, IL1
Milfred, SK1
Carceles, MD1
Aleixandre, F1
Fuente, T1
López-Vidal, J1
Laorden, ML1
Feneck, RO1
Trolese-Mongheal, Y1
Barthelemy, J1
Paire, M1
Duchene-Marullaz, P1
Ferrick, KJ1
Fein, SA1
Ferrick, AM1
Doyle, JT1
Holbrook, M1
Coker, SJ1
Lynch, JJ1
Uprichard, AC1
Frye, JW1
Driscoll, EM1
Kitzen, JM1
Lucchesi, BR1
Packer, M1
Naccarelli, GV1
Goldstein, RA1
Tommaso, CL1
Ludmer, PL1
Baim, DS1
Antman, EM1
Gauthier, DF1
Rocco, MB1
Friedman, PL1
Colucci, WS1
Anderson, JL1
Askins, JC1
Gilbert, EM1
Menlove, RL1
Lutz, JR1
Holmes, JR1
Kubo, SH1
Kligfield, P1

Reviews

2 reviews available for milrinone and Arrhythmias, Cardiac

ArticleYear
Impact of Milrinone Administration in Adult Cardiac Surgery Patients: Updated Meta-Analysis.
    Journal of cardiothoracic and vascular anesthesia, 2016, Volume: 30, Issue:6

    Topics: Arrhythmias, Cardiac; Cardiac Surgical Procedures; Cardiotonic Agents; Drug Administration Schedule;

2016
Non-glycoside, non-catecholamine inotropic agents in the treatment of congestive heart failure.
    The American journal of medicine, 1986, Feb-28, Volume: 80, Issue:2B

    Topics: Administration, Oral; Aminopyridines; Amrinone; Arrhythmias, Cardiac; Calcium; Cardiac Output; Cardi

1986

Trials

3 trials available for milrinone and Arrhythmias, Cardiac

ArticleYear
Arrhythmic Events and Mortality in Patients With Cardiogenic Shock on Inotropic Support: Results of the DOREMI Randomized Trial.
    The Canadian journal of cardiology, 2023, Volume: 39, Issue:4

    Topics: Arrhythmias, Cardiac; Dobutamine; Humans; Milrinone; Shock, Cardiogenic; Stroke Volume; Ventricular

2023
Intravenous milrinone following cardiac surgery: I. Effects of bolus infusion followed by variable dose maintenance infusion. The European Milrinone Multicentre Trial Group.
    Journal of cardiothoracic and vascular anesthesia, 1992, Volume: 6, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Cardiac Output

1992
Effect of phosphodiesterase inhibitors on survival of patients with chronic congestive heart failure.
    The American journal of cardiology, 1989, Jan-03, Volume: 63, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Clinical Trials as Topic; Heart Failure; Humans;

1989

Other Studies

23 other studies available for milrinone and Arrhythmias, Cardiac

ArticleYear
Renal Dysfunction and Arrhythmia Association in Patients Receiving Milrinone After Cardiac Surgery.
    Journal of cardiothoracic and vascular anesthesia, 2023, Volume: 37, Issue:3

    Topics: Adult; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Artery Bypass; Humans; Kidney Diseases; Mi

2023
Milrinone-Associated Cardiomyopathy and Arrhythmia in Cerebral Vasospasm.
    World neurosurgery, 2018, Volume: 114

    Topics: Adult; Arrhythmias, Cardiac; Cardiomyopathies; Female; Humans; Infusions, Intravenous; Milrinone; Re

2018
Relation of milrinone after surgery for congenital heart disease to significant postoperative tachyarrhythmias.
    The American journal of cardiology, 2011, Dec-01, Volume: 108, Issue:11

    Topics: Adolescent; Adult; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Child; Child, Preschool; Dose-

2011
Low-dose β-blocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternans in patients with acute decompensated heart failure.
    Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:7

    Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Aged; Arrhythmias, Cardiac; Cardiotonic Agents; C

2012
Combination of β-blocker and milrinone for acute heart failure.
    Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:7

    Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Cardiotonic Agents; Female; Heart Failure; Hemody

2012
Effects of sildenafil (viagra) on human myocardial contractility, in vitro arrhythmias, and tension of internal mammaria arteries and saphenous veins.
    Journal of cardiovascular pharmacology, 2003, Volume: 41, Issue:5

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Arrhythmias, Cardiac; Cyclic Nucleotide Phosphodiesterases, Typ

2003
Novel milrinone analogs of pyridine-3-carbonitrile derivatives as promising cardiotonic agents.
    European journal of medicinal chemistry, 2005, Volume: 40, Issue:12

    Topics: Adenosine Deaminase; Administration, Oral; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Diseas

2005
Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs.
    Journal of cardiovascular pharmacology and therapeutics, 2006, Volume: 11, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Vessels; Dogs; Electrophysiology; Female

2006
Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone.
    Pharmacotherapy, 2007, Volume: 27, Issue:5

    Topics: Adrenergic beta-Antagonists; Aged; Arrhythmias, Cardiac; Blood Pressure; Carbazoles; Cardiac Output,

2007
The effects of milrinone on conduction, reflection, and automaticity in canine Purkinje fibers.
    Circulation, 1984, Volume: 69, Issue:5

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Dogs; Heart Conduction System;

1984
Short-term use of intravenous milrinone for heart failure.
    The American journal of cardiology, 1995, Apr-15, Volume: 75, Issue:12

    Topics: Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Cardiac Output, Low; Cardiotonic Agents; Diast

1995
Effects of epinephrine, norepinephrine, magnesium sulfate, and milrinone on survival and the occurrence of arrhythmias in amitriptyline poisoning in the rat.
    Critical care medicine, 1994, Volume: 22, Issue:11

    Topics: Amitriptyline; Analysis of Variance; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Chi-Square D

1994
Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.
    British journal of pharmacology, 1993, Volume: 108, Issue:4

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressu

1993
Criteria for use of intravenous milrinone in adult inpatients.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1995, Sep-01, Volume: 52, Issue:17

    Topics: Adult; Arrhythmias, Cardiac; Cardiotonic Agents; Female; Heart Failure; Humans; Hypotension; Infusio

1995
Combined phosphodiesterase inhibition and beta-blockade in the GI104313, decreases ischemia-induced arrhythmias in the rat.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2001, Volume: 48, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Hemodynamics; Ma

2001
Arrhythmogenic potencies of amrinone and milrinone in unanesthetized dogs with myocardial infarct.
    General pharmacology, 1992, Volume: 23, Issue:1

    Topics: Amrinone; Analysis of Variance; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Dogs; Heart Rate;

1992
Effect of milrinone on ventricular arrhythmias in congestive heart failure.
    The American journal of cardiology, 1990, Aug-15, Volume: 66, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Cardiotonic Agents; Female; Heart Failure; Hum

1990
Comparison of the effects of isobutylmethylxanthine and milrinone on ischaemia-induced arrhythmias and platelet aggregation in anaesthetized rabbits.
    British journal of pharmacology, 1989, Volume: 98, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bloo

1989
Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction.
    Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Vessels; Dogs; Electric Stimulation; Ele

1989
Electrophysiology of phosphodiesterase inhibitors.
    The American journal of cardiology, 1989, Jan-03, Volume: 63, Issue:2

    Topics: Amrinone; Arrhythmias, Cardiac; Cardiotonic Agents; Electrocardiography; Electrophysiology; Heart Co

1989
Effects of milrinone on complex ventricular arrhythmias in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
    The American journal of cardiology, 1987, Jun-01, Volume: 59, Issue:15

    Topics: Adult; Aged; Ambulatory Care; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Coronary Disease; Elect

1987
Occurrence of ventricular arrhythmias in patients receiving acute and chronic infusions of milrinone.
    American heart journal, 1986, Volume: 111, Issue:3

    Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiotonic Agents; Drug Administration Schedule; Female; Heart F

1986
Milrinone in congestive heart failure: observations on ambulatory ventricular arrhythmias.
    American heart journal, 1985, Volume: 110, Issue:4

    Topics: Administration, Oral; Adult; Aged; Ambulatory Care; Arrhythmias, Cardiac; Cardiotonic Agents; Electr

1985