Page last updated: 2024-10-31

milrinone and Anesthesia

milrinone has been researched along with Anesthesia in 15 studies

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
" Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat."7.68Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993)
"3% end-tidal enflurane anesthesia were studied in six dogs given three successive boluses and 30-minute infusions of milrinone: 1) 40 microgram/kg plus 3 microgram."7.67Is milrinone equivalent to amrinone during enflurane anesthesia in the dog? ( Kapur, PA; Makela, VH, 1988)
" Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat."3.68Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993)
"We hypothesized that mitral regurgitation (MR) would be exacerbated, cardiac index (CI) decreased, and mean pulmonary artery pressure (MPAP) increased in patients with coexisting MR during off-pump coronary artery bypass (OPCAB) anastomosis, and that milrinone could ameliorate increases in MR that occur during OPCAB anastomosis."2.71Hemodynamic changes during off-pump coronary artery bypass anastomosis in patients with coexisting mitral regurgitation: improvement with milrinone. ( Kakihana, Y; Kanmura, Y; Kawasaki, K; Mastunaga, A; Omae, T; Sakata, R; Tsuneyoshi, I, 2005)
"Severe hypotension, cardiac arrest, and death have been reported previously."1.46Pulmonary Hypertensive Crisis on Induction of Anesthesia. ( Hilmi, I; Marquez, JM; Schisler, T; Subramaniam, K, 2017)
"Milrinone was administered intravenously either as a single bolus of 10, 30 or 100 micrograms/kg or infused at a rate of 10 micrograms/kg/min."1.27Correlation of the hemodynamic and pharmacokinetic profile of intravenous milrinone in the anesthetized dog. ( Alousi, AA; Biddlecome, C; Edelson, J; Iwan, T, 1984)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19904 (26.67)18.7374
1990's5 (33.33)18.2507
2000's5 (33.33)29.6817
2010's1 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schisler, T1
Marquez, JM1
Hilmi, I1
Subramaniam, K1
Xu, XW1
Yang, W1
Zhao, ZY1
Liu, HX1
Zeng, GY1
Nussmeier, NA1
Probert, CB1
Hirsch, D1
Cooper, JR1
Gregoric, ID1
Myers, TJ1
Frazier, OH1
Degerman, E1
Manganiello, V1
Holst, JJ1
Ahrén, B1
Omae, T1
Kakihana, Y1
Mastunaga, A1
Tsuneyoshi, I1
Kawasaki, K1
Kanmura, Y1
Sakata, R1
Use, T1
Makita, T1
Ureshino, H1
Cho, S1
Yoshitomi, O1
Akiyama, D1
Oshibuchi, M1
Hara, T1
Sumikawa, K1
Alousi, AA1
Iwan, T1
Edelson, J1
Biddlecome, C1
Jones, RB1
Frodsham, G1
Dickinson, K1
Foster, GA1
Rohde, E1
Wiesner, B1
Muschick, P1
Pagel, PS1
Hettrick, DA1
Warltier, DC1
Lee, KC1
Canniff, PC1
Hamel, DW1
Pagani, ED1
Ezrin, AM1
Lin, BB1
Chen, HL1
Falotico, R1
Haertlein, BJ1
Lakas-Weiss, CS1
Salata, JJ1
Tobia, AJ1
Holbrook, M1
Coker, SJ1
Makela, VH1
Kapur, PA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
2- Inhaled Milrinone Prevents the Increase in Pulmonary Artery Pressure After CPB[NCT00819377]Phase 2124 participants (Anticipated)Interventional2009-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for milrinone and Anesthesia

ArticleYear
Anesthetic management for implantation of the Jarvik 2000 left ventricular assist system.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:4

    Topics: Aged; Anesthesia; Aorta, Thoracic; Cardiac Output; Echocardiography, Transesophageal; Female; Heart

2003
Hemodynamic changes during off-pump coronary artery bypass anastomosis in patients with coexisting mitral regurgitation: improvement with milrinone.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:1

    Topics: Adrenergic alpha-Agonists; Aged; Anesthesia; Cardiac Output; Cardiotonic Agents; Coronary Artery Byp

2005

Other Studies

13 other studies available for milrinone and Anesthesia

ArticleYear
Pulmonary Hypertensive Crisis on Induction of Anesthesia.
    Seminars in cardiothoracic and vascular anesthesia, 2017, Volume: 21, Issue:1

    Topics: Adrenergic alpha-Agonists; Anesthesia; Bronchodilator Agents; Calcium Chloride; Cardiopulmonary Resu

2017
[Effects of recombinant human brain natriuretic peptide and milrinone on cardiac hemodynamics and renal function in anesthetized dog].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:7

    Topics: Anesthesia; Animals; Cardiotonic Agents; Dogs; Drug Interactions; Female; Heart; Hemodynamics; Kidne

2002
Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice.
    European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3

    Topics: Administration, Oral; Anesthesia; Animals; Blood Glucose; Drug Synergism; Female; Gastric Mucosa; Gl

2004
Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine.
    Cardiovascular drugs and therapy, 2006, Volume: 20, Issue:5

    Topics: Anesthesia; Animals; Cardiotonic Agents; Female; Male; Milrinone; Myocardial Contraction; Myocardial

2006
Correlation of the hemodynamic and pharmacokinetic profile of intravenous milrinone in the anesthetized dog.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 267, Issue:1

    Topics: Anesthesia; Animals; Cardiotonic Agents; Dogs; Female; Half-Life; Hemodynamics; Infusions, Parentera

1984
Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.
    British journal of pharmacology, 1993, Volume: 108, Issue:4

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressu

1993
Hemodynamic response and effects on myocardial energetics of 3-cyano-2-morpholino-5-(pyrid-4-yl)pyridine (AWD 122-14) in anesthetized minipigs.
    Die Pharmazie, 1993, Volume: 48, Issue:9

    Topics: Amrinone; Anesthesia; Animals; Calcium Channel Blockers; Cardiotonic Agents; Dopamine; Energy Metabo

1993
Influence of levosimendan, pimobendan, and milrinone on the regional distribution of cardiac output in anaesthetized dogs.
    British journal of pharmacology, 1996, Volume: 119, Issue:3

    Topics: Anesthesia; Animals; Cardiac Output; Dogs; Female; Hemodynamics; Hydrazones; Male; Milrinone; Phosph

1996
Cardiovascular and renal effects of milrinone in beta-adrenoreceptor blocked and non-blocked anaesthetized dogs.
    Drugs under experimental and clinical research, 1991, Volume: 17, Issue:3

    Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Blood Gas Analysis; Dogs; Dopamine; Electrolytes;

1991
In-vivo effects of amrinone and milrinone on left ventricular dP/dt, intraventricular pressure and heart rate in pentobarbital-anesthetized guinea pigs.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 74, Issue:2

    Topics: Amrinone; Anesthesia; Animals; Blood Pressure; Cardiotonic Agents; Dose-Response Relationship, Drug;

1991
Positive inotropic and hemodynamic properties of flosequinan, a new vasodilator, and a sulfone metabolite.
    Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:3

    Topics: Amrinone; Anesthesia; Animals; Ferrets; Heart Failure; Heart Rate; Hemodynamics; In Vitro Techniques

1989
Comparison of the effects of isobutylmethylxanthine and milrinone on ischaemia-induced arrhythmias and platelet aggregation in anaesthetized rabbits.
    British journal of pharmacology, 1989, Volume: 98, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bloo

1989
Is milrinone equivalent to amrinone during enflurane anesthesia in the dog?
    Anesthesia and analgesia, 1988, Volume: 67, Issue:4

    Topics: Amrinone; Anesthesia; Animals; Blood Pressure; Cardiotonic Agents; Catecholamines; Dogs; Dose-Respon

1988