milrinone has been researched along with Aging in 8 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Allometrically scaled body weight, AKI stages, and maturation function were identified as significant predictors of milrinone clearance." | 9.30 | Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. ( Alten, J; Cooper, DS; Gao, Z; Gist, KM; Goldstein, SL; Mizuno, T; Vinks, AA; Wempe, MF, 2019) |
| " Allometrically scaled body weight, AKI stages, and maturation function were identified as significant predictors of milrinone clearance." | 5.30 | Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. ( Alten, J; Cooper, DS; Gao, Z; Gist, KM; Goldstein, SL; Mizuno, T; Vinks, AA; Wempe, MF, 2019) |
| " This study suggests that the vasodilator pathway associated with PDE III function, the bioavailability of cAMP, and the interaction with cGMP may be preserved in healthy aging." | 2.75 | The function of vascular smooth muscle phosphodiesterase III is preserved in healthy human aging. ( Eisenach, JH; Elvebak, RL; Joyner, MJ; Nicholson, WT, 2010) |
| " Results were similar for isoproterenol, although the positive inotropic effect occurred over a wider dosage range for this drug." | 1.27 | Milrinone effects in the isolated immature rabbit heart. ( Ayres, N; Brannon, TS; Fixler, DE; Parrish, MD; Payne, A, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Orbán, C | 1 |
| Vásárhelyi, Z | 1 |
| Bajnok, A | 1 |
| Sava, F | 1 |
| Toldi, G | 1 |
| Mizuno, T | 1 |
| Gist, KM | 1 |
| Gao, Z | 1 |
| Wempe, MF | 1 |
| Alten, J | 1 |
| Cooper, DS | 1 |
| Goldstein, SL | 1 |
| Vinks, AA | 1 |
| Elvebak, RL | 1 |
| Eisenach, JH | 1 |
| Joyner, MJ | 1 |
| Nicholson, WT | 1 |
| Liles, JT | 1 |
| Ida, KK | 1 |
| Joly, KM | 1 |
| Chapo, J | 1 |
| Plato, CF | 1 |
| Akita, T | 1 |
| Joyner, RW | 1 |
| Lu, C | 1 |
| Kumar, R | 1 |
| Hartzell, HC | 1 |
| Böhm, M | 1 |
| Diet, F | 1 |
| Feiler, G | 1 |
| Kemkes, B | 1 |
| Kreuzer, E | 1 |
| Weinhold, C | 1 |
| Erdmann, E | 1 |
| Parrish, MD | 1 |
| Brannon, TS | 1 |
| Payne, A | 1 |
| Ayres, N | 1 |
| Fixler, DE | 1 |
| Artman, M | 1 |
| Kithas, PA | 1 |
| Wike, JS | 1 |
| Strada, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| USE OF ACUTE KIDNEY INJURY BIOMARKERS TO PREDICT IMPAIRED MILRINONE PHARMACOKINETICS IN CHILDREN FOLLOWING CARDIAC SURGERY[NCT01966237] | 92 participants (Actual) | Observational | 2013-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for milrinone and Aging
| Article | Year |
|---|---|
Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery.
Topics: Acute Kidney Injury; Aging; Body Weight; Cardiac Output, Low; Cardiac Surgical Procedures; Dose-Resp | 2019 |
The function of vascular smooth muscle phosphodiesterase III is preserved in healthy human aging.
Topics: Aged; Aging; Blood Vessels; Cyclic Nucleotide Phosphodiesterases, Type 3; Epoprostenol; Female; Heal | 2010 |
6 other studies available for milrinone and Aging
| Article | Year |
|---|---|
Effects of caffeine and phosphodiesterase inhibitors on activation of neonatal T lymphocytes.
Topics: Adenosine A2 Receptor Antagonists; Adult; Aging; Caffeine; Calcium Signaling; Cells, Cultured; Cycli | 2018 |
Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat.
Topics: Aging; Animals; Cardiotonic Agents; Catecholamines; Digoxin; Drug Administration Schedule; Isoproter | 2011 |
Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, | 1994 |
Subsensitivity of the failing human heart to isoprenaline and milrinone is related to beta-adrenoceptor downregulation.
Topics: Aging; Cardiotonic Agents; Coronary Disease; Electric Stimulation; Heart Failure; Humans; In Vitro T | 1988 |
Milrinone effects in the isolated immature rabbit heart.
Topics: Aging; Animals; Blood Pressure; Cardiotonic Agents; Heart; Heart Rate; In Vitro Techniques; Isoprote | 1988 |
Inotropic responses change during postnatal maturation in rabbit.
Topics: Aging; Animals; Animals, Newborn; Cardiotonic Agents; Colforsin; Female; Heart; Imidazoles; Isoprote | 1988 |