milrinone has been researched along with Acute Kidney Injury in 11 studies
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Allometrically scaled body weight, AKI stages, and maturation function were identified as significant predictors of milrinone clearance." | 9.30 | Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. ( Alten, J; Cooper, DS; Gao, Z; Gist, KM; Goldstein, SL; Mizuno, T; Vinks, AA; Wempe, MF, 2019) |
| "Levosimendan compared with milrinone did not reduce the occurrence rate of acute kidney injury in infants after total corrective heart surgery for atrioventricular septal defect, ventricular septal defect, or Tetralogy of Fallot." | 9.30 | The Effect of Levosimendan Versus Milrinone on the Occurrence Rate of Acute Kidney Injury Following Congenital Heart Surgery in Infants: A Randomized Clinical Trial. ( Castellheim, A; Keski-Nisula, J; Ricksten, SE; Romlin, BS; Suominen, PK; Synnergren, M; Thorlacius, EM; Vistnes, M; Wåhlander, H, 2019) |
| "To investigate the efficacy of zinc oxide nanoparticles (ZnO-NPs) and/or milrinone (MIL) on renal ischemia/reperfusion injury (I/RI) in rats and their possible underlying mechanisms." | 8.31 | The combined effect of zinc oxide nanoparticles and milrinone on acute renal ischemia/reperfusion injury in rats: Potential underlying mechanisms. ( Abu-Heakal, N; Ali, IS; Awadin, W; Barakat, N; Elshal, MF; Embaby, EM; Marghani, BH; Saleh, RM, 2023) |
| "Milrinone, an inotropic agent used ubiquitously in children after cardiac surgery, accumulates in acute kidney injury (AKI)." | 7.88 | Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. ( Alten, J; Altmann, C; Bennett, MR; Cooper, DS; Faubel, S; Gao, Z; Gist, KM; Goldstein, SL; Hock, KM; Joy, MS; Marino, BS; Mizuno, T; Vinks, AA; Wempe, MF; Wrona, J, 2018) |
| "Milrinone is a phosphodiesterase type III inhibitor with positive inotropic and vasodilatory effects." | 5.31 | Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis. ( Ewald, G; Mindel, G; Saab, G; Vijayan, A, 2002) |
| " Allometrically scaled body weight, AKI stages, and maturation function were identified as significant predictors of milrinone clearance." | 5.30 | Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. ( Alten, J; Cooper, DS; Gao, Z; Gist, KM; Goldstein, SL; Mizuno, T; Vinks, AA; Wempe, MF, 2019) |
| "Levosimendan compared with milrinone did not reduce the occurrence rate of acute kidney injury in infants after total corrective heart surgery for atrioventricular septal defect, ventricular septal defect, or Tetralogy of Fallot." | 5.30 | The Effect of Levosimendan Versus Milrinone on the Occurrence Rate of Acute Kidney Injury Following Congenital Heart Surgery in Infants: A Randomized Clinical Trial. ( Castellheim, A; Keski-Nisula, J; Ricksten, SE; Romlin, BS; Suominen, PK; Synnergren, M; Thorlacius, EM; Vistnes, M; Wåhlander, H, 2019) |
| "To investigate the efficacy of zinc oxide nanoparticles (ZnO-NPs) and/or milrinone (MIL) on renal ischemia/reperfusion injury (I/RI) in rats and their possible underlying mechanisms." | 4.31 | The combined effect of zinc oxide nanoparticles and milrinone on acute renal ischemia/reperfusion injury in rats: Potential underlying mechanisms. ( Abu-Heakal, N; Ali, IS; Awadin, W; Barakat, N; Elshal, MF; Embaby, EM; Marghani, BH; Saleh, RM, 2023) |
| "Milrinone, an inotropic agent used ubiquitously in children after cardiac surgery, accumulates in acute kidney injury (AKI)." | 3.88 | Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. ( Alten, J; Altmann, C; Bennett, MR; Cooper, DS; Faubel, S; Gao, Z; Gist, KM; Goldstein, SL; Hock, KM; Joy, MS; Marino, BS; Mizuno, T; Vinks, AA; Wempe, MF; Wrona, J, 2018) |
| " We examined the effects of vasopressin (arginine vasopressin [AVP]) on acute kidney injury (AKI) in postoperative period." | 3.81 | Intraoperative administration of vasopressin during coronary artery bypass surgery is associated with acute postoperative kidney injury. ( Arora, P; Davari-Farid, S; Li, CM; Nader, ND; Porhomayon, J; Pourafkari, L, 2015) |
| "Milrinone is an inotropic drug used in a variety of clinical settings in adults and children." | 2.53 | Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review. ( Gist, KM; Goldstein, SL; Joy, MS; Vinks, AA, 2016) |
| "Milrinone is an inotropic agent with vasodilating properties used in the treatment of ventricular dysfunction." | 1.42 | Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury. ( Gist, KM; Goldstein, SL; Mizuno, T; Vinks, A, 2015) |
| "Milrinone is a phosphodiesterase type III inhibitor with positive inotropic and vasodilatory effects." | 1.31 | Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis. ( Ewald, G; Mindel, G; Saab, G; Vijayan, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Embaby, EM | 1 |
| Saleh, RM | 1 |
| Marghani, BH | 1 |
| Barakat, N | 1 |
| Awadin, W | 1 |
| Elshal, MF | 1 |
| Ali, IS | 1 |
| Abu-Heakal, N | 1 |
| Alexander, PMA | 1 |
| Akcan-Arikan, A | 1 |
| Shekerdemian, LS | 1 |
| Gist, KM | 4 |
| Cooper, DS | 2 |
| Wrona, J | 1 |
| Faubel, S | 1 |
| Altmann, C | 1 |
| Gao, Z | 2 |
| Marino, BS | 1 |
| Alten, J | 2 |
| Hock, KM | 1 |
| Mizuno, T | 3 |
| Vinks, AA | 3 |
| Joy, MS | 2 |
| Wempe, MF | 2 |
| Bennett, MR | 1 |
| Goldstein, SL | 4 |
| Thorlacius, EM | 1 |
| Suominen, PK | 1 |
| Wåhlander, H | 1 |
| Keski-Nisula, J | 1 |
| Vistnes, M | 1 |
| Ricksten, SE | 1 |
| Synnergren, M | 1 |
| Romlin, BS | 1 |
| Castellheim, A | 1 |
| Morgan, CJ | 1 |
| Gill, PJ | 1 |
| Lam, S | 1 |
| Joffe, AR | 1 |
| Vinks, A | 1 |
| Porhomayon, J | 1 |
| Davari-Farid, S | 1 |
| Li, CM | 1 |
| Arora, P | 1 |
| Pourafkari, L | 1 |
| Nader, ND | 1 |
| Saab, G | 1 |
| Mindel, G | 1 |
| Ewald, G | 1 |
| Vijayan, A | 1 |
| Bellomo, R | 1 |
| Cole, L | 1 |
| Ronco, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| USE OF ACUTE KIDNEY INJURY BIOMARKERS TO PREDICT IMPAIRED MILRINONE PHARMACOKINETICS IN CHILDREN FOLLOWING CARDIAC SURGERY[NCT01966237] | 92 participants (Actual) | Observational | 2013-09-30 | Completed | |||
| Platelet and Tissue cAMP: Novel Biomarkers of Milrinone Efficacy in Children[NCT02728128] | 53 participants (Actual) | Observational | 2016-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for milrinone and Acute Kidney Injury
| Article | Year |
|---|---|
Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review.
Topics: Acute Kidney Injury; Child; Critical Illness; Dose-Response Relationship, Drug; Humans; Metabolic Cl | 2016 |
Hemodynamic support and the role of dopamine.
Topics: Acute Kidney Injury; Cardiac Output, Low; Cardiotonic Agents; Critical Care; Dobutamine; Dopamine; E | 1998 |
2 trials available for milrinone and Acute Kidney Injury
| Article | Year |
|---|---|
Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery.
Topics: Acute Kidney Injury; Aging; Body Weight; Cardiac Output, Low; Cardiac Surgical Procedures; Dose-Resp | 2019 |
The Effect of Levosimendan Versus Milrinone on the Occurrence Rate of Acute Kidney Injury Following Congenital Heart Surgery in Infants: A Randomized Clinical Trial.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Agents; Creati | 2019 |
7 other studies available for milrinone and Acute Kidney Injury
| Article | Year |
|---|---|
The combined effect of zinc oxide nanoparticles and milrinone on acute renal ischemia/reperfusion injury in rats: Potential underlying mechanisms.
Topics: Acute Kidney Injury; Animals; Caspase 3; Ischemia; Lipocalin-2; Male; Milrinone; Nanoparticles; NF-E | 2023 |
Another Outcome Lost to the Benefits of Levosimendan?
Topics: Acute Kidney Injury; Cardiotonic Agents; Heart Defects, Congenital; Humans; Milrinone; Simendan | 2019 |
Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery.
Topics: Acute Kidney Injury; Biomarkers; Cardiotonic Agents; Creatinine; Female; Hepatitis A Virus Cellular | 2018 |
Peri-operative interventions, but not inflammatory mediators, increase risk of acute kidney injury after cardiac surgery: a prospective cohort study.
Topics: Acute Kidney Injury; Arterial Pressure; Cardiac Surgical Procedures; Female; Glomerular Filtration R | 2013 |
Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury.
Topics: Acute Kidney Injury; Adolescent; Age Factors; Bayes Theorem; Child; Child, Preschool; Female; Humans | 2015 |
Intraoperative administration of vasopressin during coronary artery bypass surgery is associated with acute postoperative kidney injury.
Topics: Acute Kidney Injury; Arginine Vasopressin; Cardiopulmonary Bypass; Case-Control Studies; Coronary Ar | 2015 |
Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis.
Topics: Acute Kidney Injury; Adrenergic beta-Agonists; Amyloidosis; Cardiotonic Agents; Dobutamine; Drug Adm | 2002 |