Page last updated: 2024-08-23

mifepristone and Substance Withdrawal Syndrome

mifepristone has been researched along with Substance Withdrawal Syndrome in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's6 (40.00)29.6817
2010's8 (53.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Joshi, S; Kapur, J; Shiono, S; Williamson, J1
Berry, JN; Butler, TR; Prendergast, MA; Reynolds, AR; Sharrett-Field, L1
Forster, GL; Hassell, JE; Li, H; Renner, KJ; Scholl, JL; Tu, W; Watt, MJ1
Laorden, ML; Milanés, MV; Navarro-Zaragoza, J1
Coulton, S; Donoghue, K; Drummond, C; Little, H; Milward, J; Reed, K; Rose, A1
Croft, AP; Jacquot, C; Little, HJ; Mulholland, P; Prendergast, MA; Shaw, SG1
Cao, J; Dong, Z; Han, H; Xu, L1
Hidalgo, JM; Laorden, ML; Milanés, MV; Navarro-Zaragoza, J1
Barbier, E; Heilig, M; Koob, GF; Logrip, ML; Misra, KK; Repunte-Canonigo, V; Rivier, C; Sanna, PP; Schlosburg, JE; Vendruscolo, LF; Whitfield, TW; Zorrilla, EP1
Avila, AH; Bayer, BM; Morgan, CA1
Harris, BR; Little, HJ; Littleton, JM; Mulholland, PJ; Prendergast, MA; Self, RL1
Cao, J; Dong, Z; Han, H; Mao, R; Xu, L1
Cao, J; Dong, Z; Han, H; Luo, J; Tian, M; Xu, L; Xu, T; Zhong, W1
Hajhashemi, V; Mesripour, A; Rabbani, M1
Capasso, A; Di Giannuario, A; Loizzo, A; Pieretti, S; Sagratella, S; Sorrentino, L1

Trials

1 trial(s) available for mifepristone and Substance Withdrawal Syndrome

ArticleYear
Double-blind, 12 month follow-up, placebo-controlled trial of mifepristone on cognition in alcoholics: the MIFCOG trial protocol.
    BMC psychiatry, 2016, Feb-24, Volume: 16

    Topics: Adult; Alcohol Drinking; Alcoholics; Alcoholism; Cognition Disorders; Double-Blind Method; Follow-Up Studies; Humans; Male; Middle Aged; Mifepristone; Substance Withdrawal Syndrome

2016

Other Studies

14 other study(ies) available for mifepristone and Substance Withdrawal Syndrome

ArticleYear
Progesterone receptor activation regulates seizure susceptibility.
    Annals of clinical and translational neurology, 2019, Volume: 6, Issue:7

    Topics: Animals; Female; Mifepristone; Norprogesterones; Pilocarpine; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Seizures; Status Epilepticus; Substance Withdrawal Syndrome

2019
Mifepristone pretreatment reduces ethanol withdrawal severity in vivo.
    Alcoholism, clinical and experimental research, 2013, Volume: 37, Issue:8

    Topics: Alcoholism; Animals; Body Weight; Corticosterone; Drug Evaluation, Preclinical; Eating; Ethanol; Hormone Antagonists; Male; Mifepristone; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Severity of Illness Index; Substance Withdrawal Syndrome

2013
Serotonergic responses to stress are enhanced in the central amygdala and inhibited in the ventral hippocampus during amphetamine withdrawal.
    The European journal of neuroscience, 2014, Volume: 40, Issue:11

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Central Amygdaloid Nucleus; Central Nervous System Agents; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Hippocampus; Male; Microdialysis; Mifepristone; Motor Activity; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Restraint, Physical; Serotonin; Stress, Psychological; Substance Withdrawal Syndrome

2014
Glucocorticoid receptor but not mineralocorticoid receptor mediates the activation of ERK pathway and CREB during morphine withdrawal.
    Addiction biology, 2017, Volume: 22, Issue:2

    Topics: Analgesics, Opioid; Animals; Cyclic AMP Response Element-Binding Protein; Dopamine; Hormone Antagonists; Male; MAP Kinase Signaling System; Mifepristone; Mineralocorticoid Receptor Antagonists; Morphine; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase

2017
Effects of the glucocorticoid antagonist, mifepristone, on the consequences of withdrawal from long term alcohol consumption.
    Alcoholism, clinical and experimental research, 2008, Volume: 32, Issue:12

    Topics: Alcohol Drinking; Animals; Glucocorticoids; Hormone Antagonists; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mifepristone; Substance Withdrawal Syndrome

2008
Opioid withdrawal for 4 days prevents synaptic depression induced by low dose of morphine or naloxone in rat hippocampal CA1 area in vivo.
    Hippocampus, 2010, Volume: 20, Issue:2

    Topics: Analgesics, Opioid; Animals; CA1 Region, Hippocampal; Excitatory Postsynaptic Potentials; Male; Mifepristone; Morphine; Naloxone; Narcotic Antagonists; Neuronal Plasticity; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Substance Withdrawal Syndrome; Synapses; Synaptic Transmission; Time Factors

2010
Glucocorticoid receptors participate in the opiate withdrawal-induced stimulation of rats NTS noradrenergic activity and in the somatic signs of morphine withdrawal.
    British journal of pharmacology, 2012, Volume: 166, Issue:7

    Topics: Animals; Hormone Antagonists; Male; Mifepristone; Morphine Dependence; Naloxone; Narcotic Antagonists; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Solitary Nucleus; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase

2012
Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, May-30, Volume: 32, Issue:22

    Topics: Alcohol Drinking; Analysis of Variance; Animals; Behavior, Addictive; Brain; Central Nervous System Depressants; Compulsive Behavior; Conditioning, Operant; Ethanol; Hormone Antagonists; Male; Mifepristone; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Reinforcement Schedule; RNA, Messenger; Self Administration; Substance Withdrawal Syndrome; Up-Regulation

2012
Stress-induced suppression of the immune system after withdrawal from chronic cocaine.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1

    Topics: Adrenalectomy; Animals; Cell Division; Cocaine; Corticosterone; Disease Models, Animal; Dopamine Uptake Inhibitors; Hormone Antagonists; Hypersensitivity, Delayed; Immune System; Leukocytes; Male; Mifepristone; Rats; Stress, Physiological; Substance Withdrawal Syndrome; T-Lymphocyte Subsets; T-Lymphocytes

2003
Corticosterone increases damage and cytosolic calcium accumulation associated with ethanol withdrawal in rat hippocampal slice cultures.
    Alcoholism, clinical and experimental research, 2005, Volume: 29, Issue:5

    Topics: Animals; Calcium; Central Nervous System Depressants; Corticosterone; Cytosol; Ethanol; Female; Fluorescent Dyes; Hippocampus; Hormone Antagonists; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Organ Culture Techniques; Organic Chemicals; Propidium; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate; Spironolactone; Substance Withdrawal Syndrome

2005
Morphine withdrawal modifies antinociceptive effects of acute morphine in rats.
    Biochemical and biophysical research communications, 2006, Jul-28, Volume: 346, Issue:2

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Tolerance; Male; Mifepristone; Morphine; Morphine Dependence; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Glucocorticoid; Stress, Psychological; Substance Withdrawal Syndrome

2006
Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo.
    Hippocampus, 2006, Volume: 16, Issue:12

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Dose-Response Relationship, Radiation; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Hormone Antagonists; In Vitro Techniques; Long-Term Potentiation; Male; Mifepristone; Morpholines; Patch-Clamp Techniques; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Stress, Psychological; Substance Withdrawal Syndrome; Time Factors

2006
Metyrapone and mifepristone reverse recognition memory loss induced by spontaneous morphine withdrawal in mice.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:4

    Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Glucocorticoids; Hormone Antagonists; Injections, Subcutaneous; Male; Memory; Memory Disorders; Metyrapone; Mice; Mifepristone; Morphine; Receptors, Glucocorticoid; Recognition, Psychology; Steroid 11-beta-Hydroxylase; Substance Withdrawal Syndrome; Time Factors

2008
Dexamethasone selective inhibition of acute opioid physical dependence in isolated tissues.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cycloheximide; Dexamethasone; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mifepristone; Muscle Contraction; Naloxone; Opioid-Related Disorders; Pyrrolidines; Rabbits; Substance Withdrawal Syndrome

1996