Page last updated: 2024-08-23

mifepristone and Obesity

mifepristone has been researched along with Obesity in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (37.14)18.2507
2000's8 (22.86)29.6817
2010's12 (34.29)24.3611
2020's2 (5.71)2.80

Authors

AuthorsStudies
Abd Jamil, AH; Chung, I; Mat Adenan, NA; Omar, IS1
Andrews, ZB; Cowley, MA; Dodd, GT; Eramo, M; Henry, BA; Mitchell, CA; Tiganis, T; Xirouchaki, CE1
Grewal, S; Gubbi, S; McGlotten, R; Muniyappa, R; Nieman, LK; Sharma, ST1
Chuan, K; Du, SF; He, ZJ; Liu, SJ; Liu, YJ; Ye, CL; Yu, Q; Zhu, XY1
Hunt, H; Koorneef, LL; Kroon, J; Meijer, OC; Mol, IM; Rensen, PCN; Sips, HCM; van de Velde, NM; van den Heuvel, JK; Verzijl, CRC1
Athimulam, S; Bancos, I; Delivanis, DA1
Hasan, AU; Hashimoto, T; Igarashi, J; Kohno, M; Kosaka, H; Nagai, Y; Ohmori, K; Yamashita, T1
Akiyama, N; Akiyama, Y; Asakura, K; Hanasaki, K; Imagawa, K; Kato, H; Kuroda, T; Murayama, T; Ono, T; Shinosaki, T1
Badurek, S; Brönneke, HS; Geibel, M; Horn, JM; Koudelka, J; Minichiello, L; Vatanashevanopakorn, C; Wunderlich, CM; Wunderlich, FT1
Howland, RH1
Creinin, MD; Monmaney, JA; Reeves, MF1
Belanoff, JK; Boon, MR; Hunt, H; Meijer, OC; Pereira, AM; Peschier-van der Put, E; Rensen, PC; van Beek, L; van den Heuvel, JK; van Dijk, KW; van Harmelen, V; van Hengel, I1
Borgatta, L; Mottl-Santiago, J; Savla, A; Soodoo, N; Strafford, MA1
Mattsson, C; Olsson, T; Reynolds, RM; Simonyte, K; Walker, BR1
Campbell, JE; Fediuc, S; Hawke, TJ; Riddell, MC1
Flatt, PR; Frizzell, N; Gault, VA; McKillop, AM; Taylor, AI1
Funahashi, T; Hirata, A; Hiuge-Shimizu, A; Maeda, N; Nakatsuji, H; Okada, T; Shimomura, I1
Batur, P1
Chekhranova, MK; Iatsyshina, SB; Karpova, SK; Morozova, MS; Pankov, IuA; Sazina, ET; Zaĭtseva, TS1
Andrew, R; Homer, NZ; Karpe, F; Stimson, RH; Tan, GD; Wake, DJ; Walker, BR1
Bruch, D; Harb, G; Kieffer, TJ; Korbutt, GS; Lam, AW; Lam, NT; Oosman, SN; Unniappan, S; Webber, T; Zhang, QX1
Clifton, LG; Lin, P; McNulty, JA; Pahel, GL; Shen, Y; Stimpson, SA; Trump, RP; Yang, B1
Heikinheimo, O; Huupponen, R; Koulu, M; Lähteenmäki, P; Pesonen, U1
Alam, T; Chen, L; McCorkle, K; McGarry, JD; Ogawa, A; Ohneda, M; Pieber, TR; Stein, DT; Unger, RH1
Chen, HL; Romsos, DR1
Altemus, M; Castonguay, TW; Kramlik, SK1
Busch, BL; Curry, DL; Dallman, MF; Havel, PJ; Johnson, PR; Stern, JS1
Clapham, JC; Turner, NC1
Koulu, M; Miettinen, T; Pesonen, U; Scheinin, M1
Huupponen, R; Jolkkonen, J; Koulu, M; Pesonen, U1
Heikinheimo, O; Huupponen, R; Koulu, M; Pesonen, U1
Bray, GA; Okada, S; York, DA1
Huupponen, R; Koulu, M; Pesonen, U; Rouru, J1
Dubuc, PU; Peterson, CM1
Langley, SC; York, DA1

Reviews

1 review(s) available for mifepristone and Obesity

ArticleYear
Emergency contraception: separating fact from fiction.
    Cleveland Clinic journal of medicine, 2012, Volume: 79, Issue:11

    Topics: Abortion, Induced; Contraception, Postcoital; Counseling; Crime Victims; Female; Hospitals; Humans; Intrauterine Devices, Copper; Levonorgestrel; Mifepristone; Nonprescription Drugs; Norpregnadienes; Obesity; Practice Patterns, Physicians'; Pregnancy; Pregnancy, Unplanned; Sex Offenses; United States

2012

Trials

5 trial(s) available for mifepristone and Obesity

ArticleYear
Mifepristone Improves Adipose Tissue Insulin Sensitivity in Insulin Resistant Individuals.
    The Journal of clinical endocrinology and metabolism, 2021, 04-23, Volume: 106, Issue:5

    Topics: Adipose Tissue; Adult; Aged; Cross-Over Studies; Double-Blind Method; Female; Glucose Intolerance; Humans; Insulin Resistance; Insulin Secretion; Male; Middle Aged; Mifepristone; Obesity; Overweight; Prediabetic State; United States

2021
Predictors of uterine evacuation following early medical abortion with mifepristone and misoprostol.
    Contraception, 2016, Volume: 93, Issue:2

    Topics: Abortifacient Agents; Abortifacient Agents, Nonsteroidal; Abortifacient Agents, Steroidal; Abortion, Incomplete; Abortion, Induced; Adult; Age Factors; Female; Gestational Age; Humans; Mifepristone; Misoprostol; Obesity; Parity; Pregnancy; Suction; Uterus

2016
Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:4

    Topics: Adult; Blood Pressure; Cross-Over Studies; Double-Blind Method; Feedback; Female; Hormone Antagonists; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Middle Aged; Mifepristone; Mineralocorticoid Receptor Antagonists; Obesity; Overweight; Pituitary-Adrenal System; Placebos; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone; Waist-Hip Ratio

2009
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men.
    The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:5

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adult; Aged; Cortisone; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Fenofibrate; Gas Chromatography-Mass Spectrometry; Hormone Antagonists; Humans; Hydrocortisone; Hypolipidemic Agents; Insulin Resistance; Kinetics; Liver; Male; Metyrapone; Microdialysis; Middle Aged; Mifepristone; Obesity; PPAR alpha; PPAR gamma; Rosiglitazone; Subcutaneous Fat; Thiazolidinediones

2007
The effects of the acute administration of RU 486 on dietary fat preference in fasted lean and obese men.
    Physiology & behavior, 1993, Volume: 54, Issue:4

    Topics: Adrenocorticotropic Hormone; Adult; Blood Glucose; Dietary Fats; Double-Blind Method; Energy Intake; Energy Metabolism; Fasting; Food Preferences; Humans; Hydrocortisone; Insulin; Male; Mifepristone; Obesity; Receptors, Glucocorticoid

1993

Other Studies

29 other study(ies) available for mifepristone and Obesity

ArticleYear
MPA alters metabolic phenotype of endometrial cancer-associated fibroblasts from obese women via IRS2 signaling.
    PloS one, 2022, Volume: 17, Issue:7

    Topics: Acetates; Cancer-Associated Fibroblasts; Endometrial Neoplasms; Female; Glucose; Humans; Insulin Receptor Substrate Proteins; Medroxyprogesterone Acetate; Mifepristone; Neoplasm Recurrence, Local; Obesity; Phenotype; Progesterone; Receptors, Progesterone; RNA, Messenger

2022
Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.
    Cell reports, 2019, Sep-10, Volume: 28, Issue:11

    Topics: Adipose Tissue, White; Administration, Intranasal; Animals; Blood-Brain Barrier; Cholestanes; Diet, High-Fat; Feeding Behavior; Gliosis; Glucocorticoids; Hypothalamus; Insulin Resistance; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mifepristone; Obesity; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Spermine; Weight Loss

2019
In obese mice, exercise training increases 11β-HSD1 expression, contributing to glucocorticoid activation and suppression of pulmonary inflammation.
    Journal of applied physiology (Bethesda, Md. : 1985), 2017, Oct-01, Volume: 123, Issue:4

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; 3-Hydroxysteroid Dehydrogenases; Animals; Chemokine CCL2; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P450 Family 21; Glucocorticoids; Interleukin-18; Interleukin-1beta; Lung; Mice, Obese; Mifepristone; Obesity; Physical Conditioning, Animal; Pneumonia; Steroid 11-beta-Hydroxylase

2017
Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice.
    Endocrinology, 2018, 01-01, Volume: 159, Issue:1

    Topics: Adipocytes, Brown; Adiposity; Adrenal Glands; Animals; Anti-Obesity Agents; Cells, Cultured; Corticosterone; Dose-Response Relationship, Drug; HEK293 Cells; Hormone Antagonists; Humans; Lipid Metabolism; Liver; Male; Mice, Inbred C57BL; Mifepristone; Obesity; Organ Size; Receptors, Glucocorticoid; Recombinant Proteins; Weight Gain

2018
Modern Management of Mild Autonomous Cortisol Secretion.
    Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:6

    Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adrenocortical Adenoma; Adrenocorticotropic Hormone; Dehydroepiandrosterone Sulfate; Diabetes Mellitus, Type 2; Disease Management; Dyslipidemias; Enzyme Inhibitors; Glucocorticoids; Hormone Antagonists; Humans; Hydrocortisone; Hypertension; Incidental Findings; Ketoconazole; Metyrapone; Mifepristone; Mortality; Obesity; Osteoporosis; Postoperative Hemorrhage; Risk; Saliva; Severity of Illness Index

2019
Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: 3T3-L1 Cells; Adiponectin; Adipose Tissue; Animals; Cell Differentiation; Diet, High-Fat; Disease Models, Animal; Insulin Resistance; Male; Mice; Mifepristone; Obesity

2013
Pharmacological evaluation of adipose dysfunction via 11β-hydroxysteroid dehydrogenase type 1 in the development of diabetes in diet-induced obese mice with cortisone pellet implantation.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 349, Issue:1

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adipose Tissue; Animals; Cortisone; Diabetes Mellitus, Experimental; Diet, High-Fat; Glucocorticoids; Glucose; Insulin Resistance; Mice; Mice, Inbred C57BL; Mifepristone; Obesity; Receptors, Glucocorticoid; Up-Regulation

2014
Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity.
    Nature communications, 2014, Mar-12, Volume: 5

    Topics: Animals; Body Composition; Calorimetry, Indirect; Cholecystokinin; Cushing Syndrome; Eating; Female; GABAergic Neurons; Immunoblotting; In Situ Hybridization; Male; Membrane Glycoproteins; Mice; Mifepristone; Obesity; Protein-Tyrosine Kinases

2014
Odds and ends in psychopharmacology from the past 10 years.
    Journal of psychosocial nursing and mental health services, 2015, Volume: 53, Issue:1

    Topics: Acetamides; Anti-Obesity Agents; Antidepressive Agents; Central Nervous System Stimulants; Depression; Electroencephalography; History, 21st Century; Humans; Mifepristone; Obesity; Psychopharmacology; Stereoisomerism

2015
Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation.
    British journal of pharmacology, 2016, Volume: 173, Issue:11

    Topics: Animals; Body Weight; Diet, High-Fat; Inflammation; Male; Mice; Mice, Inbred C57BL; Mifepristone; Obesity; RAW 264.7 Cells; Receptors, Glucocorticoid

2016
Relationship of obesity to outcome of medical abortion.
    American journal of obstetrics and gynecology, 2009, Volume: 200, Issue:5

    Topics: Abortifacient Agents, Steroidal; Abortion, Induced; Adult; Body Mass Index; Female; Humans; Mifepristone; Obesity; Pregnancy; Retrospective Studies; Risk Factors; Treatment Outcome; Young Adult

2009
Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptations that facilitate lipolysis.
    Metabolism: clinical and experimental, 2009, Volume: 58, Issue:5

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 3T3-L1 Cells; Adipose Tissue; Animals; Blood Glucose; Cricetinae; Glucocorticoids; Glucose Tolerance Test; Hormone Antagonists; Immunoblotting; Insulin; Lipolysis; Male; Mesocricetus; Mice; Mifepristone; Obesity; Physical Conditioning, Animal; Random Allocation; Receptors, Glucocorticoid

2009
Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2009, Volume: 41, Issue:12

    Topics: Adipocytes; Adipose Tissue, White; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drug Administration Schedule; Epididymis; Fasting; Feeding Behavior; Gene Expression Regulation; Glucose Tolerance Test; Insulin; Liver; Male; Mice; Mice, Obese; Mifepristone; Obesity; Pancreas; RNA, Messenger; Triglycerides

2009
Contribution of glucocorticoid-mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction.
    Biochemical and biophysical research communications, 2012, Mar-09, Volume: 419, Issue:2

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 3T3-L1 Cells; Adipocytes; Adipokines; Animals; Body Mass Index; Eplerenone; Glucocorticoids; Humans; Male; Metabolic Networks and Pathways; Mice; Mice, Mutant Strains; Mifepristone; Mineralocorticoid Receptor Antagonists; Obesity; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Small Interfering; Spironolactone

2012
[Molecular and genetic study of the role of hormones, receptors, and enzymes in regulation of reproduction, lipid metabolism, and other human physiological functions].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2005, Issue:9

    Topics: Abortifacient Agents, Steroidal; Abortion, Induced; Abortion, Spontaneous; Animals; Appetite; beta-Lipotropin; Cattle; Diabetes Mellitus, Type 1; Female; Genetic Engineering; Glutamate Decarboxylase; Humans; Leptin; Lipid Metabolism; Male; Mifepristone; Mutation; Obesity; Pregnancy; Receptors, Estrogen; Receptors, Melanocortin; Receptors, Progesterone; Reproduction; Research; RNA, Messenger; Sterol Esterase; Swine; Uterus

2005
Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2008, Volume: 16, Issue:6

    Topics: Adipose Tissue; Animals; Body Weight; Cell Transplantation; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Insulin; Kidney; Leptin; Mice; Mice, Obese; Mifepristone; Obesity; RNA, Messenger; Transfection

2008
RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice.
    BMC pharmacology, 2008, May-12, Volume: 8

    Topics: Adrenocorticotropic Hormone; Animals; Blood Glucose; Chemokine CCL2; Corticosterone; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glucose-6-Phosphatase; Hormone Antagonists; Hypoglycemic Agents; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mifepristone; Obesity; Protein Serine-Threonine Kinases; Receptors, Glucocorticoid; Receptors, Leptin; Tumor Necrosis Factor-alpha

2008
Hepatic metabolism and distribution of mifepristone and its metabolites in rats.
    Human reproduction (Oxford, England), 1994, Volume: 9 Suppl 1

    Topics: Administration, Oral; Animals; Biotransformation; Body Mass Index; Female; Half-Life; Humans; Hydroxylation; Liver; Male; Methylation; Mifepristone; Obesity; Rats; Rats, Wistar; Rats, Zucker; Species Specificity; Tissue Distribution

1994
Amylin-insulin relationships in insulin resistance with and without diabetic hyperglycemia.
    The American journal of physiology, 1993, Volume: 265, Issue:3 Pt 1

    Topics: Amyloid; Animals; Dexamethasone; Diabetes Mellitus, Type 2; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Islet Amyloid Polypeptide; Male; Mifepristone; Obesity; Pancreas; Rats; Rats, Wistar; Rats, Zucker; Receptors, Glucocorticoid; RNA, Messenger; Somatostatin

1993
Type II glucocorticoid receptors in the CNS regulate metabolism in ob/ob mice independent of protein synthesis.
    The American journal of physiology, 1994, Volume: 266, Issue:3 Pt 1

    Topics: Adipose Tissue, Brown; Adrenalectomy; Animals; Anisomycin; Brain; Dexamethasone; Guanosine Diphosphate; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mifepristone; Obesity; Oxygen Consumption; Protein Biosynthesis; Receptors, Glucocorticoid

1994
Predominately glucocorticoid agonist actions of RU-486 in young specific-pathogen-free Zucker rats.
    The American journal of physiology, 1996, Volume: 271, Issue:3 Pt 2

    Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Animals, Newborn; Blood Glucose; Body Weight; Eating; Female; Germ-Free Life; Glucocorticoids; Hormone Antagonists; Hormones; Male; Mifepristone; Obesity; Organ Size; Rats; Rats, Zucker; Reference Values

1996
Effects of the glucocorticoid II receptor antagonist mifepristone on hypertension in the obese Zucker rat.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:3

    Topics: Aldosterone; Animals; Blood Pressure; Corticosterone; Hypertension; Male; Mifepristone; Obesity; Rats; Rats, Zucker; Receptors, Glucocorticoid

1997
Alpha 2-adrenoceptor density in forebrain areas of Zucker rats: no effect of genetic obesity or antiglucocorticoid treatment.
    Brain research, 1992, Mar-06, Volume: 574, Issue:1-2

    Topics: Animals; Glucocorticoids; Iodine Radioisotopes; Male; Mifepristone; Obesity; Prosencephalon; Radioligand Assay; Rats; Rats, Zucker; Receptors, Adrenergic, alpha

1992
Differential hypothalamic arginine vasopressin response to glucocorticoid receptor antagonism in lean and obese Zucker rats.
    Neuroendocrinology, 1992, Volume: 56, Issue:2

    Topics: Animals; Arginine Vasopressin; Corticosterone; Hypothalamus; In Situ Hybridization; Male; Median Eminence; Mifepristone; Obesity; Pituitary Gland; Rats; Rats, Zucker; Receptors, Glucocorticoid; RNA, Messenger

1992
The glucocorticoid antagonist mifepristone reveals abnormal regulation of the adrenocortical system in obese Zucker rats.
    The Journal of endocrinology, 1992, Volume: 132, Issue:3

    Topics: Animals; Corticosterone; Corticotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Male; Mifepristone; Obesity; Pituitary-Adrenal System; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Zucker; Receptors, Glucocorticoid; RNA, Messenger

1992
Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity.
    The American journal of physiology, 1992, Volume: 262, Issue:6 Pt 2

    Topics: Animals; Corticosterone; Dietary Fats; Female; Mifepristone; Obesity; Rats; Rats, Mutant Strains; Receptors, Glucocorticoid; Receptors, Progesterone

1992
Effects of repeated administration of mifepristone and 8-OH-DPAT on expression of preproneuropeptide Y mRNA in the arcuate nucleus of obese Zucker rats.
    Brain research. Molecular brain research, 1991, Volume: 10, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Arcuate Nucleus of Hypothalamus; Corticosterone; Gene Expression; Insulin; Male; Mifepristone; Neuropeptide Y; Nucleic Acid Hybridization; Obesity; Protein Precursors; Rats; Rats, Zucker; Reference Values; RNA, Messenger; Tetrahydronaphthalenes

1991
Ineffectiveness of parenteral fluoxetine or RU-486 to alter long-term food intake, body weight or body composition of genetically obese mice.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3

    Topics: Animals; Body Composition; Body Weight; Drug Administration Schedule; Eating; Female; Fluoxetine; Injections, Subcutaneous; Male; Mice; Mice, Obese; Mifepristone; Obesity; Parenteral Nutrition; Time Factors

1990
Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats.
    The American journal of physiology, 1990, Volume: 259, Issue:3 Pt 2

    Topics: Animals; Body Composition; Body Weight; Brain; Corticosterone; Eating; Female; Glucocorticoids; Insulin; Mifepristone; Obesity; Organ Size; Rats; Rats, Zucker

1990