Compounds > mifepristone
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mifepristone and Disease Exacerbation

mifepristone has been researched along with Disease Exacerbation in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (68.42)29.6817
2010's6 (31.58)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bai, H; Cao, Y; Du, L; Gao, L; Li, J; Liu, H; Lu, L; Lu, SL; Said, S; Serkova, N; Song, J; Wang, XJ; Wei, M; Xiao, J1
Check, D; Check, JH; Poretta, T1
Gao, L; He, M; Ni, X; Sun, Y; Tang, G; Wang, L; Xu, B; Yu, Y1
Bekker, A; Cao, J; Liang, L; Lutz, BM; Shieh, KR; Tao, YX; Wang, H; Wang, PK; Zhang, J1
Adomat, HH; Gleave, ME; Guns, ES; Hendy, SC; Locke, JA; Nelson, CC1
Check, D; Check, JH; Dix, E; Sansoucie, L1
Copel, L; Halevy, A; Halpern, Z; Samuk, I; Sandbank, J; Ziv, Y1
Emelyanov, A; Gong, Z; Koh, CH; Nguyen, AT; Parinov, S; Spitsbergen, JM1
Chua, SS; DeMayo, FJ; Ma, ZQ; Ngan, ES; Tsai, SY1
Hsu, CY; Kim, GM; Li, Q; Liu, N; Xu, J; Xu, XM; Yan, P1
Faivre, E; Lange, CA; Skildum, A1
Christov, K; Mehta, R; Wiehle, RD1
Ligtenberg, JJ; Meertens, JH; Monteban-Kooistra, WE; Oosterhuis, JK; Tulleken, JE; van den Berg, G; Zijlstra, JG1
Brooks, A; Harkins, RN; Hermiston, TW; Kretschmer, PJ; Orme, A; Petry, H; Qian, HS; Rubanyi, GM; Schaefer, C; Szymanski, P; Wang, P1
Besch-Williford, C; Brekken, RA; Hyder, SM; Liang, Y1
Balk, SP; Barb, D; Bubley, GJ; Gelmann, EP; Kantoff, PW; Manola, J; Mantzoros, C; Oh, WK; Smith, M; Taplin, ME1
Alexander, CL; Chan, WC; Greenhalgh, DA; Quinn, JA; Wu, H; Yao, D1
El Etreby, MF; Johnson, MH; Lewis, RW; Liang, Y1
DeVries, AC; Hattori, K; Hurn, PD; Morahan, MB; Sugo, N; Traystman, RJ1

Trials

1 trial(s) available for mifepristone and Disease Exacerbation

ArticleYear
A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones.
    BJU international, 2008, Volume: 101, Issue:9

    Topics: Aged; Aged, 80 and over; Androgens; Antineoplastic Agents, Hormonal; Castration; Cell Communication; Disease Progression; Hormone Antagonists; Humans; Male; Middle Aged; Mifepristone; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Treatment Outcome

2008

Other Studies

18 other study(ies) available for mifepristone and Disease Exacerbation

ArticleYear
Cooperation Between Pten and Smad4 in Murine Salivary Gland Tumor Formation and Progression.
    Neoplasia (New York, N.Y.), 2018, Volume: 20, Issue:8

    Topics: Animals; Carcinoma, Adenoid Cystic; Disease Progression; Humans; Mice; Mice, Inbred C57BL; Mifepristone; Phosphatidylinositol 3-Kinases; PTEN Phosphohydrolase; Salivary Gland Neoplasms; Salivary Glands; Signal Transduction; Smad4 Protein; TOR Serine-Threonine Kinases; Transforming Growth Factor beta

2018
Mifepristone Extends Both Length and Quality of Life in a Patient With Advanced Non-small Cell Lung Cancer that Has Progressed Despite Chemotherapy and a Check-point Inhibitor.
    Anticancer research, 2019, Volume: 39, Issue:4

    Topics: Adenocarcinoma of Lung; Aged; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Disease Progression; Female; Humans; Lung Neoplasms; Mifepristone; Neoplasm Staging; Nivolumab; Quality of Life; Time Factors; Treatment Outcome

2019
Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers.
    British journal of cancer, 2013, Sep-03, Volume: 109, Issue:5

    Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Androgen Receptor Antagonists; Androgens; beta Catenin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclofenil; Dihydrotestosterone; Disease Progression; Estradiol; Hormone Antagonists; Humans; Imidazoles; Indoles; Male; Mifepristone; Platelet Activating Factor; Prostatic Neoplasms; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Wnt Proteins

2013
Short-Term Sleep Disturbance-Induced Stress Does not Affect Basal Pain Perception, but Does Delay Postsurgical Pain Recovery.
    The journal of pain, 2015, Volume: 16, Issue:11

    Topics: Animals; Chronic Disease; Corticosterone; Disease Models, Animal; Disease Progression; Female; Ganglia, Spinal; Hormone Antagonists; Kv1.2 Potassium Channel; Lumbar Vertebrae; Male; Mifepristone; Pain Perception; Pain, Postoperative; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sleep Wake Disorders; Sleep, REM; Spinal Cord; Stress, Physiological

2015
Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts.
    The Journal of steroid biochemistry and molecular biology, 2009, Volume: 115, Issue:3-5

    Topics: Androgen Antagonists; Androgens; Anilides; Animals; Castration; Cell Line, Tumor; Cinnamates; Disease Progression; Drug Combinations; Enzyme Inhibitors; Finasteride; Gene Expression Regulation, Neoplastic; Humans; Ketoconazole; Male; Mice; Mice, Nude; Mifepristone; Molecular Structure; Neoplasm Transplantation; Nitriles; Progesterone; Prostatic Neoplasms; Steroids; Tosyl Compounds; Transplantation, Heterologous

2009
Mifepristone may halt progression of extensively metastatic human adenocarcinoma of the colon - case report.
    Anticancer research, 2009, Volume: 29, Issue:5

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Colonic Neoplasms; Disease Progression; Female; Humans; Male; Middle Aged; Mifepristone; Neoplasm Metastasis; Quality of Life

2009
Mifepristone (RU486), a pure antiprogesterone drug, in combination with vinblastine for the treatment of progesterone receptor-positive desmoid tumor.
    Techniques in coloproctology, 2010, Volume: 14, Issue:3

    Topics: Adenomatous Polyposis Coli; Adult; Anastomosis, Surgical; Disease Progression; Drug Therapy, Combination; Fatal Outcome; Fibromatosis, Aggressive; Humans; Imaging, Three-Dimensional; Male; Mifepristone; Peritoneal Neoplasms; Proctocolectomy, Restorative; Receptors, Progesterone; Tomography, X-Ray Computed; Vinblastine

2010
An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening.
    Disease models & mechanisms, 2012, Volume: 5, Issue:1

    Topics: Animals; Animals, Genetically Modified; Cell Transformation, Neoplastic; Disease Models, Animal; Disease Progression; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Humans; Liver Neoplasms; Mifepristone; Models, Biological; Proto-Oncogene Proteins c-akt; ras Proteins; Signal Transduction; Zebrafish

2012
Inducible expression of FGF-3 in mouse mammary gland.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Aug-20, Volume: 99, Issue:17

    Topics: Animals; Cell Adhesion Molecules; Disease Progression; Epithelial Cells; Female; Fibroblast Growth Factor 3; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Hyperplasia; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mice; Mice, Transgenic; Mifepristone; Ovariectomy; Proto-Oncogene Proteins; Sexual Maturation

2002
Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats.
    Experimental neurology, 2003, Volume: 183, Issue:2

    Topics: Animals; Antigens, CD; Blotting, Western; Disease Models, Animal; Disease Progression; Female; Hormone Antagonists; Methylprednisolone; Mifepristone; Neuroprotective Agents; Rats; Rats, Long-Evans; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Spinal Cord; Spinal Cord Injuries

2003
Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases.
    Molecular endocrinology (Baltimore, Md.), 2005, Volume: 19, Issue:2

    Topics: Binding Sites; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Cyclin D1; Disease Progression; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ligands; Luciferases; MAP Kinase Signaling System; Mifepristone; Phosphorylation; Point Mutation; Progestins; Receptors, Progesterone; S Phase; Serine; Time Factors; Transcription, Genetic; Transcriptional Activation; Up-Regulation

2005
Anti-progestins suppress the growth of established tumors induced by 7,12-dimethylbenz(a)anthracene: comparison between RU486 and a new 21-substituted-19-nor-progestin.
    Oncology reports, 2007, Volume: 18, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Proliferation; Disease Progression; Female; Hormone Antagonists; Mammary Neoplasms, Experimental; Mifepristone; Norpregnadienes; Progesterone Congeners; Progestins; Rats; Rats, Sprague-Dawley

2007
Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome.
    The Netherlands journal of medicine, 2007, Volume: 65, Issue:6

    Topics: Cushing Syndrome; Disease Progression; Fatal Outcome; Female; Humans; Ketoconazole; Middle Aged; Mifepristone; Opportunistic Infections; Pneumocystis carinii; Pneumonia, Pneumocystis; Risk Factors; Spironolactone

2007
Regulated expression of the interferon-beta gene in mice.
    Gene therapy, 2008, Volume: 15, Issue:1

    Topics: Animals; Biomarkers; Chemokine CXCL10; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; Genetic Therapy; Genetic Vectors; Injections, Intramuscular; Interferon-beta; Mice; Mice, Inbred Strains; Mifepristone; Multiple Sclerosis; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transgenes

2008
Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeutics.
    Cancer research, 2007, Oct-15, Volume: 67, Issue:20

    Topics: Angiogenesis Inhibitors; Animals; Aza Compounds; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Growth Processes; Disease Progression; Female; Humans; Medroxyprogesterone Acetate; Mice; Mifepristone; Neoplasms, Hormone-Dependent; Neovascularization, Pathologic; Progesterone; Progesterone Congeners; Progestins; Receptors, Estrogen; Receptors, Progesterone; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2007
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity.
    Journal of cell science, 2008, May-15, Volume: 121, Issue:Pt 10

    Topics: Animals; Cyclin D; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Disease Progression; Keratinocytes; Keratoacanthoma; Mice; Mifepristone; Oncogene Protein v-akt; Oncogene Proteins v-fos; PTEN Phosphohydrolase; Repressor Proteins; Skin Neoplasms; Tumor Suppressor Protein p53

2008
Antitumor activity of mifepristone in the human LNCaP, LNCaP-C4, and LNCaP-C4-2 prostate cancer models in nude mice.
    The Prostate, 2000, Feb-01, Volume: 42, Issue:2

    Topics: Androgens; Animals; Cell Division; Disease Models, Animal; Disease Progression; Hormone Antagonists; Humans; Male; Mice; Mice, Nude; Mifepristone; Prostatic Neoplasms; Random Allocation; Tumor Cells, Cultured

2000
Social stress exacerbates focal cerebral ischemia in mice.
    Stroke, 2002, Volume: 33, Issue:6

    Topics: Animals; Behavior, Animal; Brain Ischemia; Cognition; Corticosterone; Disease Models, Animal; Disease Progression; Hormone Antagonists; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Mifepristone; Motor Activity; Reaction Time; Receptors, Glucocorticoid; Reperfusion; Social Behavior; Social Dominance; Stress, Physiological

2002