Compounds > mifepristone
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mifepristone and Cancer of Prostate

mifepristone has been researched along with Cancer of Prostate in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (15.15)18.2507
2000's15 (45.45)29.6817
2010's12 (36.36)24.3611
2020's1 (3.03)2.80

Authors

AuthorsStudies
MacBride, MM; Muddana, SS; Peterson, BR; Price, AM1
Cen, S; Cui, X; He, Y; Huang, C; Li, X; Liu, M; Wu, M; Xie, Y; Zhang, R; Zhou, J1
Alumkal, J; Bayani, N; Bucher, E; Carroll, P; Chauchereau, A; Chiotti, K; Derrick, D; Feiler, H; Heiser, L; Korkola, JE; Liby, T; Liu, M; Smith, R1
Göös, H; Lampinen, RE; Lempiäinen, JK; Niskanen, EA; Palvimo, JJ; Varjosalo, M; Vuoti, KM1
Gao, L; He, M; Ni, X; Sun, Y; Tang, G; Wang, L; Xu, B; Yu, Y1
Cai, Y; Conzen, SD; Isikbay, M; Kach, J; Kregel, S; Otto, K; Szmulewitz, RZ; Vander Griend, DJ1
Buijs, JT; Culig, Z; Grimm, S; Hemmer, DM; Hwang, MS; Kroon, J; Marijt, KA; Masood, M; Meijer, OC; Metselaar, JM; Puhr, M; Storm, G; van der Horst, G; van der Pluijm, G1
Collins, AT; Erb, HH; Maitland, NJ; Mann, VM; Nappo, G; Rane, JK; Simms, MS; Visakorpi, T1
Jin, FS; Li, LC; Xie, LP; Yan, TZ1
Adomat, HH; Gleave, ME; Guns, ES; Hendy, SC; Locke, JA; Nelson, CC1
Braciak, TA; DeLaney, A; Gabaglia, CR; Gauldie, J; Gee, J; Graham, FL; Halder, R; Sercarz, EE1
Dotan, N; Mahajna, J; Wasser, SP1
Check, D; Check, JH; Dix, E; Wilson, C1
Garabedian, MJ; Lee, P; Lepor, H; Li, Y; Ligr, M; Logan, SK; Melamed, J; Taneja, S1
Kapoor, S1
Brandhagen, BN; Goyeneche, AA; Telleria, CM; Tieszen, CR; Tracy, MS; Ulmer, TM1
Eid, MA; El Etreby, F; Kumar, MV; Lewis, RW; Liang, Y1
Eid, MA; Kumar, MV; Lewis, RW1
Hashimoto, Y; Kwak, I; Tsai, MJ; Tsai, SY; Zhou, G1
Berrevoets, CA; Brinkmann, AO; Trapman, J; Umar, A1
Jänne, OA; Kang, Z; Palvimo, JJ1
Gao, QZ; Lü, JJ; Zhang, H; Zhang, J1
Balk, SP; Barb, D; Bubley, GJ; Gelmann, EP; Kantoff, PW; Manola, J; Mantzoros, C; Oh, WK; Smith, M; Taplin, ME1
Grunberg, SM; Kawachi, MH; Lin, FF; Lin, MF; Stallcup, MR1
Oh-ishi, S1
Chang, C; Miyamoto, H; Wilding, G; Yeh, S1
El Etreby, MF; Johnson, MH; Lewis, RW; Liang, Y1
El Etreby, MF; Lewis, RW; Liang, Y1
Vastag, B1
Ali, AA; El Etreby, MF; Kumar, MV; Lewis, RW; Liang, Y; Sridhar, S1
Brive, L; Ely, KR; Feldman, D; Krishnan, AV; Peehl, DM; Swami, S; Zhao, XY1
Hiipakka, RA; Ito, K; Kokontis, J; Liao, S1
Johnson, IE; Mobbs, BG1

Reviews

1 review(s) available for mifepristone and Cancer of Prostate

ArticleYear
[Pharmacological mechanism of action and development of anti-steroid hormones].
    Nihon rinsho. Japanese journal of clinical medicine, 1994, Volume: 52, Issue:3

    Topics: Androgen Antagonists; Animals; Breast Neoplasms; Estrogen Antagonists; Female; Humans; Male; Mifepristone; Progesterone; Prostatic Neoplasms

1994

Trials

1 trial(s) available for mifepristone and Cancer of Prostate

ArticleYear
A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones.
    BJU international, 2008, Volume: 101, Issue:9

    Topics: Aged; Aged, 80 and over; Androgens; Antineoplastic Agents, Hormonal; Castration; Cell Communication; Disease Progression; Hormone Antagonists; Humans; Male; Middle Aged; Mifepristone; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Treatment Outcome

2008

Other Studies

31 other study(ies) available for mifepristone and Cancer of Prostate

ArticleYear
11beta-alkyl-Delta9-19-nortestosterone derivatives: high-affinity ligands and potent partial agonists of the androgen receptor.
    Journal of medicinal chemistry, 2004, Oct-07, Volume: 47, Issue:21

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Animals; Antineoplastic Agents; Cell Line, Tumor; CHO Cells; Cricetinae; Cyproterone Acetate; Dimerization; Humans; Ligands; Male; Mifepristone; Nandrolone; Prostatic Neoplasms; Receptors, Androgen; Structure-Activity Relationship

2004
Rational drug design for androgen receptor and glucocorticoids receptor dual antagonist.
    European journal of medicinal chemistry, 2019, Mar-15, Volume: 166

    Topics: Androgen Receptor Antagonists; Cell Proliferation; Drug Design; Humans; Male; Molecular Docking Simulation; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Protein Conformation; Receptors, Androgen; Receptors, Glucocorticoid; RNA, Messenger; Transcription, Genetic; User-Computer Interface

2019
Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant disease.
    Scientific reports, 2020, 12-10, Volume: 10, Issue:1

    Topics: Androgen Antagonists; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression; Humans; Male; Mifepristone; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Receptors, Androgen; Receptors, Glucocorticoid; RNA

2020
Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.
    Molecular & cellular proteomics : MCP, 2017, Volume: 16, Issue:8

    Topics: A549 Cells; Benzamides; Co-Repressor Proteins; Dexamethasone; Dihydrotestosterone; DNA-Binding Proteins; Humans; Male; Mifepristone; Nitriles; Nuclear Proteins; Phenylthiohydantoin; Prostatic Neoplasms; Protein Interaction Mapping; Receptors, Androgen; Receptors, Glucocorticoid; Transcription, Genetic

2017
Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers.
    British journal of cancer, 2013, Sep-03, Volume: 109, Issue:5

    Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Androgen Receptor Antagonists; Androgens; beta Catenin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclofenil; Dihydrotestosterone; Disease Progression; Estradiol; Hormone Antagonists; Humans; Imidazoles; Indoles; Male; Mifepristone; Platelet Activating Factor; Prostatic Neoplasms; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Wnt Proteins

2013
Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer.
    Hormones & cancer, 2014, Volume: 5, Issue:2

    Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Survival; Dexamethasone; Drug Resistance, Neoplasm; HEK293 Cells; Humans; Immediate-Early Proteins; Immunoblotting; Male; Metribolone; Mice; Mice, Nude; Microscopy, Fluorescence; Mifepristone; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Receptors, Androgen; Receptors, Glucocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Xenograft Model Antitumor Assays

2014
Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer.
    Endocrine-related cancer, 2016, Volume: 23, Issue:1

    Topics: Apoptosis; Cyproterone Acetate; Docetaxel; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Hormone Antagonists; Humans; Male; Mifepristone; Prostatic Neoplasms; Receptors, Glucocorticoid; Taxoids; Tumor Cells, Cultured

2016
Inhibition of the glucocorticoid receptor results in an enhanced miR-99a/100-mediated radiation response in stem-like cells from human prostate cancers.
    Oncotarget, 2016, Aug-09, Volume: 7, Issue:32

    Topics: Cell Line, Tumor; Dexamethasone; Gene Expression Regulation, Neoplastic; Glucocorticoids; Hormone Antagonists; Humans; Male; MicroRNAs; Mifepristone; Neoplastic Stem Cells; Prostatic Neoplasms; Radiation Tolerance; Receptors, Glucocorticoid

2016
Relationship between glucocorticoid receptor signal pathway and androgen-independent prostate cancer.
    Urologia internationalis, 2008, Volume: 81, Issue:2

    Topics: Cell Line, Tumor; Hormone Antagonists; HSP90 Heat-Shock Proteins; Humans; In Vitro Techniques; Interleukin-6; Male; Mifepristone; Prostatic Neoplasms; Receptors, Androgen; Receptors, Glucocorticoid; Signal Transduction

2008
Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts.
    The Journal of steroid biochemistry and molecular biology, 2009, Volume: 115, Issue:3-5

    Topics: Androgen Antagonists; Androgens; Anilides; Animals; Castration; Cell Line, Tumor; Cinnamates; Disease Progression; Drug Combinations; Enzyme Inhibitors; Finasteride; Gene Expression Regulation, Neoplastic; Humans; Ketoconazole; Male; Mice; Mice, Nude; Mifepristone; Molecular Structure; Neoplasm Transplantation; Nitriles; Progesterone; Prostatic Neoplasms; Steroids; Tosyl Compounds; Transplantation, Heterologous

2009
Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice.
    Journal of translational medicine, 2010, Oct-14, Volume: 8

    Topics: Adenoviridae; Animals; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Genetic Vectors; Interleukin-12; Lymphatic Metastasis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mifepristone; Prostatic Neoplasms

2010
The culinary-medicinal mushroom Coprinus comatus as a natural antiandrogenic modulator.
    Integrative cancer therapies, 2011, Volume: 10, Issue:2

    Topics: Active Transport, Cell Nucleus; Androgen Antagonists; Androgens; Aniline Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coprinus; Dexamethasone; Dihydrotestosterone; Down-Regulation; Female; Flutamide; Gene Expression; Genes, Reporter; Humans; Inhibitory Concentration 50; Luciferases; Male; Mifepristone; Nitriles; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Quinolines; Receptors, Androgen; Receptors, Glucocorticoid; Tumor Stem Cell Assay; Up-Regulation

2011
Progesterone receptor antagonist therapy has therapeutic potential even in cancer restricted to males as evidenced from murine testicular and prostate cancer studies.
    Anticancer research, 2010, Volume: 30, Issue:12

    Topics: Animals; Antineoplastic Agents; Female; Hormone Antagonists; Male; Mice; Mice, Inbred C57BL; Mifepristone; Pregnancy; Progesterone; Prostatic Neoplasms; Receptors, Progesterone; Testicular Neoplasms

2010
Mifepristone inhibits GRβ coupled prostate cancer cell proliferation.
    The Journal of urology, 2012, Volume: 188, Issue:3

    Topics: Cell Proliferation; Hormone Antagonists; Humans; Male; Mifepristone; Prostatic Neoplasms; Receptors, Glucocorticoid; Tumor Cells, Cultured

2012
Re: mifepristone inhibits GRβ coupled prostate cancer cell proliferation.
    The Journal of urology, 2013, Volume: 189, Issue:5

    Topics: Cell Proliferation; Hormone Antagonists; Humans; Male; Mifepristone; Prostatic Neoplasms; Receptors, Glucocorticoid

2013
Cytostasis and morphological changes induced by mifepristone in human metastatic cancer cells involve cytoskeletal filamentous actin reorganization and impairment of cell adhesion dynamics.
    BMC cancer, 2013, Jan-26, Volume: 13

    Topics: Actin Cytoskeleton; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cytostatic Agents; Female; Hormone Antagonists; Humans; Male; Mifepristone; Neoplasm Invasiveness; Neoplasms; Nervous System Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Time Factors

2013
Mifepristone-induced secretion of transforming growth factor beta1-induced apoptosis in prostate cancer cells.
    International journal of oncology, 2002, Volume: 21, Issue:6

    Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Cytochrome c Group; Cytosol; Enzyme-Linked Immunosorbent Assay; Estrogen Antagonists; Fluorescent Dyes; Humans; Immunoblotting; Male; Mice; Mice, Nude; Mifepristone; Prostatic Neoplasms; Rhodamines; Tamoxifen; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transplantation, Heterologous; Tumor Cells, Cultured

2002
Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL).
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:10

    Topics: Apoptosis; Apoptosis Regulatory Proteins; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Carrier Proteins; Caspase 3; Caspase 7; Caspase 8; Caspase 9; Caspases; Cytochrome c Group; Cytosol; Hormone Antagonists; Humans; Male; Membrane Glycoproteins; Mifepristone; Mitochondria; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2002
Role of the steroid receptor coactivator SRC-3 in cell growth.
    Molecular and cellular biology, 2003, Volume: 23, Issue:21

    Topics: Animals; Cell Division; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Female; Histone Acetyltransferases; Hormone Antagonists; Liver; Male; Mice; Mice, Knockout; Mifepristone; Mitogen-Activated Protein Kinases; Nuclear Receptor Coactivator 3; Prostatic Neoplasms; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Steroids; TOR Serine-Threonine Kinases; Trans-Activators

2003
Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR).
    The Biochemical journal, 2004, May-01, Volume: 379, Issue:Pt 3

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Binding, Competitive; Cell Line, Tumor; CHO Cells; Cricetinae; Cyproterone Acetate; Down-Regulation; Gene Expression Regulation; Ligands; Male; Metribolone; Mice; Mifepristone; Mutation; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 2; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Repressor Proteins; Transcription Factors; Transcription, Genetic; Transfection

2004
Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor.
    Molecular endocrinology (Baltimore, Md.), 2004, Volume: 18, Issue:11

    Topics: Acetylation; Androgen Receptor Antagonists; Anilides; Cell Line, Tumor; Chromatin Immunoprecipitation; Cyproterone Acetate; DNA Polymerase II; Enhancer Elements, Genetic; Gene Expression Regulation; Histones; Humans; Male; Methylation; Mifepristone; Nitriles; Nuclear Proteins; Nuclear Receptor Coactivator 2; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Protein-Arginine N-Methyltransferases; Receptors, Androgen; Tissue Kallikreins; Tosyl Compounds; Trans-Activators; Transcription Factors; Transcription, Genetic

2004
[Induction of apoptosis by mifepristone in androgen-independent prostate cancer cell lines in vitro].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 2006, Mar-15, Volume: 44, Issue:6

    Topics: Androgens; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Colorimetry; Dose-Response Relationship, Drug; Flow Cytometry; Hormone Antagonists; Humans; Male; Mifepristone; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Time Factors; Vascular Endothelial Growth Factor A

2006
Growth inhibition of androgen-insensitive human prostate carcinoma cells by a 19-norsteroid derivative agent, mifepristone.
    The Prostate, 1995, Volume: 26, Issue:4

    Topics: Animals; Cell Division; Dexamethasone; Fluorescent Antibody Technique; Humans; Male; Mice; Mice, Inbred BALB C; Mifepristone; Progesterone; Prostatic Neoplasms; Receptors, Steroid; Tumor Cells, Cultured

1995
Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Jun-23, Volume: 95, Issue:13

    Topics: Androgen Antagonists; Androgens; Anilides; Cyproterone Acetate; Drug Interactions; Flutamide; Humans; Imidazoles; Male; Mifepristone; Nitriles; Nuclear Receptor Coactivators; Oncogene Proteins; Prostatic Neoplasms; Protein Binding; Protein Conformation; Tosyl Compounds; Trans-Activators; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured

1998
Antitumor activity of mifepristone in the human LNCaP, LNCaP-C4, and LNCaP-C4-2 prostate cancer models in nude mice.
    The Prostate, 2000, Feb-01, Volume: 42, Issue:2

    Topics: Androgens; Animals; Cell Division; Disease Models, Animal; Disease Progression; Hormone Antagonists; Humans; Male; Mice; Mice, Nude; Mifepristone; Prostatic Neoplasms; Random Allocation; Tumor Cells, Cultured

2000
Induction of apoptosis by mifepristone and tamoxifen in human LNCaP prostate cancer cells in culture.
    The Prostate, 2000, Apr-01, Volume: 43, Issue:1

    Topics: Animals; Antibodies; Apoptosis; Cell Division; Cell Survival; DNA Fragmentation; Estrogen Antagonists; Hormone Antagonists; Humans; Male; Mannosephosphates; Mice; Mice, Nude; Mifepristone; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tamoxifen; Transforming Growth Factor beta; Tumor Cells, Cultured

2000
Effect of mifepristone approval on research remains to be seen.
    Journal of the National Cancer Institute, 2000, Dec-20, Volume: 92, Issue:24

    Topics: Abortifacient Agents, Steroidal; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Drug Approval; Drug Industry; Female; France; Germany; Humans; Male; Mifepristone; Neoplasms, Hormone-Dependent; Ovarian Neoplasms; Progesterone; Prostatic Neoplasms; Research Support as Topic; Tamoxifen; United States; United States Food and Drug Administration

2000
Differential expression of members of the tumor necrosis factor alpha-related apoptosis-inducing ligand pathway in prostate cancer cells.
    Cancer research, 2001, Oct-01, Volume: 61, Issue:19

    Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Humans; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Nude; Mifepristone; Prostatic Neoplasms; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; Tamoxifen; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays

2001
A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer.
    Endocrinology, 2002, Volume: 143, Issue:5

    Topics: Androgen Antagonists; Androgens; Anilides; Binding, Competitive; Cell Line; Dihydrotestosterone; Fludrocortisone; Genes, Reporter; Glucocorticoids; Humans; Hydrocortisone; Kinetics; Ligands; Male; Mifepristone; Models, Molecular; Mutation; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Radioligand Assay; Receptors, Androgen; Tosyl Compounds; Triamcinolone

2002
Expression and function of normal and LNCaP androgen receptors in androgen-insensitive human prostatic cancer cells. Altered hormone and antihormone specificity in gene transactivation.
    Receptor, 1991, Volume: 1, Issue:4

    Topics: Androgen Antagonists; Androgens; Chloramphenicol O-Acetyltransferase; Gene Expression Regulation; Humans; Male; Mammary Tumor Virus, Mouse; Mifepristone; Prostatic Neoplasms; Protein Biosynthesis; Receptors, Androgen; Reference Values; Sensitivity and Specificity; Transcription, Genetic; Transfection; Tumor Cells, Cultured

1991
Suppression of the growth of the androgen-insensitive R3327 HI rat prostatic carcinoma by combined estrogen and antiprogestin treatment.
    The Journal of steroid biochemistry and molecular biology, 1991, Volume: 39, Issue:5A

    Topics: Animals; Cell Division; Cell Line; Diethylstilbestrol; DNA Replication; Drug Interactions; Male; Mifepristone; Prostatic Neoplasms; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Progesterone; Thymidine; Tritium

1991