Page last updated: 2024-08-23

mifepristone and Aging

mifepristone has been researched along with Aging in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.23)18.7374
1990's9 (29.03)18.2507
2000's15 (48.39)29.6817
2010's6 (19.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Agorastos, A; Demiralay, C; Steiger, A; Wiedemann, K1
Argenton, F; Benato, F; Colletti, E; Colombo, L; Dalla Valle, L; Moro, E; Skobo, T1
Amat, J; Barrientos, RM; Crysdale, NY; Frank, MG; Hale, MW; Hennessey, PA; Kitt, MM; Lowry, CA; Maier, SF; Spencer, RL; Stamper, CE; Thompson, VM; Watkins, LR1
Bacman, SR; Dillon, LM; Hida, A; Malek, TR; Moraes, CT; Morton, PD; Pickrell, AM; Pinto, M; Wang, X; Williams, SL; Yu, A1
Choi, HI; Douard, V; Elshenawy, S; Ferraris, RP; Lagunoff, D1
Poirier, L; Seroude, L; Shane, A; Zheng, J1
Alberini, CM; New, AS; Riceberg, JS; Taubenfeld, SM1
Berger, S; Deussing, JM; Ganea, K; Holsboer, F; Liebl, C; Müller, MB; Niederleitner, B; Schmidt, MV; Schütz, G; Sterlemann, V; Wagner, K1
Curtis, C; Shen, J; Tavaré, S; Tower, J1
Ling, D; Salvaterra, PM1
Hardy, J; Kerr, F; Lovestone, S; Martinez, P; Partridge, L; Rogers, I1
Cao, J; Deng, J; Li, T; Liang, C; Wei, H; Xiong, W; Xu, L; Yang, S; Yang, Y; Zhang, J; Zhou, Q1
Alles, S; Attaix, D; Brajon, B; Leydier, I; Meynial-Denis, D; Mezzarobba, V; Mignon, M; Torrent, A1
Brann, DW; De Sevilla, L; Mahesh, VB; Zamorano, PL1
Haji, A; Ohi, Y; Takeda, R; Yamazaki, H1
Jensen, BL; Madsen, K; Nielsen, FT; Skøtt, O; Stubbe, J1
Crocker, A; Joiner, WJ; Sehgal, A; White, BH1
Horiuchi, J; Nagano, S; Nakagami, Y; Saitoe, M; Tamura, T; Yamazaki, D1
Giannakou, ME; Goss, M; Jacobson, J; Leevers, SJ; Partridge, L; Vinti, G1
Ashwell, JD; Papadopoulos, V; Vacchio, MS1
Carey, F; Horan, MA; Rothwell, NJ; Strijbos, PJ1
Felsner, P; Globerson, A; Hofer, D; Rinner, I; Schauenstein, K1
Flynn, NE; Wu, G1
Pácha, J; Zemanová, Z1
Day, NK; Good, RA; Itoh, Y; Iwabuchi, K; Kizaki, T; Oh-Ishi, S; Ohno, H; Onoé, K; Ookawara, T1
Morgan, WW; Richardson, A; Sharp, ZD; Walter, CA1
Balter, M1
Csaba, G; Inczefi-Gonda, A1
Kalish, EE; Logvinenko, NS; Solenov, EI; Svitasheva, NG1
Beck, G; Chasserot-Golaz, S; Genot, G; Lechner, MC; Ribeiro, V1
Capek, K; Pácha, J; Popp, M1

Reviews

1 review(s) available for mifepristone and Aging

ArticleYear
Application of exogenously regulatable promoter systems to transgenic models for the study of aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1999, Volume: 54, Issue:1

    Topics: Aging; Animals; Disease Models, Animal; Ecdysone; Embryonic and Fetal Development; Gene Expression Regulation; Growth; Homeostasis; Mice; Mice, Knockout; Mice, Transgenic; Mifepristone; Promoter Regions, Genetic; Tetracycline; Transcription, Genetic; Transcriptional Activation

1999

Trials

1 trial(s) available for mifepristone and Aging

ArticleYear
Sleep EEG effects of anti-gluco- and anti-mineralocorticoids in old-aged men: pilot study.
    Psychiatry and clinical neurosciences, 2014, Volume: 68, Issue:5

    Topics: Aged; Aged, 80 and over; Aging; Electroencephalography; Humans; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Pilot Projects; Receptors, Glucocorticoid; Single-Blind Method; Sleep Stages; Spironolactone

2014

Other Studies

29 other study(ies) available for mifepristone and Aging

ArticleYear
A living biosensor model to dynamically trace glucocorticoid transcriptional activity during development and adult life in zebrafish.
    Molecular and cellular endocrinology, 2014, Jul-05, Volume: 392, Issue:1-2

    Topics: Aging; Animals; Animals, Genetically Modified; Biosensing Techniques; Dexamethasone; Gene Expression; Gene Knockdown Techniques; Genes, Reporter; Glucocorticoids; Green Fluorescent Proteins; Microscopy, Fluorescence; Mifepristone; Models, Biological; Morpholinos; Organ Specificity; Receptors, Glucocorticoid; Response Elements; Transcription, Genetic; Transgenes; Zebrafish

2014
Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.
    Neurobiology of aging, 2015, Volume: 36, Issue:3

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Aging; Animals; Catalysis; Cells, Cultured; Corticosterone; Hippocampus; Inflammation; Male; Memory; Memory Disorders; Microglia; Mifepristone; Physical Conditioning, Animal; Rats, Inbred F344; Receptors, Glucocorticoid

2015
Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner.
    Cell death and differentiation, 2017, Volume: 24, Issue:2

    Topics: Acetylcysteine; Aging; Animals; Apoptosis; Cell Cycle Checkpoints; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Deoxyribonucleases, Type II Site-Specific; DNA Breaks, Double-Stranded; DNA, Mitochondrial; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mifepristone; Phenotype; Reactive Oxygen Species; Thymocytes; Tumor Suppressor Protein p53

2017
Developmental reprogramming of rat GLUT5 requires glucocorticoid receptor translocation to the nucleus.
    The Journal of physiology, 2008, Aug-01, Volume: 586, Issue:15

    Topics: Active Transport, Cell Nucleus; Aging; Animals; Dexamethasone; Fructose; Gene Expression Regulation, Developmental; Glucose Transporter Type 5; Mifepristone; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid

2008
Characterization of the Drosophila gene-switch system in aging studies: a cautionary tale.
    Aging cell, 2008, Volume: 7, Issue:5

    Topics: Aging; Animals; Drosophila melanogaster; Female; Gene Expression Regulation, Developmental; Longevity; Male; Mifepristone; Models, Genetic

2008
Preclinical assessment for selectively disrupting a traumatic memory via postretrieval inhibition of glucocorticoid receptors.
    Biological psychiatry, 2009, Feb-01, Volume: 65, Issue:3

    Topics: Aging; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Electroshock; Hormone Antagonists; Male; Memory; Mental Recall; Mifepristone; Motor Activity; Rats; Rats, Long-Evans; Receptors, Glucocorticoid; Stress Disorders, Post-Traumatic; Stress Disorders, Traumatic, Acute; Wounds and Injuries

2009
Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences.
    Endocrinology, 2009, Volume: 150, Issue:6

    Topics: Adaptation, Psychological; Aging; Animals; Animals, Newborn; Corticosterone; Corticotropin-Releasing Hormone; Feedback, Physiological; Gene Deletion; Glucocorticoids; Hormone Antagonists; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Knockout; Mifepristone; Models, Animal; Paraventricular Hypothalamic Nucleus; Pituitary Gland; Pituitary-Adrenal System; Receptors, Glucocorticoid; Vasopressins

2009
A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila.
    Aging, 2009, Jan-30, Volume: 1, Issue:2

    Topics: Aging; Animals; Apoptosis; Drosophila; Female; Gene Expression Regulation; Hormone Antagonists; Larva; Longevity; Male; Mifepristone; Sex Characteristics

2009
Brain aging and Aβ₁₋₄₂ neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with aging.
    Acta neuropathologica, 2011, Volume: 121, Issue:2

    Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Autophagy; Brain; Disease Models, Animal; Drosophila; Drosophila Proteins; Gene Expression Regulation; Green Fluorescent Proteins; Hormone Antagonists; Humans; Lysosomes; Microscopy, Confocal; Microscopy, Electron, Transmission; Mifepristone; Neurons; Peptide Fragments

2011
Ageing increases vulnerability to aβ42 toxicity in Drosophila.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Aging; Amyloid beta-Peptides; Animals; Drosophila melanogaster; Gene Expression Regulation; Mifepristone; Peptide Fragments; RNA, Messenger; Solubility; Time Factors

2012
Both stress experience and age determine the impairment or enhancement effect of stress on spatial memory retrieval.
    The Journal of endocrinology, 2003, Volume: 178, Issue:1

    Topics: Aging; Animals; Hormone Antagonists; Male; Memory Disorders; Mental Recall; Mifepristone; Psychological Tests; Rats; Rats, Wistar; Receptors, Glucocorticoid; Stress, Psychological

2003
The role of adrenal hormones in the response of glutamine synthetase to fasting in adult and old rats.
    Clinical nutrition (Edinburgh, Scotland), 2003, Volume: 22, Issue:6

    Topics: Adrenal Glands; Adrenalectomy; Age Factors; Aging; Analysis of Variance; Animals; Blotting, Northern; Fasting; Glucocorticoids; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Hormone Antagonists; Male; Mifepristone; Muscle, Skeletal; Rats; Rats, Wistar; RNA, Messenger

2003
Expression of glutamate receptor subunits in the hypothalamus of the female rat during the afternoon of the proestrous luteinizing hormone surge and effects of antiprogestin treatment and aging.
    Neuroendocrinology, 2005, Volume: 81, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Blotting, Northern; Blotting, Western; Drug Interactions; Enzyme Inhibitors; Estrogens; Female; Gene Expression Regulation; Hypothalamus; Luteinizing Hormone; Mifepristone; Ovariectomy; Proestrus; Progesterone; Protein Subunits; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

2005
Effects of progesterone on apneic events during behaviorally defined sleep in male rats.
    Life sciences, 2005, Dec-12, Volume: 78, Issue:4

    Topics: Aging; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Hormone Antagonists; Hyperventilation; Injections, Intraperitoneal; Male; Mifepristone; Plethysmography, Whole Body; Progesterone; Rats; Rats, Sprague-Dawley; Respiration; Sleep; Sleep Apnea Syndromes

2005
Glucocorticoid impairs growth of kidney outer medulla and accelerates loop of Henle differentiation and urinary concentrating capacity in rat kidney development.
    American journal of physiology. Renal physiology, 2006, Volume: 291, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cell Differentiation; Dexamethasone; Female; Glucocorticoids; Kidney Medulla; Loop of Henle; Mifepristone; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Urine

2006
Sleep in Drosophila is regulated by adult mushroom bodies.
    Nature, 2006, Jun-08, Volume: 441, Issue:7094

    Topics: Aging; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drosophila melanogaster; Female; Gene Expression Regulation, Enzymologic; Homeostasis; Learning; Mifepristone; Models, Animal; Mushroom Bodies; Sleep

2006
The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan.
    Nature neuroscience, 2007, Volume: 10, Issue:4

    Topics: Aging; Animals; Animals, Genetically Modified; Behavior, Animal; Casein Kinase 1 epsilon; Conditioning, Psychological; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drosophila; Drosophila Proteins; Enzyme-Linked Immunosorbent Assay; Hormone Antagonists; Memory Disorders; Mifepristone; Mushroom Bodies; Mutation; Odorants; Survival Analysis; Time Factors

2007
Dynamics of the action of dFOXO on adult mortality in Drosophila.
    Aging cell, 2007, Volume: 6, Issue:4

    Topics: Aging; Animals; Drosophila melanogaster; Drosophila Proteins; Female; Forkhead Transcription Factors; Gene Expression Regulation; Insulin-Like Growth Factor I; Longevity; Mifepristone; Signal Transduction

2007
Steroid production in the thymus: implications for thymocyte selection.
    The Journal of experimental medicine, 1994, Jun-01, Volume: 179, Issue:6

    Topics: Aging; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Epithelial Cells; Epithelium; Fetus; Lymphocyte Depletion; Metyrapone; Mice; Mice, Inbred BALB C; Mifepristone; Organ Culture Techniques; Pregnenolone; Receptors, Antigen, T-Cell; Receptors, Glucocorticoid; Signal Transduction; T-Lymphocytes; Thymus Gland

1994
Impaired febrile responses of aging mice are mediated by endogenous lipocortin-1 (annexin-1).
    The American journal of physiology, 1993, Volume: 265, Issue:2 Pt 1

    Topics: Aging; Animals; Annexin A1; Body Temperature; Corticosterone; Dinoprostone; Female; Fever; Immune Sera; Immunoglobulin G; Interleukin-1; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mifepristone; Norepinephrine; Osmolar Concentration; Oxygen Consumption

1993
Characterization of the spontaneous apoptosis of rat thymocytes in vitro.
    International archives of allergy and immunology, 1996, Volume: 111, Issue:3

    Topics: Acridine Orange; Adrenalectomy; Aging; Animals; Anti-Inflammatory Agents; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Count; Cell Survival; Cells, Cultured; Corticosterone; Cycloheximide; DNA Damage; Flow Cytometry; Fluorescent Dyes; Hormone Antagonists; Male; Mifepristone; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Thymus Gland

1996
Glucocorticoids play an important role in mediating the enhanced metabolism of arginine and glutamine in enterocytes of postweaning pigs.
    The Journal of nutrition, 1997, Volume: 127, Issue:5

    Topics: Aging; Ammonia; Animals; Arginase; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Carbon Dioxide; Cells, Cultured; DNA; Enzyme Induction; Female; Glucocorticoids; Glutamine; Hydrocortisone; Jejunum; Male; Mifepristone; Ornithine; Proline; Receptors, Glucocorticoid; Swine; Urea; Weaning

1997
Localization of Na,K-ATPase activity in developing rat distal colon: role of corticosteroids.
    Mechanisms of ageing and development, 1998, Mar-16, Volume: 101, Issue:1-2

    Topics: 4-Nitrophenylphosphatase; Adrenal Cortex Hormones; Adrenalectomy; Aging; Aldosterone; Animals; Colon; Desoxycorticosterone; Dexamethasone; Glucocorticoids; Hormone Antagonists; Intestinal Mucosa; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Ouabain; Rats; Rats, Wistar; Receptors, Glucocorticoid; Sodium-Potassium-Exchanging ATPase; Spironolactone

1998
An increase in basal glucocorticoid concentration with age induces suppressor macrophages with high-density Fc gamma RII/III.
    Immunology, 1998, Volume: 93, Issue:3

    Topics: Aging; Animals; Glucocorticoids; Hormone Antagonists; Immune Tolerance; Macrophage Activation; Macrophage-1 Antigen; Macrophages; Male; Mice; Mice, Inbred BALB C; Mifepristone; Receptors, IgG; Spleen

1998
Profile. For 'father' of abortion drug, vindication at last.
    Science (New York, N.Y.), 2000, Oct-06, Volume: 290, Issue:5489

    Topics: Abortifacient Agents, Steroidal; Aging; Dehydroepiandrosterone; Drug Approval; Drug Industry; Female; France; History, 20th Century; Humans; Mifepristone; United States; United States Food and Drug Administration

2000
Similarities and dissimilarities of newborn and adolescent rats in the binding capacity of thymic glucocorticoid receptors.
    Mechanisms of ageing and development, 2001, Volume: 122, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Dexamethasone; Female; Male; Mifepristone; Rats; Rats, Wistar; Receptors, Glucocorticoid; Thymus Gland

2001
[The age-related characteristics of the hormonal regulation of Na+, K(+)-ATPase activity in the kidney cortex of rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1992, Volume: 114, Issue:8

    Topics: Adrenalectomy; Aging; Aldosterone; Animals; Kidney Cortex; Kidney Tubules, Collecting; Kidney Tubules, Distal; Male; Mifepristone; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Sodium-Potassium-Exchanging ATPase; Spironolactone

1992
The steroid antagonist RU38486 is metabolized by the liver microsomal P450 mono-oxygenases.
    Biochemical and biophysical research communications, 1990, Mar-30, Volume: 167, Issue:3

    Topics: Aging; Animals; Antibodies; Biotransformation; Cytochrome P-450 Enzyme System; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mifepristone; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values

1990
Corticosteroid regulation of Na+ and K+ transport in the rat distal colon during postnatal development.
    Journal of developmental physiology, 1988, Volume: 10, Issue:6

    Topics: Adrenal Cortex Hormones; Adrenalectomy; Aging; Aldosterone; Amiloride; Animals; Animals, Suckling; Colon; Corticosterone; Dexamethasone; Estrenes; Mifepristone; Potassium; Rats; Sodium; Spironolactone

1988