midostaurin has been researched along with Colonic-Neoplasms* in 2 studies
2 other study(ies) available for midostaurin and Colonic-Neoplasms
| Article | Year |
|---|---|
A Granular Approach to a Patient with Diarrhea and Flushing.
Topics: Antineoplastic Agents; Cell Degranulation; Colonic Neoplasms; Diarrhea; Flushing; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Mast Cells; Mastocytosis, Systemic; Middle Aged; Protein Kinase Inhibitors; Staurosporine; Treatment Outcome | 2019 |
Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
The intracellular signaling involved in the mechanism of action of zonula occludens toxin (ZOT) was studied using several in vitro and ex vivo models. ZOT showed a selective effect among various cell lines tested, suggesting that it may interact with a specific receptor, whose surface expression on various cells differs. When tested in IEC6 cell monolayers, ZOT-containing supernatants induced a redistribution of the F-actin cytoskeleton. Similar results were obtained with rabbit ileal mucosa, where the reorganization of F-actin paralleled the increase in tissue permeability. In endothelial cells, the cytoskeletal rearrangement involved a decrease of the soluble G-actin pool (-27%) and a reciprocal increase in the filamentous F-actin pool (+22%). This actin polymerization was time- and dose-dependent, and was reversible. Pretreatment with a specific protein kinase C inhibitor, CGP41251, completely abolished the ZOT effects on both tissue permeability and actin polymerization. In IEC6 cells ZOT induced a peak increment of the PKC-alpha isoform after 3 min incubation. Taken together, these results suggest that ZOT activates a complex intracellular cascade of events that regulate tight junction permeability, probably mimicking the effect of physiologic modulator(s) of epithelial barrier function. Topics: Actins; Adenosine Triphosphatases; Alkaloids; Animals; Carcinoma; Cattle; Cell Line; Cholera Toxin; Colonic Neoplasms; Cytoskeleton; Endothelium, Vascular; Endotoxins; Humans; Ileum; Intercellular Junctions; Intestinal Mucosa; Isoenzymes; Kidney Cortex; Male; Organ Specificity; Permeability; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Protein Kinase C; Pulmonary Artery; Rabbits; Rats; Signal Transduction; Species Specificity; Staurosporine; Swine; Tumor Cells, Cultured; Vibrio cholerae | 1995 |