midodrine has been researched along with Syncope in 23 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| " All studies were conducted in clinical syncope populations and compared the benefit of midodrine vs." | 9.22 | Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis. ( Lei, LY; Raj, SR; Sheldon, RS, 2022) |
| " Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it." | 7.68 | A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992) |
| "Midodrine has been proposed in the management of patients with these conditions but its impact on patient important outcomes remains uncertain." | 6.50 | Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review. ( Catalano, HN; González Malla, C; Guyatt, G; Izcovich, A; Manzotti, M, 2014) |
| "Midodrine is an alpha-one agonist that produces arterial and venous constriction and leads to a decrease in heart rate by baroreceptor reflexes." | 6.39 | A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions. ( Jankovic, J; McElligott, MA; Piwinski, SE, 1994) |
| " All studies were conducted in clinical syncope populations and compared the benefit of midodrine vs." | 5.22 | Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis. ( Lei, LY; Raj, SR; Sheldon, RS, 2022) |
| " Midodrine did not cause any untoward reactions in these subjects before or after flight; in fact, a modest beneficial effect was seen on postflight tachycardia (p = 0." | 5.12 | Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension. ( Meck, JV; Platts, SH; Waters, WW; Ziegler, MG, 2006) |
| "Rates of presyncope were 38% with no drug; 0% with midodrine alone; 100% with promethazine alone; and 63% with both drugs." | 3.77 | Effects of promethazine and midodrine on orthostatic tolerance. ( Meck, JV; Platts, SH; Shi, SJ; Ziegler, MG, 2011) |
| " Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it." | 3.68 | A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992) |
| "If cardiac syncope is unlikely, reflex (neurally mediated) syncope and orthostatic hypotension are the most frequent causes of transient loss of consciousness." | 2.72 | New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope. ( Brignole, M; Rivasi, G, 2021) |
| "Midodrine has been proposed in the management of patients with these conditions but its impact on patient important outcomes remains uncertain." | 2.50 | Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review. ( Catalano, HN; González Malla, C; Guyatt, G; Izcovich, A; Manzotti, M, 2014) |
| "Droxidopa is a synthetic amino acid that is converted to norepinephrine by dopa-decarboxylase, the same enzyme that converts levodopa into dopamine in the treatment of Parkinson disease." | 2.50 | New developments in the management of neurogenic orthostatic hypotension. ( Biaggioni, I, 2014) |
| "Syncope is a common symptom and accounts for approximately 1% of all emergency visits." | 2.46 | Evaluation and management of syncope. ( Borggrefe, M; Schimpf, R; Veltmann, C; Wolpert, C, 2010) |
| "Syncope is a very common presentation with a wide differential diagnosis and equally wide prognostic implications." | 2.44 | Current concepts in the evaluation and management of syncope. ( Kuriachan, V; Sheldon, RS, 2008) |
| "Midodrine is an alpha-one agonist that produces arterial and venous constriction and leads to a decrease in heart rate by baroreceptor reflexes." | 2.39 | A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions. ( Jankovic, J; McElligott, MA; Piwinski, SE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Lei, LY | 1 |
| Raj, SR | 1 |
| Sheldon, RS | 2 |
| Brignole, M | 1 |
| Rivasi, G | 1 |
| Goodman, BP | 1 |
| Gupta, F | 1 |
| Izcovich, A | 1 |
| González Malla, C | 1 |
| Manzotti, M | 1 |
| Catalano, HN | 1 |
| Guyatt, G | 1 |
| Biaggioni, I | 2 |
| Kuriachan, V | 1 |
| Veltmann, C | 1 |
| Borggrefe, M | 1 |
| Wolpert, C | 1 |
| Schimpf, R | 1 |
| Shi, SJ | 1 |
| Platts, SH | 2 |
| Ziegler, MG | 2 |
| Meck, JV | 2 |
| Credner, SC | 1 |
| Lehmann, R | 1 |
| Grubb, BP | 2 |
| Hohnloser, SH | 1 |
| Klingenheben, T | 1 |
| Cheshire, WP | 1 |
| Achem, SR | 1 |
| Moore, A | 1 |
| Watts, M | 1 |
| Sheehy, T | 1 |
| Hartnett, A | 1 |
| Clinch, D | 1 |
| Lyons, D | 1 |
| Honma, K | 1 |
| Gierelak, G | 1 |
| Makowski, K | 1 |
| Guzik, P | 1 |
| Kramarz, E | 1 |
| Kowal, J | 1 |
| Cholewa, M | 1 |
| Fitzpatrick, AP | 1 |
| Cooper, P | 1 |
| Waters, WW | 1 |
| Piwinski, SE | 1 |
| Jankovic, J | 1 |
| McElligott, MA | 1 |
| Ward, C | 1 |
| Kenny, RA | 1 |
| Jacob, G | 1 |
| Shannon, JR | 1 |
| Black, B | 1 |
| Mosqueda-Garcia, R | 1 |
| Robertson, RM | 1 |
| Robertson, D | 1 |
| Karas, B | 1 |
| Kosinski, D | 1 |
| Boehm, K | 1 |
| Low, PA | 1 |
| Cicogna, R | 1 |
| Bonomi, FG | 1 |
| Mascioli, G | 1 |
| Ferrari, R | 1 |
| Turelli, A | 1 |
| Benigno, M | 1 |
| Curnis, A | 1 |
| Visioli, O | 1 |
| Koyama, S | 1 |
| Matsubara, T | 1 |
| Aizawa, Y | 1 |
| Ohshima, M | 1 |
| Yamaguchi, T | 1 |
| Yamazaki, Y | 1 |
| Igarashi, Y | 1 |
| Tamura, Y | 1 |
| Yamazoe, M | 1 |
| Izumi, T | 1 |
| Sütsch, G | 1 |
| Vetter, W | 1 |
| Hess, OM | 1 |
| Rhyner, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of the Mechanism of Non-cardiac Syncope by 24-hour Ambulatory Blood Pressure Monitoring (ABPM) and Tilt-table Short Cardiovascular Autonomic Function Battery (SCAFB)[NCT05728255] | 275 participants (Anticipated) | Observational | 2023-04-30 | Not yet recruiting | |||
| Efficacy and Safety of Midodrine and Atomoxetine Treatment in Patients With Neurogenic Orthostatic Hypotension : A Prospective Randomized Study[NCT03350659] | Phase 4 | 50 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for midodrine and Syncope
| Article | Year |
|---|---|
Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis.
Topics: Double-Blind Method; Female; Humans; Male; Midodrine; Randomized Controlled Trials as Topic; Syncope | 2022 |
New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope.
Topics: Accidental Falls; Adenosine; Antihypertensive Agents; Atomoxetine Hydrochloride; Atrioventricular No | 2021 |
Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review.
Topics: Humans; Hypotension, Orthostatic; Midodrine; Quality of Life; Reflex; Secondary Prevention; Syncope | 2014 |
New developments in the management of neurogenic orthostatic hypotension.
Topics: Accidental Falls; Activities of Daily Living; Adrenergic alpha-1 Receptor Agonists; Aged; Aged, 80 a | 2014 |
Current concepts in the evaluation and management of syncope.
Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents; Cardiac Pacing, Artificial; Fludrocortisone; | 2008 |
Evaluation and management of syncope.
Topics: Diagnosis, Differential; Electrocardiography; Humans; Hypotension, Orthostatic; Midodrine; Practice | 2010 |
[Diabetes mellitus and orthostatic intolerance].
Topics: Bandages; Diabetic Neuropathies; Diet, Sodium-Restricted; Exercise Therapy; Heart Rate; Humans; Male | 2005 |
Diagnosis and management of patients with blackouts.
Topics: Adolescent; Adult; Aged; Electrocardiography, Ambulatory; Epilepsy; Female; Humans; Male; Mental Dis | 2006 |
A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Female; Heart Rate; Humans; Hypotens | 1994 |
5 trials available for midodrine and Syncope
| Article | Year |
|---|---|
Treatment of vasodepressor carotid sinus syndrome with midodrine: a randomized, controlled pilot study.
Topics: Accidental Falls; Aged; Aged, 80 and over; Blood Pressure; Cross-Over Studies; Double-Blind Method; | 2005 |
Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension.
Topics: Adrenergic alpha-Agonists; Astronauts; Blood Pressure; Cardiac Output; Hemodynamics; Humans; Hypoten | 2006 |
Observations on midodrine in a case of vasodepressor neurogenic syncope.
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Cardiac Pacing, Artificial; Cross-Over Studies; El | 1995 |
Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Blood Volume; Clonidine; Female; Heart | 1997 |
Preliminary observations on the use of midodrine hydrochloride in the treatment of refractory neurocardiogenic syncope.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Autonomic Nervous System D | 1999 |
9 other studies available for midodrine and Syncope
| Article | Year |
|---|---|
Defining successful treatment of neurogenic orthostatic hypotension with droxidopa in a patient with multiple system atrophy.
Topics: Accidental Falls; Aged, 80 and over; Antiparkinson Agents; Droxidopa; Female; Humans; Hypotension, O | 2017 |
Effects of promethazine and midodrine on orthostatic tolerance.
Topics: Adrenergic alpha-1 Receptor Agonists; Adult; Aldosterone; Blood Pressure; Cardiac Output; Diastole; | 2011 |
Recurrent syncope in a patient after myocardial infarction.
Topics: Aged; Humans; Male; Midodrine; Myocardial Infarction; Recurrence; Sympathomimetics; Syncope | 2003 |
Clinical history.
Topics: Blood Pressure; Chest Pain; Clonazepam; Female; Heart Rate; Humans; Hypertension; Incidence; Middle | 2004 |
Effects of therapy based on tilt testing results on the long-term outcome in patients with syncope.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Female; Fludroco | 2005 |
Update on the evaluation, pathogenesis, and management of neurogenic orthostatic hypotension: introduction.
Topics: Clinical Trials as Topic; Humans; Hypotension, Orthostatic; Midodrine; Multicenter Studies as Topic; | 1995 |
[Hemodynamic and neuroendocrine profile of 2 different cardiovascular responses in vasodepressor syncope induced by the head-up tilt test].
Topics: Adolescent; Adult; Aged; Blood Pressure; Epinephrine; Etilefrine; Female; Heart Rate; Humans; Male; | 1992 |
A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride.
Topics: Adult; Blood Pressure; Bradycardia; Female; Humans; Hypotension; Midodrine; Seizures; Syncope; Vagus | 1992 |
[Dizziness, syncope, orthostatic hypotension].
Topics: Aged; Dizziness; Epinephrine; Female; Humans; Hypotension, Orthostatic; Midodrine; Norepinephrine; S | 1988 |