Page last updated: 2024-10-31

midodrine and Syncope

midodrine has been researched along with Syncope in 23 studies

Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)

Research Excerpts

ExcerptRelevanceReference
" All studies were conducted in clinical syncope populations and compared the benefit of midodrine vs."9.22Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis. ( Lei, LY; Raj, SR; Sheldon, RS, 2022)
" Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it."7.68A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992)
"Midodrine has been proposed in the management of patients with these conditions but its impact on patient important outcomes remains uncertain."6.50Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review. ( Catalano, HN; González Malla, C; Guyatt, G; Izcovich, A; Manzotti, M, 2014)
"Midodrine is an alpha-one agonist that produces arterial and venous constriction and leads to a decrease in heart rate by baroreceptor reflexes."6.39A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions. ( Jankovic, J; McElligott, MA; Piwinski, SE, 1994)
" All studies were conducted in clinical syncope populations and compared the benefit of midodrine vs."5.22Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis. ( Lei, LY; Raj, SR; Sheldon, RS, 2022)
" Midodrine did not cause any untoward reactions in these subjects before or after flight; in fact, a modest beneficial effect was seen on postflight tachycardia (p = 0."5.12Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension. ( Meck, JV; Platts, SH; Waters, WW; Ziegler, MG, 2006)
"Rates of presyncope were 38% with no drug; 0% with midodrine alone; 100% with promethazine alone; and 63% with both drugs."3.77Effects of promethazine and midodrine on orthostatic tolerance. ( Meck, JV; Platts, SH; Shi, SJ; Ziegler, MG, 2011)
" Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it."3.68A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992)
"If cardiac syncope is unlikely, reflex (neurally mediated) syncope and orthostatic hypotension are the most frequent causes of transient loss of consciousness."2.72New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope. ( Brignole, M; Rivasi, G, 2021)
"Midodrine has been proposed in the management of patients with these conditions but its impact on patient important outcomes remains uncertain."2.50Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review. ( Catalano, HN; González Malla, C; Guyatt, G; Izcovich, A; Manzotti, M, 2014)
"Droxidopa is a synthetic amino acid that is converted to norepinephrine by dopa-decarboxylase, the same enzyme that converts levodopa into dopamine in the treatment of Parkinson disease."2.50New developments in the management of neurogenic orthostatic hypotension. ( Biaggioni, I, 2014)
"Syncope is a common symptom and accounts for approximately 1% of all emergency visits."2.46Evaluation and management of syncope. ( Borggrefe, M; Schimpf, R; Veltmann, C; Wolpert, C, 2010)
"Syncope is a very common presentation with a wide differential diagnosis and equally wide prognostic implications."2.44Current concepts in the evaluation and management of syncope. ( Kuriachan, V; Sheldon, RS, 2008)
"Midodrine is an alpha-one agonist that produces arterial and venous constriction and leads to a decrease in heart rate by baroreceptor reflexes."2.39A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions. ( Jankovic, J; McElligott, MA; Piwinski, SE, 1994)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.35)18.7374
1990's7 (30.43)18.2507
2000's8 (34.78)29.6817
2010's5 (21.74)24.3611
2020's2 (8.70)2.80

Authors

AuthorsStudies
Lei, LY1
Raj, SR1
Sheldon, RS2
Brignole, M1
Rivasi, G1
Goodman, BP1
Gupta, F1
Izcovich, A1
González Malla, C1
Manzotti, M1
Catalano, HN1
Guyatt, G1
Biaggioni, I2
Kuriachan, V1
Veltmann, C1
Borggrefe, M1
Wolpert, C1
Schimpf, R1
Shi, SJ1
Platts, SH2
Ziegler, MG2
Meck, JV2
Credner, SC1
Lehmann, R1
Grubb, BP2
Hohnloser, SH1
Klingenheben, T1
Cheshire, WP1
Achem, SR1
Moore, A1
Watts, M1
Sheehy, T1
Hartnett, A1
Clinch, D1
Lyons, D1
Honma, K1
Gierelak, G1
Makowski, K1
Guzik, P1
Kramarz, E1
Kowal, J1
Cholewa, M1
Fitzpatrick, AP1
Cooper, P1
Waters, WW1
Piwinski, SE1
Jankovic, J1
McElligott, MA1
Ward, C1
Kenny, RA1
Jacob, G1
Shannon, JR1
Black, B1
Mosqueda-Garcia, R1
Robertson, RM1
Robertson, D1
Karas, B1
Kosinski, D1
Boehm, K1
Low, PA1
Cicogna, R1
Bonomi, FG1
Mascioli, G1
Ferrari, R1
Turelli, A1
Benigno, M1
Curnis, A1
Visioli, O1
Koyama, S1
Matsubara, T1
Aizawa, Y1
Ohshima, M1
Yamaguchi, T1
Yamazaki, Y1
Igarashi, Y1
Tamura, Y1
Yamazoe, M1
Izumi, T1
Sütsch, G1
Vetter, W1
Hess, OM1
Rhyner, K1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessment of the Mechanism of Non-cardiac Syncope by 24-hour Ambulatory Blood Pressure Monitoring (ABPM) and Tilt-table Short Cardiovascular Autonomic Function Battery (SCAFB)[NCT05728255]275 participants (Anticipated)Observational2023-04-30Not yet recruiting
Efficacy and Safety of Midodrine and Atomoxetine Treatment in Patients With Neurogenic Orthostatic Hypotension : A Prospective Randomized Study[NCT03350659]Phase 450 participants (Actual)Interventional2018-01-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for midodrine and Syncope

ArticleYear
Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2022, 07-21, Volume: 24, Issue:7

    Topics: Double-Blind Method; Female; Humans; Male; Midodrine; Randomized Controlled Trials as Topic; Syncope

2022
New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope.
    Heart (British Cardiac Society), 2021, Volume: 107, Issue:11

    Topics: Accidental Falls; Adenosine; Antihypertensive Agents; Atomoxetine Hydrochloride; Atrioventricular No

2021
Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review.
    Neurology, 2014, Sep-23, Volume: 83, Issue:13

    Topics: Humans; Hypotension, Orthostatic; Midodrine; Quality of Life; Reflex; Secondary Prevention; Syncope

2014
New developments in the management of neurogenic orthostatic hypotension.
    Current cardiology reports, 2014, Volume: 16, Issue:11

    Topics: Accidental Falls; Activities of Daily Living; Adrenergic alpha-1 Receptor Agonists; Aged; Aged, 80 a

2014
Current concepts in the evaluation and management of syncope.
    Current cardiology reports, 2008, Volume: 10, Issue:5

    Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents; Cardiac Pacing, Artificial; Fludrocortisone;

2008
Evaluation and management of syncope.
    Minerva cardioangiologica, 2010, Volume: 58, Issue:6

    Topics: Diagnosis, Differential; Electrocardiography; Humans; Hypotension, Orthostatic; Midodrine; Practice

2010
[Diabetes mellitus and orthostatic intolerance].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6

    Topics: Bandages; Diabetic Neuropathies; Diet, Sodium-Restricted; Exercise Therapy; Heart Rate; Humans; Male

2005
Diagnosis and management of patients with blackouts.
    Heart (British Cardiac Society), 2006, Volume: 92, Issue:4

    Topics: Adolescent; Adult; Aged; Electrocardiography, Ambulatory; Epilepsy; Female; Humans; Male; Mental Dis

2006
A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions.
    Journal of clinical pharmacology, 1994, Volume: 34, Issue:5

    Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Female; Heart Rate; Humans; Hypotens

1994

Trials

5 trials available for midodrine and Syncope

ArticleYear
Treatment of vasodepressor carotid sinus syndrome with midodrine: a randomized, controlled pilot study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:1

    Topics: Accidental Falls; Aged; Aged, 80 and over; Blood Pressure; Cross-Over Studies; Double-Blind Method;

2005
Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension.
    Aviation, space, and environmental medicine, 2006, Volume: 77, Issue:4

    Topics: Adrenergic alpha-Agonists; Astronauts; Blood Pressure; Cardiac Output; Hemodynamics; Humans; Hypoten

2006
Observations on midodrine in a case of vasodepressor neurogenic syncope.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 1995, Volume: 5, Issue:5

    Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Cardiac Pacing, Artificial; Cross-Over Studies; El

1995
Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia.
    Circulation, 1997, Jul-15, Volume: 96, Issue:2

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Blood Volume; Clonidine; Female; Heart

1997
Preliminary observations on the use of midodrine hydrochloride in the treatment of refractory neurocardiogenic syncope.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 1999, Volume: 3, Issue:2

    Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Autonomic Nervous System D

1999

Other Studies

9 other studies available for midodrine and Syncope

ArticleYear
Defining successful treatment of neurogenic orthostatic hypotension with droxidopa in a patient with multiple system atrophy.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2017, Volume: 27, Issue:Suppl 1

    Topics: Accidental Falls; Aged, 80 and over; Antiparkinson Agents; Droxidopa; Female; Humans; Hypotension, O

2017
Effects of promethazine and midodrine on orthostatic tolerance.
    Aviation, space, and environmental medicine, 2011, Volume: 82, Issue:1

    Topics: Adrenergic alpha-1 Receptor Agonists; Adult; Aldosterone; Blood Pressure; Cardiac Output; Diastole;

2011
Recurrent syncope in a patient after myocardial infarction.
    Pacing and clinical electrophysiology : PACE, 2003, Volume: 26, Issue:4 Pt 1

    Topics: Aged; Humans; Male; Midodrine; Myocardial Infarction; Recurrence; Sympathomimetics; Syncope

2003
Clinical history.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2004, Volume: 14, Issue:1

    Topics: Blood Pressure; Chest Pain; Clonazepam; Female; Heart Rate; Humans; Hypertension; Incidence; Middle

2004
Effects of therapy based on tilt testing results on the long-term outcome in patients with syncope.
    Kardiologia polska, 2005, Volume: 63, Issue:7

    Topics: Adolescent; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Female; Fludroco

2005
Update on the evaluation, pathogenesis, and management of neurogenic orthostatic hypotension: introduction.
    Neurology, 1995, Volume: 45, Issue:4 Suppl 5

    Topics: Clinical Trials as Topic; Humans; Hypotension, Orthostatic; Midodrine; Multicenter Studies as Topic;

1995
[Hemodynamic and neuroendocrine profile of 2 different cardiovascular responses in vasodepressor syncope induced by the head-up tilt test].
    Giornale italiano di cardiologia, 1992, Volume: 22, Issue:12

    Topics: Adolescent; Adult; Aged; Blood Pressure; Epinephrine; Etilefrine; Female; Heart Rate; Humans; Male;

1992
A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride.
    Japanese circulation journal, 1992, Volume: 56, Issue:9

    Topics: Adult; Blood Pressure; Bradycardia; Female; Humans; Hypotension; Midodrine; Seizures; Syncope; Vagus

1992
[Dizziness, syncope, orthostatic hypotension].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1988, Nov-29, Volume: 77, Issue:48

    Topics: Aged; Dizziness; Epinephrine; Female; Humans; Hypotension, Orthostatic; Midodrine; Norepinephrine; S

1988