midodrine has been researched along with Postural Orthostatic Tachycardia Syndrome in 20 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Postural Orthostatic Tachycardia Syndrome: A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to explore the predictive value of the midregional fragment of pro-adrenomedullin (MR-proADM) in assessing the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS)." | 9.16 | Midregional pro-adrenomedullin as a predictor for therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome. ( Chen, L; Du, J; Jin, H; Li, X; Liao, Y; Ochs, T; Tang, C; Zhang, F, 2012) |
| " β-adrenergic blockade metoprolol in the treatment of children with postural orthostatic tachycardia syndrome (POTS)." | 9.15 | Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome. ( Chen, L; Du, J; Jin, H; Qin, J; Sun, J; Tang, C; Wang, L, 2011) |
| "To evaluate the use of erythrocytic hydrogen sulfide (H2S) in predicting the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS)." | 7.79 | Postural orthostatic tachycardia syndrome with increased erythrocytic hydrogen sulfide and response to midodrine hydrochloride. ( Chen, S; Du, J; Du, S; Fu, C; Jin, H; Li, X; Liu, D; Tang, C; Yang, J; Zhao, J, 2013) |
| "This study was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS)." | 7.79 | Flow-mediated vasodilation as a predictor of therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome. ( Ai, Y; Chen, S; Du, J; Jin, H; Liao, Y; Liu, X; Tang, C; Wang, Y; Yang, J; Zhang, F; Zhang, Q, 2013) |
| " POTS subjects received 2 weeks of treatment with midodrine or placebo, with increased dosing from 2." | 6.79 | A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropathic compared with hyperadrenergic postural tachycardia syndrome. ( Medow, MS; Ocon, AJ; Ross, AJ; Stewart, JM, 2014) |
| " β-adrenergic blockade metoprolol in the treatment of children with postural orthostatic tachycardia syndrome (POTS)." | 5.15 | Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome. ( Chen, L; Du, J; Jin, H; Qin, J; Sun, J; Tang, C; Wang, L, 2011) |
| "The study was designed to examine the effect of selective alpha1 receptor agonist midodrine hydrochloride in the treatment of children with postural orthostatic tachycardia syndrome." | 5.13 | [Effect of selective alpha1 receptor agonist in the treatment of children with postural orthostatic tachycardia syndrome]. ( Chen, L; DU, JB; Jin, HF; Li, WZ; Wang, L; Wang, YL; Zhang, QY, 2008) |
| "To evaluate the use of erythrocytic hydrogen sulfide (H2S) in predicting the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS)." | 3.79 | Postural orthostatic tachycardia syndrome with increased erythrocytic hydrogen sulfide and response to midodrine hydrochloride. ( Chen, S; Du, J; Du, S; Fu, C; Jin, H; Li, X; Liu, D; Tang, C; Yang, J; Zhao, J, 2013) |
| " POTS subjects received 2 weeks of treatment with midodrine or placebo, with increased dosing from 2." | 2.79 | A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropathic compared with hyperadrenergic postural tachycardia syndrome. ( Medow, MS; Ocon, AJ; Ross, AJ; Stewart, JM, 2014) |
| "In the OI spectrum, postural tachycardia syndrome (POTS) accounted for 826 cases (39." | 1.72 | [A 10-year retrospective analysis of spectrums and treatment options of orthostatic intolerance and sitting intolerance in children]. ( Chen, YH; Cui, YX; DU, JB; Jin, HF; Liao, Y; Liu, P; Liu, XQ; Qi, JG; Sun, CF; Sun, Y; Wang, YL; Xu, WR; Yan, H; Zhang, CY; Zhang, QY, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 15 (75.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Narasimhan, B | 1 |
| Aggarwal, D | 1 |
| Satish, P | 1 |
| Kantharia, B | 1 |
| Aronow, WS | 1 |
| Cui, YX | 1 |
| DU, JB | 4 |
| Zhang, QY | 2 |
| Liao, Y | 4 |
| Liu, P | 2 |
| Wang, YL | 2 |
| Qi, JG | 1 |
| Yan, H | 1 |
| Xu, WR | 1 |
| Liu, XQ | 1 |
| Sun, Y | 1 |
| Sun, CF | 1 |
| Zhang, CY | 2 |
| Chen, YH | 1 |
| Jin, HF | 4 |
| Abbate, G | 1 |
| De Iulio, B | 1 |
| Thomas, G | 1 |
| Priday, A | 1 |
| Biondi-Zoccai, G | 1 |
| Markley, R | 1 |
| Abbate, A | 1 |
| Yang, J | 3 |
| Zhao, J | 2 |
| Du, S | 1 |
| Liu, D | 1 |
| Fu, C | 1 |
| Li, X | 3 |
| Chen, S | 2 |
| Tang, C | 6 |
| Du, J | 7 |
| Jin, H | 7 |
| Zhang, F | 3 |
| Liu, X | 1 |
| Zhang, Q | 1 |
| Ai, Y | 1 |
| Wang, Y | 2 |
| Ross, AJ | 1 |
| Ocon, AJ | 1 |
| Medow, MS | 1 |
| Stewart, JM | 1 |
| Sidhu, B | 1 |
| Obiechina, N | 1 |
| Rattu, N | 1 |
| Mitra, S | 1 |
| Deng, W | 1 |
| Liu, Y | 1 |
| Liu, AD | 1 |
| Holmberg, L | 1 |
| Ochs, T | 2 |
| Noyes, AM | 1 |
| Kluger, J | 1 |
| Li, H | 1 |
| Zhang, C | 1 |
| Feng, X | 1 |
| Li, HX | 1 |
| Deng, WJ | 1 |
| Chen, L | 4 |
| Li, WZ | 1 |
| Wang, L | 2 |
| Lai, CC | 1 |
| Fischer, PR | 2 |
| Brands, CK | 1 |
| Fisher, JL | 1 |
| Porter, CB | 1 |
| Driscoll, SW | 1 |
| Graner, KK | 1 |
| Haensch, CA | 1 |
| Isenmann, S | 1 |
| Sun, J | 1 |
| Qin, J | 1 |
| Zhang, FW | 1 |
| Li, XY | 1 |
| Kimpinski, K | 1 |
| Figueroa, JJ | 1 |
| Singer, W | 1 |
| Sletten, DM | 1 |
| Iodice, V | 1 |
| Sandroni, P | 1 |
| Opfer-Gehrking, TL | 1 |
| Gehrking, JA | 1 |
| Low, PA | 1 |
| Benditt, DG | 1 |
| Chen, LY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gabapentin Treatment of Postural Tachycardia Syndrome (PoTS): a Pilot Study[NCT04345432] | 10 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Safety and Efficacy of Midodrine Hydrochloride in the Management of Refractory Ascites Due to Cirrhosis in Children: a Pilot Study[NCT04043858] | 20 participants (Anticipated) | Interventional | 2020-06-05 | Recruiting | |||
| Comparison of Effect of Propranolol, Bisoprolol, Pyridosgitmine in Postural Orthostatic Tachycardia Syndrome (POTS) and Prognosis After Medical Treatment[NCT02171988] | Phase 4 | 150 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for midodrine and Postural Orthostatic Tachycardia Syndrome
| Article | Year |
|---|---|
Postural orthostatic tachycardia syndrome: pathophysiology, management, and experimental therapies.
Topics: COVID-19; Deamino Arginine Vasopressin; Erythropoietin; Fludrocortisone; Humans; Immunoglobulins, In | 2022 |
Postural Orthostatic Tachycardia Syndrome After COVID-19: A Systematic Review of Therapeutic Interventions.
Topics: Adrenergic beta-Antagonists; Adult; COVID-19; Female; Heart Rate; Humans; Male; Middle Aged; Midodri | 2023 |
[Postural orthostatic tachycardia syndrome: current concepts in pathophysiology, diagnosis and therapeutic options].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Benzazepines; Blood Pressure; Cardiotonic Ag | 2011 |
6 trials available for midodrine and Postural Orthostatic Tachycardia Syndrome
| Article | Year |
|---|---|
A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropathic compared with hyperadrenergic postural tachycardia syndrome.
Topics: Adolescent; Adult; Blood Pressure; Child; Cross-Over Studies; Double-Blind Method; Female; Heart Rat | 2014 |
[Effect of selective alpha1 receptor agonist in the treatment of children with postural orthostatic tachycardia syndrome].
Topics: Adolescent; Adrenergic alpha-Agonists; Child; Child, Preschool; Female; Humans; Male; Midodrine; Pos | 2008 |
Outcomes in adolescents with postural orthostatic tachycardia syndrome treated with midodrine and beta-blockers.
Topics: Adolescent; Adrenergic beta-Antagonists; Drug Therapy, Combination; Female; Humans; Male; Midodrine; | 2009 |
Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Child; Disease-Free Survival; Female; Follow-Up St | 2011 |
[Therapies for postural tachycardia syndrome in children].
Topics: Adolescent; Child; Female; Humans; Male; Metoprolol; Midodrine; Postural Orthostatic Tachycardia Syn | 2011 |
Midregional pro-adrenomedullin as a predictor for therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome.
Topics: Adolescent; Adrenomedullin; Biomarkers; Blood Pressure; Child; Female; Heart Rate; Humans; Male; Mid | 2012 |
11 other studies available for midodrine and Postural Orthostatic Tachycardia Syndrome
| Article | Year |
|---|---|
[A 10-year retrospective analysis of spectrums and treatment options of orthostatic intolerance and sitting intolerance in children].
Topics: Child; Electrolytes; Female; Humans; Male; Metoprolol; Midodrine; Orthostatic Intolerance; Postural | 2022 |
Postural orthostatic tachycardia syndrome with increased erythrocytic hydrogen sulfide and response to midodrine hydrochloride.
Topics: Area Under Curve; Case-Control Studies; Child; Child, Preschool; Electrocardiography; Erythrocytes; | 2013 |
Flow-mediated vasodilation as a predictor of therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome.
Topics: Adrenergic alpha-1 Receptor Agonists; Blood Flow Velocity; Brachial Artery; Child; Dose-Response Rel | 2013 |
Postural orthostatic tachycardia syndrome (POTS).
Topics: Adrenergic beta-Antagonists; Adult; Benzazepines; Female; Fludrocortisone; Fluid Therapy; Humans; Iv | 2013 |
Difference between supine and upright blood pressure associates to the efficacy of midodrine on postural orthostatic tachycardia syndrome (POTS) in children.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Blood Pressure; Child; Female; Follow-Up Studies; | 2014 |
A tale of two syndromes: Lyme disease preceding postural orthostatic tachycardia syndrome.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Diet, Gluten-Free; Female; Fluid Therapy; Humans; Lyme Di | 2015 |
Plasma copeptin and therapeutic effectiveness of midodrine hydrochloride on postural tachycardia syndrome in children.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Biomarkers; Child; Child, Preschool; Female; Glyco | 2014 |
[Predictive value of baseline plasma midregional fragment of pro-adrenomedullin level on long-term outcome of postural tachycardia syndrome children treated with midodrine hydrochloride].
Topics: Adolescent; Adrenomedullin; Child; Humans; Male; Midodrine; Postural Orthostatic Tachycardia Syndrom | 2015 |
[Predictive value of upright blood pressure change for long-term prognosis of children with postural tachycardia syndrome treated with midodrine hydrochloride].
Topics: Adolescent; Blood Pressure; Child; Female; Humans; Male; Midodrine; Postural Orthostatic Tachycardia | 2016 |
A prospective, 1-year follow-up study of postural tachycardia syndrome.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adult; Anti-Inflammato | 2012 |
Peptides in postural orthostatic tachycardia syndrome: players or epiphenomena?
Topics: Adrenomedullin; Biomarkers; Female; Humans; Male; Midodrine; Peptide Fragments; Postural Orthostatic | 2012 |