midodrine has been researched along with Orthostatic Intolerance in 4 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Orthostatic Intolerance: Symptoms of cerebral hypoperfusion or autonomic overaction which develop while the subject is standing, but are relieved on recumbency. Types of this include NEUROCARDIOGENIC SYNCOPE; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; and neurogenic ORTHOSTATIC HYPOTENSION. (From Noseworthy, JH., Neurological Therapeutics Principles and Practice, 2007, p2575-2576)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the OI spectrum, postural tachycardia syndrome (POTS) accounted for 826 cases (39." | 1.72 | [A 10-year retrospective analysis of spectrums and treatment options of orthostatic intolerance and sitting intolerance in children]. ( Chen, YH; Cui, YX; DU, JB; Jin, HF; Liao, Y; Liu, P; Liu, XQ; Qi, JG; Sun, CF; Sun, Y; Wang, YL; Xu, WR; Yan, H; Zhang, CY; Zhang, QY, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, YX | 1 |
| DU, JB | 1 |
| Zhang, QY | 1 |
| Liao, Y | 1 |
| Liu, P | 1 |
| Wang, YL | 1 |
| Qi, JG | 1 |
| Yan, H | 1 |
| Xu, WR | 1 |
| Liu, XQ | 1 |
| Sun, Y | 1 |
| Sun, CF | 1 |
| Zhang, CY | 1 |
| Chen, YH | 1 |
| Jin, HF | 1 |
| Phillips, AA | 1 |
| Krassioukov, AV | 1 |
| Ainslie, PN | 1 |
| Warburton, DE | 1 |
| Li, Y | 1 |
| Li, H | 1 |
| Li, X | 2 |
| Jin, H | 1 |
| Jans, Ø | 1 |
| Mehlsen, J | 1 |
| Kjærsgaard-Andersen, P | 1 |
| Husted, H | 1 |
| Solgaard, S | 1 |
| Josiassen, J | 1 |
| Lunn, TH | 1 |
| Kehlet, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886] | 8 participants (Anticipated) | Interventional | 2021-06-08 | Recruiting | |||
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014] | Phase 4 | 22 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923] | 8 participants (Anticipated) | Interventional | 2021-12-31 | Recruiting | |||
| Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093] | 20 participants (Anticipated) | Interventional | 2021-11-29 | Recruiting | |||
| Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty[NCT03759574] | 26 participants (Anticipated) | Observational | 2019-03-18 | Recruiting | |||
| RANDOMIZED CASE-CONTROLLED TRIAL ASSESSING MIDODRINE (GUTRON®) IN POSTOPERATIVE VASOPLEGIC PATIENTS[NCT04440085] | Phase 4 | 50 participants (Anticipated) | Interventional | 2020-09-14 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for midodrine and Orthostatic Intolerance
| Article | Year |
|---|---|
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine.
Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Pressure; British Columbia; Cerebrova | 2014 |
Oral Midodrine Hydrochloride for Prevention of Orthostatic Hypotension during Early Mobilization after Hip Arthroplasty: A Randomized, Double-blind, Placebo-controlled Trial.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Agonists; Aged; Arthroplasty, Replacement, Hip; Bl | 2015 |
Oral Midodrine Hydrochloride for Prevention of Orthostatic Hypotension during Early Mobilization after Hip Arthroplasty: A Randomized, Double-blind, Placebo-controlled Trial.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Agonists; Aged; Arthroplasty, Replacement, Hip; Bl | 2015 |
Oral Midodrine Hydrochloride for Prevention of Orthostatic Hypotension during Early Mobilization after Hip Arthroplasty: A Randomized, Double-blind, Placebo-controlled Trial.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Agonists; Aged; Arthroplasty, Replacement, Hip; Bl | 2015 |
Oral Midodrine Hydrochloride for Prevention of Orthostatic Hypotension during Early Mobilization after Hip Arthroplasty: A Randomized, Double-blind, Placebo-controlled Trial.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Agonists; Aged; Arthroplasty, Replacement, Hip; Bl | 2015 |
2 other studies available for midodrine and Orthostatic Intolerance
| Article | Year |
|---|---|
[A 10-year retrospective analysis of spectrums and treatment options of orthostatic intolerance and sitting intolerance in children].
Topics: Child; Electrolytes; Female; Humans; Male; Metoprolol; Midodrine; Orthostatic Intolerance; Postural | 2022 |
Prognostic analysis of orthostatic intolerance using survival model in children.
Topics: Adolescent; Child; Female; Humans; Male; Metoprolol; Midodrine; Orthostatic Intolerance; Prognosis; | 2014 |