midodrine has been researched along with Multiple System Atrophy in 5 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the efficacy and safety of sildenafil citrate (Viagra) in men with erectile dysfunction and parkinsonism due either to Parkinson's disease or multiple system atrophy." | 9.09 | Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension. ( Brady, CM; Fowler, CJ; Hussain, IF; Mathias, CJ; Swinn, MJ, 2001) |
| "We describe a 51-year-old man with a 3-year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension." | 7.74 | Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: a possible association with oral midodrine treatment. ( Ahn, JY; Kim, BS; Kim, HT; Kim, JS; Kim, YI; Lee, KS; Lim, SC; Song, IU, 2007) |
| "To assess the efficacy and safety of sildenafil citrate (Viagra) in men with erectile dysfunction and parkinsonism due either to Parkinson's disease or multiple system atrophy." | 5.09 | Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension. ( Brady, CM; Fowler, CJ; Hussain, IF; Mathias, CJ; Swinn, MJ, 2001) |
| "We describe a 51-year-old man with a 3-year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension." | 3.74 | Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: a possible association with oral midodrine treatment. ( Ahn, JY; Kim, BS; Kim, HT; Kim, JS; Kim, YI; Lee, KS; Lim, SC; Song, IU, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goodman, BP | 1 |
| Gupta, F | 1 |
| Asahina, M | 1 |
| Akaogi, Y | 1 |
| Yamanaka, Y | 1 |
| Koyama, Y | 1 |
| Hattori, T | 1 |
| Hohler, AD | 1 |
| Singh, VJ | 1 |
| Kim, JS | 1 |
| Lee, KS | 1 |
| Lim, SC | 1 |
| Ahn, JY | 1 |
| Song, IU | 1 |
| Kim, YI | 1 |
| Kim, BS | 1 |
| Kim, HT | 1 |
| Hussain, IF | 1 |
| Brady, CM | 1 |
| Swinn, MJ | 1 |
| Mathias, CJ | 1 |
| Fowler, CJ | 1 |
1 trial available for midodrine and Multiple System Atrophy
| Article | Year |
|---|---|
Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension.
Topics: Aged; Blood Pressure; Cross-Over Studies; Diastole; Double-Blind Method; Ephedrine; Erectile Dysfunc | 2001 |
4 other studies available for midodrine and Multiple System Atrophy
| Article | Year |
|---|---|
Defining successful treatment of neurogenic orthostatic hypotension with droxidopa in a patient with multiple system atrophy.
Topics: Accidental Falls; Aged, 80 and over; Antiparkinson Agents; Droxidopa; Female; Humans; Hypotension, O | 2017 |
Differences in skin sympathetic involvements between two chronic autonomic disorders: multiple system atrophy and pure autonomic failure.
Topics: Aged; Autonomic Nervous System Diseases; Blood Flow Velocity; Blood Pressure; Female; Fludrocortison | 2009 |
Probable hereditary multiple system atrophy-autonomic (MSA-A) in a family in the United States.
Topics: Adrenergic alpha-Agonists; Aged, 80 and over; Anti-Inflammatory Agents; Autonomic Nervous System Dis | 2012 |
Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: a possible association with oral midodrine treatment.
Topics: Adrenergic alpha-Agonists; Brain; Dementia, Vascular; Humans; Magnetic Resonance Imaging; Male; Midd | 2007 |