Page last updated: 2024-10-31

midodrine and Hypovolemia

midodrine has been researched along with Hypovolemia in 6 studies

Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Hypovolemia: An abnormally low volume of blood circulating through the body. It may result in hypovolemic shock (see SHOCK).

Research Excerpts

ExcerptRelevanceReference
"Fifty patients with cirrhosis and tense refractory ascites were randomly assigned to be treated with either midodrine (n=25) (12."5.19Comparison of midodrine and albumin in the prevention of paracentesis-induced circulatory dysfunction in cirrhotic patients: a randomized pilot study. ( ElBaz, AA; Hamdy, H; Hassan, A; Hassanin, O, 2014)
"Twenty-four patients with cirrhosis and ascites were randomly assigned to be treated with either midodrine (n=11) (12."5.13Prevention of paracentesis-induced circulatory dysfunction: midodrine vs albumin. A randomized pilot study. ( Appenrodt, B; Grünhage, F; Heller, J; Lammert, F; Rabe, C; Sauerbruch, T; Schepke, M; Trebicka, J; Wolf, A, 2008)
"Midodrine therapy was cheaper than albumin therapy."2.73Midodrine versus albumin in the prevention of paracentesis-induced circulatory dysfunction in cirrhotics: a randomized pilot study. ( Bhalla, A; Chawla, D; Dheerendra, PC; Mahi, SK; Nain, CK; Sharma, N; Singh, B; Singh, V, 2008)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Joseph, A1
Wanono, R1
Flamant, M1
Vidal-Petiot, E1
Hamdy, H1
ElBaz, AA2
Hassan, A1
Hassanin, O1
Bai, M1
Han, G1
Singh, V1
Dheerendra, PC1
Singh, B1
Nain, CK1
Chawla, D1
Sharma, N1
Bhalla, A1
Mahi, SK1
Appenrodt, B1
Wolf, A1
Grünhage, F1
Trebicka, J1
Schepke, M1
Rabe, C1
Lammert, F1
Sauerbruch, T1
Heller, J1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Midodrine Versus Albumin During Large-volume Paracentesis and Its Effect on Paracentesis Induced Circulatory Disturbance in Patients With Acute on Chronic Liver Failure - A Randomized Controlled Trial[NCT05240391]Phase 350 participants (Actual)Interventional2021-02-20Completed
Vasoconstrictors as Alternatives to Albumin After Large Volume Paracentesis in Cirrhosis[NCT00108355]Phase 429 participants (Actual)Interventional2003-12-31Completed
Efficacy of Terlipressin in Cirrhotic Patients With Recidivation Ascites Treated With Paracentesis and Albumin. A Multi-center Randomized Controlled Study[NCT00986817]Phase 382 participants (Actual)Interventional2009-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Development of Post-paracentesis Circulatory Dysfunction (PCD)

Defined as an increase in Plasma Renin Activity (PRA) by >50% from baseline to a level > 4 ng/mL/h at post-paracentesis day (NCT00108355)
Timeframe: 6 days after paracentesis

Interventionparticipants (Number)
Albumin (Control Group)2
Vasoconstrictor (Treatment Group)2

Time to Recurrence of Ascites.

Comparison between Albumin (Control group) and Vasoconstrictor (Treatment group) (NCT00108355)
Timeframe: Variable depending on the patient, average 10 days

Interventiondays (Median)
Albumin (Control Group)10
Vasoconstrictor (Treatment Group)8

Reviews

1 review available for midodrine and Hypovolemia

ArticleYear
Orthostatic hypotension: A review.
    Nephrologie & therapeutique, 2017, Volume: 13 Suppl 1

    Topics: Aging; Anti-Inflammatory Agents; Drug Therapy, Combination; Fludrocortisone; Humans; Hypotension, Or

2017

Trials

3 trials available for midodrine and Hypovolemia

ArticleYear
Comparison of midodrine and albumin in the prevention of paracentesis-induced circulatory dysfunction in cirrhotic patients: a randomized pilot study.
    Journal of clinical gastroenterology, 2014, Volume: 48, Issue:2

    Topics: Albumins; Aldosterone; Ascites; Creatinine; Female; Humans; Hypovolemia; Liver Cirrhosis; Male; Midd

2014
Midodrine versus albumin in the prevention of paracentesis-induced circulatory dysfunction in cirrhotics: a randomized pilot study.
    The American journal of gastroenterology, 2008, Volume: 103, Issue:6

    Topics: Adult; Ascites; Female; Humans; Hypovolemia; Liver Cirrhosis; Male; Middle Aged; Midodrine; Paracent

2008
Prevention of paracentesis-induced circulatory dysfunction: midodrine vs albumin. A randomized pilot study.
    Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:7

    Topics: Adrenergic alpha-Agonists; Albumins; Aldosterone; Ascites; Double-Blind Method; Female; Humans; Hypo

2008
Prevention of paracentesis-induced circulatory dysfunction: midodrine vs albumin. A randomized pilot study.
    Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:7

    Topics: Adrenergic alpha-Agonists; Albumins; Aldosterone; Ascites; Double-Blind Method; Female; Humans; Hypo

2008
Prevention of paracentesis-induced circulatory dysfunction: midodrine vs albumin. A randomized pilot study.
    Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:7

    Topics: Adrenergic alpha-Agonists; Albumins; Aldosterone; Ascites; Double-Blind Method; Female; Humans; Hypo

2008
Prevention of paracentesis-induced circulatory dysfunction: midodrine vs albumin. A randomized pilot study.
    Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:7

    Topics: Adrenergic alpha-Agonists; Albumins; Aldosterone; Ascites; Double-Blind Method; Female; Humans; Hypo

2008

Other Studies

2 other studies available for midodrine and Hypovolemia

ArticleYear
Midodrine for paracentesis-induced circulatory dysfunction.
    Journal of clinical gastroenterology, 2014, Volume: 48, Issue:3

    Topics: Albumins; Ascites; Female; Humans; Hypovolemia; Male; Midodrine; Paracentesis; Vasoconstrictor Agent

2014
In response.
    Journal of clinical gastroenterology, 2014, Volume: 48, Issue:3

    Topics: Albumins; Ascites; Female; Humans; Hypovolemia; Male; Midodrine; Paracentesis; Vasoconstrictor Agent

2014