midodrine has been researched along with Flaccid Quadriplegia in 4 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that midodrine 10mg may be efficacious for treatment of hypotension and orthostatic hypotension in select persons with tetraplegia." | 5.14 | Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia. ( Bauman, WA; Handrakis, JP; Radulovic, M; Rosado-Rivera, D; Wecht, JM, 2010) |
| "A report of two cases of orthostatic hypotension in acute tetraplegia that were resistant to classic treatment interventions." | 2.41 | Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature. ( Able, AC; Barber, DB; Fredrickson, MD; Rogers, SJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krassioukov, A | 1 |
| Eng, JJ | 1 |
| Warburton, DE | 1 |
| Teasell, R | 1 |
| Wecht, JM | 2 |
| Rosado-Rivera, D | 2 |
| Handrakis, JP | 1 |
| Radulovic, M | 2 |
| Bauman, WA | 2 |
| Zhang, RL | 1 |
| LaFountaine, MF | 1 |
| Barber, DB | 1 |
| Rogers, SJ | 1 |
| Fredrickson, MD | 1 |
| Able, AC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury[NCT05942339] | 8 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | |||
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886] | 8 participants (Anticipated) | Interventional | 2021-06-08 | Recruiting | |||
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014] | Phase 4 | 22 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury[NCT03924388] | 46 participants (Anticipated) | Interventional | 2020-02-01 | Not yet recruiting | |||
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923] | 8 participants (Anticipated) | Interventional | 2021-12-31 | Recruiting | |||
| A Dose Response Trial Using 5 and 10 mg. of Midodrine Hydrochloride to Treat Orthostatic Hypotension in Persons With SCI[NCT00426842] | Phase 2 | 11 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| Prevention of Low Blood Pressure in Persons With Tetraplegia[NCT00237770] | Phase 2/Phase 3 | 16 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Safety and Efficacy of L-NAME and Midodrine to Increase MAP in Persons With Tetraplegia[NCT00835224] | Phase 2 | 34 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
brachial artery systolic blood pressure (mmHg) (NCT00426842)
Timeframe: The difference between the average supine systolic blood pressure and the average systolic blood pressure at 45 degree head-up tilt position.
| Intervention | mmHg (Mean) | |
|---|---|---|
| Baseline Blood Pressure | Head-up Tilt Blood Pressure | |
| Midodrine 10 mg | 102 | 109 |
| Midodrine 5 mg | 97 | 96 |
| No-drug | 98 | 87 |
Average systolic blood pressure over 45 minutes at 45 degrees of head-up tilt. (NCT00237770)
Timeframe: Average systolic blood pressure during head-up tilt (45 degrees) comparing active drug (L-NAME: 1.0 and 2.0 mg/kg) to placebo.
| Intervention | mmHg (Mean) |
|---|---|
| Tetraplegic Systolic Blood Pressure Responses to Placebo | 91.80 |
| Control Systolic Blood Pressure Responses to Placebo | 108.10 |
| Tetraplegic Systolic Blood Pressure Responses to L-NAME 1.0 mg | 112.04 |
| Tetraplegic Systolic Blood Pressure Responses to L-NAME 2.0 mg | 129.94 |
(NCT00835224)
Timeframe: Blood pressure during the 4 hour period after no drug, L-NAME (IV: 1.0 mg/kg) and midodrine (PO: 10.0 mg) administration
| Intervention | mmHg (Mean) |
|---|---|
| Arm 1A | 120 |
| Arm 1B | 112 |
| Arm 2A | 117 |
| Arm 2B | 109 |
| Arm 3A | 96 |
| Arm 3B | 109 |
2 reviews available for midodrine and Flaccid Quadriplegia
| Article | Year |
|---|---|
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature.
Topics: Adrenergic alpha-Agonists; Adult; Drug Resistance; Fludrocortisone; Humans; Hypotension, Orthostatic | 2000 |
1 trial available for midodrine and Flaccid Quadriplegia
| Article | Year |
|---|---|
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
1 other study available for midodrine and Flaccid Quadriplegia
| Article | Year |
|---|---|
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |