Page last updated: 2024-10-31

midodrine and Flaccid Quadriplegia

midodrine has been researched along with Flaccid Quadriplegia in 4 studies

Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Research Excerpts

ExcerptRelevanceReference
"These findings suggest that midodrine 10mg may be efficacious for treatment of hypotension and orthostatic hypotension in select persons with tetraplegia."5.14Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia. ( Bauman, WA; Handrakis, JP; Radulovic, M; Rosado-Rivera, D; Wecht, JM, 2010)
"A report of two cases of orthostatic hypotension in acute tetraplegia that were resistant to classic treatment interventions."2.41Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature. ( Able, AC; Barber, DB; Fredrickson, MD; Rogers, SJ, 2000)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Krassioukov, A1
Eng, JJ1
Warburton, DE1
Teasell, R1
Wecht, JM2
Rosado-Rivera, D2
Handrakis, JP1
Radulovic, M2
Bauman, WA2
Zhang, RL1
LaFountaine, MF1
Barber, DB1
Rogers, SJ1
Fredrickson, MD1
Able, AC1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury[NCT05942339]8 participants (Anticipated)Interventional2023-08-31Not yet recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886]8 participants (Anticipated)Interventional2021-06-08Recruiting
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014]Phase 422 participants (Actual)Interventional2018-06-01Completed
The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury[NCT03924388]46 participants (Anticipated)Interventional2020-02-01Not yet recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923]8 participants (Anticipated)Interventional2021-12-31Recruiting
A Dose Response Trial Using 5 and 10 mg. of Midodrine Hydrochloride to Treat Orthostatic Hypotension in Persons With SCI[NCT00426842]Phase 211 participants (Actual)Interventional2007-01-31Completed
Prevention of Low Blood Pressure in Persons With Tetraplegia[NCT00237770]Phase 2/Phase 316 participants (Actual)Interventional2003-06-30Completed
Safety and Efficacy of L-NAME and Midodrine to Increase MAP in Persons With Tetraplegia[NCT00835224]Phase 234 participants (Actual)Interventional2010-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Systolic Blood Pressure

brachial artery systolic blood pressure (mmHg) (NCT00426842)
Timeframe: The difference between the average supine systolic blood pressure and the average systolic blood pressure at 45 degree head-up tilt position.

,,
InterventionmmHg (Mean)
Baseline Blood PressureHead-up Tilt Blood Pressure
Midodrine 10 mg102109
Midodrine 5 mg9796
No-drug9887

Systolic Blood Pressure During Head-up Tilt

Average systolic blood pressure over 45 minutes at 45 degrees of head-up tilt. (NCT00237770)
Timeframe: Average systolic blood pressure during head-up tilt (45 degrees) comparing active drug (L-NAME: 1.0 and 2.0 mg/kg) to placebo.

InterventionmmHg (Mean)
Tetraplegic Systolic Blood Pressure Responses to Placebo91.80
Control Systolic Blood Pressure Responses to Placebo108.10
Tetraplegic Systolic Blood Pressure Responses to L-NAME 1.0 mg112.04
Tetraplegic Systolic Blood Pressure Responses to L-NAME 2.0 mg129.94

Blood Pressure

(NCT00835224)
Timeframe: Blood pressure during the 4 hour period after no drug, L-NAME (IV: 1.0 mg/kg) and midodrine (PO: 10.0 mg) administration

InterventionmmHg (Mean)
Arm 1A120
Arm 1B112
Arm 2A117
Arm 2B109
Arm 3A96
Arm 3B109

Reviews

2 reviews available for midodrine and Flaccid Quadriplegia

ArticleYear
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
A systematic review of the management of orthostatic hypotension after spinal cord injury.
    Archives of physical medicine and rehabilitation, 2009, Volume: 90, Issue:5

    Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever

2009
Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature.
    Spinal cord, 2000, Volume: 38, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Drug Resistance; Fludrocortisone; Humans; Hypotension, Orthostatic

2000

Trials

1 trial available for midodrine and Flaccid Quadriplegia

ArticleYear
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010

Other Studies

1 other study available for midodrine and Flaccid Quadriplegia

ArticleYear
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:11

    Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido

2011