midodrine has been researched along with Flaccid Quadriplegia in 4 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Excerpt | Relevance | Reference |
---|---|---|
"These findings suggest that midodrine 10mg may be efficacious for treatment of hypotension and orthostatic hypotension in select persons with tetraplegia." | 5.14 | Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia. ( Bauman, WA; Handrakis, JP; Radulovic, M; Rosado-Rivera, D; Wecht, JM, 2010) |
"A report of two cases of orthostatic hypotension in acute tetraplegia that were resistant to classic treatment interventions." | 2.41 | Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature. ( Able, AC; Barber, DB; Fredrickson, MD; Rogers, SJ, 2000) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (50.00) | 29.6817 |
2010's | 2 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Krassioukov, A | 1 |
Eng, JJ | 1 |
Warburton, DE | 1 |
Teasell, R | 1 |
Wecht, JM | 2 |
Rosado-Rivera, D | 2 |
Handrakis, JP | 1 |
Radulovic, M | 2 |
Bauman, WA | 2 |
Zhang, RL | 1 |
LaFountaine, MF | 1 |
Barber, DB | 1 |
Rogers, SJ | 1 |
Fredrickson, MD | 1 |
Able, AC | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury[NCT05942339] | 8 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | |||
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886] | 8 participants (Anticipated) | Interventional | 2021-06-08 | Recruiting | |||
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014] | Phase 4 | 22 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury[NCT03924388] | 46 participants (Anticipated) | Interventional | 2020-02-01 | Not yet recruiting | |||
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923] | 8 participants (Anticipated) | Interventional | 2021-12-31 | Recruiting | |||
A Dose Response Trial Using 5 and 10 mg. of Midodrine Hydrochloride to Treat Orthostatic Hypotension in Persons With SCI[NCT00426842] | Phase 2 | 11 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
Prevention of Low Blood Pressure in Persons With Tetraplegia[NCT00237770] | Phase 2/Phase 3 | 16 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
Safety and Efficacy of L-NAME and Midodrine to Increase MAP in Persons With Tetraplegia[NCT00835224] | Phase 2 | 34 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
brachial artery systolic blood pressure (mmHg) (NCT00426842)
Timeframe: The difference between the average supine systolic blood pressure and the average systolic blood pressure at 45 degree head-up tilt position.
Intervention | mmHg (Mean) | |
---|---|---|
Baseline Blood Pressure | Head-up Tilt Blood Pressure | |
Midodrine 10 mg | 102 | 109 |
Midodrine 5 mg | 97 | 96 |
No-drug | 98 | 87 |
Average systolic blood pressure over 45 minutes at 45 degrees of head-up tilt. (NCT00237770)
Timeframe: Average systolic blood pressure during head-up tilt (45 degrees) comparing active drug (L-NAME: 1.0 and 2.0 mg/kg) to placebo.
Intervention | mmHg (Mean) |
---|---|
Tetraplegic Systolic Blood Pressure Responses to Placebo | 91.80 |
Control Systolic Blood Pressure Responses to Placebo | 108.10 |
Tetraplegic Systolic Blood Pressure Responses to L-NAME 1.0 mg | 112.04 |
Tetraplegic Systolic Blood Pressure Responses to L-NAME 2.0 mg | 129.94 |
(NCT00835224)
Timeframe: Blood pressure during the 4 hour period after no drug, L-NAME (IV: 1.0 mg/kg) and midodrine (PO: 10.0 mg) administration
Intervention | mmHg (Mean) |
---|---|
Arm 1A | 120 |
Arm 1B | 112 |
Arm 2A | 117 |
Arm 2B | 109 |
Arm 3A | 96 |
Arm 3B | 109 |
2 reviews available for midodrine and Flaccid Quadriplegia
Article | Year |
---|---|
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
A systematic review of the management of orthostatic hypotension after spinal cord injury.
Topics: Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic; Injury Sever | 2009 |
Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature.
Topics: Adrenergic alpha-Agonists; Adult; Drug Resistance; Fludrocortisone; Humans; Hypotension, Orthostatic | 2000 |
1 trial available for midodrine and Flaccid Quadriplegia
Article | Year |
---|---|
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H | 2010 |
1 other study available for midodrine and Flaccid Quadriplegia
Article | Year |
---|---|
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |
Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia.
Topics: Adult; Cerebrovascular Circulation; Dizziness; Female; Hemodynamics; Humans; Male; Middle Aged; Mido | 2011 |