midodrine has been researched along with Drop Attack in 23 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " All studies were conducted in clinical syncope populations and compared the benefit of midodrine vs." | 9.22 | Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis. ( Lei, LY; Raj, SR; Sheldon, RS, 2022) |
| " Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it." | 7.68 | A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992) |
| "Midodrine has been proposed in the management of patients with these conditions but its impact on patient important outcomes remains uncertain." | 6.50 | Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review. ( Catalano, HN; González Malla, C; Guyatt, G; Izcovich, A; Manzotti, M, 2014) |
| "Midodrine is an alpha-one agonist that produces arterial and venous constriction and leads to a decrease in heart rate by baroreceptor reflexes." | 6.39 | A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions. ( Jankovic, J; McElligott, MA; Piwinski, SE, 1994) |
| " All studies were conducted in clinical syncope populations and compared the benefit of midodrine vs." | 5.22 | Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis. ( Lei, LY; Raj, SR; Sheldon, RS, 2022) |
| " Midodrine did not cause any untoward reactions in these subjects before or after flight; in fact, a modest beneficial effect was seen on postflight tachycardia (p = 0." | 5.12 | Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension. ( Meck, JV; Platts, SH; Waters, WW; Ziegler, MG, 2006) |
| "Rates of presyncope were 38% with no drug; 0% with midodrine alone; 100% with promethazine alone; and 63% with both drugs." | 3.77 | Effects of promethazine and midodrine on orthostatic tolerance. ( Meck, JV; Platts, SH; Shi, SJ; Ziegler, MG, 2011) |
| " Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it." | 3.68 | A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992) |
| "If cardiac syncope is unlikely, reflex (neurally mediated) syncope and orthostatic hypotension are the most frequent causes of transient loss of consciousness." | 2.72 | New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope. ( Brignole, M; Rivasi, G, 2021) |
| "Midodrine has been proposed in the management of patients with these conditions but its impact on patient important outcomes remains uncertain." | 2.50 | Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review. ( Catalano, HN; González Malla, C; Guyatt, G; Izcovich, A; Manzotti, M, 2014) |
| "Droxidopa is a synthetic amino acid that is converted to norepinephrine by dopa-decarboxylase, the same enzyme that converts levodopa into dopamine in the treatment of Parkinson disease." | 2.50 | New developments in the management of neurogenic orthostatic hypotension. ( Biaggioni, I, 2014) |
| "Syncope is a common symptom and accounts for approximately 1% of all emergency visits." | 2.46 | Evaluation and management of syncope. ( Borggrefe, M; Schimpf, R; Veltmann, C; Wolpert, C, 2010) |
| "Syncope is a very common presentation with a wide differential diagnosis and equally wide prognostic implications." | 2.44 | Current concepts in the evaluation and management of syncope. ( Kuriachan, V; Sheldon, RS, 2008) |
| "Midodrine is an alpha-one agonist that produces arterial and venous constriction and leads to a decrease in heart rate by baroreceptor reflexes." | 2.39 | A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions. ( Jankovic, J; McElligott, MA; Piwinski, SE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Lei, LY | 1 |
| Raj, SR | 1 |
| Sheldon, RS | 2 |
| Brignole, M | 1 |
| Rivasi, G | 1 |
| Goodman, BP | 1 |
| Gupta, F | 1 |
| Izcovich, A | 1 |
| González Malla, C | 1 |
| Manzotti, M | 1 |
| Catalano, HN | 1 |
| Guyatt, G | 1 |
| Biaggioni, I | 2 |
| Kuriachan, V | 1 |
| Veltmann, C | 1 |
| Borggrefe, M | 1 |
| Wolpert, C | 1 |
| Schimpf, R | 1 |
| Shi, SJ | 1 |
| Platts, SH | 2 |
| Ziegler, MG | 2 |
| Meck, JV | 2 |
| Credner, SC | 1 |
| Lehmann, R | 1 |
| Grubb, BP | 2 |
| Hohnloser, SH | 1 |
| Klingenheben, T | 1 |
| Cheshire, WP | 1 |
| Achem, SR | 1 |
| Moore, A | 1 |
| Watts, M | 1 |
| Sheehy, T | 1 |
| Hartnett, A | 1 |
| Clinch, D | 1 |
| Lyons, D | 1 |
| Honma, K | 1 |
| Gierelak, G | 1 |
| Makowski, K | 1 |
| Guzik, P | 1 |
| Kramarz, E | 1 |
| Kowal, J | 1 |
| Cholewa, M | 1 |
| Fitzpatrick, AP | 1 |
| Cooper, P | 1 |
| Waters, WW | 1 |
| Piwinski, SE | 1 |
| Jankovic, J | 1 |
| McElligott, MA | 1 |
| Ward, C | 1 |
| Kenny, RA | 1 |
| Jacob, G | 1 |
| Shannon, JR | 1 |
| Black, B | 1 |
| Mosqueda-Garcia, R | 1 |
| Robertson, RM | 1 |
| Robertson, D | 1 |
| Karas, B | 1 |
| Kosinski, D | 1 |
| Boehm, K | 1 |
| Low, PA | 1 |
| Cicogna, R | 1 |
| Bonomi, FG | 1 |
| Mascioli, G | 1 |
| Ferrari, R | 1 |
| Turelli, A | 1 |
| Benigno, M | 1 |
| Curnis, A | 1 |
| Visioli, O | 1 |
| Koyama, S | 1 |
| Matsubara, T | 1 |
| Aizawa, Y | 1 |
| Ohshima, M | 1 |
| Yamaguchi, T | 1 |
| Yamazaki, Y | 1 |
| Igarashi, Y | 1 |
| Tamura, Y | 1 |
| Yamazoe, M | 1 |
| Izumi, T | 1 |
| Sütsch, G | 1 |
| Vetter, W | 1 |
| Hess, OM | 1 |
| Rhyner, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of the Mechanism of Non-cardiac Syncope by 24-hour Ambulatory Blood Pressure Monitoring (ABPM) and Tilt-table Short Cardiovascular Autonomic Function Battery (SCAFB)[NCT05728255] | 275 participants (Anticipated) | Observational | 2023-04-30 | Not yet recruiting | |||
| Efficacy and Safety of Midodrine and Atomoxetine Treatment in Patients With Neurogenic Orthostatic Hypotension : A Prospective Randomized Study[NCT03350659] | Phase 4 | 50 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for midodrine and Drop Attack
| Article | Year |
|---|---|
Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis.
Topics: Double-Blind Method; Female; Humans; Male; Midodrine; Randomized Controlled Trials as Topic; Syncope | 2022 |
New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope.
Topics: Accidental Falls; Adenosine; Antihypertensive Agents; Atomoxetine Hydrochloride; Atrioventricular No | 2021 |
Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review.
Topics: Humans; Hypotension, Orthostatic; Midodrine; Quality of Life; Reflex; Secondary Prevention; Syncope | 2014 |
New developments in the management of neurogenic orthostatic hypotension.
Topics: Accidental Falls; Activities of Daily Living; Adrenergic alpha-1 Receptor Agonists; Aged; Aged, 80 a | 2014 |
Current concepts in the evaluation and management of syncope.
Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents; Cardiac Pacing, Artificial; Fludrocortisone; | 2008 |
Evaluation and management of syncope.
Topics: Diagnosis, Differential; Electrocardiography; Humans; Hypotension, Orthostatic; Midodrine; Practice | 2010 |
[Diabetes mellitus and orthostatic intolerance].
Topics: Bandages; Diabetic Neuropathies; Diet, Sodium-Restricted; Exercise Therapy; Heart Rate; Humans; Male | 2005 |
Diagnosis and management of patients with blackouts.
Topics: Adolescent; Adult; Aged; Electrocardiography, Ambulatory; Epilepsy; Female; Humans; Male; Mental Dis | 2006 |
A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Female; Heart Rate; Humans; Hypotens | 1994 |
5 trials available for midodrine and Drop Attack
| Article | Year |
|---|---|
Treatment of vasodepressor carotid sinus syndrome with midodrine: a randomized, controlled pilot study.
Topics: Accidental Falls; Aged; Aged, 80 and over; Blood Pressure; Cross-Over Studies; Double-Blind Method; | 2005 |
Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension.
Topics: Adrenergic alpha-Agonists; Astronauts; Blood Pressure; Cardiac Output; Hemodynamics; Humans; Hypoten | 2006 |
Observations on midodrine in a case of vasodepressor neurogenic syncope.
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Cardiac Pacing, Artificial; Cross-Over Studies; El | 1995 |
Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Blood Volume; Clonidine; Female; Heart | 1997 |
Preliminary observations on the use of midodrine hydrochloride in the treatment of refractory neurocardiogenic syncope.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Autonomic Nervous System D | 1999 |
9 other studies available for midodrine and Drop Attack
| Article | Year |
|---|---|
Defining successful treatment of neurogenic orthostatic hypotension with droxidopa in a patient with multiple system atrophy.
Topics: Accidental Falls; Aged, 80 and over; Antiparkinson Agents; Droxidopa; Female; Humans; Hypotension, O | 2017 |
Effects of promethazine and midodrine on orthostatic tolerance.
Topics: Adrenergic alpha-1 Receptor Agonists; Adult; Aldosterone; Blood Pressure; Cardiac Output; Diastole; | 2011 |
Recurrent syncope in a patient after myocardial infarction.
Topics: Aged; Humans; Male; Midodrine; Myocardial Infarction; Recurrence; Sympathomimetics; Syncope | 2003 |
Clinical history.
Topics: Blood Pressure; Chest Pain; Clonazepam; Female; Heart Rate; Humans; Hypertension; Incidence; Middle | 2004 |
Effects of therapy based on tilt testing results on the long-term outcome in patients with syncope.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Female; Fludroco | 2005 |
Update on the evaluation, pathogenesis, and management of neurogenic orthostatic hypotension: introduction.
Topics: Clinical Trials as Topic; Humans; Hypotension, Orthostatic; Midodrine; Multicenter Studies as Topic; | 1995 |
[Hemodynamic and neuroendocrine profile of 2 different cardiovascular responses in vasodepressor syncope induced by the head-up tilt test].
Topics: Adolescent; Adult; Aged; Blood Pressure; Epinephrine; Etilefrine; Female; Heart Rate; Humans; Male; | 1992 |
A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride.
Topics: Adult; Blood Pressure; Bradycardia; Female; Humans; Hypotension; Midodrine; Seizures; Syncope; Vagus | 1992 |
[Dizziness, syncope, orthostatic hypotension].
Topics: Aged; Dizziness; Epinephrine; Female; Humans; Hypotension, Orthostatic; Midodrine; Norepinephrine; S | 1988 |