Page last updated: 2024-10-31

midodrine and Critical Illness

midodrine has been researched along with Critical Illness in 4 studies

Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Critical Illness: A disease or state in which death is possible or imminent.

Research Excerpts

ExcerptRelevanceReference
"Midodrine has been used as an oral agent for haemodynamic support in patients with orthostatic hypotension or cirrhosis."5.72Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis. ( Bagshaw, SM; Fiest, K; Kamaleldin, M; Karvellas, CJ; Kilcommons, S; Kutsogiannis, J; Lau, V; MacIntyre, E; Opgenorth, D; Rewa, OG; Rochwerg, B; Senaratne, J; Slemko, J; Sligl, W; Wang, X, 2022)
"Midodrine is an orally administered alpha-1 adrenergic agonist while methylene blue is an intravenously administered blue dye used to restore vascular tone and increase blood pressure."2.66Clinical utility of midodrine and methylene blue as catecholamine-sparing agents in intensive care unit patients with shock. ( Sullivan, JB; Tchen, S, 2020)
"Midodrine has been used as an oral agent for haemodynamic support in patients with orthostatic hypotension or cirrhosis."1.72Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis. ( Bagshaw, SM; Fiest, K; Kamaleldin, M; Karvellas, CJ; Kilcommons, S; Kutsogiannis, J; Lau, V; MacIntyre, E; Opgenorth, D; Rewa, OG; Rochwerg, B; Senaratne, J; Slemko, J; Sligl, W; Wang, X, 2022)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's4 (100.00)2.80

Authors

AuthorsStudies
Opgenorth, D4
Baig, N1
Fiest, K4
Karvellas, C1
Kutsogiannis, J4
Lau, V4
Macintyre, E4
Senaratne, J4
Slemko, J4
Sligl, W4
Wang, X4
Bagshaw, SM4
Rewa, OG4
Kamaleldin, M3
Kilcommons, S3
Karvellas, CJ3
Rochwerg, B3
Tchen, S1
Sullivan, JB1
Riker, RR1
Gagnon, DJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Midodrine for the Early Liberation From Vasopressor Support in the ICU - The LIBERATE Multi-Site Study[NCT05058612]Phase 4350 participants (Anticipated)Interventional2021-03-22Recruiting
RANDOMIZED CASE-CONTROLLED TRIAL ASSESSING MIDODRINE (GUTRONĀ®) IN POSTOPERATIVE VASOPLEGIC PATIENTS[NCT04440085]Phase 450 participants (Anticipated)Interventional2020-09-14Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for midodrine and Critical Illness

ArticleYear
Clinical utility of midodrine and methylene blue as catecholamine-sparing agents in intensive care unit patients with shock.
    Journal of critical care, 2020, Volume: 57

    Topics: Blood Pressure; Catecholamines; Critical Care; Critical Illness; Humans; Hypotension; Intensive Care

2020

Trials

1 trial available for midodrine and Critical Illness

ArticleYear
LIBERATE: a study protocol for midodrine for the early liberation from vasopressor support in the intensive care unit (LIBERATE): protocol for a randomized controlled trial.
    Trials, 2022, Mar-04, Volume: 23, Issue:1

    Topics: Administration, Intravenous; Adolescent; Adult; Critical Illness; Humans; Intensive Care Units; Mido

2022

Other Studies

2 other studies available for midodrine and Critical Illness

ArticleYear
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 11-23, Volume: 12, Issue:11

    Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature

2022
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 11-23, Volume: 12, Issue:11

    Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature

2022
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 11-23, Volume: 12, Issue:11

    Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature

2022
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 11-23, Volume: 12, Issue:11

    Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature

2022
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 11-23, Volume: 12, Issue:11

    Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature

2022
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 11-23, Volume: 12, Issue:11

    Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature

2022
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 11-23, Volume: 12, Issue:11

    Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature

2022
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 11-23, Volume: 12, Issue:11

    Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature

2022
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
    BMJ open, 2022, 11-23, Volume: 12, Issue:11

    Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature

2022
Midodrine administration during critical illness: fixed-dose or titrate to response?
    Intensive care medicine, 2021, Volume: 47, Issue:2

    Topics: Critical Illness; Humans; Hypotension; Intensive Care Units; Midodrine; Vasoconstrictor Agents

2021