midodrine has been researched along with Critical Illness in 4 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Midodrine has been used as an oral agent for haemodynamic support in patients with orthostatic hypotension or cirrhosis." | 5.72 | Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis. ( Bagshaw, SM; Fiest, K; Kamaleldin, M; Karvellas, CJ; Kilcommons, S; Kutsogiannis, J; Lau, V; MacIntyre, E; Opgenorth, D; Rewa, OG; Rochwerg, B; Senaratne, J; Slemko, J; Sligl, W; Wang, X, 2022) |
| "Midodrine is an orally administered alpha-1 adrenergic agonist while methylene blue is an intravenously administered blue dye used to restore vascular tone and increase blood pressure." | 2.66 | Clinical utility of midodrine and methylene blue as catecholamine-sparing agents in intensive care unit patients with shock. ( Sullivan, JB; Tchen, S, 2020) |
| "Midodrine has been used as an oral agent for haemodynamic support in patients with orthostatic hypotension or cirrhosis." | 1.72 | Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis. ( Bagshaw, SM; Fiest, K; Kamaleldin, M; Karvellas, CJ; Kilcommons, S; Kutsogiannis, J; Lau, V; MacIntyre, E; Opgenorth, D; Rewa, OG; Rochwerg, B; Senaratne, J; Slemko, J; Sligl, W; Wang, X, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Opgenorth, D | 4 |
| Baig, N | 1 |
| Fiest, K | 4 |
| Karvellas, C | 1 |
| Kutsogiannis, J | 4 |
| Lau, V | 4 |
| Macintyre, E | 4 |
| Senaratne, J | 4 |
| Slemko, J | 4 |
| Sligl, W | 4 |
| Wang, X | 4 |
| Bagshaw, SM | 4 |
| Rewa, OG | 4 |
| Kamaleldin, M | 3 |
| Kilcommons, S | 3 |
| Karvellas, CJ | 3 |
| Rochwerg, B | 3 |
| Tchen, S | 1 |
| Sullivan, JB | 1 |
| Riker, RR | 1 |
| Gagnon, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Midodrine for the Early Liberation From Vasopressor Support in the ICU - The LIBERATE Multi-Site Study[NCT05058612] | Phase 4 | 350 participants (Anticipated) | Interventional | 2021-03-22 | Recruiting | ||
| RANDOMIZED CASE-CONTROLLED TRIAL ASSESSING MIDODRINE (GUTRON®) IN POSTOPERATIVE VASOPLEGIC PATIENTS[NCT04440085] | Phase 4 | 50 participants (Anticipated) | Interventional | 2020-09-14 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midodrine and Critical Illness
| Article | Year |
|---|---|
Clinical utility of midodrine and methylene blue as catecholamine-sparing agents in intensive care unit patients with shock.
Topics: Blood Pressure; Catecholamines; Critical Care; Critical Illness; Humans; Hypotension; Intensive Care | 2020 |
1 trial available for midodrine and Critical Illness
| Article | Year |
|---|---|
LIBERATE: a study protocol for midodrine for the early liberation from vasopressor support in the intensive care unit (LIBERATE): protocol for a randomized controlled trial.
Topics: Administration, Intravenous; Adolescent; Adult; Critical Illness; Humans; Intensive Care Units; Mido | 2022 |
2 other studies available for midodrine and Critical Illness
| Article | Year |
|---|---|
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature | 2022 |
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature | 2022 |
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature | 2022 |
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature | 2022 |
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature | 2022 |
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature | 2022 |
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature | 2022 |
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature | 2022 |
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.
Topics: Critical Illness; Humans; Intensive Care Units; Meta-Analysis as Topic; Midodrine; Review Literature | 2022 |
Midodrine administration during critical illness: fixed-dose or titrate to response?
Topics: Critical Illness; Humans; Hypotension; Intensive Care Units; Midodrine; Vasoconstrictor Agents | 2021 |