Page last updated: 2024-10-31

midodrine and Chronic Kidney Failure

midodrine has been researched along with Chronic Kidney Failure in 21 studies

Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Research Excerpts

ExcerptRelevanceReference
"Cool dialysate and midodrine have been used successfully to treat intradialytic hypotension (IDH) in the end-stage renal disease population."9.10Hemodynamics in patients with intradialytic hypotension treated with cool dialysate or midodrine. ( Abu-Alfa, AK; Hoeben, H; Mahnensmith, R; Perazella, MA, 2002)
" Midodrine is an α1 vasoconstrictor commonly used for the treatment of pulmonary arterial hypertension (PAH) and intradialytic hypotension."7.91Midodrine treatment in a patient with treprostinil-induced hypotension receiving hemodialysis. ( Alobaidi, A; Bielnicka, P; Drambarean, B, 2019)
"Outpatient dialysis is possible and relieves the symptoms of congestive heart failure in patients with poor heart function, low blood pressure, and advanced age when midodrine is given immediately before and during the procedure."7.75Hemodialysis in hypotensive heart failure using midodrine. ( Bergman, SM, 2009)
"Midodrine appears to be an effective and safe treatment for HD patients with symptomatic IDH, and remains beneficial when used for an extended period of time."6.69Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up. ( Brickel, HM; Cruz, DN; Mahnensmith, RL; Perazella, MA, 1998)
"Oral midodrine appears to be a safe and effective therapy for the treatment of hemodialysis hypotension."6.68Midodrine treatment for patients with hemodialysis hypotension. ( Caruso, FS; Flynn, JJ; McElligott, MA; Mitchell, MC, 1996)
"Midodrine treatment also significantly increased postdialysis systolic and diastolic blood pressures from baseline values of 90."6.68Midodrine for the treatment of intradialytic hypotension. ( Li, HP; Lim, PS; Lim, YT; Yang, CC; Yeh, CH, 1997)
"Midodrine is an alpha-agonist that causes peripheral vasoconstriction, resulting in increased blood pressure."6.44Midodrine-induced vascular ischemia in a hemodialysis patient: a case report and literature review. ( Haimov, M; Ross, MJ; Rubinstein, S, 2008)
"Other than scalp paresthesia in one patient, no adverse effects were noted."5.30Intradialytic hypotension: is midodrine beneficial in symptomatic hemodialysis patients? ( Cruz, DN; Mahnensmith, RL; Perazella, MA, 1997)
" The pharmacokinetic characteristics of the prodrug midodrine and the active metabolite de-glymidodrine in this patient with end-stage renal disease approximate those reported for patients with normal renal function."5.29Midodrine efficacy and pharmacokinetics in a patient with recurrent intradialytic hypotension. ( Balfe, JW; Blowey, DL; Gajaria, MM; Gupta, I; Koren, G, 1996)
"Cool dialysate and midodrine have been used successfully to treat intradialytic hypotension (IDH) in the end-stage renal disease population."5.10Hemodynamics in patients with intradialytic hypotension treated with cool dialysate or midodrine. ( Abu-Alfa, AK; Hoeben, H; Mahnensmith, R; Perazella, MA, 2002)
" Midodrine is an α1 vasoconstrictor commonly used for the treatment of pulmonary arterial hypertension (PAH) and intradialytic hypotension."3.91Midodrine treatment in a patient with treprostinil-induced hypotension receiving hemodialysis. ( Alobaidi, A; Bielnicka, P; Drambarean, B, 2019)
"Midodrine is prescribed to prevent symptomatic hypotension and decrease complications associated with hypotension during dialysis."3.83Pretransplant Midodrine Use: A Newly Identified Risk Marker for Complications After Kidney Transplantation. ( Alhamad, T; Axelrod, D; Brennan, DC; Brifkani, Z; Dharnidharka, VR; Lentine, KL; Schnitzler, MA; Segev, DL; Xiao, H, 2016)
"Outpatient dialysis is possible and relieves the symptoms of congestive heart failure in patients with poor heart function, low blood pressure, and advanced age when midodrine is given immediately before and during the procedure."3.75Hemodialysis in hypotensive heart failure using midodrine. ( Bergman, SM, 2009)
"Midodrine users were more commonly older (56."2.87Influence of pretransplant midodrine use on outcomes after kidney transplantation. ( Brennan, DC; Gharabagi, A; Hagopian, JC; Horwedel, TA; Pottebaum, AA, 2018)
"Midodrine appears to be an effective and safe treatment for HD patients with symptomatic IDH, and remains beneficial when used for an extended period of time."2.69Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up. ( Brickel, HM; Cruz, DN; Mahnensmith, RL; Perazella, MA, 1998)
"Oral midodrine appears to be a safe and effective therapy for the treatment of hemodialysis hypotension."2.68Midodrine treatment for patients with hemodialysis hypotension. ( Caruso, FS; Flynn, JJ; McElligott, MA; Mitchell, MC, 1996)
"Midodrine treatment also significantly increased postdialysis systolic and diastolic blood pressures from baseline values of 90."2.68Midodrine for the treatment of intradialytic hypotension. ( Li, HP; Lim, PS; Lim, YT; Yang, CC; Yeh, CH, 1997)
"Midodrine is an alpha-agonist that causes peripheral vasoconstriction, resulting in increased blood pressure."2.44Midodrine-induced vascular ischemia in a hemodialysis patient: a case report and literature review. ( Haimov, M; Ross, MJ; Rubinstein, S, 2008)
"Other than scalp paresthesia in one patient, no adverse effects were noted."1.30Intradialytic hypotension: is midodrine beneficial in symptomatic hemodialysis patients? ( Cruz, DN; Mahnensmith, RL; Perazella, MA, 1997)
" The pharmacokinetic characteristics of the prodrug midodrine and the active metabolite de-glymidodrine in this patient with end-stage renal disease approximate those reported for patients with normal renal function."1.29Midodrine efficacy and pharmacokinetics in a patient with recurrent intradialytic hypotension. ( Balfe, JW; Blowey, DL; Gajaria, MM; Gupta, I; Koren, G, 1996)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (28.57)18.2507
2000's8 (38.10)29.6817
2010's7 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pottebaum, AA1
Hagopian, JC1
Brennan, DC2
Gharabagi, A1
Horwedel, TA1
Brunelli, SM1
Cohen, DE1
Marlowe, G1
Van Wyck, D1
Raina, R1
Lam, S1
Raheja, H1
Krishnappa, V1
Hothi, D1
Davenport, A1
Chand, D1
Kapur, G1
Schaefer, F1
Sethi, SK1
McCulloch, M1
Bagga, A1
Bunchman, T1
Warady, BA1
Drambarean, B1
Bielnicka, P1
Alobaidi, A1
Tanabe, N1
Takane, K1
Yokoyama, K1
Tanno, Y1
Yamamoto, I1
Ohkido, I1
Yokoo, T1
Alhamad, T1
Brifkani, Z1
Xiao, H1
Schnitzler, MA1
Dharnidharka, VR1
Axelrod, D1
Segev, DL1
Lentine, KL1
Rubinstein, S1
Haimov, M1
Ross, MJ1
Bergman, SM1
Hassinger, AB1
Garimella, S1
Blowey, DL1
Balfe, JW1
Gupta, I1
Gajaria, MM1
Koren, G1
Flynn, JJ1
Mitchell, MC1
Caruso, FS1
McElligott, MA1
Lim, PS1
Yang, CC1
Li, HP1
Lim, YT1
Yeh, CH1
Cruz, DN3
Mahnensmith, RL3
Perazella, MA6
Brickel, HM2
Han, SY1
Kwon, YJ1
Shin, JH1
Pyo, HJ1
Kim, AR1
Montagnac, R2
Clavel, P2
Delhotal-Landes, B2
Flouvat, B2
Poulain, S2
Schillinger, F1
Alappan, R1
Cruz, D1
Abu-Alfa, AK2
Mahnensmith, R2
Schllinger, F1
Hoeben, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hemodynamic Effects of Low vs. High Dialysate Temperature or Bicarbonate Concentration in Chronic Hemodialysis Patients[NCT05052151]16 participants (Actual)Interventional2021-08-25Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for midodrine and Chronic Kidney Failure

ArticleYear
Midodrine-induced vascular ischemia in a hemodialysis patient: a case report and literature review.
    Renal failure, 2008, Volume: 30, Issue:8

    Topics: Adrenergic alpha-Agonists; Female; Humans; Ischemia; Kidney Failure, Chronic; Leg; Middle Aged; Mido

2008
Pharmacologic options available to treat symptomatic intradialytic hypotension.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 38, Issue:4 Suppl 4

    Topics: Adrenergic Agents; Autonomic Nervous System; Caffeine; Carnitine; Ephedrine; Fludrocortisone; Hemodi

2001

Trials

7 trials available for midodrine and Chronic Kidney Failure

ArticleYear
Influence of pretransplant midodrine use on outcomes after kidney transplantation.
    Clinical transplantation, 2018, Volume: 32, Issue:9

    Topics: Delayed Graft Function; Female; Follow-Up Studies; Glomerular Filtration Rate; Graft Rejection; Graf

2018
Midodrine treatment for patients with hemodialysis hypotension.
    Clinical nephrology, 1996, Volume: 45, Issue:4

    Topics: Adrenergic alpha-Agonists; Aged; Blood Pressure; Female; Humans; Hypotension; Kidney Failure, Chroni

1996
Midodrine for the treatment of intradialytic hypotension.
    Nephron, 1997, Volume: 77, Issue:3

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Aged; Blood Pressure; Body Weight; Female; H

1997
Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up.
    Clinical nephrology, 1998, Volume: 50, Issue:2

    Topics: Adrenergic alpha-Agonists; Case-Control Studies; Female; Follow-Up Studies; Humans; Hypotension; Kid

1998
Midodrine and cool dialysate are effective therapies for symptomatic intradialytic hypotension.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1999, Volume: 33, Issue:5

    Topics: Aged; Aged, 80 and over; Blood Pressure; Cold Temperature; Combined Modality Therapy; Cross-Over Stu

1999
Treatment of Severe Intradialytic Hypotension With the Addition of High Dialysate Calcium Concentration to Midodrine and/or Cool Dialysate.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 37, Issue:2

    Topics: Blood Pressure; Calcium; Female; Hemodialysis Solutions; Humans; Hypotension; Kidney Failure, Chroni

2001
Hemodynamics in patients with intradialytic hypotension treated with cool dialysate or midodrine.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 39, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Blood Pressure; Blood Volume; Cardiac Output; Cold Temperatu

2002

Other Studies

12 other studies available for midodrine and Chronic Kidney Failure

ArticleYear
The Impact of Midodrine on Outcomes in Patients with Intradialytic Hypotension.
    American journal of nephrology, 2018, Volume: 48, Issue:5

    Topics: Aged; Aged, 80 and over; Blood Pressure; Female; Follow-Up Studies; Hospitalization; Humans; Hypoten

2018
Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup.
    Pediatric nephrology (Berlin, Germany), 2019, Volume: 34, Issue:5

    Topics: Age Factors; Blood Pressure; Blood Pressure Determination; Child; Consensus; Continuous Renal Replac

2019
Midodrine treatment in a patient with treprostinil-induced hypotension receiving hemodialysis.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2019, Jan-01, Volume: 76, Issue:1

    Topics: Antihypertensive Agents; Dose-Response Relationship, Drug; Epoprostenol; Humans; Hypotension; Kidney

2019
Dialysate temperature adjustment as an effective treatment for baroreflex failure syndrome in hemodialysis patient.
    BMC nephrology, 2014, Sep-17, Volume: 15

    Topics: Aged; Baroreflex; Carotid Sinus; Cold Temperature; Dialysis Solutions; Dizziness; Droxidopa; Enteral

2014
Pretransplant Midodrine Use: A Newly Identified Risk Marker for Complications After Kidney Transplantation.
    Transplantation, 2016, Volume: 100, Issue:5

    Topics: Adolescent; Adult; Aged; Blood Pressure; Delayed Graft Function; Female; Genetic Markers; Graft Surv

2016
Hemodialysis in hypotensive heart failure using midodrine.
    The American journal of the medical sciences, 2009, Volume: 338, Issue:6

    Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Blood Pressure; Female; Heart Failure; Humans; H

2009
Refractory hypotension after bilateral nephrectomies in a Denys-Drash patient with phenylketonuria.
    Pediatric nephrology (Berlin, Germany), 2013, Volume: 28, Issue:2

    Topics: Adrenergic alpha-1 Receptor Agonists; Denys-Drash Syndrome; Female; Humans; Hypotension; Infant; Inf

2013
Midodrine efficacy and pharmacokinetics in a patient with recurrent intradialytic hypotension.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 28, Issue:1

    Topics: Adolescent; Adrenergic alpha-Agonists; Half-Life; Humans; Hypotension; Kidney Failure, Chronic; Male

1996
Intradialytic hypotension: is midodrine beneficial in symptomatic hemodialysis patients?
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1997, Volume: 30, Issue:6

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Blood Pressure; Diastole;

1997
Nonocclusive mesenteric ischemia in a patient on maintenance hemodialysis.
    The Korean journal of internal medicine, 2000, Volume: 15, Issue:1

    Topics: Aged; Colectomy; Colon; Female; Humans; Ischemia; Kidney Failure, Chronic; Mesentery; Midodrine; Ren

2000
[Midodrine (Gutron) treatment of permanent arterial hypotension in a chronic hemodialysis patient].
    Nephrologie, 2000, Volume: 21, Issue:4

    Topics: Adrenergic alpha-Agonists; Chronic Disease; Heart Failure; Humans; Hypertrophy, Left Ventricular; Hy

2000
Use of midodrine (Gutron) to treat permanent hypotension in a chronic hemodialysis patient.
    Clinical nephrology, 2001, Volume: 56, Issue:2

    Topics: Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypotension; Kidney Failure, Chronic; Male

2001