midodrine has been researched along with Chronic Illness in 11 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of midodrine on chronic hypotension in hemodialysis (HD) patients have not been well investigated." | 7.72 | Midodrine improves chronic hypotension in hemodialysis patients. ( Denq, JC; Lin, SH; Lin, YF; Wang, JY, 2003) |
| "Midodrine hydrochloride is an alpha-mimetic drug acting directly on the peripheral alpha-receptor and increases blood pressure." | 5.29 | Midodrine hydrochloride in patients on hemodialysis with chronic hypotension. ( Fang, JT; Huang, CC, 1996) |
| "The effects of midodrine on chronic hypotension in hemodialysis (HD) patients have not been well investigated." | 3.72 | Midodrine improves chronic hypotension in hemodialysis patients. ( Denq, JC; Lin, SH; Lin, YF; Wang, JY, 2003) |
| "However, treatment of hypotension is uncommon in the SCI population because there are few safe and effective pharmacological options available." | 2.94 | Double-blinded, placebo-controlled crossover trial to determine the effects of midodrine on blood pressure during cognitive testing in persons with SCI. ( Bauman, WA; Chiaravalloti, ND; Dyson-Hudson, TA; Katzelnick, CG; Kirshblum, SC; Weber, E; Wecht, JM; Weir, JP, 2020) |
| "Chronic low blood pressure is typically accompanied by symptoms such as fatigue, reduced drive, dizziness, headaches and cold limbs." | 2.74 | Hemodynamic determinants of chronic hypotension and their modification through vasopressor application. ( Buechner, B; Duschek, S; Heiss, H; Reyes del Paso, GA; Schandry, R; Werner, N, 2009) |
| "Chronic low blood pressure is typically accompanied with symptoms such as fatigue, reduced drive, dizziness, headaches and cold limbs." | 2.74 | Modulations of autonomic cardiovascular control following acute alpha-adrenergic treatment in chronic hypotension. ( Duschek, S; Heiss, H; Reyes del Paso, GA; Werner, N, 2009) |
| "Midodrine hydrochloride is an alpha-mimetic drug acting directly on the peripheral alpha-receptor and increases blood pressure." | 1.29 | Midodrine hydrochloride in patients on hemodialysis with chronic hypotension. ( Fang, JT; Huang, CC, 1996) |
| "This led to successfully oral treatment of the orthostatic hypotension with clonidine 150 micrograms bd and midodrine 10 mg bd." | 1.28 | Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report. ( Arias, A; Berlan, M; Montastruc, JL; Rascol, A; Senard, JM; Tran, MA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Sinagra, G | 1 |
| Fabris, E | 1 |
| Wecht, JM | 1 |
| Weir, JP | 1 |
| Katzelnick, CG | 1 |
| Chiaravalloti, ND | 1 |
| Kirshblum, SC | 1 |
| Dyson-Hudson, TA | 1 |
| Weber, E | 1 |
| Bauman, WA | 1 |
| Duschek, S | 2 |
| Heiss, H | 2 |
| Buechner, B | 1 |
| Werner, N | 2 |
| Schandry, R | 1 |
| Reyes del Paso, GA | 2 |
| Parati, G | 1 |
| Di Rienzo, M | 1 |
| Coruzzi, P | 1 |
| Castiglioni, P | 1 |
| Goldstein, DS | 1 |
| Holmes, C | 1 |
| Dendi, R | 1 |
| Li, ST | 1 |
| Brentzel, S | 1 |
| Vernino, S | 1 |
| Lin, YF | 1 |
| Wang, JY | 1 |
| Denq, JC | 1 |
| Lin, SH | 1 |
| Fang, JT | 1 |
| Huang, CC | 1 |
| Montagnac, R | 1 |
| Clavel, P | 1 |
| Delhotal-Landes, B | 1 |
| Flouvat, B | 1 |
| Poulain, S | 1 |
| Schillinger, F | 1 |
| Hirayama, M | 1 |
| Koike, Y | 1 |
| Ieda, T | 1 |
| Takahashi, A | 1 |
| Sobue, G | 1 |
| Senard, JM | 1 |
| Arias, A | 1 |
| Berlan, M | 1 |
| Tran, MA | 1 |
| Rascol, A | 1 |
| Montastruc, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Blood Pressure, Cerebral Blood Flow and Cognition in SCI[NCT02307565] | Phase 3 | 60 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| Plasma Exchange for Autoimmune Autonomic Failure[NCT00359346] | 3 participants | Observational | 2006-07-14 | Completed | |||
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014] | Phase 4 | 22 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for midodrine and Chronic Illness
| Article | Year |
|---|---|
Double-blinded, placebo-controlled crossover trial to determine the effects of midodrine on blood pressure during cognitive testing in persons with SCI.
Topics: Adult; Blood Pressure; Cerebrovascular Circulation; Chronic Disease; Cognition; Cross-Over Studies; | 2020 |
Hemodynamic determinants of chronic hypotension and their modification through vasopressor application.
Topics: Adult; Blood Pressure; Body Height; Body Mass Index; Cardiac Output; Chronic Disease; Double-Blind M | 2009 |
Modulations of autonomic cardiovascular control following acute alpha-adrenergic treatment in chronic hypotension.
Topics: Adrenergic alpha-Agonists; Adult; Autonomic Nervous System; Baroreflex; Blood Pressure; Chronic Dise | 2009 |
[A one-month combined use of selective adrenergic beta 1- and alpha 1-agonists for postprandial hypotension in patients with autonomic failure].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aged; Autonomic Nervous System Diseases; Chroni | 2000 |
7 other studies available for midodrine and Chronic Illness
| Article | Year |
|---|---|
Might midodrine be useful in patients with decompensated and worsening chronic heart failure? Author's reply.
Topics: Blood Pressure; Chronic Disease; Heart Failure; Humans; Midodrine | 2022 |
Chronic hypotension and modulation of autonomic cardiovascular regulation.
Topics: Adrenergic alpha-Agonists; Autonomic Nervous System; Baroreflex; Cardiovascular Physiological Phenom | 2009 |
Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor.
Topics: Adrenergic alpha-Agonists; Aged; Autoantibodies; Autoimmune Diseases; Autonomic Nervous System; Auto | 2002 |
Midodrine improves chronic hypotension in hemodialysis patients.
Topics: Adrenergic alpha-Agonists; Adult; Autonomic Nervous System; Chronic Disease; Female; Hemodynamics; H | 2003 |
Midodrine hydrochloride in patients on hemodialysis with chronic hypotension.
Topics: Administration, Oral; Adult; Aged; Chronic Disease; Combined Modality Therapy; Drug Evaluation; Fema | 1996 |
[Midodrine (Gutron) treatment of permanent arterial hypotension in a chronic hemodialysis patient].
Topics: Adrenergic alpha-Agonists; Chronic Disease; Heart Failure; Humans; Hypertrophy, Left Ventricular; Hy | 2000 |
Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report.
Topics: Blood Pressure; Chronic Disease; Clonidine; Efferent Pathways; Humans; Hypotension, Orthostatic; Mal | 1991 |