midodrine has been researched along with Bradycardia in 4 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a man in his 40s with a history of chronic intranasal cocaine use and C5-C7 incomplete quadriplegia complicated by neurogenic orthostatic hypotension, admitted to the intensive care unit for worsening bradycardia and hypotension requiring initiation of dopamine and an increase of his home midodrine dose." | 8.31 | Refractory bradycardia and hypotension in patients with autonomic dysfunction treated with pseudoephedrine. ( Curran, C; Davoudi, F; Foster, G; Gordan, P, 2023) |
| " Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it." | 7.68 | A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992) |
| "We describe a man in his 40s with a history of chronic intranasal cocaine use and C5-C7 incomplete quadriplegia complicated by neurogenic orthostatic hypotension, admitted to the intensive care unit for worsening bradycardia and hypotension requiring initiation of dopamine and an increase of his home midodrine dose." | 4.31 | Refractory bradycardia and hypotension in patients with autonomic dysfunction treated with pseudoephedrine. ( Curran, C; Davoudi, F; Foster, G; Gordan, P, 2023) |
| " Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it." | 3.68 | A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992) |
| "If cardiac syncope is unlikely, reflex (neurally mediated) syncope and orthostatic hypotension are the most frequent causes of transient loss of consciousness." | 2.72 | New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope. ( Brignole, M; Rivasi, G, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Curran, C | 1 |
| Davoudi, F | 1 |
| Foster, G | 1 |
| Gordan, P | 1 |
| Brignole, M | 1 |
| Rivasi, G | 1 |
| Wong, LY | 1 |
| Wong, A | 1 |
| Robertson, T | 1 |
| Burns, K | 1 |
| Roberts, M | 1 |
| Isbister, GK | 1 |
| Koyama, S | 1 |
| Matsubara, T | 1 |
| Aizawa, Y | 1 |
| Ohshima, M | 1 |
| Yamaguchi, T | 1 |
| Yamazaki, Y | 1 |
| Igarashi, Y | 1 |
| Tamura, Y | 1 |
| Yamazoe, M | 1 |
| Izumi, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of the Mechanism of Non-cardiac Syncope by 24-hour Ambulatory Blood Pressure Monitoring (ABPM) and Tilt-table Short Cardiovascular Autonomic Function Battery (SCAFB)[NCT05728255] | 275 participants (Anticipated) | Observational | 2023-04-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midodrine and Bradycardia
| Article | Year |
|---|---|
New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope.
Topics: Accidental Falls; Adenosine; Antihypertensive Agents; Atomoxetine Hydrochloride; Atrioventricular No | 2021 |
3 other studies available for midodrine and Bradycardia
| Article | Year |
|---|---|
Refractory bradycardia and hypotension in patients with autonomic dysfunction treated with pseudoephedrine.
Topics: Autonomic Nervous System Diseases; Bradycardia; Dopamine; Humans; Hypotension; Hypotension, Orthosta | 2023 |
Severe Hypertension and Bradycardia Secondary to Midodrine Overdose.
Topics: Adrenergic alpha-1 Receptor Antagonists; Blood Pressure; Bradycardia; Drug Overdose; Female; Glasgow | 2017 |
A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride.
Topics: Adult; Blood Pressure; Bradycardia; Female; Humans; Hypotension; Midodrine; Seizures; Syncope; Vagus | 1992 |