Page last updated: 2024-10-31

midodrine and Blood Pressure, Low

midodrine has been researched along with Blood Pressure, Low in 73 studies

Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Research Excerpts

ExcerptRelevanceReference
"To assess the feasibility and physiological efficacy of adjunctive midodrine in patients with vasopressor-dependent hypotension."9.51A pilot, feasibility, randomised controlled trial of midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension in intensive care patients: The MAVERIC study. ( Bellomo, R; Brown, A; Costa-Pinto, R; Eastwood, G; Udy, A; Yanase, F; Yong, ZT; Young, C; Young, PJ, 2022)
"Prophylactic administration of 10-mg midodrine tablets before spinal anesthesia is an effective method in the prevention of hypotension in young adult patients undergoing elective orthopedic knee surgery."9.51Efficacy of Preoperative Oral Midodrine in Preventing Hypotension After Spinal Anesthesia in Young Adults: A Randomized Controlled Trial. ( Abdelsalam, TA; Alseoudy, MM; Nasr, MO, 2022)
"Midodrine did not accelerate liberation from intravenous vasopressors and was not effective for the treatment of hypotension in critically ill patients."9.34Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial. ( Anstey, MH; Eikermann, M; Houle, TT; Parsons, CS; Patrocínio, MD; Santer, P; Shaefi, S; Shay, D; Teja, B; Wibrow, B, 2020)
"Cool dialysate and midodrine have been used successfully to treat intradialytic hypotension (IDH) in the end-stage renal disease population."9.10Hemodynamics in patients with intradialytic hypotension treated with cool dialysate or midodrine. ( Abu-Alfa, AK; Hoeben, H; Mahnensmith, R; Perazella, MA, 2002)
"Midodrine lessens the fall in arterial pressure during hemodialysis, in patients with symptomatic hypotension."9.10[Effects of midodrine on symptomatic hypotension during hemodialysis]. ( Alvo, M; Cotera, A; Cuadra, C; Elgueta, L; Gormaz, JP; Ibáñez, C; Sanhueza, ME, 2002)
"We describe a man in his 40s with a history of chronic intranasal cocaine use and C5-C7 incomplete quadriplegia complicated by neurogenic orthostatic hypotension, admitted to the intensive care unit for worsening bradycardia and hypotension requiring initiation of dopamine and an increase of his home midodrine dose."8.31Refractory bradycardia and hypotension in patients with autonomic dysfunction treated with pseudoephedrine. ( Curran, C; Davoudi, F; Foster, G; Gordan, P, 2023)
" After the procedure, he developed prolonged post-carotid artery stenting hypotension, which was resistant to intravenous fluids and inotropes but immediately showed a promising response to oral midodrine."8.12Treatment via oral midodrine in a patient with prolonged hypotension following carotid artery stenting: a case report. ( Abtahi-Eivary, SM; Hosseini, K; Jenab, Y, 2022)
"Midodrine is widely used in the treatment of hypotensive states, there have been no reports of myoclonus associated with midodrine use in hypotension with chronic kidney disease."7.96Case report: severe myoclonus associated with oral midodrine treatment for hypotension. ( Chen, M; Ling, B; Ren, Y; Song, F; Wu, J; Wu, S; Xuan, Z; Ye, X; Zhang, H, 2020)
"A 49-year-old patient tolerated 60-mg daily doses of midodrine along with 30-mg intradialytic doses for the management of treprostinil-induced hypotension and prevention of HD interruption, without adverse effects."7.91Midodrine treatment in a patient with treprostinil-induced hypotension receiving hemodialysis. ( Alobaidi, A; Bielnicka, P; Drambarean, B, 2019)
" We report a case of ingestion of topical minoxidil [Rogaine® (Johnson & Johnson Healthcare Products, Division of McNeil-PPC, Inc)] resulting in refractory hypotension that was successfully managed with the oral α (1) agonist midodrine."7.77Refractory hypotension due to Rogaine® (minoxidil) ingestion managed with midodrine. ( Aaronson, P; Garrard, A; Sollee, D; Wood, A, 2011)
"Outpatient dialysis is possible and relieves the symptoms of congestive heart failure in patients with poor heart function, low blood pressure, and advanced age when midodrine is given immediately before and during the procedure."7.75Hemodialysis in hypotensive heart failure using midodrine. ( Bergman, SM, 2009)
"Midodrine improves chronic hypotension in HD patients by modulating autonomic function and its direct effects on peripheral vessels."7.72Midodrine improves chronic hypotension in hemodialysis patients. ( Denq, JC; Lin, SH; Lin, YF; Wang, JY, 2003)
" Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it."7.68A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992)
"Midodrine appears to be an effective and safe treatment for HD patients with symptomatic IDH, and remains beneficial when used for an extended period of time."6.69Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up. ( Brickel, HM; Cruz, DN; Mahnensmith, RL; Perazella, MA, 1998)
"Midodrine treatment also significantly increased postdialysis systolic and diastolic blood pressures from baseline values of 90."6.68Midodrine for the treatment of intradialytic hypotension. ( Li, HP; Lim, PS; Lim, YT; Yang, CC; Yeh, CH, 1997)
"Oral midodrine appears to be a safe and effective therapy for the treatment of hemodialysis hypotension."6.68Midodrine treatment for patients with hemodialysis hypotension. ( Caruso, FS; Flynn, JJ; McElligott, MA; Mitchell, MC, 1996)
" The effective oral dosage in infancy and childhood is 0."6.65[Infectious toxic hypotension--effect and dosage of midodrine (author's transl)]. ( Weippl, G, 1979)
"Midodrine is an oral, peripherally acting alpha-adrenergic agonist."6.55The Role of Midodrine for Hypotension Outside of the Intensive Care Unit. ( Gutman, LB; Wilson, BJ, 2017)
"Dialysis-induced hypotension is an important complication of haemodialysis."6.42Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review. ( Garg, AX; Heidenheim, AP; House, AA; Prakash, S, 2004)
" This medication has been demonstrated to be effective and safe in the acute and chronic treatment of haemodialysis-associated hypotension in end stage renal disease patients."6.42Efficacy and safety of midodrine in the treatment of dialysis-associated hypotension. ( Perazella, MA, 2003)
" Midodrine is a prodrug that is almost completely absorbed after oral administration and converted into its active drug de-glymidodrine in the systematic circulation, with a bioavailability of 93%."6.41Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension. ( Cruz, DN, 2000)
"Midodrine was started as a last resort attempt to wean off vasopressors."5.91Midodrine in end-stage heart failure. ( Franqui-Rivera, H; Gonzalez-Cordero, A; Mesa-Pabón, M; Nieves-Rivera, J; Ortiz-Troche, S, 2023)
"Midodrine (10 mg) administered in the home environment effectively increases BP and reduces the incidence of hypotension; however these beneficial effects come at the expense of worsened BP instability and AD symptom intensity."5.69Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury. ( Bauman, WA; Dyson-Hudson, TA; Katzelnick, CG; Kirshblum, SC; Wecht, JM; Weir, JP, 2023)
"Prophylactic administration of 10-mg midodrine tablets before spinal anesthesia is an effective method in the prevention of hypotension in young adult patients undergoing elective orthopedic knee surgery."5.51Efficacy of Preoperative Oral Midodrine in Preventing Hypotension After Spinal Anesthesia in Young Adults: A Randomized Controlled Trial. ( Abdelsalam, TA; Alseoudy, MM; Nasr, MO, 2022)
"To assess the feasibility and physiological efficacy of adjunctive midodrine in patients with vasopressor-dependent hypotension."5.51A pilot, feasibility, randomised controlled trial of midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension in intensive care patients: The MAVERIC study. ( Bellomo, R; Brown, A; Costa-Pinto, R; Eastwood, G; Udy, A; Yanase, F; Yong, ZT; Young, C; Young, PJ, 2022)
"Hypotension is commonly encountered during carotid artery stenting (CAS), mediated by vagal stimulation and suppression of sympathetic outflow."5.35Oral midodrine is effective for the treatment of hypotension associated with carotid artery stenting. ( Bhambi, B; Lardizabal, JA; Sharma, S, 2008)
"Midodrine did not accelerate liberation from intravenous vasopressors and was not effective for the treatment of hypotension in critically ill patients."5.34Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial. ( Anstey, MH; Eikermann, M; Houle, TT; Parsons, CS; Patrocínio, MD; Santer, P; Shaefi, S; Shay, D; Teja, B; Wibrow, B, 2020)
"We used the oral agent midodrine to treat hypotension that complicated myocardial stunning after successful revascularization with percutaneous coronary intervention in the setting of myocardial infarction and ischemia."5.33Successful treatment of hypotension associated with stunned myocardium with oral midodrine therapy. ( Bhambi, B; Sharma, S, 2005)
"Other than scalp paresthesia in one patient, no adverse effects were noted."5.30Intradialytic hypotension: is midodrine beneficial in symptomatic hemodialysis patients? ( Cruz, DN; Mahnensmith, RL; Perazella, MA, 1997)
"Midodrine hydrochloride was administered at a dose of 2."5.29Midodrine hydrochloride in patients on hemodialysis with chronic hypotension. ( Fang, JT; Huang, CC, 1996)
" The pharmacokinetic characteristics of the prodrug midodrine and the active metabolite de-glymidodrine in this patient with end-stage renal disease approximate those reported for patients with normal renal function."5.29Midodrine efficacy and pharmacokinetics in a patient with recurrent intradialytic hypotension. ( Balfe, JW; Blowey, DL; Gajaria, MM; Gupta, I; Koren, G, 1996)
"These findings suggest that midodrine 10mg may be efficacious for treatment of hypotension and orthostatic hypotension in select persons with tetraplegia."5.14Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia. ( Bauman, WA; Handrakis, JP; Radulovic, M; Rosado-Rivera, D; Wecht, JM, 2010)
"Cool dialysate and midodrine have been used successfully to treat intradialytic hypotension (IDH) in the end-stage renal disease population."5.10Hemodynamics in patients with intradialytic hypotension treated with cool dialysate or midodrine. ( Abu-Alfa, AK; Hoeben, H; Mahnensmith, R; Perazella, MA, 2002)
"Midodrine lessens the fall in arterial pressure during hemodialysis, in patients with symptomatic hypotension."5.10[Effects of midodrine on symptomatic hypotension during hemodialysis]. ( Alvo, M; Cotera, A; Cuadra, C; Elgueta, L; Gormaz, JP; Ibáñez, C; Sanhueza, ME, 2002)
"We describe a man in his 40s with a history of chronic intranasal cocaine use and C5-C7 incomplete quadriplegia complicated by neurogenic orthostatic hypotension, admitted to the intensive care unit for worsening bradycardia and hypotension requiring initiation of dopamine and an increase of his home midodrine dose."4.31Refractory bradycardia and hypotension in patients with autonomic dysfunction treated with pseudoephedrine. ( Curran, C; Davoudi, F; Foster, G; Gordan, P, 2023)
" After the procedure, he developed prolonged post-carotid artery stenting hypotension, which was resistant to intravenous fluids and inotropes but immediately showed a promising response to oral midodrine."4.12Treatment via oral midodrine in a patient with prolonged hypotension following carotid artery stenting: a case report. ( Abtahi-Eivary, SM; Hosseini, K; Jenab, Y, 2022)
"Midodrine is widely used in the treatment of hypotensive states, there have been no reports of myoclonus associated with midodrine use in hypotension with chronic kidney disease."3.96Case report: severe myoclonus associated with oral midodrine treatment for hypotension. ( Chen, M; Ling, B; Ren, Y; Song, F; Wu, J; Wu, S; Xuan, Z; Ye, X; Zhang, H, 2020)
"A 49-year-old patient tolerated 60-mg daily doses of midodrine along with 30-mg intradialytic doses for the management of treprostinil-induced hypotension and prevention of HD interruption, without adverse effects."3.91Midodrine treatment in a patient with treprostinil-induced hypotension receiving hemodialysis. ( Alobaidi, A; Bielnicka, P; Drambarean, B, 2019)
"Midodrine is an α1-agonist approved for orthostatic hypotension."3.91Continuation of Newly Initiated Midodrine Therapy After Intensive Care and Hospital Discharge: A Single-Center Retrospective Study. ( Barreto, EF; Gajic, O; Mara, KC; Nei, AM; Rizvi, MS, 2019)
"Midodrine is prescribed to prevent symptomatic hypotension and decrease complications associated with hypotension during dialysis."3.83Pretransplant Midodrine Use: A Newly Identified Risk Marker for Complications After Kidney Transplantation. ( Alhamad, T; Axelrod, D; Brennan, DC; Brifkani, Z; Dharnidharka, VR; Lentine, KL; Schnitzler, MA; Segev, DL; Xiao, H, 2016)
" We report a case of ingestion of topical minoxidil [Rogaine® (Johnson & Johnson Healthcare Products, Division of McNeil-PPC, Inc)] resulting in refractory hypotension that was successfully managed with the oral α (1) agonist midodrine."3.77Refractory hypotension due to Rogaine® (minoxidil) ingestion managed with midodrine. ( Aaronson, P; Garrard, A; Sollee, D; Wood, A, 2011)
"Outpatient dialysis is possible and relieves the symptoms of congestive heart failure in patients with poor heart function, low blood pressure, and advanced age when midodrine is given immediately before and during the procedure."3.75Hemodialysis in hypotensive heart failure using midodrine. ( Bergman, SM, 2009)
"Fludrocortisone is recommended in patients with orthostatic hypotension and a benefit has been suggested in hemodialysis patients with severe hypokaliemia."3.73Effect of mineralocorticoids on interdialytic weight gain in hemodialysis patients with perdialytic hypotension. ( Mercadal, L; Petitclerc, T, 2005)
"Midodrine improves chronic hypotension in HD patients by modulating autonomic function and its direct effects on peripheral vessels."3.72Midodrine improves chronic hypotension in hemodialysis patients. ( Denq, JC; Lin, SH; Lin, YF; Wang, JY, 2003)
"In order to treat postprandial hypotension (PPH), we orally administered a combination of denopamine (10 mg, a selective beta 1-adrenergic agonist) and midodrine-HCl (4 mg, a selective alpha 1-adrenergic agonist) to eight patients with autonomic failure (AF) prior to and after eating."3.68Treatment of postprandial hypotension with selective alpha 1 and beta 1 adrenergic agonists. ( Hakusui, S; Hirayama, M; Kaneoke, Y; Koike, Y; Sakurai, N; Takahashi, A; Watanabe, H, 1993)
" Although a beta blocker was not effective in preventing tilt-induced hypotension and bradycardia, midodrine hydrochloride (alpha-1 stimulant) or atropine prevented it."3.68A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride. ( Aizawa, Y; Igarashi, Y; Izumi, T; Koyama, S; Matsubara, T; Ohshima, M; Tamura, Y; Yamaguchi, T; Yamazaki, Y; Yamazoe, M, 1992)
"However, treatment of hypotension is uncommon in the SCI population because there are few safe and effective pharmacological options available."2.94Double-blinded, placebo-controlled crossover trial to determine the effects of midodrine on blood pressure during cognitive testing in persons with SCI. ( Bauman, WA; Chiaravalloti, ND; Dyson-Hudson, TA; Katzelnick, CG; Kirshblum, SC; Weber, E; Wecht, JM; Weir, JP, 2020)
"Midodrine is an oral α 1-adrenergic receptor agonist that offers a potential means of liberating patients from IV vasopressor therapy."2.82Putting midodrine on the MAP: An approach to liberation from intravenous vasopressors in vasodilatory shock. ( Floris, LM; Hawkins, WA; Patterson, JM; Peters, NA; Smith, SE, 2022)
"Chronic low blood pressure is typically accompanied with symptoms such as fatigue, reduced drive, dizziness, headaches and cold limbs."2.74Modulations of autonomic cardiovascular control following acute alpha-adrenergic treatment in chronic hypotension. ( Duschek, S; Heiss, H; Reyes del Paso, GA; Werner, N, 2009)
"Chronic low blood pressure is typically accompanied by symptoms such as fatigue, reduced drive, dizziness, headaches and cold limbs."2.74Hemodynamic determinants of chronic hypotension and their modification through vasopressor application. ( Buechner, B; Duschek, S; Heiss, H; Reyes del Paso, GA; Schandry, R; Werner, N, 2009)
"If cardiac syncope is unlikely, reflex (neurally mediated) syncope and orthostatic hypotension are the most frequent causes of transient loss of consciousness."2.72New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope. ( Brignole, M; Rivasi, G, 2021)
"Midodrine appears to be an effective and safe treatment for HD patients with symptomatic IDH, and remains beneficial when used for an extended period of time."2.69Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up. ( Brickel, HM; Cruz, DN; Mahnensmith, RL; Perazella, MA, 1998)
"Oral midodrine appears to be a safe and effective therapy for the treatment of hemodialysis hypotension."2.68Midodrine treatment for patients with hemodialysis hypotension. ( Caruso, FS; Flynn, JJ; McElligott, MA; Mitchell, MC, 1996)
"Midodrine treatment also significantly increased postdialysis systolic and diastolic blood pressures from baseline values of 90."2.68Midodrine for the treatment of intradialytic hypotension. ( Li, HP; Lim, PS; Lim, YT; Yang, CC; Yeh, CH, 1997)
"Midodrine is an orally administered alpha-1 adrenergic agonist while methylene blue is an intravenously administered blue dye used to restore vascular tone and increase blood pressure."2.66Clinical utility of midodrine and methylene blue as catecholamine-sparing agents in intensive care unit patients with shock. ( Sullivan, JB; Tchen, S, 2020)
"5 mg midodrine tablets and dosage was adjusted according to each patient's condition."2.65Controlled clinical investigation of dimetophrine versus midodrine in the management of moderately decreased arterial blood pressure. ( Cecchi, A; Marini, U; Venturini, M, 1984)
" The effective oral dosage in infancy and childhood is 0."2.65[Infectious toxic hypotension--effect and dosage of midodrine (author's transl)]. ( Weippl, G, 1979)
"Midodrine is an oral, peripherally acting alpha-adrenergic agonist."2.55The Role of Midodrine for Hypotension Outside of the Intensive Care Unit. ( Gutman, LB; Wilson, BJ, 2017)
" This medication has been demonstrated to be effective and safe in the acute and chronic treatment of haemodialysis-associated hypotension in end stage renal disease patients."2.42Efficacy and safety of midodrine in the treatment of dialysis-associated hypotension. ( Perazella, MA, 2003)
"Dialysis-induced hypotension is an important complication of haemodialysis."2.42Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review. ( Garg, AX; Heidenheim, AP; House, AA; Prakash, S, 2004)
" Midodrine is a prodrug that is almost completely absorbed after oral administration and converted into its active drug de-glymidodrine in the systematic circulation, with a bioavailability of 93%."2.41Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension. ( Cruz, DN, 2000)
"Midodrine was started as a last resort attempt to wean off vasopressors."1.91Midodrine in end-stage heart failure. ( Franqui-Rivera, H; Gonzalez-Cordero, A; Mesa-Pabón, M; Nieves-Rivera, J; Ortiz-Troche, S, 2023)
"Arterial hypotension is a frequently encountered phenomenon in clinical practice."1.48[Arterial hypotension: behind the scenes]. ( Pechere-Bertschi, A; Roukain, A, 2018)
"Midodrine treatment was associated with an increase in the magnitude of decline of the IV vasopressor rate."1.39Oral midodrine treatment accelerates the liberation of intensive care unit patients from intravenous vasopressor infusions. ( Ball, SA; Berg, S; Bittner, EA; Eikermann, M; Kalman, R; Levine, AR; Meyer, MJ; Ryan, C; Stanislaus, AB, 2013)
"Hypotension is commonly encountered during carotid artery stenting (CAS), mediated by vagal stimulation and suppression of sympathetic outflow."1.35Oral midodrine is effective for the treatment of hypotension associated with carotid artery stenting. ( Bhambi, B; Lardizabal, JA; Sharma, S, 2008)
"We used the oral agent midodrine to treat hypotension that complicated myocardial stunning after successful revascularization with percutaneous coronary intervention in the setting of myocardial infarction and ischemia."1.33Successful treatment of hypotension associated with stunned myocardium with oral midodrine therapy. ( Bhambi, B; Sharma, S, 2005)
"Other than scalp paresthesia in one patient, no adverse effects were noted."1.30Intradialytic hypotension: is midodrine beneficial in symptomatic hemodialysis patients? ( Cruz, DN; Mahnensmith, RL; Perazella, MA, 1997)
"Midodrine hydrochloride was administered at a dose of 2."1.29Midodrine hydrochloride in patients on hemodialysis with chronic hypotension. ( Fang, JT; Huang, CC, 1996)
" The pharmacokinetic characteristics of the prodrug midodrine and the active metabolite de-glymidodrine in this patient with end-stage renal disease approximate those reported for patients with normal renal function."1.29Midodrine efficacy and pharmacokinetics in a patient with recurrent intradialytic hypotension. ( Balfe, JW; Blowey, DL; Gajaria, MM; Gupta, I; Koren, G, 1996)

Research

Studies (73)

TimeframeStudies, this research(%)All Research%
pre-19907 (9.59)18.7374
1990's12 (16.44)18.2507
2000's23 (31.51)29.6817
2010's14 (19.18)24.3611
2020's17 (23.29)2.80

Authors

AuthorsStudies
Costa-Pinto, R1
Yong, ZT1
Yanase, F1
Young, C1
Brown, A1
Udy, A1
Young, PJ1
Eastwood, G1
Bellomo, R1
Jenab, Y1
Hosseini, K1
Abtahi-Eivary, SM1
Smith, SE1
Peters, NA1
Floris, LM1
Patterson, JM1
Hawkins, WA1
Alseoudy, MM1
Nasr, MO1
Abdelsalam, TA1
Wecht, JM3
Weir, JP2
Katzelnick, CG2
Dyson-Hudson, TA2
Bauman, WA3
Kirshblum, SC2
House, AA2
McIntyre, CW1
Husarek, K1
Brunelli, SM2
Kim, JP1
Chang, TI1
Curran, C1
Davoudi, F1
Foster, G1
Gordan, P1
Tchen, S1
Sullivan, JB1
Chiaravalloti, ND1
Weber, E1
Gonzalez-Cordero, A1
Ortiz-Troche, S1
Nieves-Rivera, J1
Mesa-Pabón, M1
Franqui-Rivera, H1
Santer, P2
Anstey, MH1
Patrocínio, MD1
Wibrow, B1
Teja, B1
Shay, D1
Shaefi, S1
Parsons, CS1
Houle, TT1
Eikermann, M3
Ye, X1
Ling, B1
Wu, J1
Wu, S1
Ren, Y1
Zhang, H1
Song, F1
Xuan, Z1
Chen, M1
Riker, RR1
Gagnon, DJ1
Brignole, M1
Rivasi, G1
Gutman, LB1
Wilson, BJ1
Roukain, A1
Pechere-Bertschi, A1
Cohen, DE1
Marlowe, G1
Van Wyck, D1
Hammes, M1
Bakris, GL1
Raina, R1
Lam, S1
Raheja, H1
Krishnappa, V1
Hothi, D1
Davenport, A1
Chand, D1
Kapur, G1
Schaefer, F1
Sethi, SK1
McCulloch, M1
Bagga, A1
Bunchman, T1
Warady, BA1
Rizvi, MS1
Nei, AM1
Gajic, O1
Mara, KC1
Barreto, EF1
Drambarean, B1
Bielnicka, P1
Alobaidi, A1
Levine, AR1
Meyer, MJ1
Bittner, EA1
Berg, S1
Kalman, R1
Stanislaus, AB1
Ryan, C1
Ball, SA1
Phillips, AA1
Warburton, DE1
Ainslie, PN1
Krassioukov, AV1
Tanabe, N1
Takane, K1
Yokoyama, K1
Tanno, Y1
Yamamoto, I1
Ohkido, I1
Yokoo, T1
Alhamad, T1
Brennan, DC1
Brifkani, Z1
Xiao, H1
Schnitzler, MA1
Dharnidharka, VR1
Axelrod, D1
Segev, DL1
Lentine, KL1
Hothi, DK1
Harvey, E1
Goia, CM1
Geary, D1
Newton, JL1
Sheth, A1
Shin, J1
Pairman, J1
Wilton, K1
Burt, JA1
Jones, DE1
Duschek, S2
Heiss, H2
Buechner, B1
Werner, N2
Schandry, R1
Reyes del Paso, GA2
Parati, G1
Di Rienzo, M1
Coruzzi, P1
Castiglioni, P1
Bergman, SM1
Rosado-Rivera, D1
Handrakis, JP1
Radulovic, M1
Garrard, A1
Wood, A1
Sollee, D1
Aaronson, P1
Hassinger, AB1
Garimella, S1
Cotera, A1
Alvo, M1
Sanhueza, ME1
Elgueta, L1
Gormaz, JP1
Ibáñez, C1
Cuadra, C1
O'Donnell, B1
Synnott, A1
Lin, YF1
Wang, JY1
Denq, JC1
Lin, SH1
Perazella, MA7
Schrage, WG1
Eisenach, JH1
Dinenno, FA1
Roberts, SK1
Johnson, CP1
Sandroni, P1
Low, PA1
Joyner, MJ1
Prakash, S1
Garg, AX1
Heidenheim, AP1
Maule, S1
Tredici, M1
Dematteis, A1
Matteoda, C1
Chiandussi, L1
Sharma, S2
Bhambi, B2
Mercadal, L1
Petitclerc, T1
Lardizabal, JA1
Hebenstreit, G1
Marini, U1
Cecchi, A1
Venturini, M1
Hirayama, M3
Watanabe, H2
Koike, Y3
Kaneoke, Y2
Sakurai, N1
Hakusui, S1
Takahashi, A3
Blowey, DL1
Balfe, JW1
Gupta, I1
Gajaria, MM1
Koren, G1
Fang, JT1
Huang, CC1
Flynn, JJ1
Mitchell, MC1
Caruso, FS1
McElligott, MA1
Lim, PS1
Yang, CC1
Li, HP1
Lim, YT1
Yeh, CH1
Cruz, DN4
Mahnensmith, RL3
Brickel, HM2
Izhar, M1
Montagnac, R2
Clavel, P2
Delhotal-Landes, B2
Flouvat, B2
Poulain, S2
Schillinger, F1
Alappan, R1
Cruz, D1
Abu-Alfa, AK2
Mahnensmith, R2
Ieda, T1
Sobue, G1
Schllinger, F1
Hoeben, H1
Lacbnit, VK1
Kiesewetter, E1
Deimer, E1
Fischer, M1
Höcker, P1
Mermon, R1
Mostbeck, A1
Pittner, H3
Witek, F1
Stormann, H1
Enzenhofer, R1
Sazovsky, H1
Weippl, G1
Dabasaki, T1
Shimojo, M1
Ishikawa, H1
Uemura, A1
Koyama, S1
Matsubara, T1
Aizawa, Y1
Ohshima, M1
Yamaguchi, T1
Yamazaki, Y1
Igarashi, Y1
Tamura, Y1
Yamazoe, M1
Izumi, T1

Clinical Trials (11)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Preoperative Midodrine for Improving Hemodynamics in Orthopedic Patients Undergoing Spinal Anesthesia[NCT04396548]70 participants (Actual)Interventional2020-06-08Completed
RANDOMIZED CASE-CONTROLLED TRIAL ASSESSING MIDODRINE (GUTRON®) IN POSTOPERATIVE VASOPLEGIC PATIENTS[NCT04440085]Phase 450 participants (Anticipated)Interventional2020-09-14Not yet recruiting
Blood Pressure, Cerebral Blood Flow and Cognition in SCI[NCT02307565]Phase 360 participants (Actual)Interventional2014-03-31Completed
Assessment of the Mechanism of Non-cardiac Syncope by 24-hour Ambulatory Blood Pressure Monitoring (ABPM) and Tilt-table Short Cardiovascular Autonomic Function Battery (SCAFB)[NCT05728255]275 participants (Anticipated)Observational2023-04-30Not yet recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886]8 participants (Anticipated)Interventional2021-06-08Recruiting
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014]Phase 422 participants (Actual)Interventional2018-06-01Completed
The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury[NCT03924388]46 participants (Anticipated)Interventional2020-02-01Not yet recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923]8 participants (Anticipated)Interventional2021-12-31Recruiting
Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093]20 participants (Anticipated)Interventional2021-11-29Recruiting
A Dose Response Trial Using 5 and 10 mg. of Midodrine Hydrochloride to Treat Orthostatic Hypotension in Persons With SCI[NCT00426842]Phase 211 participants (Actual)Interventional2007-01-31Completed
Hemodynamic Effects of Low vs. High Dialysate Temperature or Bicarbonate Concentration in Chronic Hemodialysis Patients[NCT05052151]16 participants (Actual)Interventional2021-08-25Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Systolic Blood Pressure

brachial artery systolic blood pressure (mmHg) (NCT00426842)
Timeframe: The difference between the average supine systolic blood pressure and the average systolic blood pressure at 45 degree head-up tilt position.

,,
InterventionmmHg (Mean)
Baseline Blood PressureHead-up Tilt Blood Pressure
Midodrine 10 mg102109
Midodrine 5 mg9796
No-drug9887

Reviews

8 reviews available for midodrine and Blood Pressure, Low

ArticleYear
Putting midodrine on the MAP: An approach to liberation from intravenous vasopressors in vasodilatory shock.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2022, 06-23, Volume: 79, Issue:13

    Topics: Administration, Intravenous; Adult; Humans; Hypotension; Intensive Care Units; Midodrine; Multicente

2022
Clinical utility of midodrine and methylene blue as catecholamine-sparing agents in intensive care unit patients with shock.
    Journal of critical care, 2020, Volume: 57

    Topics: Blood Pressure; Catecholamines; Critical Care; Critical Illness; Humans; Hypotension; Intensive Care

2020
New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope.
    Heart (British Cardiac Society), 2021, Volume: 107, Issue:11

    Topics: Accidental Falls; Adenosine; Antihypertensive Agents; Atomoxetine Hydrochloride; Atrioventricular No

2021
The Role of Midodrine for Hypotension Outside of the Intensive Care Unit.
    Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique, 2017, 08-23, Volume: 24, Issue:3

    Topics: Adrenergic alpha-Agonists; Humans; Hypotension; Intensive Care Units; Midodrine; Prodrugs; Pruritus

2017
Efficacy and safety of midodrine in the treatment of dialysis-associated hypotension.
    Expert opinion on drug safety, 2003, Volume: 2, Issue:1

    Topics: Animals; Attitude of Health Personnel; Blood Pressure; Comorbidity; Humans; Hypotension; Midodrine;

2003
Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:10

    Topics: Adrenergic alpha-Agonists; Humans; Hypotension; Midodrine; Renal Dialysis; Treatment Outcome

2004
Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension.
    Expert opinion on pharmacotherapy, 2000, Volume: 1, Issue:4

    Topics: Adrenergic alpha-Agonists; Humans; Hypotension; Hypotension, Orthostatic; Midodrine; Renal Dialysis

2000
Pharmacologic options available to treat symptomatic intradialytic hypotension.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 38, Issue:4 Suppl 4

    Topics: Adrenergic Agents; Autonomic Nervous System; Caffeine; Carnitine; Ephedrine; Fludrocortisone; Hemodi

2001

Trials

23 trials available for midodrine and Blood Pressure, Low

ArticleYear
A pilot, feasibility, randomised controlled trial of midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension in intensive care patients: The MAVERIC study.
    Journal of critical care, 2022, Volume: 67

    Topics: Critical Care; Feasibility Studies; Humans; Hypotension; Midodrine; Vasoconstrictor Agents

2022
Efficacy of Preoperative Oral Midodrine in Preventing Hypotension After Spinal Anesthesia in Young Adults: A Randomized Controlled Trial.
    Anesthesia and analgesia, 2022, 11-01, Volume: 135, Issue:5

    Topics: Anesthesia, Spinal; Bupivacaine; Double-Blind Method; Ephedrine; Fentanyl; Humans; Hypotension; Mido

2022
Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury.
    The journal of spinal cord medicine, 2023, Volume: 46, Issue:4

    Topics: Autonomic Dysreflexia; Blood Pressure Monitoring, Ambulatory; Humans; Hypotension; Hypotension, Orth

2023
Double-blinded, placebo-controlled crossover trial to determine the effects of midodrine on blood pressure during cognitive testing in persons with SCI.
    Spinal cord, 2020, Volume: 58, Issue:9

    Topics: Adult; Blood Pressure; Cerebrovascular Circulation; Chronic Disease; Cognition; Cross-Over Studies;

2020
Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial.
    Intensive care medicine, 2020, Volume: 46, Issue:10

    Topics: Adult; Australia; Humans; Hypotension; Intensive Care Units; Midodrine; Vasoconstrictor Agents

2020
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Blood Flow Velocity; Cerebrovascular Circul

2014
Lower ambulatory blood pressure in chronic fatigue syndrome.
    Psychosomatic medicine, 2009, Volume: 71, Issue:3

    Topics: Blood Pressure Monitoring, Ambulatory; Fatigue Syndrome, Chronic; Female; Heart Rate; Humans; Hypote

2009
Hemodynamic determinants of chronic hypotension and their modification through vasopressor application.
    The journal of physiological sciences : JPS, 2009, Volume: 59, Issue:2

    Topics: Adult; Blood Pressure; Body Height; Body Mass Index; Cardiac Output; Chronic Disease; Double-Blind M

2009
Modulations of autonomic cardiovascular control following acute alpha-adrenergic treatment in chronic hypotension.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2009, Volume: 32, Issue:11

    Topics: Adrenergic alpha-Agonists; Adult; Autonomic Nervous System; Baroreflex; Blood Pressure; Chronic Dise

2009
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:9

    Topics: Adult; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Humans; Hypotension; H

2010
[Effects of midodrine on symptomatic hypotension during hemodialysis].
    Revista medica de Chile, 2002, Volume: 130, Issue:9

    Topics: Adrenergic alpha-Agonists; Blood Pressure; Double-Blind Method; Female; Humans; Hypotension; Male; M

2002
Effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure.
    Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 97, Issue:5

    Topics: Adrenergic alpha-Agonists; Aged; Autonomic Nervous System Diseases; Bicycling; Blood Pressure; Cardi

2004
[Treatment of hypotension caused by psychopharmacological drugs (author's transl)].
    Wiener medizinische Wochenschrift (1946), 1981, Feb-28, Volume: 131, Issue:4

    Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Blood Pressure; Double-Blind Method; Ethanolamin

1981
Controlled clinical investigation of dimetophrine versus midodrine in the management of moderately decreased arterial blood pressure.
    Current medical research and opinion, 1984, Volume: 9, Issue:4

    Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Ethanolamines; Female; Heart Rate; Humans; Hy

1984
Midodrine treatment for patients with hemodialysis hypotension.
    Clinical nephrology, 1996, Volume: 45, Issue:4

    Topics: Adrenergic alpha-Agonists; Aged; Blood Pressure; Female; Humans; Hypotension; Kidney Failure, Chroni

1996
Midodrine for the treatment of intradialytic hypotension.
    Nephron, 1997, Volume: 77, Issue:3

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Aged; Blood Pressure; Body Weight; Female; H

1997
Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up.
    Clinical nephrology, 1998, Volume: 50, Issue:2

    Topics: Adrenergic alpha-Agonists; Case-Control Studies; Female; Follow-Up Studies; Humans; Hypotension; Kid

1998
Midodrine and cool dialysate are effective therapies for symptomatic intradialytic hypotension.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1999, Volume: 33, Issue:5

    Topics: Aged; Aged, 80 and over; Blood Pressure; Cold Temperature; Combined Modality Therapy; Cross-Over Stu

1999
Treatment of Severe Intradialytic Hypotension With the Addition of High Dialysate Calcium Concentration to Midodrine and/or Cool Dialysate.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 37, Issue:2

    Topics: Blood Pressure; Calcium; Female; Hemodialysis Solutions; Humans; Hypotension; Kidney Failure, Chroni

2001
[A one-month combined use of selective adrenergic beta 1- and alpha 1-agonists for postprandial hypotension in patients with autonomic failure].
    Rinsho shinkeigaku = Clinical neurology, 2000, Volume: 40, Issue:8

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aged; Autonomic Nervous System Diseases; Chroni

2000
Hemodynamics in patients with intradialytic hypotension treated with cool dialysate or midodrine.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 39, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Blood Pressure; Blood Volume; Cardiac Output; Cold Temperatu

2002
[Infectious toxic hypotension--effect and dosage of midodrine (author's transl)].
    Padiatrie und Padologie, 1979, Volume: 14, Issue:2

    Topics: Bacterial Infections; Blood Pressure; Child; Child, Preschool; Clinical Trials as Topic; Drug Evalua

1979
[Effect of combined therapy with selective beta 1- and alpha 1-adrenergic agonists upon postprandial hypotension in patients with progressive autonomic failure].
    Rinsho shinkeigaku = Clinical neurology, 1992, Volume: 32, Issue:11

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Autonomic Nervous

1992

Other Studies

42 other studies available for midodrine and Blood Pressure, Low

ArticleYear
Treatment via oral midodrine in a patient with prolonged hypotension following carotid artery stenting: a case report.
    Journal of medical case reports, 2022, Feb-09, Volume: 16, Issue:1

    Topics: Aged, 80 and over; Carotid Arteries; Carotid Stenosis; Humans; Hypotension; Male; Midodrine; Stents

2022
Midodrine Is an Effective Therapy for Resistant Intradialytic Hypotension: PRO.
    Kidney360, 2023, 03-01, Volume: 4, Issue:3

    Topics: Humans; Hypotension; Midodrine; Renal Dialysis

2023
Midodrine Is an Effective Therapy for Resistant Intradialytic Hypotension: CON.
    Kidney360, 2023, 03-01, Volume: 4, Issue:3

    Topics: Humans; Hypotension; Midodrine; Renal Dialysis

2023
Midodrine Is an Effective Therapy for Resistant Intradialytic Hypotension: COMMENTARY.
    Kidney360, 2023, 03-01, Volume: 4, Issue:3

    Topics: Humans; Hypotension; Midodrine; Renal Dialysis

2023
Refractory bradycardia and hypotension in patients with autonomic dysfunction treated with pseudoephedrine.
    BMJ case reports, 2023, Apr-26, Volume: 16, Issue:4

    Topics: Autonomic Nervous System Diseases; Bradycardia; Dopamine; Humans; Hypotension; Hypotension, Orthosta

2023
Midodrine in end-stage heart failure.
    BMJ supportive & palliative care, 2023, Volume: 13, Issue:e1

    Topics: Heart Failure; Hospitalization; Humans; Hypotension; Male; Midodrine; Vasoconstrictor Agents

2023
Case report: severe myoclonus associated with oral midodrine treatment for hypotension.
    Medicine, 2020, Oct-02, Volume: 99, Issue:40

    Topics: Administration, Oral; Adrenergic alpha-1 Receptor Agonists; Female; Humans; Hypotension; Middle Aged

2020
Midodrine administration during critical illness: fixed-dose or titrate to response?
    Intensive care medicine, 2021, Volume: 47, Issue:2

    Topics: Critical Illness; Humans; Hypotension; Intensive Care Units; Midodrine; Vasoconstrictor Agents

2021
High-dose midodrine is not effective for treatment of persistent hypotension in the intensive care unit.
    Intensive care medicine, 2021, Volume: 47, Issue:2

    Topics: Humans; Hypotension; Intensive Care Units; Midodrine; Vasoconstrictor Agents

2021
[Arterial hypotension: behind the scenes].
    Revue medicale suisse, 2018, Sep-12, Volume: 14, Issue:618

    Topics: Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Droxidopa; Humans; Hypotension; Hypoten

2018
The Impact of Midodrine on Outcomes in Patients with Intradialytic Hypotension.
    American journal of nephrology, 2018, Volume: 48, Issue:5

    Topics: Aged; Aged, 80 and over; Blood Pressure; Female; Follow-Up Studies; Hospitalization; Humans; Hypoten

2018
Intradialytic Hypotension: Is Midodrine the Answer?
    American journal of nephrology, 2018, Volume: 48, Issue:5

    Topics: Humans; Hypotension; Midodrine; Renal Dialysis

2018
Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup.
    Pediatric nephrology (Berlin, Germany), 2019, Volume: 34, Issue:5

    Topics: Age Factors; Blood Pressure; Blood Pressure Determination; Child; Consensus; Continuous Renal Replac

2019
Continuation of Newly Initiated Midodrine Therapy After Intensive Care and Hospital Discharge: A Single-Center Retrospective Study.
    Critical care medicine, 2019, Volume: 47, Issue:8

    Topics: Aged; Female; Humans; Hypotension; Intensive Care Units; Length of Stay; Male; Middle Aged; Midodrin

2019
Midodrine treatment in a patient with treprostinil-induced hypotension receiving hemodialysis.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2019, Jan-01, Volume: 76, Issue:1

    Topics: Antihypertensive Agents; Dose-Response Relationship, Drug; Epoprostenol; Humans; Hypotension; Kidney

2019
Oral midodrine treatment accelerates the liberation of intensive care unit patients from intravenous vasopressor infusions.
    Journal of critical care, 2013, Volume: 28, Issue:5

    Topics: Administration, Oral; Aged; Female; Humans; Hypotension; Infusions, Intravenous; Intensive Care Unit

2013
Dialysate temperature adjustment as an effective treatment for baroreflex failure syndrome in hemodialysis patient.
    BMC nephrology, 2014, Sep-17, Volume: 15

    Topics: Aged; Baroreflex; Carotid Sinus; Cold Temperature; Dialysis Solutions; Dizziness; Droxidopa; Enteral

2014
Pretransplant Midodrine Use: A Newly Identified Risk Marker for Complications After Kidney Transplantation.
    Transplantation, 2016, Volume: 100, Issue:5

    Topics: Adolescent; Adult; Aged; Blood Pressure; Delayed Graft Function; Female; Genetic Markers; Graft Surv

2016
The value of sequential dialysis, mannitol and midodrine in managing children prone to dialysis failure.
    Pediatric nephrology (Berlin, Germany), 2009, Volume: 24, Issue:8

    Topics: Adolescent; Child; Female; Humans; Hypotension; Male; Mannitol; Midodrine; Renal Dialysis; Treatment

2009
Chronic hypotension and modulation of autonomic cardiovascular regulation.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2009, Volume: 32, Issue:11

    Topics: Adrenergic alpha-Agonists; Autonomic Nervous System; Baroreflex; Cardiovascular Physiological Phenom

2009
Hemodialysis in hypotensive heart failure using midodrine.
    The American journal of the medical sciences, 2009, Volume: 338, Issue:6

    Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Blood Pressure; Female; Heart Failure; Humans; H

2009
Refractory hypotension due to Rogaine® (minoxidil) ingestion managed with midodrine.
    Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:10

    Topics: Administration, Oral; Adrenergic alpha-1 Receptor Agonists; Blood Pressure; Emergency Service, Hospi

2011
Refractory hypotension after bilateral nephrectomies in a Denys-Drash patient with phenylketonuria.
    Pediatric nephrology (Berlin, Germany), 2013, Volume: 28, Issue:2

    Topics: Adrenergic alpha-1 Receptor Agonists; Denys-Drash Syndrome; Female; Humans; Hypotension; Infant; Inf

2013
Midodrine, an alternative to intravenous vasopressor therapy after spinal surgery.
    European journal of anaesthesiology, 2002, Volume: 19, Issue:11

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Humans; Hypotension; Infusions, Intravenous;

2002
Midodrine improves chronic hypotension in hemodialysis patients.
    The American journal of the medical sciences, 2003, Volume: 325, Issue:5

    Topics: Adrenergic alpha-Agonists; Adult; Autonomic Nervous System; Chronic Disease; Female; Hemodynamics; H

2003
Postprandial hypotension treated with acarbose in a patient with type 1 diabetes mellitus.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2004, Volume: 14, Issue:6

    Topics: Acarbose; Adrenergic alpha-Agonists; Anti-Inflammatory Agents; Blood Pressure; Diabetes Mellitus, Ty

2004
Successful treatment of hypotension associated with stunned myocardium with oral midodrine therapy.
    Journal of cardiovascular pharmacology and therapeutics, 2005, Volume: 10, Issue:1

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Aged; Humans; Hypotension; Male; Middle Aged; Midod

2005
Effect of mineralocorticoids on interdialytic weight gain in hemodialysis patients with perdialytic hypotension.
    Hemodialysis international. International Symposium on Home Hemodialysis, 2005, Volume: 9, Issue:4

    Topics: Adrenergic alpha-Agonists; Aged; Anti-Inflammatory Agents; Blood Pressure; Drug Resistance; Female;

2005
Oral midodrine is effective for the treatment of hypotension associated with carotid artery stenting.
    Journal of cardiovascular pharmacology and therapeutics, 2008, Volume: 13, Issue:2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Cardiotonic Agents; Carotid Stenosis; Dopamine; Femal

2008
Treatment of postprandial hypotension with selective alpha 1 and beta 1 adrenergic agonists.
    Journal of the autonomic nervous system, 1993, Volume: 45, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aged; Blood Pressure; Cardiac Output; Drug Ther

1993
Midodrine efficacy and pharmacokinetics in a patient with recurrent intradialytic hypotension.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 28, Issue:1

    Topics: Adolescent; Adrenergic alpha-Agonists; Half-Life; Humans; Hypotension; Kidney Failure, Chronic; Male

1996
Midodrine hydrochloride in patients on hemodialysis with chronic hypotension.
    Renal failure, 1996, Volume: 18, Issue:2

    Topics: Administration, Oral; Adult; Aged; Chronic Disease; Combined Modality Therapy; Drug Evaluation; Fema

1996
Intradialytic hypotension: is midodrine beneficial in symptomatic hemodialysis patients?
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1997, Volume: 30, Issue:6

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Blood Pressure; Diastole;

1997
Midodrine in intradialytic hypotension.
    The International journal of artificial organs, 1999, Volume: 22, Issue:8

    Topics: Clinical Trials as Topic; Humans; Hypotension; Midodrine; Renal Dialysis; Treatment Outcome; Vasocon

1999
[Midodrine (Gutron) treatment of permanent arterial hypotension in a chronic hemodialysis patient].
    Nephrologie, 2000, Volume: 21, Issue:4

    Topics: Adrenergic alpha-Agonists; Chronic Disease; Heart Failure; Humans; Hypertrophy, Left Ventricular; Hy

2000
Use of midodrine (Gutron) to treat permanent hypotension in a chronic hemodialysis patient.
    Clinical nephrology, 2001, Volume: 56, Issue:2

    Topics: Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypotension; Kidney Failure, Chronic; Male

2001
[Treatment of hypotension in general practice with Gutron].
    Wiener medizinische Wochenschrift (1946), 1975, Jun-20, Volume: 125, Issue:25-27

    Topics: Adult; Drug Evaluation; Ethanolamines; Family Practice; Female; Humans; Hypotension; Male; Middle Ag

1975
[Tolerance tests of alpha-sympathomimetic agent, Gutron].
    Wiener medizinische Wochenschrift. Supplement, 1976, Dec-03, Volume: 37

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Blood Coagulation; Drug Evaluation; Drug Toleran

1976
Pharmacodynamic actions of midodrine, a new alpha-adrenergic stimulating agent, and its main metabolite, ST 1059.
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:12

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Capillary Permeability; Cats; Decerebrate State;

1976
[Diagnosis and therapy of hypotensive circulatory disorders in general practice. Experiences with Gutron using the Thulesius-diagram for diagnosis and supervision of therapy].
    Fortschritte der Medizin, 1979, Apr-19, Volume: 97, Issue:15

    Topics: Adult; Ethanolamines; Female; Humans; Hypotension; Hypotension, Orthostatic; Male; Methods; Midodrin

1979
Anti-hypotensive effects of M6434, an orally active alpha 1-adrenoceptor agonist, in rats.
    Japanese journal of pharmacology, 1992, Volume: 59, Issue:2

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Blood Pressure; Decerebrate State; Dihydro

1992
A case of vasovagal syncope with convulsions--the effects of midodrine hydrochloride.
    Japanese circulation journal, 1992, Volume: 56, Issue:9

    Topics: Adult; Blood Pressure; Bradycardia; Female; Humans; Hypotension; Midodrine; Seizures; Syncope; Vagus

1992