Page last updated: 2024-10-31

midodrine and Blood Pressure, High

midodrine has been researched along with Blood Pressure, High in 13 studies

Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Research Excerpts

ExcerptRelevanceReference
"Midodrine, a drug used to treat symptomatic orthostatic hypotension, may cause or exacerbate supine hypertension."7.71Supine hypertension during general anesthesia in a patient taking midodrine. ( Chaimberg, KH; Travis, KW, 2002)
"The comparative effects of droxidopa and midodrine on standing systolic blood pressure (sSBP) and risk of supine hypertension in patients with neurogenic orthostatic hypotension (NOH) are unknown."4.98Standing and Supine Blood Pressure Outcomes Associated With Droxidopa and Midodrine in Patients With Neurogenic Orthostatic Hypotension: A Bayesian Meta-analysis and Mixed Treatment Comparison of Randomized Trials. ( Chen, JJ; Dashtipour, K; Han, Y; Hauser, RA; Portillo, I; Tang, J, 2018)
"Midodrine, a drug used to treat symptomatic orthostatic hypotension, may cause or exacerbate supine hypertension."3.71Supine hypertension during general anesthesia in a patient taking midodrine. ( Chaimberg, KH; Travis, KW, 2002)
"Particularly debilitating is neurogenic orthostatic hypotension (nOH) caused by deficient neurotransmission of norepinephrine, which is the primary neurotransmitter released at sympathetic peripheral vascular nerve terminals in response to orthostatic stress."2.61Chemical pharmacotherapy for the treatment of orthostatic hypotension. ( Cheshire, WP, 2019)
"Fludrocortisone did not increase angiotensinogen in these mice, implying that the rise in angiotensinogen in the siRNA-treated rats must have depended on the liver, most likely reflecting diminished cleavage by renin."1.72Conventional Vasopressor and Vasopressor-Sparing Strategies to Counteract the Blood Pressure-Lowering Effect of Small Interfering RNA Targeting Angiotensinogen. ( Danser, AHJ; Daugherty, A; Foster, D; Garrelds, IM; Hoorn, EJ; Lu, HS; Mirabito Colafella, KM; Nioi, P; Ren, L; Uijl, E; van Veghel, R; Ye, D, 2022)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's3 (23.08)29.6817
2010's7 (53.85)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Uijl, E1
Ye, D1
Ren, L1
Mirabito Colafella, KM1
van Veghel, R1
Garrelds, IM1
Lu, HS1
Daugherty, A1
Hoorn, EJ1
Nioi, P1
Foster, D1
Danser, AHJ1
Wegner Wippel, C1
Deshpande, H1
Patwa, H1
Peixoto, AJ1
Cannom, DS1
Chen, JJ1
Han, Y1
Tang, J1
Portillo, I1
Hauser, RA1
Dashtipour, K1
Cheshire, WP2
Sadeghpour, M1
Bunick, CG1
Robinson, DM1
Galan, A1
Tigelaar, RE1
Imaeda, S1
Tanabe, N1
Takane, K1
Yokoyama, K1
Tanno, Y1
Yamamoto, I1
Ohkido, I1
Yokoo, T1
Wong, LY1
Wong, A1
Robertson, T1
Burns, K1
Roberts, M1
Isbister, GK1
Lagi, A1
Spini, S1
Chaimberg, KH1
Travis, KW1
Achem, SR1
Sandroni, P1
Benarroch, EE1
Wijdicks, EF1

Reviews

3 reviews available for midodrine and Blood Pressure, High

ArticleYear
Standing and Supine Blood Pressure Outcomes Associated With Droxidopa and Midodrine in Patients With Neurogenic Orthostatic Hypotension: A Bayesian Meta-analysis and Mixed Treatment Comparison of Randomized Trials.
    The Annals of pharmacotherapy, 2018, Volume: 52, Issue:12

    Topics: Antiparkinson Agents; Bayes Theorem; Blood Pressure; Droxidopa; Humans; Hypertension; Hypotension, O

2018
Chemical pharmacotherapy for the treatment of orthostatic hypotension.
    Expert opinion on pharmacotherapy, 2019, Volume: 20, Issue:2

    Topics: Blood Pressure; Comorbidity; Droxidopa; Humans; Hypertension; Hypotension, Orthostatic; Midodrine

2019
Clinostatic hypertension and orthostatic hypotension.
    Clinical cardiology, 2010, Volume: 33, Issue:6

    Topics: Antihypertensive Agents; Autonomic Nervous System; Blood Pressure; Humans; Hypertension; Hypotension

2010

Other Studies

10 other studies available for midodrine and Blood Pressure, High

ArticleYear
Conventional Vasopressor and Vasopressor-Sparing Strategies to Counteract the Blood Pressure-Lowering Effect of Small Interfering RNA Targeting Angiotensinogen.
    Journal of the American Heart Association, 2022, 08-02, Volume: 11, Issue:15

    Topics: Angiotensin II; Angiotensinogen; Animals; Blood Pressure; Fludrocortisone; Hypertension; Mice; Midod

2022
Neurogenic orthostatic hypotension after treatment with sorafenib.
    BMJ case reports, 2022, Dec-22, Volume: 15, Issue:12

    Topics: Humans; Hypertension; Hypotension, Orthostatic; Male; Midodrine; Sorafenib; Vascular Endothelial Gro

2022
Management of coexistent neurogenic orthostatic hypotension and supine hypertension.
    Journal of clinical hypertension (Greenwich, Conn.), 2019, Volume: 21, Issue:11

    Topics: Accidental Falls; Central Nervous System Agents; Droxidopa; Drug Substitution; Female; Humans; Hyper

2019
Midodrine-induced acute generalized exanthematous pustulosis.
    Cutis, 2014, Volume: 93, Issue:5

    Topics: Acute Generalized Exanthematous Pustulosis; Humans; Hypertension; Male; Middle Aged; Midodrine; Vaso

2014
Dialysate temperature adjustment as an effective treatment for baroreflex failure syndrome in hemodialysis patient.
    BMC nephrology, 2014, Sep-17, Volume: 15

    Topics: Aged; Baroreflex; Carotid Sinus; Cold Temperature; Dialysis Solutions; Dizziness; Droxidopa; Enteral

2014
Severe Hypertension and Bradycardia Secondary to Midodrine Overdose.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2017, Volume: 13, Issue:1

    Topics: Adrenergic alpha-1 Receptor Antagonists; Blood Pressure; Bradycardia; Drug Overdose; Female; Glasgow

2017
Supine hypertension during general anesthesia in a patient taking midodrine.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:5

    Topics: Adult; Amputation, Surgical; Anesthesia, General; Blood Pressure; Diabetes Mellitus, Type 1; Humans;

2002
Clinical history.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2004, Volume: 14, Issue:1

    Topics: Blood Pressure; Chest Pain; Clonazepam; Female; Heart Rate; Humans; Hypertension; Incidence; Middle

2004
Midodrine marketed for orthostatic hypotension.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1996, Nov-01, Volume: 53, Issue:21

    Topics: Adrenergic alpha-Agonists; Humans; Hypertension; Hypotension, Orthostatic; Midodrine; Prodrugs

1996
Caudate hemorrhage as a possible complication of midodrine-induced supine hypertension.
    Mayo Clinic proceedings, 2001, Volume: 76, Issue:12

    Topics: Aged; Caudate Nucleus; Cerebral Hemorrhage; Humans; Hypertension; Hypotension, Orthostatic; Male; Mi

2001