midodrine has been researched along with Autonomic Dysreflexia in 3 studies
Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Autonomic Dysreflexia: A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Midodrine (10 mg) administered in the home environment effectively increases BP and reduces the incidence of hypotension; however these beneficial effects come at the expense of worsened BP instability and AD symptom intensity." | 5.69 | Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury. ( Bauman, WA; Dyson-Hudson, TA; Katzelnick, CG; Kirshblum, SC; Wecht, JM; Weir, JP, 2023) |
| "To explore the effectiveness of various sources of self-stimulation, including oral midodrine, in triggering ejaculation in men with spinal cord injury (SCI), and to document the systematic variations in blood pressure at ejaculation and consider a revised definition of autonomic dysreflexia." | 3.74 | Blood pressure changes during sexual stimulation, ejaculation and midodrine treatment in men with spinal cord injury. ( Bélanger, M; Charvier, KF; Côté, M; Courtois, FJ; Leriche, A; Vézina, JG, 2008) |
| "Oral midodrine may further increase ejaculation success, while maintaining autonomy." | 1.35 | Perceived physiological and orgasmic sensations at ejaculation in spinal cord injured men. ( Bélanger, M; Charvier, K; Côté, I; Courtois, F; Fournier, C; Jacquemin, G; Leriche, A; Raymond, D; Vézina, JG, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wecht, JM | 1 |
| Weir, JP | 1 |
| Katzelnick, CG | 1 |
| Dyson-Hudson, TA | 1 |
| Bauman, WA | 1 |
| Kirshblum, SC | 1 |
| Courtois, FJ | 1 |
| Charvier, KF | 1 |
| Leriche, A | 2 |
| Vézina, JG | 2 |
| Côté, M | 1 |
| Bélanger, M | 2 |
| Courtois, F | 1 |
| Charvier, K | 1 |
| Côté, I | 1 |
| Raymond, D | 1 |
| Jacquemin, G | 1 |
| Fournier, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014] | Phase 4 | 22 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for midodrine and Autonomic Dysreflexia
| Article | Year |
|---|---|
Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury.
Topics: Autonomic Dysreflexia; Blood Pressure Monitoring, Ambulatory; Humans; Hypotension; Hypotension, Orth | 2023 |
2 other studies available for midodrine and Autonomic Dysreflexia
| Article | Year |
|---|---|
Blood pressure changes during sexual stimulation, ejaculation and midodrine treatment in men with spinal cord injury.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Autonomic Dysreflexia; Blood Pressure; Ejaculati | 2008 |
Perceived physiological and orgasmic sensations at ejaculation in spinal cord injured men.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Autonomic Dysreflexia; Autonomic Nervous System Diseas | 2008 |