Page last updated: 2024-10-31

midodrine and Autonomic Dysreflexia

midodrine has been researched along with Autonomic Dysreflexia in 3 studies

Midodrine: An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
midodrine : An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Autonomic Dysreflexia: A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60)

Research Excerpts

ExcerptRelevanceReference
"Midodrine (10 mg) administered in the home environment effectively increases BP and reduces the incidence of hypotension; however these beneficial effects come at the expense of worsened BP instability and AD symptom intensity."5.69Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury. ( Bauman, WA; Dyson-Hudson, TA; Katzelnick, CG; Kirshblum, SC; Wecht, JM; Weir, JP, 2023)
"To explore the effectiveness of various sources of self-stimulation, including oral midodrine, in triggering ejaculation in men with spinal cord injury (SCI), and to document the systematic variations in blood pressure at ejaculation and consider a revised definition of autonomic dysreflexia."3.74Blood pressure changes during sexual stimulation, ejaculation and midodrine treatment in men with spinal cord injury. ( Bélanger, M; Charvier, KF; Côté, M; Courtois, FJ; Leriche, A; Vézina, JG, 2008)
"Oral midodrine may further increase ejaculation success, while maintaining autonomy."1.35Perceived physiological and orgasmic sensations at ejaculation in spinal cord injured men. ( Bélanger, M; Charvier, K; Côté, I; Courtois, F; Fournier, C; Jacquemin, G; Leriche, A; Raymond, D; Vézina, JG, 2008)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Wecht, JM1
Weir, JP1
Katzelnick, CG1
Dyson-Hudson, TA1
Bauman, WA1
Kirshblum, SC1
Courtois, FJ1
Charvier, KF1
Leriche, A2
Vézina, JG2
Côté, M1
Bélanger, M2
Courtois, F1
Charvier, K1
Côté, I1
Raymond, D1
Jacquemin, G1
Fournier, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014]Phase 422 participants (Actual)Interventional2018-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for midodrine and Autonomic Dysreflexia

ArticleYear
Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury.
    The journal of spinal cord medicine, 2023, Volume: 46, Issue:4

    Topics: Autonomic Dysreflexia; Blood Pressure Monitoring, Ambulatory; Humans; Hypotension; Hypotension, Orth

2023

Other Studies

2 other studies available for midodrine and Autonomic Dysreflexia

ArticleYear
Blood pressure changes during sexual stimulation, ejaculation and midodrine treatment in men with spinal cord injury.
    BJU international, 2008, Volume: 101, Issue:3

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Autonomic Dysreflexia; Blood Pressure; Ejaculati

2008
Perceived physiological and orgasmic sensations at ejaculation in spinal cord injured men.
    The journal of sexual medicine, 2008, Volume: 5, Issue:10

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Autonomic Dysreflexia; Autonomic Nervous System Diseas

2008