Page last updated: 2024-10-31

midazolam and Tachycardia

midazolam has been researched along with Tachycardia in 19 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.

Research Excerpts

ExcerptRelevanceReference
"We studied the pressor and tachycardiac responses to ephedrine in elderly and young patients given either clonidine or midazolam during propofol anesthesia."9.10The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003)
"We report two patients who experienced status epilepticus after carbamazepine overdose."7.71Status epilepticus after massive carbamazepine overdose. ( Carlisle, RD; Spiller, HA, 2002)
"We studied the pressor and tachycardiac responses to ephedrine in elderly and young patients given either clonidine or midazolam during propofol anesthesia."5.10The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003)
"A 13-month-old male who ingested 20 diphenhydramine (25 mg) tablets presented with seizures and ultimately progressed to status epilepticus and wide-complex tachycardia."3.77Survival after diphenhydramine ingestion with hemodialysis in a toddler. ( Hendrickson, RG; Horowitz, BZ; McKeown, NJ; West, PL, 2011)
"We report two patients who experienced status epilepticus after carbamazepine overdose."3.71Status epilepticus after massive carbamazepine overdose. ( Carlisle, RD; Spiller, HA, 2002)
"Hypertension and tachycardia are common during fiber-optic bronchoscopy (FOB), and this may lead to cardiac ischemia."2.73Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study. ( Ben-Zvi, I; Fox, BD; Kramer, MR; Krylov, Y; Leon, P; Peled, N; Shitrit, D, 2008)
"Atracurium or rocuronium was administered at a dose of 0."2.71[Ephedrine shortens the onset of action of rocuronium but not atracurium]. ( Alvarez, JC; Castillo, J; Mansilla, R; Navarro, J; Pardina, B; Santiveri, X, 2003)
"Midazolam was administered during the procedure by staff who were blinded to the state/trait anxiety scores and the type of consent the patient had received."2.68Effect of informed consent on anxiety in patients undergoing diagnostic electrophysiology studies. ( Goldberger, JJ; Kadish, AH; Kruse, J; Parker, MA, 1997)
" The mean dosage of propofol in group A was significantly higher (62."1.56Pre-endoscopic tachycardia predicts increased sedation dose and lower adenoma detection rate in patients undergoing endoscopic procedures: a case control study. ( Ahmad, HS; Baker, FA; Kadah, A; Khoury, T; Mahajnah, M; Mahamid, M; Mari, A; Pellicano, R; Sbeit, W, 2020)
"Prolonged dexmedetomidine administration in children with heart disease appears to be safe and is associated with decreased opioid and benzodiazepine requirement and decreased inotropic support."1.38Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*. ( Gossett, JM; Gupta, P; Roth, SJ; Sabati, A; Tesoro, TM; Tobias, JD; Whiteside, W, 2012)
"Midazolam was administered by slow infusion."1.34Effects of sedation during upper gastrointestinal endoscopy on endocrine response and cardiorespiratory function. ( Akgün, I; Eren, N; Oba, S; Paksoy, I; Uludag, M; Yetkin, G, 2007)
"When midazolam was readministered, all symptoms disappeared."1.29Benzodiazepine withdrawal reaction in two children following discontinuation of sedation with midazolam. ( Booy, LH; Gimbrere, JS; van Engelen, BG, 1993)
"Midazolam has several advantages over diazepam as a sedative agent in electrophysiologic studies, but its electrophysiologic effects in humans are unknown."1.28Lack of effect of midazolam on inducibility of arrhythmias at electrophysiologic study. ( Davis, L; Ho, DS; McGuire, MA; Richards, DA; Ross, DL; Uther, JB; Yip, AS, 1992)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (36.84)18.2507
2000's5 (26.32)29.6817
2010's6 (31.58)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Mari, A1
Khoury, T1
Mahajnah, M1
Kadah, A1
Ahmad, HS1
Baker, FA1
Pellicano, R1
Mahamid, M1
Sbeit, W1
Park, CH1
Park, SW1
Hyun, B1
Lee, J1
Kae, SH1
Jang, HJ1
Koh, DH1
Choi, MH1
Yen, P1
Prior, S1
Riley, C1
Johnston, W1
Smiley, M1
Thikkurissy, S1
Quesada, L1
Gomila, I1
Yates, C1
Barcelo, C1
Puiguriguer, J1
Barcelo, B1
Abouchedid, R1
Ho, JH1
Hudson, S1
Dines, A1
Archer, JR1
Wood, DM1
Dargan, PI1
McKeown, NJ1
West, PL1
Hendrickson, RG1
Horowitz, BZ1
Gupta, P1
Whiteside, W1
Sabati, A1
Tesoro, TM1
Gossett, JM1
Tobias, JD1
Roth, SJ1
Ishiyama, T1
Kashimoto, S1
Oguchi, T1
Matsukawa, T1
Kumazawa, T1
Santiveri, X1
Mansilla, R1
Pardina, B1
Navarro, J1
Alvarez, JC1
Castillo, J1
Yetkin, G1
Oba, S1
Uludag, M1
Paksoy, I1
Akgün, I1
Eren, N1
Fox, BD1
Krylov, Y1
Leon, P1
Ben-Zvi, I1
Peled, N1
Shitrit, D1
Kramer, MR1
van Engelen, BG1
Gimbrere, JS1
Booy, LH1
Goldberger, JJ1
Kruse, J1
Parker, MA1
Kadish, AH1
Massanari, M1
Novitsky, J1
Reinstein, LJ1
Spiller, HA1
Carlisle, RD1
Yip, AS1
McGuire, MA1
Davis, L1
Ho, DS1
Richards, DA1
Uther, JB1
Ross, DL1
Haines, DJ1
Bibbey, D1
Green, JR1
Chraemmer-Jørgensen, B1
Høilund-Carlsen, PF1
Marving, J1
Strøm, J1
Nielsen, MD1
Jensen, BH1
Lønborg-Jensen, H1
Schmidt, K1
Ferguson, DB1
Quinones, JI1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Opioid-Free Versus Transitional Anesthetic With Opioids From Tonsillectomy[NCT04528173]Phase 4550 participants (Anticipated)Interventional2020-07-22Recruiting
Auricular Acupressure as an Adjunct Treatment for Opioid Tapering in a Pediatric Cardiac Intensive Care Unit: A Pilot Feasibility Study[NCT05025384]40 participants (Actual)Interventional2021-10-25Completed
Safety and Efficacy of Sedation for Flexible Fiberoptic Bronchoscopy: Comparison of Propofol/Alfentanil With Propofol/Ketamine[NCT02000206]80 participants (Anticipated)Interventional2014-02-28Not yet recruiting
[NCT00394537]Phase 472 participants (Anticipated)InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

7 trials available for midazolam and Tachycardia

ArticleYear
Efficacy and safety of etomidate-based sedation compared with propofol-based sedation during ERCP in low-risk patients: a double-blind, randomized, noninferiority trial.
    Gastrointestinal endoscopy, 2018, Volume: 87, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Cholangiopancreatography, Endoscopic Retro

2018
A comparison of fospropofol to midazolam for moderate sedation during outpatient dental procedures.
    Anesthesia progress, 2013,Winter, Volume: 60, Issue:4

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Ambulatory Care; Analysis of Variance; Anesthesia Recovery

2013
The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:1

    Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia, Intravenous; Anest

2003
[Ephedrine shortens the onset of action of rocuronium but not atracurium].
    Revista espanola de anestesiologia y reanimacion, 2003, Volume: 50, Issue:4

    Topics: Adult; Aged; Androstanols; Atracurium; Blood Flow Velocity; Blood Pressure; Double-Blind Method; Dru

2003
Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study.
    Respiratory medicine, 2008, Volume: 102, Issue:7

    Topics: Adrenergic beta-Antagonists; Alfentanil; Analgesics, Opioid; Antihypertensive Agents; Benzodiazepine

2008
Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study.
    Respiratory medicine, 2008, Volume: 102, Issue:7

    Topics: Adrenergic beta-Antagonists; Alfentanil; Analgesics, Opioid; Antihypertensive Agents; Benzodiazepine

2008
Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study.
    Respiratory medicine, 2008, Volume: 102, Issue:7

    Topics: Adrenergic beta-Antagonists; Alfentanil; Analgesics, Opioid; Antihypertensive Agents; Benzodiazepine

2008
Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study.
    Respiratory medicine, 2008, Volume: 102, Issue:7

    Topics: Adrenergic beta-Antagonists; Alfentanil; Analgesics, Opioid; Antihypertensive Agents; Benzodiazepine

2008
Effect of informed consent on anxiety in patients undergoing diagnostic electrophysiology studies.
    American heart journal, 1997, Volume: 134, Issue:1

    Topics: Anti-Anxiety Agents; Anxiety; Arrhythmias, Cardiac; Bradycardia; Cardiac Catheterization; Cardiac Ou

1997
Does nasal oxygen reduce the cardiorespiratory problems experienced by elderly patients undergoing endoscopic retrograde cholangiopancreatography?
    Gut, 1992, Volume: 33, Issue:7

    Topics: Administration, Intranasal; Aged; Aged, 80 and over; Anesthesia; Cholangiopancreatography, Endoscopi

1992

Other Studies

12 other studies available for midazolam and Tachycardia

ArticleYear
Pre-endoscopic tachycardia predicts increased sedation dose and lower adenoma detection rate in patients undergoing endoscopic procedures: a case control study.
    Minerva medica, 2020, Volume: 111, Issue:2

    Topics: Adenoma; Adult; Aged; Anxiety; Case-Control Studies; Colonoscopy; Endoscopy, Gastrointestinal; Femal

2020
Elimination half-life of alpha-pyrrolidinovalerophenone in an acute non-fatal intoxication.
    Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:6

    Topics: Acute Disease; Administration, Intravenous; Central Nervous System Stimulants; Dose-Response Relatio

2016
Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:4

    Topics: Adamantane; Administration, Intravenous; Anti-Anxiety Agents; Cannabinoid Receptor Agonists; Citalop

2016
Survival after diphenhydramine ingestion with hemodialysis in a toddler.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:2

    Topics: Diphenhydramine; Humans; Hypnotics and Sedatives; Infant; Injections, Intramuscular; Male; Midazolam

2011
Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:6

    Topics: Blood Pressure; Child, Preschool; Critical Care; Critical Illness; Dexmedetomidine; Female; Heart Di

2012
Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:6

    Topics: Blood Pressure; Child, Preschool; Critical Care; Critical Illness; Dexmedetomidine; Female; Heart Di

2012
Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:6

    Topics: Blood Pressure; Child, Preschool; Critical Care; Critical Illness; Dexmedetomidine; Female; Heart Di

2012
Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:6

    Topics: Blood Pressure; Child, Preschool; Critical Care; Critical Illness; Dexmedetomidine; Female; Heart Di

2012
Effects of sedation during upper gastrointestinal endoscopy on endocrine response and cardiorespiratory function.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2007, Volume: 40, Issue:12

    Topics: Adult; Aged; Anesthetics, Intravenous; Blood Pressure; C-Reactive Protein; Electrocardiography; Fema

2007
Benzodiazepine withdrawal reaction in two children following discontinuation of sedation with midazolam.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:5

    Topics: Aerophagy; Conscious Sedation; Fever; Humans; Infant; Infant, Newborn; Male; Midazolam; Substance Wi

1993
Paradoxical reactions in children associated with midazolam use during endoscopy.
    Clinical pediatrics, 1997, Volume: 36, Issue:12

    Topics: Adjuvants, Anesthesia; Adolescent; Adolescent Behavior; Aggression; Akathisia, Drug-Induced; Anti-An

1997
Status epilepticus after massive carbamazepine overdose.
    Journal of toxicology. Clinical toxicology, 2002, Volume: 40, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Drug Overdose; Fatal Outcome; Female; Humans; Hypnotics

2002
Lack of effect of midazolam on inducibility of arrhythmias at electrophysiologic study.
    The American journal of cardiology, 1992, Sep-01, Volume: 70, Issue:6

    Topics: Adolescent; Adult; Aged; Cardiac Pacing, Artificial; Diazepam; Female; Heart Conduction System; Huma

1992
Left-ventricular performance, volumes, and catecholamine responses during anaesthesia induction--monitoring by combined radionuclide cardiography and right heart catheterization.
    European journal of anaesthesiology, 1991, Volume: 8, Issue:6

    Topics: Adult; Anesthesia, Intravenous; Blood Pressure; Cardiac Catheterization; Cardiac Volume; Epinephrine

1991
Effectiveness of midazolam as a sedative for cardioverting patients with tachydysrhythmias in the awake state.
    The American journal of emergency medicine, 1990, Volume: 8, Issue:3

    Topics: Adult; Aged; Electric Countershock; Humans; Male; Midazolam; Tachycardia; Wakefulness

1990