Page last updated: 2024-10-31

midazolam and Stroke

midazolam has been researched along with Stroke in 8 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
" Each patient underwent baseline testing for motor function, aphasia, and left hemispatial neglect, after which intravenous midazolam was delivered until mild drowsiness was detected."9.10Reemergence of stroke deficits with midazolam challenge. ( Berman, MF; Bustillo, MA; Fitzsimmons, BF; Lazar, RM; Marshall, RS; Mohr, JP; Robinson, JV; Shah, J; Young, WL, 2002)
"To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures."7.83Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."7.78Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
" Each patient underwent baseline testing for motor function, aphasia, and left hemispatial neglect, after which intravenous midazolam was delivered until mild drowsiness was detected."5.10Reemergence of stroke deficits with midazolam challenge. ( Berman, MF; Bustillo, MA; Fitzsimmons, BF; Lazar, RM; Marshall, RS; Mohr, JP; Robinson, JV; Shah, J; Young, WL, 2002)
"To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures."3.83Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."3.78Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
"Neonatal stroke is the second cause of acute symptomatic neonatal seizures after hypoxic-ischemic encephalopathy."2.82Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review. ( Criscione, R; Falsaperla, R; Marino, S; Pisani, F; Praticò, A; Ruggieri, M; Sortino, V, 2022)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's3 (37.50)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Sortino, V1
Praticò, A1
Marino, S1
Criscione, R1
Ruggieri, M1
Pisani, F1
Falsaperla, R1
Bai, P1
Feng, Y1
Chen, J1
Chang, H1
Weeke, LC1
Toet, MC1
van Rooij, LG1
Groenendaal, F1
Boylan, GB1
Pressler, RM1
Hellström-Westas, L1
van den Broek, MP1
de Vries, LS1
Lazar, RM2
Berman, MF2
Festa, JR1
Geller, AE1
Matejovsky, TG1
Marshall, RS2
Jennekens, W1
Dankers, F1
Janssen, F1
Toet, M1
van der Aa, N1
Niemarkt, H1
van Pul, C1
de Vries, L1
Andriessen, P1
Bardutzky, J1
Georgiadis, D1
Kollmar, R1
Schwarz, S1
Schwab, S1
Fitzsimmons, BF1
Bustillo, MA1
Young, WL1
Mohr, JP1
Shah, J1
Robinson, JV1
Di Piero, V1
Di Legge, S1
Altieri, M1
Lenzi, GL1

Reviews

1 review available for midazolam and Stroke

ArticleYear
Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review.
    Acta bio-medica : Atenei Parmensis, 2022, 12-16, Volume: 93, Issue:6

    Topics: Anticonvulsants; Bumetanide; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetirac

2022

Trials

1 trial available for midazolam and Stroke

ArticleYear
Reemergence of stroke deficits with midazolam challenge.
    Stroke, 2002, Volume: 33, Issue:1

    Topics: Adult; Aged; Aphasia; Female; GABA Modulators; Humans; Hypnotics and Sedatives; Male; Midazolam; Mid

2002

Other Studies

6 other studies available for midazolam and Stroke

ArticleYear
Diffuse posterior leukoencephalopathy in MELAS without stroke-like episodes: A case report.
    Medicine, 2023, May-05, Volume: 102, Issue:18

    Topics: Acidosis, Lactic; Ascorbic Acid; Female; Humans; Leukoencephalopathies; Levetiracetam; Male; MELAS S

2023
Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants.
    Epilepsia, 2016, Volume: 57, Issue:2

    Topics: Anticonvulsants; Central Nervous System Infections; Cohort Studies; Electroencephalography; Female;

2016
GABAergic but not anti-cholinergic agents re-induce clinical deficits after stroke.
    Journal of the neurological sciences, 2010, May-15, Volume: 292, Issue:1-2

    Topics: Aged; Analysis of Variance; Aphasia; Cholinergic Antagonists; Cross-Over Studies; Double-Blind Metho

2010
Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:6

    Topics: Anticonvulsants; Brain Ischemia; Data Interpretation, Statistical; Electroencephalography; Epilepsy;

2012
Energy demand in patients with stroke who are sedated and receiving mechanical ventilation.
    Journal of neurosurgery, 2004, Volume: 100, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Calorimetry, Indirect; Consciousness Disorders; Energy Metabolism; F

2004
When is a stroke actually "stable"?
    Stroke, 2002, Volume: 33, Issue:6

    Topics: Anti-Anxiety Agents; Cell Count; Cerebrovascular Circulation; Humans; Midazolam; Neurons; Receptors,

2002