midazolam and Stroke
midazolam has been researched along with Stroke in 8 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Each patient underwent baseline testing for motor function, aphasia, and left hemispatial neglect, after which intravenous midazolam was delivered until mild drowsiness was detected." | 9.10 | Reemergence of stroke deficits with midazolam challenge. ( Berman, MF; Bustillo, MA; Fitzsimmons, BF; Lazar, RM; Marshall, RS; Mohr, JP; Robinson, JV; Shah, J; Young, WL, 2002) |
| "To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures." | 7.83 | Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016) |
| " To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings." | 7.78 | Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012) |
| " Each patient underwent baseline testing for motor function, aphasia, and left hemispatial neglect, after which intravenous midazolam was delivered until mild drowsiness was detected." | 5.10 | Reemergence of stroke deficits with midazolam challenge. ( Berman, MF; Bustillo, MA; Fitzsimmons, BF; Lazar, RM; Marshall, RS; Mohr, JP; Robinson, JV; Shah, J; Young, WL, 2002) |
| "To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures." | 3.83 | Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016) |
| " To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings." | 3.78 | Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012) |
| "Neonatal stroke is the second cause of acute symptomatic neonatal seizures after hypoxic-ischemic encephalopathy." | 2.82 | Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review. ( Criscione, R; Falsaperla, R; Marino, S; Pisani, F; Praticò, A; Ruggieri, M; Sortino, V, 2022) |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sortino, V | 1 |
| Praticò, A | 1 |
| Marino, S | 1 |
| Criscione, R | 1 |
| Ruggieri, M | 1 |
| Pisani, F | 1 |
| Falsaperla, R | 1 |
| Bai, P | 1 |
| Feng, Y | 1 |
| Chen, J | 1 |
| Chang, H | 1 |
| Weeke, LC | 1 |
| Toet, MC | 1 |
| van Rooij, LG | 1 |
| Groenendaal, F | 1 |
| Boylan, GB | 1 |
| Pressler, RM | 1 |
| Hellström-Westas, L | 1 |
| van den Broek, MP | 1 |
| de Vries, LS | 1 |
| Lazar, RM | 2 |
| Berman, MF | 2 |
| Festa, JR | 1 |
| Geller, AE | 1 |
| Matejovsky, TG | 1 |
| Marshall, RS | 2 |
| Jennekens, W | 1 |
| Dankers, F | 1 |
| Janssen, F | 1 |
| Toet, M | 1 |
| van der Aa, N | 1 |
| Niemarkt, H | 1 |
| van Pul, C | 1 |
| de Vries, L | 1 |
| Andriessen, P | 1 |
| Bardutzky, J | 1 |
| Georgiadis, D | 1 |
| Kollmar, R | 1 |
| Schwarz, S | 1 |
| Schwab, S | 1 |
| Fitzsimmons, BF | 1 |
| Bustillo, MA | 1 |
| Young, WL | 1 |
| Mohr, JP | 1 |
| Shah, J | 1 |
| Robinson, JV | 1 |
| Di Piero, V | 1 |
| Di Legge, S | 1 |
| Altieri, M | 1 |
| Lenzi, GL | 1 |
Reviews
1 review available for midazolam and Stroke
| Article | Year |
|---|---|
Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review.
Topics: Anticonvulsants; Bumetanide; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetirac | 2022 |
Trials
1 trial available for midazolam and Stroke
| Article | Year |
|---|---|
Reemergence of stroke deficits with midazolam challenge.
Topics: Adult; Aged; Aphasia; Female; GABA Modulators; Humans; Hypnotics and Sedatives; Male; Midazolam; Mid | 2002 |
Other Studies
6 other studies available for midazolam and Stroke
| Article | Year |
|---|---|
Diffuse posterior leukoencephalopathy in MELAS without stroke-like episodes: A case report.
Topics: Acidosis, Lactic; Ascorbic Acid; Female; Humans; Leukoencephalopathies; Levetiracetam; Male; MELAS S | 2023 |
Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants.
Topics: Anticonvulsants; Central Nervous System Infections; Cohort Studies; Electroencephalography; Female; | 2016 |
GABAergic but not anti-cholinergic agents re-induce clinical deficits after stroke.
Topics: Aged; Analysis of Variance; Aphasia; Cholinergic Antagonists; Cross-Over Studies; Double-Blind Metho | 2010 |
Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke.
Topics: Anticonvulsants; Brain Ischemia; Data Interpretation, Statistical; Electroencephalography; Epilepsy; | 2012 |
Energy demand in patients with stroke who are sedated and receiving mechanical ventilation.
Topics: Adult; Aged; Aged, 80 and over; Calorimetry, Indirect; Consciousness Disorders; Energy Metabolism; F | 2004 |
When is a stroke actually "stable"?
Topics: Anti-Anxiety Agents; Cell Count; Cerebrovascular Circulation; Humans; Midazolam; Neurons; Receptors, | 2002 |