Page last updated: 2024-10-31

midazolam and Stress Disorders, Post-Traumatic

midazolam has been researched along with Stress Disorders, Post-Traumatic in 18 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Stress Disorders, Post-Traumatic: A class of traumatic stress disorders with symptoms that last more than one month.

Research Excerpts

ExcerptRelevanceReference
" Eighty-two patients with self-reported dental anxiety either completed treatment with dentist-administered cognitive behavioural therapy (D-CBT, n = 36), or received dental treatment while sedated with midazolam combined with the systemized communication technique "The Four Habits Model" (Four Habits/midazolam, n = 41)."5.69Changes in symptoms of anxiety, depression, and PTSD in an RCT-study of dentist-administered treatment of dental anxiety. ( Hauge, MS; Stora, B; Willumsen, T, 2023)
"27 individuals diagnosed with PTSD were randomly assigned to receive either ketamine (0."3.30Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. ( Amen, S; Duek, O; Gordon, C; Harpaz-Rotem, I; Kelmendi, B; Korem, N; Krystal, JH; Levy, I; Li, Y; Milne, M, 2023)
"Ketamine infusion was associated with significant and rapid reduction in PTSD symptom severity, compared with midazolam, when assessed 24 hours after infusion (mean difference in Impact of Event Scale-Revised score, 12."2.79Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. ( Aan Het Rot, M; Charney, DS; Feder, A; Iosifescu, D; Kirkwood, K; Lapidus, KA; Morgan, JE; Murrough, JW; Parides, MK; Perez, AM; Saxena, S; Wan, LB, 2014)
"The incidence of PTSD was 16."1.72COVID-19 induced PTSD: Stressors for trauma and acute care surgeons. ( Esposito, TJ; James, MK; McKenzie, K; Robitsek, RJ; Valenzuela, JY, 2022)
"While post-traumatic stress disorder (PTSD) can develop after exposure to severe traumatic events, data have shown that individuals with high sensation-seeking personality traits are less prone to developing PTSD."1.56Environmental enrichment increases cue-dependent freezing and behavioral despair but decreases anxiety-like behavior in rats. ( Chacho, NM; Dravid, SM; Pipitone, L; Stairs, DJ; Wunsch, C, 2020)
"Background Psychomotor agitation can be problematic in an overcrowded emergency department (ED) during uncontrolled procedural sedation."1.51Post-traumatic stress disorder or emergence phenomena? A case of psychomotor agitation after procedural sedation and analgesia. ( Akbari, H; Bahreini, M; Jalali, A, 2019)
"Post-traumatic stress disorder (PTSD) is a debilitating anxiety disorder that may develop after an individual has experienced or witnessed a severe traumatic event."1.40Midazolam ameliorates the behavior deficits of a rat posttraumatic stress disorder model through dual 18 kDa translocator protein and central benzodiazepine receptor and neurosteroidogenesis. ( Fang, WW; Guo, WZ; Li, BW; Li, YF; Liu, J; Liu, Y; Miao, YL; Shi, WZ; Wu, W, 2014)
"Posttraumatic stress disorder (PTSD) is characterized by the occurrence of a traumatic event that is beyond the normal range of human experience."1.40Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression. ( Bentley, M; Ceremuga, GA; Ceremuga, TE; Crawford, D; Edwards, R; Herron, GM; Kemper, JL; Martinson, S; Padron, G; Revels, R; Townsend, WL; Washington, J; Wojcicki, J, 2014)
"Posttraumatic stress disorder PTSD is based on memory of a traumatic event."1.35The relationship of intravenous midazolam and posttraumatic stress disorder development in burned soldiers. ( Black, IH; DeSocio, PA; Garza, TH; Gaylord, KM; Maani, CV; McGhee, LL, 2009)
"Current PTSD symptoms were substantially elevated in (S)-ketamine subjects, while there was no difference observed between opioids and racemic ketamines."1.33Effects of peritraumatic ketamine medication on early and sustained posttraumatic stress symptoms in moderately injured accident victims. ( Badke, A; Domes, G; Hautzinger, M; Reichwald, U; Schönenberg, M, 2005)
"Midazolam was judged comparably effective to amobarbital and easier to use."1.29The use of midazolam with pulse oximetry in the drug-assisted interview. ( Marcum, JM, 1996)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.56)18.2507
2000's3 (16.67)29.6817
2010's9 (50.00)24.3611
2020's5 (27.78)2.80

Authors

AuthorsStudies
James, MK1
Robitsek, RJ1
McKenzie, K1
Valenzuela, JY1
Esposito, TJ1
Duek, O1
Korem, N1
Li, Y1
Kelmendi, B1
Amen, S1
Gordon, C1
Milne, M1
Krystal, JH1
Levy, I1
Harpaz-Rotem, I1
Hauge, MS1
Willumsen, T1
Stora, B1
Jalali, A1
Akbari, H1
Bahreini, M1
Stairs, DJ1
Chacho, NM1
Wunsch, C1
Pipitone, L1
Dravid, SM1
Long, D1
Gibbons, K1
Le Brocque, R1
Schults, JA1
Kenardy, J1
Dow, B1
Nunes, SL1
Forsberg, S1
Blomqvist, H1
Berggren, L1
Sörberg, M1
Sarapohja, T1
Wickerts, CJ1
Ceremuga, TE2
Shellabarger, P1
Persson, T1
Fanning, M1
Galey, P1
Robinson, D1
Bertsch, S1
Ceremuga, GA2
Bentley, M2
Feder, A1
Parides, MK1
Murrough, JW1
Perez, AM1
Morgan, JE1
Saxena, S1
Kirkwood, K1
Aan Het Rot, M1
Lapidus, KA1
Wan, LB1
Iosifescu, D1
Charney, DS1
Miao, YL1
Guo, WZ1
Shi, WZ1
Fang, WW1
Liu, Y1
Liu, J1
Li, BW1
Wu, W1
Li, YF1
Martinson, S1
Washington, J1
Revels, R1
Wojcicki, J1
Crawford, D1
Edwards, R1
Kemper, JL1
Townsend, WL1
Herron, GM1
Padron, G1
Vet, NJ1
de Wildt, SN1
Verlaat, CW1
Mooij, MG1
Tibboel, D1
de Hoog, M1
Buysse, CM1
McGhee, LL1
Maani, CV1
Garza, TH1
DeSocio, PA1
Gaylord, KM1
Black, IH1
Wallace, S1
Mecklenburg, B1
Hanling, S1
Schofield, J1
Johnston, AM1
de Mello, WF1
Strøm, T1
Schönenberg, M1
Reichwald, U1
Domes, G1
Badke, A1
Hautzinger, M1
Marcum, JM1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Non-interventional Comparison of Sedatives on Weaning From Mechanical Ventilation in Intensive Care Patients[NCT01707680]155 participants (Actual)Observational2012-06-01Terminated (stopped due to Halted due to slow recruitment)
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder[NCT00749203]Phase 241 participants (Actual)Interventional2009-01-31Completed
Low Dose Ketamine Infusion for Comorbid Posttraumatic Stress Disorder and Chronic Pain Patients[NCT04322968]Phase 341 participants (Actual)Interventional2018-01-09Completed
A Single Ketamine Infusion Combined With Music for Suicidal Ideation During a Depressive Episode: A Randomized Open Label Clinical Trial[NCT04658420]Phase 2200 participants (Anticipated)Interventional2021-07-01Not yet recruiting
Music as a Potential Intervention to Improve Hemodynamic Tolerability of Repetitive Sub-Anesthetic IV Ketamine Infusions in Bipolar and Unipolar Depression: A Pilot Study[NCT04701866]32 participants (Actual)Interventional2021-01-11Completed
A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885]Phase 26 participants (Anticipated)Interventional2022-08-26Recruiting
Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department[NCT04260607]Phase 32 participants (Actual)Interventional2020-01-14Terminated (stopped due to As a busy MTF we were unable to retain a health care provider with the appropriate expertise to buy-in to this study once the initiating PI left military service.)
Assessing a Combined Ketamine and Online Cognitive Behavioural Therapy Intervention for Treatment Resistant Post-Traumatic Stress Disorder[NCT04771767]Phase 216 participants (Anticipated)Interventional2021-08-01Recruiting
The Effect of Therapeutic Ketamine Infusions on the Symptoms of Post-Traumatic Stress Disorder in Combat Veterans[NCT03088384]30 participants (Actual)Observational2016-11-28Completed
Dexmedetomidine Compared to Midazolam for Symptom Control in Advanced Cancer Patients: A Pilot Randomized Controlled Trial (RCT)[NCT01687751]Phase 20 participants (Actual)Interventional2012-11-30Withdrawn (stopped due to Study design determined to be not likely feasible)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinician-Administered PTSD Scale (CAPS)

Clinician-administered structured interview measuring PTSD symptoms. frequency score - scale 0 = none of the time to 4 = most or all of the time intensity score - scale 0 = none to 4 = extreme To meet criteria for a symptom, a patient must meet criteria in both frequency and intensity score for each item. Frequency and intensity and then combined to form a single severity score. 30 questions scale, with total score ranging from 0 to 240. (NCT00749203)
Timeframe: 7 days after first infusion

Interventionunits on a scale (Mean)
Ketamine54
Midazolam65.69

Impact of Event Scale - Revised (IES-R)

"A 22-item self-report questionnaire measuring PTSD symptoms. Items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score ranging from 0 (not at all) to 88 (extremely)" (NCT00749203)
Timeframe: 7 days after first infusion

Interventionunits on a scale (Mean)
Ketamine25.76
Midazolam36.32

Montgomery-Asberg Depression Rating Scale (MADRS)

Clinician-administered questionnaire measuring depressive symptoms. The MADRS-S has 10-items which are based on mood symptoms over the past 7 days. Each items is scored 0 (normal) to 6 (severe depression) with overall score ranges from 0 (normal) to 60 (severe depression). Mean difference between baseline and 2 weeks. (NCT00749203)
Timeframe: 24 hours after first infusion

Interventionunits on a scale (Mean)
Ketamine12.6
Midazolam10.1

Quick Inventory of Depressive Symptomatology - Self Report (QIDS-SR)

Self-report questionnaire measuring depressive symptoms. Each item is rated 0 (no depression) to 3 (severe depression). The total score ranges from 0-27. (NCT00749203)
Timeframe: 24 hours after first infusion

Interventionunits on a scale (Mean)
Ketamine12.4
Midazolam11.3

Impact of Event Scale-Revised (IES-R)

"Severity of PTSD symptoms; items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score (ranging from 0 to 88); higher scores mean worse symptoms" (NCT04322968)
Timeframe: 1 week post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion28.22
Chronic Pain With PTSD+IV Ketorolac Infusion33.66666667
Chronic Pain Without PTSD+IV Ketamine Infusion11.44
Chronic Pain Without PTSD+IV Ketorolac Infusion13.41

Impact of Event Scale-Revised (IES-R)

"Severity of PTSD symptoms; items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score (ranging from 0 to 88); higher scores mean worse symptoms" (NCT04322968)
Timeframe: 24 hrs post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion36.33333333
Chronic Pain With PTSD+IV Ketorolac Infusion37
Chronic Pain Without PTSD+IV Ketamine Infusion10.44444444
Chronic Pain Without PTSD+IV Ketorolac Infusion15.64705882

Visual Analogue Scale (VAS)

"Severity of chronic pain symptoms; using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the no pain anchor and the patient's mark, providing a range of scores from 0-100; a higher score indicates greater pain intensity." (NCT04322968)
Timeframe: 1 week post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion48.22
Chronic Pain With PTSD+IV Ketorolac Infusion52.88
Chronic Pain Without PTSD+IV Ketamine Infusion43.33
Chronic Pain Without PTSD+IV Ketorolac Infusion48.23

Visual Analogue Scale (VAS)

"Severity of chronic pain symptoms; using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the no pain anchor and the patient's mark, providing a range of scores from 0-100; a higher score indicates greater pain intensity." (NCT04322968)
Timeframe: 24 hrs post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion37.22222222
Chronic Pain With PTSD+IV Ketorolac Infusion49.66666667
Chronic Pain Without PTSD+IV Ketamine Infusion29.88888889
Chronic Pain Without PTSD+IV Ketorolac Infusion38.70588235

Brief Pain Inventory (Short Form)

"Severity of pain, impact of pain on daily function, location of pain, pain medications and amount of pain relief in the past 24 hours or the past week; No scoring algorithm, but worst pain or the arithmetic mean of the four severity items can be used as measures of pain severity (a range of 0-10, with 10 being worse scores); the arithmetic mean of the seven interference items can be used as a measure of pain interference (a range of 0-10, with 10 being worse scores). The total score is reported for severity items and interference items, which range from 0-40 and 0-70, respectively. Higher values represent worse outcome." (NCT04322968)
Timeframe: 1 week post-infusion

,,,
Interventionunits on a scale (Mean)
Pain interference ScalePain severity Scale
Chronic Pain With PTSD+IV Ketamine Infusion38.6220.75
Chronic Pain With PTSD+IV Ketorolac Infusion25.6614.66
Chronic Pain Without PTSD+IV Ketamine Infusion9.6212.75
Chronic Pain Without PTSD+IV Ketorolac Infusion28.3322.66

Trials

4 trials available for midazolam and Stress Disorders, Post-Traumatic

ArticleYear
Long term structural and functional neural changes following a single infusion of Ketamine in PTSD.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023, Volume: 48, Issue:11

    Topics: Extinction, Psychological; Humans; Ketamine; Midazolam; Pilot Projects; Psychotherapy; Stress Disord

2023
Changes in symptoms of anxiety, depression, and PTSD in an RCT-study of dentist-administered treatment of dental anxiety.
    BMC oral health, 2023, 06-22, Volume: 23, Issue:1

    Topics: Anxiety; Dental Anxiety; Dentists; Depression; Humans; Midazolam; Professional Role; Stress Disorder

2023
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Short-Term Health-Related Quality of Life of Critically Ill Children Following Daily Sedation Interruption.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2016, Volume: 17, Issue:11

    Topics: Adolescent; Child; Child, Preschool; Clinical Protocols; Critical Care; Critical Illness; Deep Sedat

2016

Other Studies

14 other studies available for midazolam and Stress Disorders, Post-Traumatic

ArticleYear
COVID-19 induced PTSD: Stressors for trauma and acute care surgeons.
    American journal of surgery, 2022, Volume: 224, Issue:3

    Topics: Adult; COVID-19; Female; Hospitals, University; Humans; Male; Midazolam; Pandemics; Stress Disorders

2022
Post-traumatic stress disorder or emergence phenomena? A case of psychomotor agitation after procedural sedation and analgesia.
    Drug metabolism and personalized therapy, 2019, 12-18, Volume: 34, Issue:4

    Topics: Analgesia; Analgesics; Conscious Sedation; Emergency Service, Hospital; Humans; Injections, Intramus

2019
Environmental enrichment increases cue-dependent freezing and behavioral despair but decreases anxiety-like behavior in rats.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 196

    Topics: Animals; Anxiety; Behavior, Animal; Conditioning, Classical; Cues; Fear; Male; Midazolam; Rats; Rats

2020
Midazolam exposure in the paediatric intensive care unit predicts acute post-traumatic stress symptoms in children.
    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 2022, Volume: 35, Issue:4

    Topics: Australia; Child; Child, Preschool; Humans; Intensive Care Units, Pediatric; Longitudinal Studies; M

2022
Effect of Sedation Regimen on Weaning from Mechanical Ventilation in the Intensive Care Unit.
    Clinical drug investigation, 2018, Volume: 38, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Critical Care; Delirium; Dexmedetomidine; Female; Humans; H

2018
Effects of tetrahydropalmatine on post-traumatic stress disorder-induced changes in rat brain gene expression.
    Journal of integrative neuroscience, 2013, Volume: 12, Issue:4

    Topics: Adjuvants, Anesthesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Berberine Alkaloids;

2013
Midazolam ameliorates the behavior deficits of a rat posttraumatic stress disorder model through dual 18 kDa translocator protein and central benzodiazepine receptor and neurosteroidogenesis.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Carrier Proteins; Disease Models, Anim

2014
Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression.
    TheScientificWorldJournal, 2014, Volume: 2014

    Topics: Analysis of Variance; Animals; Beverages; Brain; Gene Expression Regulation; Glutamates; Male; Midaz

2014
The relationship of intravenous midazolam and posttraumatic stress disorder development in burned soldiers.
    The Journal of trauma, 2009, Volume: 66, Issue:4 Suppl

    Topics: Anti-Anxiety Agents; Brief Psychiatric Rating Scale; Burns; Case-Control Studies; Humans; Intraopera

2009
Profound reduction in sedation and analgesic requirements using extended dexmedetomidine infusions in a patient with an open abdomen.
    Military medicine, 2009, Volume: 174, Issue:11

    Topics: Abdominal Injuries; Analgesics, Non-Narcotic; Dexmedetomidine; Fentanyl; Humans; Infusions, Intraven

2009
Morphine after combat injury and post-traumatic stress disorder.
    The New England journal of medicine, 2010, Apr-08, Volume: 362, Issue:14

    Topics: Analgesia; Analgesics, Opioid; Benzodiazepines; Fentanyl; Humans; Iraq War, 2003-2011; Ketamine; Mid

2010
Sedation in the ICU.
    Danish medical journal, 2012, Volume: 59, Issue:5

    Topics: Academic Dissertations as Topic; Acute Kidney Injury; Aged; Anxiety; Critical Care; Deep Sedation; D

2012
Effects of peritraumatic ketamine medication on early and sustained posttraumatic stress symptoms in moderately injured accident victims.
    Psychopharmacology, 2005, Volume: 182, Issue:3

    Topics: Accidents; Adult; Aged; Female; Humans; Ketamine; Male; Midazolam; Middle Aged; Retrospective Studie

2005
The use of midazolam with pulse oximetry in the drug-assisted interview.
    The Journal of clinical psychiatry, 1996, Volume: 57, Issue:3

    Topics: Adult; Amobarbital; Barbiturates; Conscious Sedation; Depressive Disorder; Female; Humans; Infusions

1996