midazolam has been researched along with Sleep Wake Disorders in 20 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess and compare the impact of overnight sedation with midazolam or propofol on anxiety and depression levels, as well as sleep quality, in non-intubated patients in intensive care." | 9.08 | Overnight sedation with midazolam or propofol in the ICU: effects on sleep quality, anxiety and depression. ( Borgeat, A; Fuchs-Buder, T; Gachoud, JP; Suter, PM; Treggiari-Venzi, M, 1996) |
| "Melatonin was not only as effective as midazolam in alleviating preoperative anxiety in children, but it was also associated with a tendency towards faster recovery, lower incidence of excitement postoperatively and a lower incidence of sleep disturbance at week 2 postoperatively." | 5.11 | Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. ( Albassam, A; Aldammas, F; Alotibi, W; Naguib, M; Riad, W; Samarkandi, A; Thalaj, A, 2005) |
| "To assess and compare the impact of overnight sedation with midazolam or propofol on anxiety and depression levels, as well as sleep quality, in non-intubated patients in intensive care." | 5.08 | Overnight sedation with midazolam or propofol in the ICU: effects on sleep quality, anxiety and depression. ( Borgeat, A; Fuchs-Buder, T; Gachoud, JP; Suter, PM; Treggiari-Venzi, M, 1996) |
| "Five cases are reported in which confusional states and total anterograde amnesia occurred after oral intake of recommended doses of midazolam, a new ultra-short acting benzodiazepine." | 3.67 | [Confusional states following administration of the hypnotic midazolam]. ( Schneider-Helmert, D, 1985) |
| "Midazolam (15 mg p." | 2.65 | Effect of midazolam on sleep. ( Klotz, U; Ludwig, L; Ziegler, G, 1983) |
| "Midazolam was well tolerated with no side-effects." | 2.65 | Efficacy and safety of midazolam in the treatment of night terrors in children. ( Corfariu, O; Popoviciu, L, 1983) |
| "Midazolam has the lowest residual fraction of all known benzodiazepines and thus, administered in the appropriate dosage, also has the shortest duration of activity." | 1.27 | Pharmacokinetic and clinical considerations in the choice of a hypnotic. ( Amrein, R; Eckert, M; Haefeli, H; Leishman, B, 1983) |
| "Efficacy (sleep--sedation) and tolerance of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) in a dosage of 10 mg to 30 mg p." | 1.26 | Evaluation of efficacy and safety of midazolam administered orally in sleep disorders. A dose-finding study. ( Buch, JP; Lupolover, R, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (65.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Narita, M | 2 |
| Niikura, K | 1 |
| Nanjo-Niikura, K | 1 |
| Furuya, M | 1 |
| Yamashita, A | 1 |
| Saeki, M | 1 |
| Matsushima, Y | 1 |
| Imai, S | 1 |
| Shimizu, T | 1 |
| Asato, M | 1 |
| Kuzumaki, N | 1 |
| Okutsu, D | 1 |
| Miyoshi, K | 1 |
| Suzuki, M | 1 |
| Tsukiyama, Y | 1 |
| Konno, M | 1 |
| Yomiya, K | 1 |
| Matoba, M | 1 |
| Suzuki, T | 1 |
| Boodhoo, L | 1 |
| Mitchell, A | 1 |
| Ujhelyi, M | 1 |
| Sulke, N | 1 |
| Samarkandi, A | 1 |
| Naguib, M | 1 |
| Riad, W | 1 |
| Thalaj, A | 1 |
| Alotibi, W | 1 |
| Aldammas, F | 1 |
| Albassam, A | 1 |
| Lupolover, R | 1 |
| Buch, JP | 1 |
| Fischbach, R | 2 |
| Lachnit, KS | 1 |
| Proszowski, E | 1 |
| Rieder, L | 1 |
| Amrein, R | 1 |
| Eckert, M | 1 |
| Haefeli, H | 1 |
| Leishman, B | 1 |
| Ziegler, G | 1 |
| Ludwig, L | 1 |
| Klotz, U | 1 |
| Popoviciu, L | 1 |
| Corfariu, O | 1 |
| Turner, R | 1 |
| Elson, E | 1 |
| Treggiari-Venzi, M | 1 |
| Borgeat, A | 1 |
| Fuchs-Buder, T | 1 |
| Gachoud, JP | 1 |
| Suter, PM | 1 |
| Török, K | 1 |
| Lavie, P | 1 |
| Forgo, I | 1 |
| Francescangeli, MA | 1 |
| Omicini, A | 1 |
| Gentili, P | 1 |
| Loew, F | 1 |
| Pawlak, C | 1 |
| Benaroyo, L | 1 |
| Junod, JP | 1 |
| Schneider-Helmert, D | 1 |
| Fraenkel, HM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309] | Phase 3 | 25 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol in Mechanically Ventilated Traumatic Brain Injury Patient: RCT[NCT04034771] | Phase 3 | 38 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 trials available for midazolam and Sleep Wake Disorders
| Article | Year |
|---|---|
Improving the acceptability of the atrial defibrillator: patient-activated cardioversion versus automatic night cardioversion with and without sedation (ADSAS 2).
Topics: Anxiety; Atrial Fibrillation; Cross-Over Studies; Defibrillators, Implantable; Electric Countershock | 2004 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Hypnotic efficacy and safety of midazolam and oxazepam in hospitalized female patients.
Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Dr | 1983 |
Efficacy and safety of midazolam and vesparax in treatment of sleep disorders.
Topics: Adult; Aged; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Drug Combinations; Female; Humans; | 1983 |
Midazolam in the treatment of sleep disorders in geriatric patients.
Topics: Aged; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Clinical Trials as Topic; Double-Blind Met | 1983 |
Effect of midazolam on sleep.
Topics: Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Female; Humans; Male; Midazolam; Middl | 1983 |
Efficacy and safety of midazolam in the treatment of night terrors in children.
Topics: Adolescent; Anti-Anxiety Agents; Benzodiazepines; Child; Humans; Midazolam; Sleep; Sleep Stages; Sle | 1983 |
Overnight sedation with midazolam or propofol in the ICU: effects on sleep quality, anxiety and depression.
Topics: Adult; Aged; Anxiety; Critical Care; Depression; Female; Hemodynamics; Humans; Hypnotics and Sedativ | 1996 |
Effects of midazolam on sleep disturbances associated with westward and eastward flights: evidence for directional effects.
Topics: Adult; Circadian Rhythm; Double-Blind Method; Female; Humans; Male; Midazolam; Middle Aged; Sleep Wa | 1990 |
[Treatment of situation-related sleep disorders with midazolam and triazolam--a comparative study of athletes].
Topics: Adult; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Male | 1986 |
[Double-blind parallel comparison of midazolam and triazolam in sleep disorders in the aged].
Topics: Age Factors; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Midazolam; M | 1987 |
Comparison of midazolam and oxazepam as hypnotics in elderly hospitalized patients. A double-blind clinical trial.
Topics: Aged; Aged, 80 and over; Aging; Body Weight; Clinical Trials as Topic; Double-Blind Method; Dreams; | 1988 |
8 other studies available for midazolam and Sleep Wake Disorders
| Article | Year |
|---|---|
Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex.
Topics: Analysis of Variance; Animals; Anisoles; Disease Models, Animal; Electroencephalography; Electromyog | 2011 |
Evaluation of efficacy and safety of midazolam administered orally in sleep disorders. A dose-finding study.
Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; Drug Evaluation | 1981 |
Proceedings of the First International Sleep Symposium on Midazolam. 25-26 June 1981, St Moritz, Switzerland.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Humans; Midazolam; Sleep Wake Disorders | 1983 |
Pharmacokinetic and clinical considerations in the choice of a hypnotic.
Topics: Anti-Anxiety Agents; Benzodiazepines; Drug Utilization; Humans; Hypnotics and Sedatives; Kinetics; M | 1983 |
Sleep disorders. Steroids cause sleep disturbance.
Topics: Adult; Dexamethasone; Humans; Male; Midazolam; Sleep Wake Disorders; Steroids | 1993 |
Use of Dormicum sleeping pills in everyday practice.
Topics: Adult; Aged; Aged, 80 and over; Drug Evaluation; Family Practice; Female; Humans; Male; Midazolam; M | 1992 |
[Confusional states following administration of the hypnotic midazolam].
Topics: Adolescent; Adult; Amnesia; Benzodiazepines; Cognition Disorders; Confusion; Female; Humans; Hypnoti | 1985 |
[Approval of midazolam as a sedative is undesirable].
Topics: Humans; Midazolam; Sleep Wake Disorders; Substance-Related Disorders | 1986 |