midazolam has been researched along with Serotonin Syndrome in 7 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present 3 cases of severe serotonin syndrome in adolescents requiring intubation that were refractory to midazolam and/or propofol." | 7.80 | Dexmedetomidine in the treatment of serotonin syndrome. ( Charlton, NP; Rushton, WF, 2014) |
| "To report a case of serotonin syndrome (SS) after sibutramine overdose in a child." | 7.75 | Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma. ( Barros, RF; Bucaretchi, F; da Costa, JL; de Capitani, EM; Fernandes, LC; Hyslop, S; Lanaro, R; Mello, SM, 2009) |
| "8-OH-DPAT-treated rats showed serotonin syndrome-like behaviors (low body posture, forepaw treading), hyperlocomotion, and decreased body temperature, which were completely inhibited by pretreatment with WAY 100635, a selective 5-HT1A antagonist (n = 8)." | 5.42 | A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats. ( Eguchi, S; Iwata, H; Kadono, T; Kaminaga, S; Kawano, T; Takahashi, T; Yamanaka, D; Yokoyama, M, 2015) |
| "Even small doses of fentanyl administered to patients taking multiple serotonergic medications and herbal supplements may trigger serotonin syndrome." | 3.85 | Serotonergic medications, herbal supplements, and perioperative serotonin syndrome. ( Naranjo, J; Pollard, EM; Sprung, J; Warner, MA; Warner, ME; Weingarten, TN, 2017) |
| "We present 3 cases of severe serotonin syndrome in adolescents requiring intubation that were refractory to midazolam and/or propofol." | 3.80 | Dexmedetomidine in the treatment of serotonin syndrome. ( Charlton, NP; Rushton, WF, 2014) |
| "A 6-year-old girl displayed symptoms of serotonin syndrome after accidental ingestion of Vyvanse (lisdexamfetamine dimesylate)." | 3.78 | Dexmedetomidine to treat lisdexamfetamine overdose and serotonin toxidrome in a 6-year-old girl. ( Akingbola, OA; Singh, D, 2012) |
| "To report a case of serotonin syndrome (SS) after sibutramine overdose in a child." | 3.75 | Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma. ( Barros, RF; Bucaretchi, F; da Costa, JL; de Capitani, EM; Fernandes, LC; Hyslop, S; Lanaro, R; Mello, SM, 2009) |
| "BACKGROUND Serotonin syndrome is a life-threatening condition that can lead to neurologic complications and is associated with the use of serotonergic medications." | 1.48 | Serotonin Syndrome in the Perioperative Setting. ( Nookala, AU; Olatoye, OO; Pollard, EM; Smischney, NJ, 2018) |
| "8-OH-DPAT-treated rats showed serotonin syndrome-like behaviors (low body posture, forepaw treading), hyperlocomotion, and decreased body temperature, which were completely inhibited by pretreatment with WAY 100635, a selective 5-HT1A antagonist (n = 8)." | 1.42 | A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats. ( Eguchi, S; Iwata, H; Kadono, T; Kaminaga, S; Kawano, T; Takahashi, T; Yamanaka, D; Yokoyama, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warner, ME | 1 |
| Naranjo, J | 1 |
| Pollard, EM | 2 |
| Weingarten, TN | 1 |
| Warner, MA | 1 |
| Sprung, J | 1 |
| Smischney, NJ | 1 |
| Nookala, AU | 1 |
| Olatoye, OO | 1 |
| Rushton, WF | 1 |
| Charlton, NP | 1 |
| Kawano, T | 1 |
| Takahashi, T | 1 |
| Kaminaga, S | 1 |
| Kadono, T | 1 |
| Yamanaka, D | 1 |
| Iwata, H | 1 |
| Eguchi, S | 1 |
| Yokoyama, M | 1 |
| Zhang, P | 1 |
| Austin, E | 1 |
| Thompson, M | 1 |
| Lin, S | 1 |
| Bucaretchi, F | 1 |
| de Capitani, EM | 1 |
| Mello, SM | 1 |
| Lanaro, R | 1 |
| Barros, RF | 1 |
| Fernandes, LC | 1 |
| da Costa, JL | 1 |
| Hyslop, S | 1 |
| Akingbola, OA | 1 |
| Singh, D | 1 |
7 other studies available for midazolam and Serotonin Syndrome
| Article | Year |
|---|---|
Serotonergic medications, herbal supplements, and perioperative serotonin syndrome.
Topics: Aged; Curcuma; Dietary Supplements; Drug Interactions; Fentanyl; Fluoxetine; Humans; Male; Midazolam | 2017 |
Serotonin Syndrome in the Perioperative Setting.
Topics: Aged; Humans; Hypnotics and Sedatives; Male; Midazolam; Prostatectomy; Prostatic Hyperplasia; Seroto | 2018 |
Dexmedetomidine in the treatment of serotonin syndrome.
Topics: Adolescent; Adrenergic alpha-Agonists; Benzodiazepines; Dexmedetomidine; Female; Humans; Hypnotics a | 2014 |
A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzodiazepines; Dexmedetomidine; Hypnotics and Sed | 2015 |
Challenges in a large mixed drug overdose patient.
Topics: Adult; Anticonvulsants; Body Temperature Regulation; Critical Care; Delirium; Diazepam; Drug Overdos | 2016 |
Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma.
Topics: Antidotes; Appetite Depressants; Child, Preschool; Chloral Hydrate; Chromatography, High Pressure Li | 2009 |
Dexmedetomidine to treat lisdexamfetamine overdose and serotonin toxidrome in a 6-year-old girl.
Topics: Adrenergic alpha-2 Receptor Agonists; Anti-Anxiety Agents; Central Nervous System Stimulants; Child; | 2012 |