midazolam has been researched along with Sensitivity and Specificity in 83 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This investigation determined the ability of alfentanil miosis and single-point concentrations to detect various degrees of CYP3A inhibition." | 9.11 | Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. ( Hoffer, C; Kharasch, ED; Sheffels, P; Walker, A, 2005) |
| "The objective of this article is to evaluate the effect of dexmedetomidine on emergence agitation (EA) and recovery profiles in children after sevoflurane anesthesia and its pharmacological mechanisms." | 8.91 | Meta-analysis of dexmedetomidine on emergence agitation and recovery profiles in children after sevoflurane anesthesia: different administration and different dosage. ( Niu, K; Wang, G; Wang, H; Zhu, A; Zhu, M, 2015) |
| "Routine use of midazolam could not reduce the occurrence of radial artery spasm during transradial coronary angiography." | 5.22 | Procedural sedation during transradial coronary angiography to prevent spasm. ( Agus, HZ; Astarcioglu, MA; Dogan, A; Durmus, HI; Gozubuyuk, G; Kalcik, M; Karakoyun, S; Kilit, C; Ozkan, M; Sen, T; Yesin, M, 2016) |
| "This investigation determined the ability of alfentanil miosis and single-point concentrations to detect various degrees of CYP3A inhibition." | 5.11 | Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. ( Hoffer, C; Kharasch, ED; Sheffels, P; Walker, A, 2005) |
| "The objective of this article is to evaluate the effect of dexmedetomidine on emergence agitation (EA) and recovery profiles in children after sevoflurane anesthesia and its pharmacological mechanisms." | 4.91 | Meta-analysis of dexmedetomidine on emergence agitation and recovery profiles in children after sevoflurane anesthesia: different administration and different dosage. ( Niu, K; Wang, G; Wang, H; Zhu, A; Zhu, M, 2015) |
| " The data suggest that dosing diltiazem XR for 2 days predicts the change in midazolam AUC as reliably as 5 days of XR dosing and 2 days of CR dosing." | 2.76 | Effect of different durations and formulations of diltiazem on the single-dose pharmacokinetics of midazolam: how long do we go? ( Bergman, AJ; Chodakewitz, J; Fraser, IP; Friedman, EJ; Larson, PJ; Li, CC; Stoch, SA; Wagner, JA; Wang, YH, 2011) |
| " Further studies should address the optimization of dosing and lock out setting." | 2.74 | Remifentanil vs. meperidine for patient-controlled analgesia during colonoscopy: a randomized double-blind trial. ( Agostoni, M; Alberto, TP; Antonio, F; Facciorusso, A; Fanti, L; Gambino, G; Gemma, M; Giorgio, T; Giulia, G; Guslandi, M; Marco, G; Mario, G; Massimo, A; Testoni, PA; Torri, G, 2009) |
| " Pharmacokinetic and pharmacodynamic data were simultaneously fitted to a semiparametric model." | 2.68 | Simultaneous modeling of the pharmacokinetics and pharmacodynamics of midazolam and diazepam. ( Choma, N; Crews, T; DeFeo, TM; Limjuco, R; Milla, G; Mould, DR; Patel, IH; Reele, S, 1995) |
| "Midazolam was not a substrate for any of the tested transporters." | 2.44 | Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. ( Baker, SD; Franke, RM; Mathijssen, RH; Schuetz, EG; Sparreboom, A, 2008) |
| " Multiple models have been developed for midazolam, the typical probe substrate for CYP3A activity, but no population pharmacokinetic models have been developed for use with inhibition or induction." | 1.56 | Composite midazolam and 1'-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity. ( Meid, AD; Mikus, G; Wiebe, ST, 2020) |
| "Midazolam was administered to all patients." | 1.46 | Bronchoscopic diagnosis of peripheral pulmonary lung cancer employing sedation with fentanyl and midazolam. ( Ando, C; Fujiwara, K; Iwamoto Md, Y; Minami, D; Nakasuka, T; Sato, K; Sato, T; Shibayama, T; Yonei Md PhD, T, 2017) |
| "Midazolam is a commonly used marker substrate for the in vivo assessment of CYP3A activity." | 1.46 | An ultra-sensitive LC-MS/MS method to determine midazolam levels in human plasma: development, validation and application to a clinical study. ( Chen, M; Fraier, D; Kang, L; Lin, ZJ; Lu, W; Lu, Y; Ottaviani, G; Wang, W; Zhao, H, 2017) |
| "One hundred sixty consecutive cardiac arrest patients treated with therapeutic hypothermia." | 1.40 | Early bispectral index and sedation requirements during therapeutic hypothermia predict neurologic recovery following cardiac arrest. ( Billings, FT; Burjek, NE; Hollenbeck, RD; McPherson, JA; Wagner, CE; Wang, L; Yu, C, 2014) |
| "Pleuroscopy is considered a safe procedure with a high diagnostic accuracy but this record is based on studies published by pulmonologists experienced in performing the procedure." | 1.39 | Safety and accuracy of semirigid pleuroscopy performed by pulmonary fellows at a major university hospital: our initial experience. ( Bajwa, AA; Cury, JD; Jones, L; Shujaat, A; Usman, F, 2013) |
| "Midazolam (MDZ) was used as a substrate for phenotyping CYP3A4 activity; the concentrations of MDZ and its main metabolite 1'-hydroxymidazolam (1-OH MDZ) were compared between the DBS method from finger punctures, plasma and whole blood (WB), drawn by venipuncture, whereby several methodological parameters were studied (i." | 1.37 | Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers. ( Chen, L; de Boer, T; den Daas, I; Meulman, E; Renkema, G; Reuvers, M; van Iersel, T; Wemer, J; Wieling, J, 2011) |
| "Midazolam-d4 was used as an internal standard for the determination of parent drug and its active metabolite." | 1.37 | Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam. ( Jarho, P; Kaartama, R; Kokki, H; Lehtonen, M; Savolainen, J, 2011) |
| " The method is simple, rapid and rugged, and has been applied successfully to sample analysis in support of a drug-drug interaction study." | 1.36 | Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions. ( Bertelsen, K; Guo, P; Han, F; Huang, MQ; Lin, ZJ; Weng, N; Zhang, W; Zhao, H, 2010) |
| "Midazolam is an ultra short acting benzodiazepine derivative and a specific probe for phenotyping cytochrome P450 (P450) 3A4/5 activity." | 1.36 | Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1'-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry. ( Akhlaghi, F; Chitnis, SD; Dostalek, M; Ionita, IA; Macwan, JS, 2010) |
| " The pharmacokinetic profile of intravenous midazolam was characterized before and after itraconazole administration (200 mg once daily for 4 days) and also after rifampin (INN, rifampicin) pretreatment (600 mg once daily for 10 days), with a washout period of 2 weeks in between." | 1.32 | Effect of the CYP3A5 genotype on the pharmacokinetics of intravenous midazolam during inhibited and induced metabolic states. ( Cho, JY; Chung, JY; Hong, KS; Jang, IJ; Kim, JR; Lim, HS; Liu, KH; Oh, DS; Shin, JG; Shin, SG; Yi, SY; Yu, KS, 2004) |
| "Based on a few reports that describe obstructive sleep apnea (OSA) patients as having an increased risk of acute upper airway obstruction (UAO) after pharmacological sedation, this population is less likely to receive sedation prior to surgery." | 1.31 | Preoperative sedation in pediatric patients with sleep-disordered breathing. ( Bennett, GH; Bernstein, J; Cultrara, A; Goldstein, N; Lazar, C, 2002) |
| " Cumulative dose-response curves for chlordiazepoxide were obtained before and during chronic chlordiazepoxide administration and during chronic saline administration." | 1.29 | Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity. ( Alastra, AJ; Cohen, C; Goldberg, SR; Marley, RJ; Sannerud, CA; Serdikoff, SL, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (22.89) | 18.2507 |
| 2000's | 39 (46.99) | 29.6817 |
| 2010's | 22 (26.51) | 24.3611 |
| 2020's | 3 (3.61) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 1 |
| Sun, Y | 1 |
| He, Z | 1 |
| Eagles, SK | 1 |
| Wang, X | 1 |
| Gross, AS | 1 |
| McLachlan, AJ | 1 |
| Wiebe, ST | 1 |
| Meid, AD | 1 |
| Mikus, G | 1 |
| do Nascimento, SB | 1 |
| de Lima Nascimento, M | 1 |
| Duarte-Almeida, JM | 1 |
| de Oliveira, FM | 1 |
| do Carmo Vieira, M | 1 |
| Siqueira, JM | 1 |
| de Andrade, FP | 1 |
| da Costa César, I | 1 |
| de Castro, WV | 1 |
| Minami, D | 1 |
| Nakasuka, T | 1 |
| Ando, C | 1 |
| Iwamoto Md, Y | 1 |
| Sato, K | 1 |
| Fujiwara, K | 1 |
| Shibayama, T | 1 |
| Yonei Md PhD, T | 1 |
| Sato, T | 1 |
| Muhlhofer, WG | 1 |
| Layfield, S | 1 |
| Lowenstein, D | 1 |
| Lin, CP | 1 |
| Johnson, RD | 1 |
| Saini, S | 1 |
| Szaflarski, JP | 1 |
| Mooiman, KD | 1 |
| Maas-Bakker, RF | 1 |
| Rosing, H | 1 |
| Beijnen, JH | 1 |
| Schellens, JH | 1 |
| Meijerman, I | 1 |
| Shujaat, A | 1 |
| Bajwa, AA | 1 |
| Usman, F | 1 |
| Jones, L | 1 |
| Cury, JD | 1 |
| Burjek, NE | 1 |
| Wagner, CE | 1 |
| Hollenbeck, RD | 1 |
| Wang, L | 1 |
| Yu, C | 1 |
| McPherson, JA | 1 |
| Billings, FT | 1 |
| Liu, LY | 1 |
| Han, YL | 1 |
| Zhu, JH | 1 |
| Yu, Q | 1 |
| Yang, QJ | 1 |
| Lu, J | 1 |
| Guo, C | 1 |
| Jeyabalan, A | 1 |
| Medford, AR | 1 |
| Oliveira, RV | 1 |
| Henion, J | 2 |
| Wickremsinhe, ER | 1 |
| Arnhard, K | 1 |
| Gottschall, A | 1 |
| Pitterl, F | 1 |
| Oberacher, H | 1 |
| Zhu, M | 1 |
| Wang, H | 1 |
| Zhu, A | 1 |
| Niu, K | 1 |
| Wang, G | 1 |
| Astarcioglu, MA | 1 |
| Sen, T | 1 |
| Kilit, C | 1 |
| Durmus, HI | 1 |
| Gozubuyuk, G | 1 |
| Agus, HZ | 1 |
| Kalcik, M | 1 |
| Karakoyun, S | 1 |
| Yesin, M | 1 |
| Dogan, A | 1 |
| Ozkan, M | 1 |
| Dhooria, S | 1 |
| Sehgal, IS | 1 |
| Gupta, N | 1 |
| Aggarwal, AN | 1 |
| Behera, D | 1 |
| Agarwal, R | 1 |
| Chen, M | 1 |
| Lu, W | 1 |
| Lu, Y | 1 |
| Kang, L | 1 |
| Zhao, H | 2 |
| Lin, ZJ | 2 |
| Wang, W | 1 |
| Fraier, D | 1 |
| Ottaviani, G | 1 |
| Franke, RM | 1 |
| Baker, SD | 1 |
| Mathijssen, RH | 1 |
| Schuetz, EG | 1 |
| Sparreboom, A | 2 |
| Link, B | 1 |
| Haschke, M | 1 |
| Grignaschi, N | 1 |
| Bodmer, M | 1 |
| Aschmann, YZ | 1 |
| Wenk, M | 1 |
| Krähenbühl, S | 1 |
| Dewitt, J | 1 |
| McGreevy, K | 1 |
| Sherman, S | 1 |
| Imperiale, TF | 1 |
| Youdim, KA | 1 |
| Lyons, R | 1 |
| Payne, L | 1 |
| Jones, BC | 1 |
| Saunders, K | 1 |
| Zhang, S | 1 |
| Song, N | 1 |
| Li, Q | 1 |
| Fan, H | 1 |
| Liu, C | 1 |
| Morillo, JS | 1 |
| Ripoll, JS | 1 |
| Roldán, CS | 1 |
| Pérez, ME | 1 |
| Bellido, PV | 1 |
| Vázquez, JS | 1 |
| Fanti, L | 1 |
| Agostoni, M | 1 |
| Massimo, A | 1 |
| Gemma, M | 1 |
| Marco, G | 1 |
| Gambino, G | 1 |
| Giulia, G | 1 |
| Facciorusso, A | 1 |
| Antonio, F | 1 |
| Guslandi, M | 1 |
| Mario, G | 1 |
| Torri, G | 1 |
| Giorgio, T | 1 |
| Testoni, PA | 1 |
| Alberto, TP | 1 |
| Leung, JW | 1 |
| Mann, SK | 1 |
| Siao-Salera, R | 1 |
| Ransibrahmanakul, K | 1 |
| Lim, B | 1 |
| Cabrera, H | 1 |
| Canete, W | 1 |
| Barredo, P | 1 |
| Gutierrez, R | 1 |
| Leung, FW | 1 |
| Zhang, W | 1 |
| Han, F | 1 |
| Guo, P | 1 |
| Huang, MQ | 1 |
| Bertelsen, K | 1 |
| Weng, N | 1 |
| Dostalek, M | 2 |
| Macwan, JS | 1 |
| Chitnis, SD | 1 |
| Ionita, IA | 1 |
| Akhlaghi, F | 1 |
| Cortright, KA | 1 |
| Wetzlich, SE | 1 |
| Craigmill, AL | 1 |
| de Loor, H | 1 |
| de Jonge, H | 1 |
| Verbeke, K | 1 |
| Vanrenterghem, Y | 1 |
| Kuypers, DR | 1 |
| Friedman, EJ | 1 |
| Fraser, IP | 1 |
| Wang, YH | 1 |
| Bergman, AJ | 1 |
| Li, CC | 1 |
| Larson, PJ | 1 |
| Chodakewitz, J | 1 |
| Wagner, JA | 1 |
| Stoch, SA | 1 |
| de Boer, T | 1 |
| Wieling, J | 1 |
| Meulman, E | 1 |
| Reuvers, M | 1 |
| Renkema, G | 1 |
| den Daas, I | 1 |
| van Iersel, T | 1 |
| Wemer, J | 1 |
| Chen, L | 1 |
| Kaartama, R | 1 |
| Jarho, P | 1 |
| Savolainen, J | 1 |
| Kokki, H | 1 |
| Lehtonen, M | 1 |
| Ravesloot, MJ | 1 |
| de Vries, N | 1 |
| Gupta, S | 1 |
| Macneil, R | 1 |
| Bryson, G | 1 |
| Ghassabian, S | 1 |
| Moosavi, SM | 1 |
| Valero, YG | 1 |
| Shekar, K | 1 |
| Fraser, JF | 1 |
| Smith, MT | 1 |
| Shou, WZ | 1 |
| Chen, YL | 1 |
| Eerkes, A | 1 |
| Tang, YQ | 1 |
| Magis, L | 1 |
| Jiang, X | 1 |
| Naidong, W | 1 |
| Cultrara, A | 1 |
| Bennett, GH | 1 |
| Lazar, C | 1 |
| Bernstein, J | 1 |
| Goldstein, N | 1 |
| Shiran, MR | 1 |
| Gregory, A | 1 |
| Rostami-Hodjegan, A | 1 |
| Tucker, GT | 1 |
| Lennard, MS | 1 |
| ter Horst, PG | 1 |
| Foudraine, NA | 1 |
| Cuypers, G | 1 |
| van Dijk, EA | 1 |
| Oldenhof, NJ | 1 |
| Laviana, L | 1 |
| Llorente, I | 1 |
| Bayod, M | 1 |
| Blanco, D | 1 |
| Kapron, JT | 1 |
| Pace, E | 1 |
| Van Pelt, CK | 1 |
| Saraswat, LD | 1 |
| Caserta, KA | 1 |
| Laws, K | 1 |
| Wei, D | 1 |
| Jones, SS | 1 |
| Adedoyin, A | 1 |
| Harris, SR | 1 |
| Gedge, JI | 1 |
| Nedderman, AN | 1 |
| Roffey, SJ | 1 |
| Savage, M | 1 |
| Lepper, ER | 1 |
| Hicks, JK | 1 |
| Verweij, J | 1 |
| Zhai, S | 1 |
| Figg, WD | 1 |
| Wilkinson, GR | 1 |
| Yu, KS | 1 |
| Cho, JY | 1 |
| Jang, IJ | 1 |
| Hong, KS | 1 |
| Chung, JY | 1 |
| Kim, JR | 1 |
| Lim, HS | 1 |
| Oh, DS | 1 |
| Yi, SY | 1 |
| Liu, KH | 1 |
| Shin, JG | 1 |
| Shin, SG | 1 |
| Jerdi, MC | 1 |
| Daali, Y | 1 |
| Oestreicher, MK | 1 |
| Cherkaoui, S | 1 |
| Dayer, P | 1 |
| Plumb, R | 1 |
| Castro-Perez, J | 1 |
| Granger, J | 1 |
| Beattie, I | 1 |
| Joncour, K | 1 |
| Wright, A | 1 |
| Yasui-Furukori, N | 1 |
| Inoue, Y | 2 |
| Tateishi, T | 1 |
| Quintela, O | 1 |
| Cruz, A | 1 |
| Concheiro, M | 1 |
| de Castro, A | 1 |
| López-Rivadulla, M | 1 |
| Salo, PK | 1 |
| Salomies, H | 1 |
| Harju, K | 1 |
| Ketola, RA | 1 |
| Kotiaho, T | 1 |
| Yli-Kauhaluoma, J | 1 |
| Kostiainen, R | 1 |
| Muchohi, SN | 1 |
| Ward, SA | 1 |
| Preston, L | 1 |
| Newton, CR | 1 |
| Edwards, G | 1 |
| Kokwaro, GO | 1 |
| Jabor, VA | 1 |
| Coelho, EB | 1 |
| Dos Santos, NA | 1 |
| Bonato, PS | 1 |
| Lanchote, VL | 1 |
| Kharasch, ED | 1 |
| Walker, A | 1 |
| Hoffer, C | 1 |
| Sheffels, P | 1 |
| Huang, YY | 1 |
| Chu, YC | 1 |
| Chang, KY | 1 |
| Wang, YC | 1 |
| Chan, KH | 1 |
| Tsou, MY | 1 |
| Di, L | 1 |
| Kerns, EH | 1 |
| Li, SQ | 1 |
| Carter, GT | 1 |
| Collie, A | 1 |
| Darekar, A | 1 |
| Weissgerber, G | 1 |
| Toh, MK | 1 |
| Snyder, PJ | 1 |
| Maruff, P | 1 |
| Huggins, JP | 1 |
| Jurica, J | 1 |
| Konecný, J | 1 |
| Glatz, Z | 1 |
| Hadasová, E | 1 |
| Tomandl, J | 1 |
| Li, W | 1 |
| Luo, S | 1 |
| Smith, HT | 1 |
| Tse, FL | 1 |
| Bytzer, P | 1 |
| Lindeberg, B | 1 |
| Malviya, S | 1 |
| Voepel-Lewis, T | 1 |
| Tait, AR | 1 |
| Watcha, MF | 1 |
| Sadhasivam, S | 1 |
| Friesen, RH | 1 |
| Qadeer, MA | 1 |
| Vargo, JJ | 1 |
| Patel, S | 1 |
| Dumot, JA | 1 |
| Lopez, AR | 1 |
| Trolli, PA | 1 |
| Conwell, DL | 1 |
| Stevens, T | 1 |
| Zuccaro, G | 1 |
| Acri, JB | 1 |
| Wong, G | 1 |
| Witkin, JM | 1 |
| Salord, F | 1 |
| Pelissou-Guyotat, I | 1 |
| Peillon, D | 1 |
| Chacornac, R | 1 |
| Mould, DR | 1 |
| DeFeo, TM | 1 |
| Reele, S | 1 |
| Milla, G | 1 |
| Limjuco, R | 1 |
| Crews, T | 1 |
| Choma, N | 1 |
| Patel, IH | 1 |
| Ben-David, B | 1 |
| Vaida, S | 1 |
| Gaitini, L | 1 |
| Lauber, R | 1 |
| Mosimann, M | 1 |
| Bührer, M | 1 |
| Zbinden, AM | 1 |
| Mastey, V | 1 |
| Panneton, AC | 1 |
| Donati, F | 1 |
| Varin, F | 1 |
| Sannerud, CA | 1 |
| Marley, RJ | 1 |
| Serdikoff, SL | 1 |
| Alastra, AJ | 1 |
| Cohen, C | 1 |
| Goldberg, SR | 1 |
| Lehmann, B | 1 |
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| Banditt, P | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Efficacy Evaluation of Remimazolam for Endoscopic Ultrasound-guided Fine Needle Aspiration/Biopsy[NCT05437497] | 264 participants (Anticipated) | Interventional | 2021-08-01 | Recruiting | |||
| The Comparison of Two Different Techniques of Remifentanil Consumption During Implantable Vascular Access Device Procedures[NCT04749069] | 107 participants (Actual) | Interventional | 2012-08-01 | Completed | |||
| A Randomized, Controlled Trial Comparing Maximal and Half-maximal Suction Pressure Applied During Water Exchange in Colonoscopy[NCT01948284] | 74 participants (Anticipated) | Interventional | 2013-08-31 | Recruiting | |||
| Comparative Efficacy of Water & Indigo Carmine vs Water or Air Method[NCT01607255] | Phase 4 | 480 participants (Actual) | Interventional | 2013-05-16 | Completed | ||
| A Randomized Controlled Comparison of Warm Water Infusion in Lieu of Air Insufflation vs. Air Insufflation for Aiding Colonoscopy Insertion in Sedated Patients Undergoing Colorectal Cancer (CRC) Screening and Surveillance.[NCT00785889] | 56 participants (Actual) | Interventional | 2008-03-31 | Completed | |||
| Comparison of Study Method Versus Conventional Method for Performing Unsedated Colonoscopy for Colorectal Cancer Screening and Surveillance[NCT01383252] | 10 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| Randomized Controlled Trial (RCT) to Compare Adenoma Detection Rate of Combined Chromoendoscopy (Indigo Carmine) With Water Infusion in Lieu of Air Insufflation (Water Method) vs. Water Method Alone in Screening Colonoscopy[NCT01383265] | 1,177 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| Water Colonoscopy Versus Air Colonoscopy for Unsedated Patients With Prior Abdominal or Pelvic Surgery: a Prospective Randomized, Controlled Trial[NCT01485133] | 110 participants (Actual) | Observational | 2011-11-30 | Completed | |||
| Comparing Air Insufflation, Water Immersion and Water Exchange Methods During Minimal Sedated Colonoscopy, a Randomized, Controlled Trial[NCT01535326] | 270 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| Water Infusion and Carbon Dioxide Insufflation Versus Air Insufflation Versus Air Insufflation Techniques in Screening Colonoscopies in the United States: A Comparative Study Evaluating Safety, Efficacy and Adenoma Detection Rate (ADR)[NCT01782014] | Phase 3 | 450 participants (Anticipated) | Interventional | 2013-02-28 | Terminated | ||
| Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone in Human Subjects[NCT00504413] | Phase 1 | 20 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| Bispectral Index Monitoring for Sedation in Elective Colonoscopies of Adult Patients: a Randomized Controlled Trial[NCT03453359] | 180 participants (Actual) | Interventional | 2018-01-28 | Completed | |||
| The Effect of Caudal Anesthesia Block on Perioperative Pain Control and Reduction of the Anesthetic Agent in Pediatric Infra-umbilical Surgery: A Prospective Randomized Trial Study[NCT05581940] | 72 participants (Actual) | Observational [Patient Registry] | 2020-01-05 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Proximal diminutive adenoma detection rate (ADR) in screening colonoscopy performed with the unusual air method, versus the water (exchange) method and with dye added to the water (exchange) method (NCT01607255)
Timeframe: 36 months
| Intervention | participants (Number) | |
|---|---|---|
| Proximal ADR | Serrated Lesion | |
| Air Method | 83 | 18 |
| Water (Exchange) Method | 86 | 38 |
| Water (Exchange) Plus Dye Method | 89 | 42 |
the number of participants with at least one adenoma in each of the study groups. (NCT01535326)
Timeframe: 9 to 12 months
| Intervention | participants (Number) |
|---|---|
| Air Insufflation | 39 |
| Water Immersion | 41 |
| Water Exchange | 51 |
The maximal pain score during insertion phase of colonoscopy was assessed with 0 to 10 scale VAS score (0: no pain; 10: maximal pain) (NCT01535326)
Timeframe: 9 to 12 months
| Intervention | units on a scale (Median) |
|---|---|
| Air Insufflation | 3.5 |
| Water Immersion | 1.8 |
| Water Exchange | 0 |
satisfaction score obtained after colonoscopy 0 = no satisfied; 10 = most satisfied (NCT01535326)
Timeframe: 9 to 12 months
| Intervention | units on a scale (Median) |
|---|---|
| Air Insufflation | 10 |
| Water Immersion | 10 |
| Water Exchange | 10 |
proportion of patients without insertion pain during colonoscopy (NCT01535326)
Timeframe: up to 12 months
| Intervention | participants (Number) |
|---|---|
| Air Insufflation | 27 |
| Water Immersion | 39 |
| Water Exchange | 55 |
3 reviews available for midazolam and Sensitivity and Specificity
| Article | Year |
|---|---|
Meta-analysis of dexmedetomidine on emergence agitation and recovery profiles in children after sevoflurane anesthesia: different administration and different dosage.
Topics: Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Child; Dexmedetomidine; Fentanyl; H | 2015 |
Influence of solute carriers on the pharmacokinetics of CYP3A4 probes.
Topics: Breath Tests; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Administration Schedule | 2008 |
Effect of age and sedative agent on the accuracy of bispectral index in detecting depth of sedation in children.
Topics: Adolescent; Age Factors; Analgesics, Opioid; Anesthetics, Dissociative; Child; Child, Preschool; Chl | 2007 |
13 trials available for midazolam and Sensitivity and Specificity
67 other studies available for midazolam and Sensitivity and Specificity
| Article | Year |
|---|---|
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.
Topics: Biosensing Techniques; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Syste | 2020 |
Composite midazolam and 1'-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity.
Topics: Adult; Area Under Curve; Biological Variation, Population; Cytochrome P-450 CYP3A; Cytochrome P-450 | 2020 |
Validation of a HPLC method for quantification of midazolam in rat plasma: Application during a Maytenus ilicifolia-drug interaction study.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Herb-Drug Interactions; Linea | 2021 |
Bronchoscopic diagnosis of peripheral pulmonary lung cancer employing sedation with fentanyl and midazolam.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biopsy; Bronchoscopy; Carcinoma, Squamous Cell; Conscious S | 2017 |
Duration of therapeutic coma and outcome of refractory status epilepticus.
Topics: Adult; Aged; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Causality; Conf | 2019 |
Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures.
Topics: Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Stability; H | 2013 |
Safety and accuracy of semirigid pleuroscopy performed by pulmonary fellows at a major university hospital: our initial experience.
Topics: Fellowships and Scholarships; Female; Fentanyl; Hospitals, University; Humans; Male; Midazolam; Midd | 2013 |
Early bispectral index and sedation requirements during therapeutic hypothermia predict neurologic recovery following cardiac arrest.
Topics: Adult; Aged; Central Nervous System; Cohort Studies; Consciousness Monitors; Female; Fentanyl; Heart | 2014 |
A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates.
Topics: Bupropion; Calibration; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 | 2015 |
Endobronchial ultrasound-guided transbronchial needle aspiration: patient satisfaction under light conscious sedation.
Topics: Anesthetics, Intravenous; Bronchoscopy; Carcinoma; Conscious Sedation; Endoscopic Ultrasound-Guided | 2014 |
Automated high-capacity on-line extraction and bioanalysis of dried blood spot samples using liquid chromatography/high-resolution accurate mass spectrometry.
Topics: Automation; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Linear Models; Male; Midazolam | 2014 |
Applying 'Sequential Windowed Acquisition of All Theoretical Fragment Ion Mass Spectra' (SWATH) for systematic toxicological analysis with liquid chromatography-high-resolution tandem mass spectrometry.
Topics: Chromatography, Liquid; Forensic Toxicology; Humans; Lidocaine; Midazolam; Morphine; Sensitivity and | 2015 |
Diagnostic Yield and Complications of EBUS-TBNA Performed Under Bronchoscopist-directed Conscious Sedation: Single Center Experience of 1004 Subjects.
Topics: Adult; Bronchoscopy; Conscious Sedation; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Female | 2017 |
An ultra-sensitive LC-MS/MS method to determine midazolam levels in human plasma: development, validation and application to a clinical study.
Topics: Chromatography, Liquid; Drug Stability; Humans; Midazolam; Reproducibility of Results; Sensitivity a | 2017 |
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.
Topics: Aryl Hydrocarbon Hydroxylases; Biological Assay; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cy | 2008 |
Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.
Topics: Animals; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 | 2008 |
[The bispectral index as a predictor of anterograde amnesia caused by premedication with intranasal midazolam].
Topics: Administration, Intranasal; Amnesia, Anterograde; Electroencephalography; Female; Humans; Hypnotics | 2008 |
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions.
Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Discovery; Drug Inter | 2010 |
Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1'-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry.
Topics: Chromatography, Liquid; Humans; Least-Squares Analysis; Microsomes, Liver; Midazolam; Reproducibilit | 2010 |
A highly sensitive liquid chromatography tandem mass spectrometry method for simultaneous quantification of midazolam, 1'-hydroxymidazolam and 4-hydroxymidazolam in human plasma.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Kidney Transplantation; Midazolam; Non | 2011 |
Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers.
Topics: Adult; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Stabilit | 2011 |
Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam.
Topics: Administration, Sublingual; Animals; Area Under Curve; Drug Stability; Gas Chromatography-Mass Spect | 2011 |
One hundred consecutive patients undergoing drug-induced sleep endoscopy: results and evaluation.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Cohort Studies; Endoscopy; Female; Humans; Male; | 2011 |
Laryngoscopy in conscious patients with remifentanil: how useful is an "awake look"?
Topics: Adult; Anesthetics, Intravenous; Canada; Elective Surgical Procedures; Female; Humans; Laryngoscopy; | 2012 |
High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS.
Topics: Chromatography, Liquid; Drug Stability; Fentanyl; High-Throughput Screening Assays; Humans; Linear M | 2012 |
Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns.
Topics: Animals; Chromatography, Liquid; Humans; Macaca fascicularis; Midazolam; Morphine; Morphine Derivati | 2002 |
Preoperative sedation in pediatric patients with sleep-disordered breathing.
Topics: Academic Medical Centers; Adenoidectomy; Adolescent; Airway Resistance; Child; Child, Preschool; Con | 2002 |
Determination of midazolam and 1'-hydroxymidazolam by liquid chromatography-mass spectrometry in plasma of patients undergoing methadone maintenance treatment.
Topics: Adjuvants, Anesthesia; Anti-Anxiety Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Metha | 2003 |
Simultaneous determination of levomepromazine, midazolam and their major metabolites in human plasma by reversed-phase liquid chromatography.
Topics: Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Humans; Hypnotics and Sedatives; Met | 2003 |
In-process control of midazolam synthesis by HPLC.
Topics: Chromatography, High Pressure Liquid; Hypnotics and Sedatives; Manganese Compounds; Midazolam; Oxide | 2003 |
Quantitation of midazolam in human plasma by automated chip-based infusion nanoelectrospray tandem mass spectrometry.
Topics: Automation; Calibration; Drug Monitoring; Humans; Midazolam; Molecular Structure; Nanotechnology; Ph | 2003 |
A high-throughput method for enzyme kinetic studies.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP | 2003 |
A sensitive HPLC-MS-MS assay for quantitative determination of midazolam in dog plasma.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Area Under Curve; Calibration; Chromatography, H | 2004 |
Determination of midazolam in human plasma by liquid chromatography with mass-spectrometric detection.
Topics: Humans; Hypnotics and Sedatives; Midazolam; Sensitivity and Specificity | 2004 |
Genetic variability in cytochrome P450 3A5 and in vivo cytochrome P450 3A activity: some answers but still questions.
Topics: Biological Availability; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytoch | 2004 |
Effect of the CYP3A5 genotype on the pharmacokinetics of intravenous midazolam during inhibited and induced metabolic states.
Topics: Adult; Asian People; Biological Availability; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome | 2004 |
A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes.
Topics: Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; D | 2004 |
Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Microchemistry; Midazolam; Nanotechnology; Part | 2004 |
Sensitive determination of midazolam and 1'-hydroxymidazolam in plasma by liquid-liquid extraction and column-switching liquid chromatography with ultraviolet absorbance detection and its application for measuring CYP3A activity.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; | 2004 |
A sensitive, rapid and specific determination of midazolam in human plasma and saliva by liquid chromatography/electrospray mass spectrometry.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Midazolam; Reference Standards; Reproduci | 2004 |
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Atmospheric Pressure; Chromatography, Thin Layer; Metoprolol; Midazolam; Models, Molecular; Molecula | 2005 |
Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children.
Topics: Anticonvulsants; Child; Chromatography, High Pressure Liquid; Humans; Kenya; Malaria, Falciparum; Mi | 2005 |
A highly sensitive LC-MS-MS assay for analysis of midazolam and its major metabolite in human plasma: applications to drug metabolism.
Topics: Adult; Chromatography, Liquid; Female; Humans; Mass Spectrometry; Midazolam; Reproducibility of Resu | 2005 |
Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP | 2007 |
Cognitive testing in early-phase clinical trials: development of a rapid computerized test battery and application in a simulated Phase I study.
Topics: Adolescent; Adult; Brain; Clinical Trials, Phase I as Topic; Cognition; Diagnosis, Computer-Assisted | 2007 |
HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats.
Topics: Animals; Chromatography, High Pressure Liquid; Hypnotics and Sedatives; Male; Midazolam; Perfusion; | 2007 |
Simultaneous determination of midazolam and 1'-hydroxymidazolam in human plasma by liquid chromatography with tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Humans; Midazolam; Reference Standards; Reproducibility of Resu | 2007 |
Bispectral index monitoring of conscious sedation with the combination of meperidine and midazolam during endoscopy.
Topics: Adjuvants, Anesthesia; Aged; Ambulatory Care; Conscious Sedation; Deep Sedation; Drug Therapy, Combi | 2008 |
Stereospecific transduction of behavioral effects via diazepam-insensitive GABAA receptors.
Topics: Animals; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; | 1995 |
[Indications of planned sedation following intracranial neurosurgery. Prospective study of decisional criteria].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Clinical Protocols; Decision Making; Female; | 1994 |
Automated determination of midazolam in human plasma by high-performance liquid chromatography using column switching.
Topics: Autoanalysis; Chromatography, High Pressure Liquid; Drug Stability; Humans; Hydrogen-Ion Concentrati | 1994 |
Determination of midazolam and two of its metabolites in human plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Hydroxylation; Midazolam; | 1994 |
Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Carbolines; Chlordiazepoxide; Chlorides; Chlorine; | 1993 |
Determination of midazolam and its unconjugated 1-hydroxy metabolite in human plasma by high-performance liquid chromatography.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Midazolam; Reproducibility of Results; Se | 1995 |
Gas chromatographic determination of midazolam in low-volume plasma samples.
Topics: Adjuvants, Anesthesia; Animals; Chromatography, Gas; Humans; Hydrogen-Ion Concentration; Hypnotics a | 1996 |
Determination of midazolam and its metabolites in serum microsamples by high-performance liquid chromatography and its application to pharmacokinetics in rats.
Topics: Animals; Anti-Anxiety Agents; Calibration; Chromatography, High Pressure Liquid; Circadian Rhythm; H | 1996 |
Simultaneous determination of midazolam and its metabolites 1-hydroxymidazolam and 4-hydroxymidazolam in human serum using gas chromatography-mass spectrometry.
Topics: Anesthetics, Intravenous; Gas Chromatography-Mass Spectrometry; Humans; Hypnotics and Sedatives; Mid | 1997 |
Analysis of midazolam and metabolites in plasma by high-performance liquid chromatography: probe of CYP3A.
Topics: Adult; Anti-Anxiety Agents; Aryl Hydrocarbon Hydroxylases; Biomarkers; Chromatography, High Pressure | 1998 |
Premedication with Xylocaine spray does not lead to a false positive rapid urease test.
Topics: Anesthetics, Local; False Positive Reactions; Female; Helicobacter Infections; Helicobacter pylori; | 1998 |
Sensitive assay for midazolam and its metabolite 1'-hydroxymidazolam in human plasma by capillary high-performance liquid chromatography.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochr | 1998 |
Capillary electrophoresis-mass spectrometry coupling versus micro-high-performance liquid chromatography-mass spectrometry coupling: a case study.
Topics: Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Evaluation Studies as Topic; Human | 1998 |
Simultaneous determination of fentanyl and midazolam using high-performance liquid chromatography with ultraviolet detection.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Chromatography, High Pressure Liquid; Fentanyl; Humans; M | 1999 |
Reversed-phase ion-pair HPLC method for the direct analysis of 1-OH midazolam glucuronide in human serum.
Topics: Calibration; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Midazolam; Reproducibil | 1999 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyto | 1999 |
Sensitive and specific determination of midazolam and 1-hydroxymidazolam in human serum by liquid chromatography-electrospray mass spectrometry.
Topics: Anesthetics, Intravenous; Chromatography, Liquid; Humans; Hypnotics and Sedatives; Mass Spectrometry | 1999 |
Evaluation of dextromethorphan N-demethylation activity as a biomarker for cytochrome P450 3A activity in man.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP3A; Dextromethorphan; Humans; | 2002 |