midazolam has been researched along with Seizures, Febrile in 14 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Seizures, Febrile: Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine effectiveness of intramuscular midazolam to control acute seizures in children as compared to intravenous diazepam." | 9.11 | Intramuscular midazolam vs intravenous diazepam for acute seizures. ( Deshmukh, CT; Shah, I, 2005) |
| "Fosphenytoin (fPHT) and continuous intravenous midazolam (cMDL) had commonly been used as second-line treatments for pediatric status epilepticus (SE) in Japan." | 7.88 | Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus. ( Fujita, K; Iijima, K; Ishida, Y; Kurosawa, H; Maruyama, A; Morioka, I; Nagase, H; Nishiyama, M; Nozu, K; Takada, S; Tanaka, T; Taniguchi-Ikeda, M; Tomioka, K; Toyoshima, D; Uetani, Y; Yamaguchi, H, 2018) |
| "To determine effectiveness of intramuscular midazolam to control acute seizures in children as compared to intravenous diazepam." | 5.11 | Intramuscular midazolam vs intravenous diazepam for acute seizures. ( Deshmukh, CT; Shah, I, 2005) |
| "Fosphenytoin (fPHT) and continuous intravenous midazolam (cMDL) had commonly been used as second-line treatments for pediatric status epilepticus (SE) in Japan." | 3.88 | Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus. ( Fujita, K; Iijima, K; Ishida, Y; Kurosawa, H; Maruyama, A; Morioka, I; Nagase, H; Nishiyama, M; Nozu, K; Takada, S; Tanaka, T; Taniguchi-Ikeda, M; Tomioka, K; Toyoshima, D; Uetani, Y; Yamaguchi, H, 2018) |
| "Eclampsia is specifically addressed by 85% (28/33) of agencies." | 1.46 | Prehospital Care for the Adult and Pediatric Seizure Patient: Current Evidence-based Recommendations. ( Brown, JF; Gausche-Hill, M; Gilbert, GH; Koenig, KL; Lemieux, JM; Rudnick, EM; Salvucci, AA; Silverman, EC; Sporer, KA, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (71.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Silverman, EC | 1 |
| Sporer, KA | 1 |
| Lemieux, JM | 1 |
| Brown, JF | 1 |
| Koenig, KL | 1 |
| Gausche-Hill, M | 1 |
| Rudnick, EM | 1 |
| Salvucci, AA | 1 |
| Gilbert, GH | 1 |
| Nishiyama, M | 1 |
| Nagase, H | 1 |
| Tomioka, K | 1 |
| Tanaka, T | 1 |
| Yamaguchi, H | 1 |
| Ishida, Y | 1 |
| Toyoshima, D | 1 |
| Fujita, K | 1 |
| Maruyama, A | 1 |
| Kurosawa, H | 1 |
| Uetani, Y | 1 |
| Nozu, K | 1 |
| Taniguchi-Ikeda, M | 1 |
| Morioka, I | 1 |
| Takada, S | 1 |
| Iijima, K | 1 |
| Yano, T | 1 |
| Okubo, S | 1 |
| Naruo, H | 1 |
| Iwasaki, T | 1 |
| Takasaki, M | 1 |
| Tsuneyoshi, I | 1 |
| Saz, EU | 1 |
| Karapinar, B | 1 |
| Ozcetin, M | 1 |
| Polat, M | 1 |
| Tosun, A | 1 |
| Serdaroglu, G | 1 |
| Gokben, S | 1 |
| Tekgul, H | 1 |
| Aksu, R | 1 |
| Kumandas, S | 1 |
| Akin, A | 1 |
| Bicer, C | 1 |
| Gümüş, H | 1 |
| Güler, G | 1 |
| Per, H | 1 |
| Bayram, A | 1 |
| Boyaci, A | 1 |
| Riedl, B | 1 |
| Shah, I | 1 |
| Deshmukh, CT | 1 |
| Koren, G | 1 |
| Lahat, E | 1 |
| Goldman, M | 1 |
| Barr, J | 1 |
| Bistritzer, T | 1 |
| Berkovitch, M | 1 |
| Scott, RC | 1 |
| Besag, FM | 1 |
| Neville, BG | 1 |
| Johnson, T | 1 |
| Harnden, A | 1 |
| Phillips, B | 1 |
| Appleton, R | 1 |
| Wassner, E | 1 |
| Morris, B | 1 |
| Fernando, L | 1 |
| Rao, M | 1 |
| Whitehouse, WP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612] | Phase 2 | 358 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of seizure. (NCT00326612)
Timeframe: 24 hours
| Intervention | Minutes (Median) |
|---|---|
| Intranasal Midazolam | 3.0 |
| Rectal Diazepam | 4.3 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 21 |
| Rectal Diazepam | 17 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 4 |
| Rectal Diazepam | 3 |
(NCT00326612)
Timeframe: 12 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 1 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 5 |
| Rectal Diazepam | 5 |
Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 0 |
Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 3 |
| Rectal Diazepam | 1 |
3 trials available for midazolam and Seizures, Febrile
| Article | Year |
|---|---|
The comparison of the effects of dexmedetomidine and midazolam sedation on electroencephalography in pediatric patients with febrile convulsion.
Topics: Blood Pressure; Child; Child, Preschool; Conscious Sedation; Dexmedetomidine; Dose-Response Relation | 2011 |
Intramuscular midazolam vs intravenous diazepam for acute seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Humans; Infant; Injections, Intramuscular; Injec | 2005 |
Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study.
Topics: Administration, Intranasal; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infa | 2000 |
11 other studies available for midazolam and Seizures, Febrile
| Article | Year |
|---|---|
Prehospital Care for the Adult and Pediatric Seizure Patient: Current Evidence-based Recommendations.
Topics: Administration, Intranasal; Administration, Intravenous; Adult; Anticonvulsants; Benzodiazepines; Ca | 2017 |
Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus.
Topics: Anticonvulsants; Child; Child, Preschool; Cohort Studies; Female; Humans; Infant; Male; Midazolam; O | 2018 |
Two cases with past and family history of febrile convulsion developed seizure-like movements during sevoflurane anesthesia.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Appendectomy; Appendicitis; | 2008 |
Convulsive status epilepticus in children: etiology, treatment protocol and outcome.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Encephalitis; Female; Humans; Infant; Male; Meni | 2011 |
[A common emergency in childhood. Febrile convulsions -- what to do?].
Topics: Acetaminophen; Administration, Rectal; Age Factors; Analgesics, Non-Narcotic; Anticonvulsants; Clona | 2003 |
Intranasal midazolam for febrile seizures. A step forward in treating a common and distressing condition.
Topics: Administration, Intranasal; Child; Humans; Midazolam; Seizures, Febrile | 2000 |
Intranasal midazolam for treating febrile seizures in children. Buccal midazolam should be preferred to nasal midazolam.
Topics: Administration, Intranasal; Administration, Oral; Anticonvulsants; Humans; Midazolam; Seizures, Febr | 2001 |
Intranasal midazolam for treating febrile seizures in children. Caution is advised in interpreting trial conclusions.
Topics: Administration, Intranasal; Anticonvulsants; Humans; Midazolam; Seizures, Febrile; Treatment Outcome | 2001 |
Intranasal midazolam for treating febrile seizures in children. Caution is required in applying hospital based evidence to primary care population.
Topics: Administration, Intranasal; Anticonvulsants; Child; Hospitalization; Humans; Midazolam; Seizures, Fe | 2001 |
Intranasal midazolam for treating febrile seizures in children. Safety is as important as efficacy.
Topics: Administration, Intranasal; Anticonvulsants; Child; Humans; Midazolam; Seizures, Febrile | 2001 |
Intranasal midazolam for treating febrile seizures in children. Buccal midazolam for childhood seizures at home preferred to rectal diazepam.
Topics: Administration, Oral; Administration, Rectal; Anticonvulsants; Child; Diazepam; Humans; Midazolam; S | 2001 |