midazolam has been researched along with Rheumatoid Arthritis in 5 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This therapeutic protein-drug interaction study evaluated the disease-mediated effect of sirukumab (anti-interleukin 6 [anti-IL-6] monoclonal antibody) on the pharmacokinetics of the cytochrome P450 (CYP) probe substrates midazolam (CYP3A), omeprazole (CYP2C19), warfarin (CYP2C9), and caffeine (CYP1A2) in patients with active rheumatoid arthritis (RA)." | 5.20 | Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-interleukin-6 monoclonal antibody (sirukumab) and cytochrome P450 activities in a phase 1 study in patients with rheumatoid arthritis using a cocktail approach. ( Chen, D; Davis, HM; de Vries, DE; Leon, F; Marciniak, SJ; Xu, Z; Zhou, H; Zhuang, Y, 2015) |
| " In this respect, we describe a 60-year-old female patient who presented with a diagnosis of RA with pulmonary fibrosis, and was scheduled for orthopaedic surgery for subcapital fracture of femur which was successfully managed using intrathecal bupivacaine and midazolam." | 3.78 | Subarachnoid block in a case of rheumatoid arthritis with severe pulmonary fibrosis. ( Ahmad Siddiqui, O; Ahmad, Z; Ansari, MS; Habib, SK, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dunvald, AD | 1 |
| Søltoft, K | 1 |
| Sheetal, E | 1 |
| Just, SA | 1 |
| Frederiksen, IEB | 1 |
| Nielsen, F | 1 |
| Olsen, DA | 1 |
| Madsen, JS | 1 |
| Hendricks, O | 1 |
| Stage, TB | 1 |
| Zhuang, Y | 1 |
| de Vries, DE | 1 |
| Xu, Z | 1 |
| Marciniak, SJ | 1 |
| Chen, D | 1 |
| Leon, F | 1 |
| Davis, HM | 1 |
| Zhou, H | 1 |
| Ansari, MS | 1 |
| Habib, SK | 1 |
| Ahmad Siddiqui, O | 1 |
| Ahmad, Z | 1 |
| Avery, JK | 1 |
| Alfa, JA | 1 |
| Bamgbade, OA | 1 |
1 trial available for midazolam and Rheumatoid Arthritis
| Article | Year |
|---|---|
Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-interleukin-6 monoclonal antibody (sirukumab) and cytochrome P450 activities in a phase 1 study in patients with rheumatoid arthritis using a cocktail approach.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheum | 2015 |
4 other studies available for midazolam and Rheumatoid Arthritis
| Article | Year |
|---|---|
Cytochrome P450 activity in rheumatoid arthritis patients during continuous IL-6 receptor antagonist therapy.
Topics: Arthritis, Rheumatoid; Cholesterol; Cytochrome P-450 CYP3A; Humans; Inflammation; Midazolam; Recepto | 2023 |
Subarachnoid block in a case of rheumatoid arthritis with severe pulmonary fibrosis.
Topics: Anesthesia, Spinal; Arthritis, Rheumatoid; Female; Femoral Fractures; Humans; Hypnotics and Sedative | 2012 |
Technique in question.
Topics: Adjuvants, Anesthesia; Anesthesiology; Anesthetics, Intravenous; Anesthetics, Local; Arthritis, Rheu | 2006 |
Acute myoclonus following spinal anaesthesia.
Topics: Acute Disease; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, Intr | 2008 |