Page last updated: 2024-10-31

midazolam and Rett Syndrome

midazolam has been researched along with Rett Syndrome in 1 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Rett Syndrome: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)

Research Excerpts

ExcerptRelevanceReference
"Rett syndrome is a severe neurodevelopmental disease caused by mutations of the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2) that induce complex, disabling symptoms, including breathing symptoms."1.37The benzodiazepine Midazolam mitigates the breathing defects of Mecp2-deficient mice. ( Hilaire, G; Voituron, N, 2011)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Voituron, N1
Hilaire, G1

Other Studies

1 other study available for midazolam and Rett Syndrome

ArticleYear
The benzodiazepine Midazolam mitigates the breathing defects of Mecp2-deficient mice.
    Respiratory physiology & neurobiology, 2011, Jun-30, Volume: 177, Issue:1

    Topics: Animals; Benzodiazepines; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Methyl-CpG

2011