midazolam has been researched along with Respiratory Distress Syndrome in 17 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Respiratory Distress Syndrome: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " >4 days) plus midazolam-based sedation for acute respiratory distress syndrome." | 7.81 | Effect of flumazenil on diaphragm electrical activation during weaning from mechanical ventilation after acute respiratory distress syndrome. ( Dewitte, A; Fleureau, C; Germain, A; Joannes-Boyau, O; Ouattara, A; Perrier, V; Rozé, H, 2015) |
| " >4 days) plus midazolam-based sedation for acute respiratory distress syndrome." | 3.81 | Effect of flumazenil on diaphragm electrical activation during weaning from mechanical ventilation after acute respiratory distress syndrome. ( Dewitte, A; Fleureau, C; Germain, A; Joannes-Boyau, O; Ouattara, A; Perrier, V; Rozé, H, 2015) |
| "Plasma concentration-time profiles of sufentanil and pharmacokinetic parameters such as initial postinfusion half-life (t(1/2alpha)), elimination half-life (t(1/2beta)), total clearance (Cl), volume of distribution (Vdbeta), and time required to obtain a 50% decrease in plasma concentration (tcp(0/2))." | 2.71 | Pharmacokinetics of long-term sufentanil infusion for sedation in ICU patients. ( Assoune, P; Boudaoud, S; Ethuin, F; Eurin, B; Jacob, L; Le Moing, JP; Leblanc, I; Levron, JC; Marie, O; Troje, C, 2003) |
| "Thirty patients with multiple trauma were randomly assigned to either breathe spontaneously with APRV (APRV Group) (n = 15) or to receive pressure-controlled, time-cycled mechanical ventilation (PCV) for 72 h followed by weaning with APRV (PCV Group) (n = 15)." | 2.70 | Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. ( Mutz, N; Putensen, C; Stüber, F; Von Spiegel, T; Wrigge, H; Zech, S; Zinserling, J, 2001) |
| "In patients with acute respiratory distress syndrome, whether inverse ratio ventilation differs from high positive end-expiratory pressure (PEEP) for gas exchange under a similar mean airway pressure has not been adequately examined." | 2.70 | Effects of inverse ratio ventilation versus positive end-expiratory pressure on gas exchange and gastric intramucosal PCO(2) and pH under constant mean airway pressure in acute respiratory distress syndrome. ( Chang, YC; Hsu, KH; Huang, CC; Shih, MJ; Tsai, YH; Tsao, TC, 2001) |
| " Body weight, age, hepatic and renal functions, and the UGT2B7 rs62298861 polymorphism are relevant predictors of midazolam pharmacokinetic variables." | 1.51 | Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study. ( Bradfield, J; Conrado, DJ; Curley, MAQ; Gastonguay, MR; Gastonguay, MS; Hakonarson, H; Moorthy, G; Prodell, J; Zane, NR; Zuppa, AF, 2019) |
| "At the end of life of cancer patients, sedation is sometimes needed, in order to palliate unbearable symptoms that other treatments fail to relieve." | 1.46 | [Towards a better use of midazolam in end of life: A survey in a department of medical oncology]. ( Beneton, A; Brosse, C; Magné, N; Morisson, S; Pacaut, C; Poenou, G; Vallard, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, X | 1 |
| Ai, Y | 1 |
| Zhang, L | 1 |
| Zhao, C | 1 |
| Li, L | 1 |
| Ma, X | 1 |
| Shudofsky, KN | 1 |
| Janssen, PKC | 1 |
| Foudraine, N | 1 |
| le Noble, JLML | 1 |
| Cortellazzo Wiel, L | 1 |
| Monasta, L | 1 |
| Pascolo, P | 1 |
| Servidio, AG | 1 |
| Levantino, L | 1 |
| Fasoli, S | 1 |
| Saccari, A | 1 |
| Cozzi, G | 1 |
| Barbi, E | 1 |
| Verkerk, BS | 1 |
| Dzierba, AL | 2 |
| Muir, J | 2 |
| Der-Nigoghossian, C | 1 |
| Brodie, D | 2 |
| Bacchetta, M | 2 |
| Rietdijk, W | 2 |
| Bakker, J | 2 |
| Beneton, A | 1 |
| Vallard, A | 1 |
| Brosse, C | 1 |
| Poenou, G | 1 |
| Pacaut, C | 1 |
| Magné, N | 1 |
| Morisson, S | 1 |
| Zuppa, AF | 1 |
| Conrado, DJ | 1 |
| Zane, NR | 1 |
| Curley, MAQ | 1 |
| Bradfield, J | 1 |
| Hakonarson, H | 1 |
| Gastonguay, MS | 1 |
| Moorthy, G | 1 |
| Prodell, J | 1 |
| Gastonguay, MR | 1 |
| Selbst, SM | 1 |
| Rozé, H | 1 |
| Germain, A | 1 |
| Perrier, V | 1 |
| Dewitte, A | 1 |
| Joannes-Boyau, O | 1 |
| Fleureau, C | 1 |
| Ouattara, A | 1 |
| Baust, H | 1 |
| Glatz, U | 1 |
| Quabach, R | 1 |
| Sitina, M | 1 |
| Wasson, L | 1 |
| Colabraro, M | 1 |
| Gannon, W | 1 |
| Connolly, K | 1 |
| Biscotti, M | 1 |
| Moitra, V | 1 |
| Haitsma, JJ | 1 |
| Lachmann, B | 1 |
| Papadakos, PJ | 1 |
| Ferguson, ND | 1 |
| Cook, DJ | 1 |
| Guyatt, GH | 1 |
| Mehta, S | 1 |
| Hand, L | 1 |
| Austin, P | 1 |
| Zhou, Q | 1 |
| Matte, A | 1 |
| Walter, SD | 1 |
| Lamontagne, F | 1 |
| Granton, JT | 1 |
| Arabi, YM | 1 |
| Arroliga, AC | 1 |
| Stewart, TE | 1 |
| Slutsky, AS | 1 |
| Meade, MO | 1 |
| Karch, AM | 1 |
| Karch, FE | 1 |
| Ethuin, F | 1 |
| Boudaoud, S | 1 |
| Leblanc, I | 1 |
| Troje, C | 1 |
| Marie, O | 1 |
| Levron, JC | 1 |
| Le Moing, JP | 1 |
| Assoune, P | 1 |
| Eurin, B | 1 |
| Jacob, L | 1 |
| Bouchut, JC | 1 |
| Mallet, E | 1 |
| Putensen, C | 1 |
| Zech, S | 1 |
| Wrigge, H | 1 |
| Zinserling, J | 1 |
| Stüber, F | 1 |
| Von Spiegel, T | 1 |
| Mutz, N | 1 |
| Huang, CC | 1 |
| Shih, MJ | 1 |
| Tsai, YH | 1 |
| Chang, YC | 1 |
| Tsao, TC | 1 |
| Hsu, KH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Cardio-respiratory Variables Between Low-frequency High Frequency Oscillation With/Without Tracheal Gas Insufflation and High-frequency High-frequency Oscillation in Severe ARDS.[NCT02027129] | Phase 1 | 17 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| Early Use of Airway Pressure ReLease Ventilation in Critically Ill Adults With Moderate-to-severe Acute Respiratory Distress Syndrome[NCT04156438] | 1 participants (Actual) | Interventional | 2020-06-29 | Completed | |||
| The Oscillation for ARDS Treated Early (OSCILLATE) Trial Pilot Study[NCT00474656] | 94 participants (Actual) | Interventional | 2007-06-30 | Completed | |||
| The Oscillation for ARDS Treated Early (OSCILLATE) Trial[NCT01506401] | Phase 3 | 548 participants (Actual) | Interventional | 2009-06-30 | Terminated (stopped due to Enrolment halted by Steering Committee on advice from Data Monitoring Committee.) | ||
| Esophageal Pressure-Guided Optimal PEEP/mPaw in CMV and HFOV: The EPOCH Study[NCT02342756] | 20 participants (Anticipated) | Interventional | 2015-01-31 | Active, not recruiting | |||
| The Pharmacokinetics of Fentanyl in Intensive Care Patients[NCT02587273] | Phase 4 | 150 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | ||
| Impact of Proportional Assisted Ventilation on Dyspnea and Asynchrony in Mechanically Ventilated Patients[NCT02801994] | 34 participants (Actual) | Interventional | 2016-02-24 | Completed | |||
| Driving Pressure Variation During Proportional Assisted Ventilation: Comparison Between NAVA and PSV[NCT03719365] | 20 participants (Anticipated) | Interventional | 2018-11-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for midazolam and Respiratory Distress Syndrome
| Article | Year |
|---|---|
Ketamine use in sedation management in patients receiving extracorporeal membrane oxygenation.
Topics: Analgesics, Opioid; Analysis of Variance; Anesthetics, Dissociative; Case-Control Studies; Dose-Resp | 2016 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
High-frequency oscillation in early acute respiratory distress syndrome.
Topics: Adult; Aged; Female; High-Frequency Ventilation; Hospital Mortality; Humans; Hypnotics and Sedatives | 2013 |
Pharmacokinetics of long-term sufentanil infusion for sedation in ICU patients.
Topics: Adult; Aged; Analgesics, Opioid; APACHE; Conscious Sedation; Critical Care; Drug Monitoring; Drug Th | 2003 |
Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Female; Humans; Injury Severity Score; Length | 2001 |
Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Female; Humans; Injury Severity Score; Length | 2001 |
Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Female; Humans; Injury Severity Score; Length | 2001 |
Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Female; Humans; Injury Severity Score; Length | 2001 |
Effects of inverse ratio ventilation versus positive end-expiratory pressure on gas exchange and gastric intramucosal PCO(2) and pH under constant mean airway pressure in acute respiratory distress syndrome.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; APACHE; Blood Gas Analysis; Female; Gastri | 2001 |
12 other studies available for midazolam and Respiratory Distress Syndrome
| Article | Year |
|---|---|
Sedation and analgesia requirements during venovenous extracorporeal membrane oxygenation in acute respiratory distress syndrome patients.
Topics: Adult; Analgesia; Benzodiazepines; Extracorporeal Membrane Oxygenation; Humans; Midazolam; Morphine | 2023 |
Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome.
Topics: Aged; Continuous Renal Replacement Therapy; COVID-19; COVID-19 Drug Treatment; Critical Illness; Dee | 2022 |
Recovery characteristics and parental satisfaction in pediatric procedural sedation.
Topics: Child; Conscious Sedation; Dexmedetomidine; Hallucinations; Humans; Hypnotics and Sedatives; Ketamin | 2022 |
Opioid and Benzodiazepine Requirements in Obese Adult Patients Receiving Extracorporeal Membrane Oxygenation.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Extracorporeal Membrane Oxygenation; Female; Fentanyl; H | 2020 |
[Towards a better use of midazolam in end of life: A survey in a department of medical oncology].
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Checklist; Clinical Decision-Making; Female; France; Guidel | 2017 |
Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.
Topics: Child; Critical Illness; Dose-Response Relationship, Drug; Humans; Hypnotics and Sedatives; Male; Mi | 2019 |
Pediatric emergency medicine: legal briefs.
Topics: Accidents, Traffic; Amputation, Surgical; Baseball; Brain Damage, Chronic; Child; Colon; Commitment | 2013 |
Effect of flumazenil on diaphragm electrical activation during weaning from mechanical ventilation after acute respiratory distress syndrome.
Topics: Adult; Aged; Aged, 80 and over; Blood Gas Analysis; Diaphragm; Electrophysiological Phenomena; Femal | 2015 |
[Not Available].
Topics: Cesarean Section; Chronic Pain; Europe; Female; Humans; Hypnotics and Sedatives; Hypothermia, Induce | 2016 |
Additives in intravenous anesthesia modulate pulmonary inflammation in a model of LPS-induced respiratory distress.
Topics: Acute Lung Injury; Adjuvants, Anesthesia; Anesthesia, Intravenous; Animals; Bronchoalveolar Lavage F | 2009 |
Not so fast!
Topics: Female; Humans; Hypnotics and Sedatives; Injections, Intravenous; Medication Errors; Midazolam; Midd | 2003 |
Weaning directly from high frequency oscillatory ventilation: the 'open lung' strategy expanded to weaning?
Topics: Anesthetics, Intravenous; Blood Gas Analysis; Bronchiolitis; Bronchodilator Agents; Female; Fentanyl | 2004 |