midazolam has been researched along with Respiratory Distress Syndrome, Newborn in 13 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Respiratory Distress Syndrome, Newborn: A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The impact of midazolam on the overall performance of morphine therapy for pain in ventilated neonates with respiratory distress syndrome (RDS) has never been investigated." | 8.02 | Clinical and Economic Evaluation of the Impact of Midazolam on Morphine Therapy for Pain Relief in Critically Ill Ventilated Infants with Respiratory Distress Syndrome. ( Abdelaal, M; Abounahia, FF; Abushanab, D; Al-Badriyeh, D; Alsoukhni, O, 2021) |
| "The impact of midazolam on the overall performance of morphine therapy for pain in ventilated neonates with respiratory distress syndrome (RDS) has never been investigated." | 4.02 | Clinical and Economic Evaluation of the Impact of Midazolam on Morphine Therapy for Pain Relief in Critically Ill Ventilated Infants with Respiratory Distress Syndrome. ( Abdelaal, M; Abounahia, FF; Abushanab, D; Al-Badriyeh, D; Alsoukhni, O, 2021) |
| "Midazolam and placebo were administered as bolus (0." | 2.70 | Midazolam sedation in mechanically ventilated newborns: a double blind randomized placebo controlled trial. ( Arya, V; Ramji, S, 2001) |
| "Midazolam was given over only a few days and the limited effects on heart rate and blood pressure that we report should not encourage long-term administration." | 2.67 | Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies. ( Beaufils, F; Burtin, P; Daoud, P; Desplanques, L; Jacqz-Aigrain, E, 1994) |
| " Vital signs before and after dosing were not significantly different." | 1.51 | Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit. ( Bidegain, M; Cotten, CM; Fisher, K; Goldberg, RN; Greenberg, RG; Hornik, CD; Ku, LC; Simmons, C; Smith, PB, 2019) |
| "Infant delirium is an under-recognized clinical entity in neonatal intensive care, and earlier identification and treatment could minimize morbidities associated with this condition." | 1.46 | A case of infant delirium in the neonatal intensive care unit. ( Bidegain, M; Cotten, CM; Edwards, LE; Hornik, CD; Hutchison, LB; Smith, PB, 2017) |
| "The remifentanil infusion was started at dose 0." | 1.33 | Remifentanil for sedation and analgesia in a preterm neonate with respiratory distress syndrome. ( Barbosa, RF; Gomez, RS; Pereira e Silva, Y; Simões e Silva, AC, 2005) |
| "Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and children." | 1.28 | Pharmacokinetics of midazolam in critically ill neonates. ( Jacqz-Aigrain, E; Robieux, I; Wood, C, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Abushanab, D | 1 |
| Abounahia, FF | 1 |
| Alsoukhni, O | 1 |
| Abdelaal, M | 1 |
| Al-Badriyeh, D | 1 |
| Milési, C | 3 |
| Baleine, J | 2 |
| Mura, T | 1 |
| Benito-Castro, F | 1 |
| Ferragu, F | 1 |
| Thiriez, G | 1 |
| Thévenot, P | 1 |
| Combes, C | 2 |
| Carbajal, R | 1 |
| Cambonie, G | 2 |
| Ku, LC | 1 |
| Simmons, C | 1 |
| Smith, PB | 2 |
| Greenberg, RG | 1 |
| Fisher, K | 1 |
| Hornik, CD | 2 |
| Cotten, CM | 2 |
| Goldberg, RN | 1 |
| Bidegain, M | 2 |
| Mesnage, R | 1 |
| Rideau Batista Novais, A | 1 |
| Durand, S | 1 |
| Edwards, LE | 1 |
| Hutchison, LB | 1 |
| Pereira e Silva, Y | 1 |
| Gomez, RS | 1 |
| Barbosa, RF | 1 |
| Simões e Silva, AC | 1 |
| Jacqz-Aigrain, E | 3 |
| Daoud, P | 2 |
| Burtin, P | 2 |
| Desplanques, L | 1 |
| Beaufils, F | 1 |
| Magny, JF | 1 |
| d'Allest, AM | 1 |
| Nedelcoux, H | 1 |
| Zupan, V | 1 |
| Dehan, M | 1 |
| Arya, V | 1 |
| Ramji, S | 1 |
| Mussat, P | 1 |
| Moriette, G | 1 |
| Schlünder, C | 1 |
| Houben, F | 1 |
| Hartwig, S | 1 |
| Theisohn, M | 1 |
| Roth, B | 1 |
| Wood, C | 1 |
| Robieux, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intranasal Midazolam Versus Intranasal Ketamine to Sedate Newborns for Intubation in Delivery Room.[NCT01517828] | Phase 3 | 62 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | ||
| Comparative Study of the Use of Remifentanil Versus Morphine for Sedation and Analgesia of Premature Neonates During Mechanical Ventilation in the Treatment of Respiratory Distress Syndrome (RDS)[NCT00391105] | Phase 4 | 0 participants | Interventional | 2004-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for midazolam and Respiratory Distress Syndrome, Newborn
| Article | Year |
|---|---|
Nasal midazolam vs ketamine for neonatal intubation in the delivery room: a randomised trial.
Topics: Administration, Intranasal; Anesthetics; Delivery Rooms; Double-Blind Method; Female; France; Humans | 2018 |
Intubation in the delivery room: experience with nasal midazolam.
Topics: Administration, Intranasal; Delivery Rooms; Female; Humans; Hypnotics and Sedatives; Infant, Newborn | 2014 |
Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies.
Topics: Blood Pressure; Child Behavior; Double-Blind Method; Gestational Age; Heart Rate; Hemodynamics; Huma | 1994 |
Midazolam sedation in mechanically ventilated newborns: a double blind randomized placebo controlled trial.
Topics: Conscious Sedation; Double-Blind Method; Female; Humans; India; Infant, Newborn; Intensive Care Unit | 2001 |
9 other studies available for midazolam and Respiratory Distress Syndrome, Newborn
| Article | Year |
|---|---|
Clinical and Economic Evaluation of the Impact of Midazolam on Morphine Therapy for Pain Relief in Critically Ill Ventilated Infants with Respiratory Distress Syndrome.
Topics: Cost-Benefit Analysis; Critical Illness; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; I | 2021 |
Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit.
Topics: Administration, Intranasal; Analgesics, Opioid; Arterial Pressure; Bradycardia; Catheterization, Per | 2019 |
[Is it acceptable in 2014 that three-quarters of newborns are intubated without any sedation in the delivery room?].
Topics: Analgesics; Delivery Rooms; Delivery, Obstetric; Humans; Hypnotics and Sedatives; Infant, Newborn; I | 2014 |
A case of infant delirium in the neonatal intensive care unit.
Topics: Amines; Analgesics, Opioid; Anti-Anxiety Agents; Cardiac Catheterization; Cyclohexanecarboxylic Acid | 2017 |
Remifentanil for sedation and analgesia in a preterm neonate with respiratory distress syndrome.
Topics: Analgesics; Analgesics, Opioid; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Infant, Pr | 2005 |
Midazolam and myoclonus in neonate.
Topics: Electroencephalography; Humans; Infant, Newborn; Midazolam; Myoclonus; Respiratory Distress Syndrome | 1994 |
Hypotension with midazolam and fentanyl in the newborn.
Topics: Drug Synergism; Drug Therapy, Combination; Fentanyl; Humans; Hypotension; Infant, Newborn; Midazolam | 1991 |
[Analgesia and sedation in neonatal-pediatric intensive care].
Topics: Analgesia; Analgesics, Opioid; Child, Preschool; Conscious Sedation; Dose-Response Relationship, Dru | 1991 |
Pharmacokinetics of midazolam in critically ill neonates.
Topics: Chromatography, High Pressure Liquid; Critical Care; Diazepam; Half-Life; Humans; Infant, Newborn; I | 1990 |