midazolam has been researched along with Reperfusion Injury in 14 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to investigate the effects of renal ischaemia/reperfusion (I/R)-induced acute kidney injury (AKI) on the distribution of midazolam (MDZ), a probe drug for cytochrome P450 3A (CYP3A) activity." | 7.91 | Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats. ( Fumoto, S; Miyamoto, H; Nishida, K; Tokunaga, A, 2019) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 7.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "Pre-treatment with midazolam diminishes increased expression of cerebral endothelial intercellular adhesion molecule-1 and P-selectin expression following hypoxia-reoxygenation." | 5.35 | The effect of midazolam on cerebral endothelial (P-selectin and ICAM-1) adhesion molecule expression during hypoxia-reperfusion injury in vitro. ( Ghori, K; Harmon, D; Lan, W; Seigne, P; Shorten, GD; Walsh, F, 2008) |
| " We concluded that within this dosage midazolam does not have any antioxidant effect in reperfused rat kidneys following ischemia." | 5.31 | Is midazolam effective as an antioxidant in preventing reperfusion injury in rat kidney? ( Aslan, R; Erol, A; Erol, U; Gurdal, M; Konukoğlu, D; Onmus, H, 2002) |
| "This study aimed to investigate the effects of renal ischaemia/reperfusion (I/R)-induced acute kidney injury (AKI) on the distribution of midazolam (MDZ), a probe drug for cytochrome P450 3A (CYP3A) activity." | 3.91 | Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats. ( Fumoto, S; Miyamoto, H; Nishida, K; Tokunaga, A, 2019) |
| " The objectives of this in-vitro investigation were to examine the effect of midazolam on neutrophil p38 MAPK activation (phosphorylation) following in-vitro ischaemia-reperfusion injury, and the expression of adhesion molecule CD11b/CD18." | 3.76 | The effect of midazolam on neutrophil mitogen-activated protein kinase. ( Ghori, K; O'Driscoll, J; Shorten, G, 2010) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 3.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "In baclofen/muscimol treated eyes the ERG b-wave went from 426+/-101 microV to 148+/-118 microV (n=6)." | 1.35 | GABA agonists fail to protect the retina from ischemia-reperfusion injury. ( Agnarsson, BA; Eysteinsson, T; Stefánsson, E; Traustason, S, 2009) |
| "Unlike LRT, renal failure derived from long ischemia time was observed in CRT recipients, and it is speculated that renal failure affects the PK of CyA." | 1.35 | Comparison of pharmacokinetics of cyclosporine A in cadaveric and living-related renal transplant recipients and in an experimental rat model of renal failure. ( Fujimoto, K; Fukushima, K; Ito, Y; Kokuhu, T; Okamoto, M; Sugioka, N; Takada, K; Tanaka, Y; Yoshimura, N, 2009) |
| "Pre-treatment with midazolam diminishes increased expression of cerebral endothelial intercellular adhesion molecule-1 and P-selectin expression following hypoxia-reoxygenation." | 1.35 | The effect of midazolam on cerebral endothelial (P-selectin and ICAM-1) adhesion molecule expression during hypoxia-reperfusion injury in vitro. ( Ghori, K; Harmon, D; Lan, W; Seigne, P; Shorten, GD; Walsh, F, 2008) |
| " We concluded that within this dosage midazolam does not have any antioxidant effect in reperfused rat kidneys following ischemia." | 1.31 | Is midazolam effective as an antioxidant in preventing reperfusion injury in rat kidney? ( Aslan, R; Erol, A; Erol, U; Gurdal, M; Konukoğlu, D; Onmus, H, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tokunaga, A | 1 |
| Miyamoto, H | 1 |
| Fumoto, S | 1 |
| Nishida, K | 1 |
| Yuan, J | 1 |
| Yang, MC | 1 |
| Wu, MJ | 1 |
| Gou, YS | 1 |
| Oyama, Y | 1 |
| Bartman, CM | 1 |
| Gile, J | 1 |
| Sehrt, D | 1 |
| Eckle, T | 1 |
| Traustason, S | 1 |
| Eysteinsson, T | 1 |
| Agnarsson, BA | 1 |
| Stefánsson, E | 1 |
| Sugioka, N | 1 |
| Fujimoto, K | 1 |
| Tanaka, Y | 1 |
| Fukushima, K | 1 |
| Ito, Y | 1 |
| Kokuhu, T | 1 |
| Okamoto, M | 1 |
| Yoshimura, N | 1 |
| Takada, K | 1 |
| Ghori, K | 2 |
| O'Driscoll, J | 1 |
| Shorten, G | 1 |
| Harman, F | 1 |
| Hasturk, AE | 1 |
| Yaman, M | 1 |
| Arca, T | 1 |
| Kilinc, K | 1 |
| Sargon, MF | 1 |
| Kaptanoglu, E | 1 |
| Li, Q | 1 |
| Liu, Y | 2 |
| Jiao, J | 1 |
| Zhang, C | 1 |
| Lou, J | 1 |
| Erol, U | 1 |
| Gurdal, M | 1 |
| Erol, A | 1 |
| Aslan, R | 1 |
| Konukoğlu, D | 1 |
| Onmus, H | 1 |
| Chen, L | 1 |
| Gong, Q | 1 |
| Xiao, C | 1 |
| Zhang, PB | 1 |
| Li, J | 1 |
| Chen, XL | 1 |
| Tian, YF | 1 |
| Sun, JJ | 1 |
| Liu, JX | 1 |
| Harmon, D | 1 |
| Lan, W | 1 |
| Seigne, P | 1 |
| Walsh, F | 1 |
| Shorten, GD | 1 |
| Ito, H | 1 |
| Watanabe, Y | 1 |
| Isshiki, A | 1 |
| Uchino, H | 1 |
| Cheng, YJ | 1 |
| Wang, YP | 1 |
| Chien, CT | 1 |
| Chen, CF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Bright Light Exposure in Critical Ill Patients and Patients Undergoing Cardiac Surgery[NCT03822949] | 70 participants (Anticipated) | Interventional | 2019-07-12 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for midazolam and Reperfusion Injury
| Article | Year |
|---|---|
Small-dose propofol sedation attenuates the formation of reactive oxygen species in tourniquet-induced ischemia-reperfusion injury under spinal anesthesia.
Topics: Aged; Anesthesia, Spinal; Arthroplasty, Replacement, Knee; Female; Free Radical Scavengers; Humans; | 2002 |
13 other studies available for midazolam and Reperfusion Injury
| Article | Year |
|---|---|
Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats.
Topics: Acute Kidney Injury; Animals; Cytochrome P-450 CYP3A; Disease Models, Animal; Male; Midazolam; Prote | 2019 |
Sedative depth on neurological outcomes in a juvenile rat model of cardiopulmonary resuscitation.
Topics: Animals; Apoptosis; Brain; Cardiopulmonary Resuscitation; Child; Disease Models, Animal; Electroence | 2019 |
The Circadian PER2 Enhancer Nobiletin Reverses the Deleterious Effects of Midazolam in Myocardial Ischemia and Reperfusion Injury.
Topics: Animals; Disease Models, Animal; Flavones; Mice; Mice, Knockout; Midazolam; Myocardial Ischemia; Per | 2018 |
GABA agonists fail to protect the retina from ischemia-reperfusion injury.
Topics: Animals; Baclofen; Drug Combinations; Drug Evaluation, Preclinical; Electroretinography; Female; GAB | 2009 |
Comparison of pharmacokinetics of cyclosporine A in cadaveric and living-related renal transplant recipients and in an experimental rat model of renal failure.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Area Under Curve; Child; Cycl | 2009 |
The effect of midazolam on neutrophil mitogen-activated protein kinase.
Topics: CD11b Antigen; CD18 Antigens; Enzyme Inhibitors; Humans; Hypnotics and Sedatives; Imidazoles; Midazo | 2010 |
Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model.
Topics: Animals; Disease Models, Animal; Embryo, Mammalian; Etomidate; Female; Lipid Peroxidation; Male; Mic | 2012 |
Assessment of effects of IR and IPC on activities of cytochrome P450 isozymes in rats by a five-drug cocktail approach.
Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactio | 2014 |
Is midazolam effective as an antioxidant in preventing reperfusion injury in rat kidney?
Topics: Animals; Antioxidants; Kidney; Midazolam; Rats; Rats, Wistar; Reperfusion Injury | 2002 |
Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acids; Male; M | 2003 |
[Effects of ketamine-midazolam anesthesia on focal cerebral ischemic injury in rats].
Topics: Adjuvants, Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Apoptosis; Infarct | 2004 |
The effect of midazolam on cerebral endothelial (P-selectin and ICAM-1) adhesion molecule expression during hypoxia-reperfusion injury in vitro.
Topics: Animals; Brain; Cell Adhesion Molecules; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, | 2008 |
Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; GABA | 1999 |