midazolam has been researched along with Pulmonary Edema in 8 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Pulmonary Edema: Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The MIMO clinical trial showed that patients with acute cardiogenic pulmonary edema (ACPE) treated with midazolam had fewer serious adverse events than those treated with morphine." | 9.69 | Midazolam versus morphine in acute cardiogenic pulmonary edema patients with and without atrial fibrillation: findings from the MIMO trial. ( Abreu-Gonzalez, P; Burillo-Putze, G; Calvo-Rodriguez, R; Domínguez-Rodríguez, A; Gil, V; Hernandez-Vaquero, D; Llorens, P; Martín-Sánchez, FJ; Miró, Ò; Piñera-Salmeron, P; Suero-Mendez, C, 2023) |
| "The MIMO trial randomized 111 patients with acute pulmonary edema to receive intravenous midazolam in 1-mg doses to a maximum of 3 mg (n = 55) or morphine in 2- to 4-mg doses to a maximum of 8 mg (n= 56)." | 9.69 | Effects of midazolam vs morphine in patients with acute pulmonary edema with left ventricular systolic dysfunction: a secondary analysis of data from the MIMO trial. ( Abreu-González, P; Burillo-Putze, G; Calvo-Rodríguez, R; Domínguez-Rodríguez, A; Formica, F; Gil, V; Hernández-Vaquero, D; Llorens, P; Martín-Sánchez, FJ; Miró, Ò; Piñera-Salmerón, P; Suero-Méndez, C, 2023) |
| "Morphine has been used for several decades in cases of acute pulmonary edema (APE) due to the anxiolytic and vasodilatory properties of the drug." | 9.24 | Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema": MIMO Trial. ( Abreu-Gonzalez, P; Aldea-Perona, A; Burillo-Putze, G; Dominguez-Rodriguez, A; Garcia-Saiz, MDM; Harmand, MG; Mirò, O, 2017) |
| "The MIMO clinical trial showed that patients with acute cardiogenic pulmonary edema (ACPE) treated with midazolam had fewer serious adverse events than those treated with morphine." | 5.69 | Midazolam versus morphine in acute cardiogenic pulmonary edema patients with and without atrial fibrillation: findings from the MIMO trial. ( Abreu-Gonzalez, P; Burillo-Putze, G; Calvo-Rodriguez, R; Domínguez-Rodríguez, A; Gil, V; Hernandez-Vaquero, D; Llorens, P; Martín-Sánchez, FJ; Miró, Ò; Piñera-Salmeron, P; Suero-Mendez, C, 2023) |
| "The MIMO trial randomized 111 patients with acute pulmonary edema to receive intravenous midazolam in 1-mg doses to a maximum of 3 mg (n = 55) or morphine in 2- to 4-mg doses to a maximum of 8 mg (n= 56)." | 5.69 | Effects of midazolam vs morphine in patients with acute pulmonary edema with left ventricular systolic dysfunction: a secondary analysis of data from the MIMO trial. ( Abreu-González, P; Burillo-Putze, G; Calvo-Rodríguez, R; Domínguez-Rodríguez, A; Formica, F; Gil, V; Hernández-Vaquero, D; Llorens, P; Martín-Sánchez, FJ; Miró, Ò; Piñera-Salmerón, P; Suero-Méndez, C, 2023) |
| "Morphine has been used for several decades in cases of acute pulmonary edema (APE) due to the anxiolytic and vasodilatory properties of the drug." | 5.24 | Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema": MIMO Trial. ( Abreu-Gonzalez, P; Aldea-Perona, A; Burillo-Putze, G; Dominguez-Rodriguez, A; Garcia-Saiz, MDM; Harmand, MG; Mirò, O, 2017) |
| " midazolam for patients with acute cardiogenic pulmonary edema and hypoxemia during the treatment of non-invasive ventilation (NIV)." | 5.16 | Dexmedetomidine versus midazolam for the sedation of patients with non-invasive ventilation failure. ( Chen, YS; Huang, Z; Liu, JY; Yang, ZL, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 4 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Domínguez-Rodríguez, A | 4 |
| Suero-Mendez, C | 3 |
| Burillo-Putze, G | 4 |
| Gil, V | 3 |
| Calvo-Rodriguez, R | 3 |
| Piñera-Salmeron, P | 3 |
| Llorens, P | 3 |
| Martín-Sánchez, FJ | 3 |
| Abreu-Gonzalez, P | 4 |
| Miró, Ò | 4 |
| Neto Gonçalves, T | 1 |
| Margarida Andrade, M | 1 |
| Hernandez-Vaquero, D | 2 |
| Formica, F | 1 |
| Garcia-Saiz, MDM | 1 |
| Aldea-Perona, A | 1 |
| Harmand, MG | 1 |
| Huang, Z | 1 |
| Chen, YS | 1 |
| Yang, ZL | 1 |
| Liu, JY | 1 |
| Noble, WH | 1 |
| Baker, A | 1 |
| Brimacombe, J | 1 |
| Archdeacon, J | 1 |
| Newell, S | 1 |
| Martin, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Study Comparing the Efficacy and Safety of 100 mcg and 200 mcg of Intranasal Fentanyl Pectin Spray as an Analgesic in Adult Males Undergoing Outpatient Cystoscopic Procedures[NCT01756651] | Phase 1 | 20 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for midazolam and Pulmonary Edema
| Article | Year |
|---|---|
Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open-label, randomized controlled trial.
Topics: Adolescent; Heart Failure; Hospital Mortality; Humans; Midazolam; Morphine; Pulmonary Edema | 2022 |
Morphine use in acute cardiogenic pulmonary oedema: is MIMO trial enough to change practice? Letter regarding the article 'Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open-label, randomized controlled trial'.
Topics: Acute Disease; Heart Failure; Humans; Midazolam; Morphine; Pulmonary Edema | 2022 |
Midazolam versus morphine in acute cardiogenic pulmonary edema patients with and without atrial fibrillation: findings from the MIMO trial.
Topics: Adolescent; Atrial Fibrillation; Comorbidity; Female; Humans; Midazolam; Morphine; Pulmonary Edema | 2023 |
Effects of midazolam vs morphine in patients with acute pulmonary edema with left ventricular systolic dysfunction: a secondary analysis of data from the MIMO trial.
Topics: Humans; Midazolam; Morphine; Pulmonary Edema; Stroke Volume; Ventricular Dysfunction, Left; Ventricu | 2023 |
Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema": MIMO Trial.
Topics: Acute Disease; Administration, Intravenous; Anti-Anxiety Agents; Cardiopulmonary Resuscitation; Clin | 2017 |
Dexmedetomidine versus midazolam for the sedation of patients with non-invasive ventilation failure.
Topics: Aged; Cohort Studies; Cross Infection; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Hyp | 2012 |
2 other studies available for midazolam and Pulmonary Edema
| Article | Year |
|---|---|
MAO inhibitors and coronary artery surgery: a patient death.
Topics: Acidosis; Anesthesia, Intravenous; Angina, Unstable; Cause of Death; Coronary Artery Bypass; Fentany | 1992 |
Two cases of naloxone-induced pulmonary oedema--the possible use of phentolamine in management.
Topics: Adolescent; Aged; Bronchial Spasm; Furosemide; Humans; Hydrocortisone; Male; Midazolam; Naloxone; Ph | 1991 |