midazolam has been researched along with Pain, Procedural in 23 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Pain, Procedural: Pain associated with examination, treatment or procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 9.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "The aim of this study was to investigate how effective a combination of rectally administered midazolam and racemic ketamine was for reducing pain in paediatric cerebral palsy patients receiving intramuscular injections of botulinum neurotoxin A." | 9.24 | A rectally administered combination of midazolam and ketamine was easy, effective and feasible for procedural pain in children with cerebral palsy. ( Askljung, B; Brunsson, I; Himmelmann, K; Nilsson, S; Påhlman, M, 2017) |
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 5.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "The aim of this study was to investigate how effective a combination of rectally administered midazolam and racemic ketamine was for reducing pain in paediatric cerebral palsy patients receiving intramuscular injections of botulinum neurotoxin A." | 5.24 | A rectally administered combination of midazolam and ketamine was easy, effective and feasible for procedural pain in children with cerebral palsy. ( Askljung, B; Brunsson, I; Himmelmann, K; Nilsson, S; Påhlman, M, 2017) |
| "When administered ~5 min prior to entering the OR, propofol, 20mg IV, was as effective as midazolam 2mg IV in reducing anxiety." | 5.22 | Propofol versus midazolam for premedication: a placebo‑controlled, randomized double‑blinded study. ( Anand, KK; Cao, X; Elvir Lazo, OL; Hausman, J; Hemaya, EG; Hernandez Conte, A; Tang, J; Wender, RH; White, PF; Yumul, F; Yumul, R; Zhang, X, 2016) |
| " We included any duration of drug treatment and any dosage given continuously or as bolus; we excluded studies that gave opioids to ventilated infants for procedures." | 2.72 | Opioids for newborn infants receiving mechanical ventilation. ( Bellù, R; Bruschettini, M; de Waal, KA; Nava, C; Romantsik, O; Zanini, R, 2021) |
| " The primary outcome measures were adverse events and failed laceration repair." | 1.51 | Safety and effectiveness of intranasal midazolam and fentanyl used in combination in the pediatric emergency department. ( Cosgrove, P; Kienstra, AJ; Ryan, PM; Vezzetti, R; Wilkinson, M, 2019) |
| " Vital signs before and after dosing were not significantly different." | 1.51 | Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit. ( Bidegain, M; Cotten, CM; Fisher, K; Goldberg, RN; Greenberg, RG; Hornik, CD; Ku, LC; Simmons, C; Smith, PB, 2019) |
| "The sevoflurane flow rate was 7±3 mL/h in INSP group, and 3." | 1.51 | Sevoflurane sedation for weaning from mechanical ventilation in pediatric intensive care unit. ( Groselj Grenc, M; Pavcnik, M, 2019) |
| " Adverse events in CAPS patients were recorded." | 1.51 | Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe. ( Beecher, R; Chiorean, M; Drennan, F; Gluck, M; Koch, J; Kozarek, RA; La Selva, D; Larsen, M; Lin, OS; McCormick, S; Ross, A; Tombs, D; Venu, N; Weigel, W, 2019) |
| " There are no previous studies of validated anxiety scores with pharmacokinetic data to support optimal procedure timing." | 1.46 | Evaluating Clinical Effectiveness and Pharmacokinetic Profile of Atomized Intranasal Midazolam in Children Undergoing Laceration Repair. ( Adelgais, K; Bourne, D; Brent, A; Brou, L; Galinkin, J; Mellion, SA; Wathen, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (82.61) | 24.3611 |
| 2020's | 4 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Brant, AR | 1 |
| Reeves, MF | 1 |
| Ye, PP | 1 |
| Scott, RK | 1 |
| Floyd, S | 1 |
| Tefera, E | 1 |
| Lotke, PS | 1 |
| Lund, M | 1 |
| Erichsen, R | 1 |
| Njor, SH | 1 |
| Laurberg, S | 1 |
| Valori, R | 1 |
| Andersen, B | 1 |
| Cinotti, R | 1 |
| Besnard, N | 1 |
| Desmedt, L | 1 |
| Floch, RL | 1 |
| Perrot, P | 1 |
| Bekara, F | 1 |
| Klouche, K | 1 |
| Larcher, R | 1 |
| Mahé, PJ | 1 |
| Frasca, D | 1 |
| Asehnoune, K | 1 |
| Jung, B | 1 |
| Roquilly, A | 1 |
| Fernández-Cantalejo Padial, J | 1 |
| Heras, E | 1 |
| Hernández, B | 1 |
| Jiménez, AB | 1 |
| Martínez, A | 1 |
| López-Herce, J | 1 |
| Mencía, S | 1 |
| Lai, SF | 1 |
| Lam, MT | 1 |
| Li, HWR | 1 |
| Ng, EHY | 1 |
| Bellù, R | 1 |
| Romantsik, O | 1 |
| Nava, C | 1 |
| de Waal, KA | 1 |
| Zanini, R | 1 |
| Bruschettini, M | 1 |
| Burns-Nader, S | 1 |
| Joe, L | 1 |
| Pinion, K | 1 |
| Cevik, B | 1 |
| Tuncer, M | 1 |
| Erkal, KH | 1 |
| Eryildirim, B | 1 |
| Sarica, K | 1 |
| Valori, RM | 1 |
| Damery, S | 1 |
| Gavin, DR | 1 |
| Anderson, JT | 1 |
| Donnelly, MT | 1 |
| Williams, JG | 1 |
| Swarbrick, ET | 1 |
| Mellion, SA | 1 |
| Bourne, D | 1 |
| Brou, L | 1 |
| Brent, A | 1 |
| Adelgais, K | 1 |
| Galinkin, J | 1 |
| Wathen, J | 1 |
| Wangüemert Pérez, AL | 1 |
| González Expósito, H | 1 |
| Pascual Fernández, L | 1 |
| Nusrat, S | 1 |
| Madhoun, MF | 1 |
| Tierney, WM | 1 |
| Chayapathi, V | 1 |
| Kalra, M | 1 |
| Bakshi, AS | 1 |
| Mahajan, A | 1 |
| Ryan, PM | 1 |
| Kienstra, AJ | 1 |
| Cosgrove, P | 1 |
| Vezzetti, R | 1 |
| Wilkinson, M | 1 |
| Wang, Z | 1 |
| Hu, Z | 1 |
| Dai, T | 1 |
| Cabadas Avión, R | 1 |
| Baluja, A | 1 |
| Ojea Cendón, M | 1 |
| Leal Ruiloba, MS | 1 |
| Vázquez López, S | 1 |
| Rey Martínez, M | 1 |
| Magdalena López, P | 1 |
| Álvarez-Escudero, J | 1 |
| Ku, LC | 1 |
| Simmons, C | 1 |
| Smith, PB | 1 |
| Greenberg, RG | 1 |
| Fisher, K | 1 |
| Hornik, CD | 1 |
| Cotten, CM | 1 |
| Goldberg, RN | 1 |
| Bidegain, M | 1 |
| Pavcnik, M | 1 |
| Groselj Grenc, M | 1 |
| Grossmann, B | 1 |
| Nilsson, A | 1 |
| Sjöberg, F | 1 |
| Nilsson, L | 1 |
| Lin, OS | 1 |
| La Selva, D | 1 |
| Kozarek, RA | 1 |
| Tombs, D | 1 |
| Weigel, W | 1 |
| Beecher, R | 1 |
| Koch, J | 1 |
| McCormick, S | 1 |
| Chiorean, M | 1 |
| Drennan, F | 1 |
| Gluck, M | 1 |
| Venu, N | 1 |
| Larsen, M | 1 |
| Ross, A | 1 |
| Wall, SL | 1 |
| Clarke, DL | 1 |
| Allorto, NL | 1 |
| Elvir Lazo, OL | 1 |
| White, PF | 1 |
| Tang, J | 1 |
| Yumul, R | 1 |
| Cao, X | 1 |
| Yumul, F | 1 |
| Hausman, J | 1 |
| Hernandez Conte, A | 1 |
| Anand, KK | 1 |
| Hemaya, EG | 1 |
| Zhang, X | 1 |
| Wender, RH | 1 |
| Nilsson, S | 1 |
| Brunsson, I | 1 |
| Askljung, B | 1 |
| Påhlman, M | 1 |
| Himmelmann, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905] | Phase 4 | 130 participants (Actual) | Interventional | 2017-05-26 | Completed | ||
| A Randomized Study on Use of Virtual Reality Technology for Pain Relief in Transvaginal Oocyte Retrieval Under Conscious Sedation[NCT05218382] | 160 participants (Anticipated) | Interventional | 2022-12-01 | Recruiting | |||
| Dose-Finding Study of Intranasal Midazolam for Procedural Sedation in Children[NCT04586504] | Phase 1/Phase 2 | 150 participants (Anticipated) | Interventional | 2021-09-08 | Recruiting | ||
| Effect of an Adjunctive Sedative for the Patients With Histories of Paradoxical Reaction to Midazolam During Sedative Endoscopy[NCT03940391] | 220 participants (Anticipated) | Interventional | 2019-05-01 | Enrolling by invitation | |||
| A Randomized Controlled Trial of Intranasal Fentanyl in Combination With Midazolam Versus Midazolam Alone for Analgesia and Anxiolysis During Pediatric Facial Laceration Repair[NCT04745260] | 100 participants (Anticipated) | Interventional | 2021-03-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for midazolam and Pain, Procedural
| Article | Year |
|---|---|
Opioids for newborn infants receiving mechanical ventilation.
Topics: Analgesics, Opioid; Bias; Child Development; Fentanyl; Heroin; Humans; Hypnotics and Sedatives; Infa | 2021 |
The comparison of propofol and midazolam for bronchoscopy: A meta-analysis of randomized controlled studies.
Topics: Anesthetics, Intravenous; Bronchoscopy; Humans; Hypnotics and Sedatives; Midazolam; Pain, Procedural | 2018 |
8 trials available for midazolam and Pain, Procedural
| Article | Year |
|---|---|
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain | 2023 |
A randomized double-blinded non-inferiority trial comparing fentanyl and midazolam with pethidine and diazepam for pain relief during oocyte retrieval.
Topics: Adult; Analgesics; Conscious Sedation; Diazepam; Double-Blind Method; Drug Therapy, Combination; Fem | 2020 |
Computer tablet distraction reduces pain and anxiety in pediatric burn patients undergoing hydrotherapy: A randomized trial.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Burns; Child; Child, Preschool; Computers, Handhel | 2017 |
Use of diphenhydramine as an adjunctive sedative for colonoscopy in patients on chronic opioid therapy: a randomized controlled trial.
Topics: Aged; Analgesics, Opioid; Anesthetics, Intravenous; Colonoscopy; Deep Sedation; Diphenhydramine; Fem | 2018 |
A comparison of ketamine + midazolam to propofol for procedural sedation for lumbar puncture in pediatric oncology by nonanesthesiologists-a randomized comparative trial.
Topics: Antineoplastic Agents; Child; Child, Preschool; Conscious Sedation; Female; Humans; Hypnotics and Se | 2018 |
Rectal ketamine during paediatric burn wound dressing procedures: a randomised dose-finding study.
Topics: Analgesics; Bandages; Burns; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method | 2019 |
Propofol versus midazolam for premedication: a placebo‑controlled, randomized double‑blinded study.
Topics: Anesthetics, Intravenous; Anxiety; Conscious Sedation; Double-Blind Method; Female; Humans; Hypnotic | 2016 |
A rectally administered combination of midazolam and ketamine was easy, effective and feasible for procedural pain in children with cerebral palsy.
Topics: Administration, Rectal; Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Child, Preschoo | 2017 |
13 other studies available for midazolam and Pain, Procedural
| Article | Year |
|---|---|
The performance indicator of colonic intubation (PICI) in a FIT-based colorectal cancer screening program.
Topics: Adenoma; Age Factors; Aged; Cecum; Clinical Competence; Colonic Polyps; Colonoscopy; Colorectal Neop | 2019 |
Feasibility and impact of the implementation of a clinical scale-based sedation-analgesia protocol in severe burn patients undergoing mechanical ventilation. A before-after bi-center study.
Topics: Adult; Analgesics, Opioid; Burns; Clinical Protocols; Controlled Before-After Studies; Dose-Response | 2020 |
Results after implementation of a sedoanalgesia protocol for procedures in hospital environment.
Topics: Analgesia; Analgesics, Non-Narcotic; Anesthesia; Child; Child, Preschool; Clinical Protocols; Family | 2019 |
Procedural sedation and analgesia for pediatric shock wave lithotripsy: a 10 year experience of single institution.
Topics: Adolescent; Age Factors; Analgesia; Analgesics; Child; Child, Preschool; Female; Humans; Hypnotics a | 2018 |
A new composite measure of colonoscopy: the Performance Indicator of Colonic Intubation (PICI).
Topics: Age Factors; Aged; Cecum; Clinical Competence; Colonic Polyps; Colonoscopy; Female; Humans; Hypnotic | 2018 |
Evaluating Clinical Effectiveness and Pharmacokinetic Profile of Atomized Intranasal Midazolam in Children Undergoing Laceration Repair.
Topics: Adjuvants, Anesthesia; Administration, Intranasal; Anxiety; Child; Child, Preschool; Conscious Sedat | 2017 |
Assessment of Midazolam Sedation in Ultrasound-Guided Percutaneous Biopsy of Peripheral Lung Lesions.
Topics: Aged; Aged, 80 and over; Anxiety; Biopsy, Fine-Needle; Case-Control Studies; Female; Humans; Hypnoti | 2018 |
Safety and effectiveness of intranasal midazolam and fentanyl used in combination in the pediatric emergency department.
Topics: Administration, Intranasal; Analgesics, Opioid; Anxiety; Child; Child, Preschool; Drug Therapy, Comb | 2019 |
Effectiveness and safety of gastrointestinal endoscopy during a specific sedation training program for non-anesthesiologists.
Topics: Adult; Aged; Conscious Sedation; Endoscopy, Gastrointestinal; Female; Fentanyl; Gastroenterologists; | 2019 |
Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit.
Topics: Administration, Intranasal; Analgesics, Opioid; Arterial Pressure; Bradycardia; Catheterization, Per | 2019 |
Sevoflurane sedation for weaning from mechanical ventilation in pediatric intensive care unit.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Conscious Sedation; Consciousness Disorders | 2019 |
Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Anesthetists; Blood Gas Monitorin | 2019 |
Analgesia protocols for burns dressings: Challenges with implementation.
Topics: Academic Medical Centers; Acetaminophen; Analgesics; Anesthetics, Inhalation; Bandages; Burns; Child | 2019 |