midazolam has been researched along with Osteonecrosis in 1 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Midazolam clearance was compared between the groups, and the relationship between the level of hepatic CYP3A activity and the prevalence of ONFH was evaluated by multivariate analysis." | 2.72 | Low hepatic cytochrome P450 3A activity is a risk for corticosteroid-induced osteonecrosis. ( Hirota, Y; Iwaki, H; Iwakiri, K; Kaneshiro, Y; Kondo, K; Masada, T; Oda, Y; Takaoka, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaneshiro, Y | 1 |
| Oda, Y | 1 |
| Iwakiri, K | 1 |
| Masada, T | 1 |
| Iwaki, H | 1 |
| Hirota, Y | 1 |
| Kondo, K | 1 |
| Takaoka, K | 1 |
1 trial available for midazolam and Osteonecrosis
| Article | Year |
|---|---|
Low hepatic cytochrome P450 3A activity is a risk for corticosteroid-induced osteonecrosis.
Topics: Adrenal Cortex Hormones; Adult; Cytochrome P-450 CYP3A; Female; Femur Head; Humans; Liver; Male; Mid | 2006 |