midazolam has been researched along with Orphan Diseases in 8 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Orphan Diseases: Rare diseases that have not been well studied.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally administered cytochrome P450 (CYP) probe substrates (caffeine, S-warfarin, omeprazole, dextromethorphan, midazolam, and simvastatin)." | 1.51 | Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations. ( Ducray, PS; Endo-Tsukude, C; Gardner, I; Gill, KL; Hatley, OJ; Machavaram, KK; Parrott, N; Terao, K, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Machavaram, KK | 1 |
| Endo-Tsukude, C | 1 |
| Terao, K | 1 |
| Gill, KL | 1 |
| Hatley, OJ | 1 |
| Gardner, I | 1 |
| Parrott, N | 1 |
| Ducray, PS | 1 |
| Mehmet Mutlu, N | 1 |
| Kirdemir, P | 1 |
| Nermin, G | 1 |
| Canbay, O | 1 |
| Kose, EA | 1 |
| Celebi, N | 1 |
| Karagoz, AH | 1 |
| Ozgen, S | 1 |
| Hudcova, J | 1 |
| Schumann, R | 1 |
| Alfa, JA | 1 |
| Bamgbade, OA | 1 |
| Iodice, F | 1 |
| Harban, F | 1 |
| Walker, I | 1 |
| Ozkalkanli, MY | 1 |
| Katircioglu, K | 1 |
| Duzenli, VE | 1 |
| Unal, I | 1 |
| Savaci, S | 1 |
| Schmidt, A | 1 |
| Karlson-Stiber, C | 1 |
8 other studies available for midazolam and Orphan Diseases
| Article | Year |
|---|---|
Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations.
Topics: Administration, Oral; Adult; Caffeine; Clinical Trials as Topic; Computer Simulation; Cytochrome P-4 | 2019 |
Juvenile hyaline fibromatosis.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Fibroma; Genes, Recessive; Gingival Hyperp | 2004 |
Anesthesia for congenital insensitivity to pain with anhidrosis.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Debridement; Fentanyl | 2007 |
Undiagnosed catecholamine-secreting paraganglioma and coexisting carcinoid in a patient with MH susceptibility: an unusual anesthetic challenge.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intravenou | 2007 |
Acute myoclonus following spinal anaesthesia.
Topics: Acute Disease; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, Intr | 2008 |
Anesthetic management of a patient with bilateral congenital lobar emphysema.
Topics: Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Atracurium; Fenta | 2008 |
Brachial plexus block for the child with Kartagener's syndrome.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Brachial Plexus; Child; Dextrocar | 2008 |
Caffeine poisoning and lactate rise: an overlooked toxic effect?
Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Anxiety Agents; Antidotes; Anxiety; Caffeine; Central | 2008 |