midazolam has been researched along with Organophosphorus Poisoning in 6 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 5.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| "Two cases of organophosphorus poisoning are reported." | 5.28 | Use of glycopyrrolate and atropine in acute organophosphorus poisoning. ( Gallagher, H; Tracey, JA, 1990) |
| "Midazolam is a benzodiazepine hypnotic with a rapid onset and short duration of action." | 2.52 | Midazolam as an anticonvulsant antidote for organophosphate intoxication--A pharmacotherapeutic appraisal. ( Reddy, DS; Reddy, SD, 2015) |
| "Rapid control of seizure activity is important to minimize neuronal injury and the resulting neurological and behavioral disorders; however, early treatment will not be possible after mass release of OPs or NAs." | 1.51 | Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure. ( Bealer, SL; Dudek, FE; Pouliot, W; Roach, B; Spampanato, J, 2019) |
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 1.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| "Brain edema was maximal on MR imaging 3 h after poisoning." | 1.42 | Early brain magnetic resonance imaging can predict short and long-term outcomes after organophosphate poisoning in a rat model. ( Cohen, Y; Eisenkraft, A; Kadar, T; Kassirer, M; Milk, N; Rosman, Y; Shiyovich, A; Shrot, S; Tauber, M, 2015) |
| "Two cases of organophosphorus poisoning are reported." | 1.28 | Use of glycopyrrolate and atropine in acute organophosphorus poisoning. ( Gallagher, H; Tracey, JA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, X | 1 |
| Kuruba, R | 1 |
| Reddy, DS | 2 |
| Spampanato, J | 1 |
| Pouliot, W | 1 |
| Bealer, SL | 1 |
| Roach, B | 1 |
| Dudek, FE | 1 |
| Shrot, S | 1 |
| Tauber, M | 1 |
| Shiyovich, A | 1 |
| Milk, N | 1 |
| Rosman, Y | 1 |
| Eisenkraft, A | 2 |
| Kadar, T | 1 |
| Kassirer, M | 1 |
| Cohen, Y | 1 |
| Reddy, SD | 1 |
| Gilat, E | 1 |
| Chapman, S | 1 |
| Baranes, S | 1 |
| Egoz, I | 1 |
| Levy, A | 1 |
| Tracey, JA | 1 |
| Gallagher, H | 1 |
1 review available for midazolam and Organophosphorus Poisoning
| Article | Year |
|---|---|
Midazolam as an anticonvulsant antidote for organophosphate intoxication--A pharmacotherapeutic appraisal.
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Midazolam; Organophosphate Poisoning | 2015 |
5 other studies available for midazolam and Organophosphorus Poisoning
| Article | Year |
|---|---|
Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Brain Injuries; Cholinesterase Inhibitors; Drug Re | 2018 |
Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Isoflurophate; Male; Midazolam; Neuroprotective Ag | 2019 |
Early brain magnetic resonance imaging can predict short and long-term outcomes after organophosphate poisoning in a rat model.
Topics: Animals; Aspartic Acid; Atropine; Behavior, Animal; Brain; Brain Edema; Choline; Cholinesterase Reac | 2015 |
Efficacy of the bone injection gun in the treatment of organophosphate poisoning.
Topics: Animals; Anticonvulsants; Antidotes; Biological Availability; Dose-Response Relationship, Drug; Infu | 2007 |
Use of glycopyrrolate and atropine in acute organophosphorus poisoning.
Topics: Adult; Atropine; Diazepam; Drug Therapy, Combination; Glycopyrrolate; Humans; Insecticides; Male; Mi | 1990 |