Page last updated: 2024-10-31

midazolam and Neutropenia

midazolam has been researched along with Neutropenia in 2 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.

Research Excerpts

ExcerptRelevanceReference
" In univariate analysis, high midazolam concentration and free DCX AUC were associated with severe neutropenia and FN."3.74Relationship between cytochrome 3A activity, inflammatory status and the risk of docetaxel-induced febrile neutropenia: a prospective study. ( Alexandre, J; Dieras, V; Girre, V; Goldwasser, F; Grabar, S; Hérait, P; Jullien, V; Montheil, V; Pons, G; Rabillon, F; Rey, E; Tran, A; Treluyer, JM, 2007)
"Fixed dosing was found to be feasible, without increased variability of clearance or neutrophil toxicity compared to BSA-based dosing."2.73A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers. ( Goh, BC; Lee, HS; Lee, SC; Soo, R; Sukri, N; Tham, LS; Wang, LZ; Wong, CI; Yong, WP, 2008)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alexandre, J1
Rey, E1
Girre, V1
Grabar, S1
Tran, A1
Montheil, V1
Rabillon, F1
Dieras, V1
Jullien, V1
Hérait, P1
Pons, G1
Treluyer, JM1
Goldwasser, F1
Yong, WP1
Wang, LZ1
Tham, LS1
Wong, CI1
Lee, SC1
Soo, R1
Sukri, N1
Lee, HS1
Goh, BC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-label Randomized Clinical Trial to Compare the Toxicities and Efficacy of Pharmacokinetically-guided and BSA Fixed Dosing Strategy of Docetaxel and Paclitaxel in Chinese Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma, and Breast Cancer Patie[NCT01891123]300 participants (Anticipated)Interventional2013-06-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for midazolam and Neutropenia

ArticleYear
A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers.
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:2

    Topics: Antineoplastic Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Docetaxel; Dose-R

2008

Other Studies

1 other study available for midazolam and Neutropenia

ArticleYear
Relationship between cytochrome 3A activity, inflammatory status and the risk of docetaxel-induced febrile neutropenia: a prospective study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:1

    Topics: Aged; Antineoplastic Agents; Area Under Curve; Cytochrome P-450 CYP3A; Docetaxel; Female; Ferritins;

2007