midazolam has been researched along with Neuromuscular Blockade in 27 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol 2 mg x kg(-1) was superior to thiopentone 6 mg x kg(-1) and etomidate 0." | 6.71 | Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade. ( Alper, I; Erhan, E; Gunusen, I; Ozyar, B; Ugur, G, 2003) |
| "Propofol is a widely used drug in anesthesia practice, and its pharmacological characteristics are well known." | 5.37 | Possible augmentation of neuromuscular blockade by propofol during recovery from rocuronium. ( Braehler, MR; Miller, RD; Ruschulte, H; Ward, TA, 2011) |
| "Propofol or remifentanil anesthesia was associated with a higher incidence of OCR during pediatric strabismus surgery than sevoflurane and desflurane anesthesia, when either ketamine or midazolam was used as an induction agent." | 5.14 | Effect of different anesthetic agents on oculocardiac reflex in pediatric strabismus surgery. ( Choi, SR; Chung, CJ; Lee, JH; Lee, SC; Park, SW, 2009) |
| " Ventilator-free days, alive at day 28, and dose and duration of sedation (propofol and midazolam), analgesia (fentanyl and morphine), and neuromuscular blockade (NMB) were compared." | 4.90 | Association between tidal volume size, duration of ventilation, and sedation needs in patients without acute respiratory distress syndrome: an individual patient data meta-analysis. ( Barbas, CS; Biehl, M; de Abreu, MG; de Oliveira, RP; Determann, RM; Elmer, J; Friedman, G; Gajic, O; Goldstein, JN; Horn, J; Juffermans, NP; Linko, R; Pelosi, P; Schultz, MJ; Serpa Neto, A; Simonis, FD; Sundar, S; Talmor, D; Wolthuis, EK, 2014) |
| "In this large, pediatric multicenter registry, fentanyl, midazolam, and ketamine were the most commonly used induction agents, and the majority of tracheal intubations involved neuromuscular blockade." | 3.81 | Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study. ( Brown, CA; Howell, JD; Hsing, DD; Montgomery, V; Nadkarni, VM; Nishisaki, A; Parker, MM; Tarquinio, KM; Turner, DA; Walls, RM, 2015) |
| "To investigate the relationship between total body weight (TBW) or body mass index (BMI) and atracurium reversal time." | 3.70 | Antagonism of atracurium-induced block in obese patients. ( Kirkegaard-Nielsen, H; Lindholm, P; Petersen, HS; Severinsen, IK, 1998) |
| " Neuromuscular blockade was induced and maintained with atracurium." | 3.70 | New equipment for neuromuscular transmission monitoring: a comparison of the TOF-Guard with the Myograph 2000. ( Helbo-Hansen, HS; Kirkegaard-Nielsen, H; Lindholm, P; Pedersen, HS; Schmidt, MB; Severinsen, IK, 1998) |
| "Propofol 2 mg x kg(-1) was superior to thiopentone 6 mg x kg(-1) and etomidate 0." | 2.71 | Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade. ( Alper, I; Erhan, E; Gunusen, I; Ozyar, B; Ugur, G, 2003) |
| "Adult patients with head injuries were prospectively enrolled over a 1-year period by using the following inclusion criteria: Glasgow Coma Scale score of 3 to 8, transport time of greater than 10 minutes, and inability to intubate without RSI." | 2.70 | Paramedic-performed rapid sequence intubation of patients with severe head injuries. ( Bailey, D; Davis, D; Hoyt, D; Marshall, L; Ochs, M; Rosen, P, 2002) |
| "To compare the pharmacokinetic behaviour of doxacurium in patients undergoing normothermic or hypothermic cardiopulmonary bypass (CPB) for coronary artery bypass graft surgery." | 2.69 | Pharmacokinetics of doxacurium during normothermic and hypothermic cardiopulmonary bypass surgery. ( Asokumar, B; Cheng, D; Chung, F; Peniston, C; Sandler, A; Varin, F, 1998) |
| "Intubation of the trachea and mechanical ventilation are ubiquitous painful procedures in the neonatal intensive care unit that are poorly assessed and treated." | 2.49 | Sedation and analgesia to facilitate mechanical ventilation. ( Colby, CE; Nemergut, ME; Yaster, M, 2013) |
| "Propofol is a widely used drug in anesthesia practice, and its pharmacological characteristics are well known." | 1.37 | Possible augmentation of neuromuscular blockade by propofol during recovery from rocuronium. ( Braehler, MR; Miller, RD; Ruschulte, H; Ward, TA, 2011) |
| "The ease of endotracheal intubation has been recently shown to affect the incidence of laryngeal injury." | 1.33 | Tracheal intubation in routine practice with and without muscular relaxation: an observational study. ( Adnet, F; Ait Kaci, F; Baillard, C; Borron, SW; Cupa, M; Fournier, JL; Larmignat, P; Racine, SX; Samama, CM, 2005) |
| "3 mg/kg), and to compare the accuracy of the dosing of midazolam for ED RSI with the accuracy of dosing of other agents." | 1.32 | Underdosing of midazolam in emergency endotracheal intubation. ( Barton, ED; Chiang, V; Sagarin, MJ; Sakles, JC; Vissers, RJ; Walls, RM, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 9 (33.33) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Inata, Y | 1 |
| Sofue, T | 1 |
| Hatachi, T | 1 |
| Kyogoku, M | 1 |
| Takeuchi, M | 1 |
| Ozawa, Y | 1 |
| Ades, A | 1 |
| Foglia, EE | 1 |
| DeMeo, S | 1 |
| Barry, J | 1 |
| Sawyer, T | 1 |
| Singh, N | 1 |
| Glass, K | 1 |
| Jung, P | 1 |
| Quek, BH | 1 |
| Johnston, L | 1 |
| Kim, J | 1 |
| Napolitano, N | 1 |
| Shults, J | 1 |
| Nadkarni, VM | 2 |
| Nishisaki, A | 2 |
| Nemergut, ME | 1 |
| Yaster, M | 1 |
| Colby, CE | 1 |
| Serpa Neto, A | 1 |
| Simonis, FD | 1 |
| Barbas, CS | 1 |
| Biehl, M | 1 |
| Determann, RM | 1 |
| Elmer, J | 1 |
| Friedman, G | 1 |
| Gajic, O | 1 |
| Goldstein, JN | 1 |
| Horn, J | 1 |
| Juffermans, NP | 1 |
| Linko, R | 1 |
| de Oliveira, RP | 1 |
| Sundar, S | 1 |
| Talmor, D | 1 |
| Wolthuis, EK | 1 |
| de Abreu, MG | 1 |
| Pelosi, P | 1 |
| Schultz, MJ | 1 |
| Gupta, B | 1 |
| Ayub, A | 1 |
| Bindra, A | 1 |
| Gupta, S | 1 |
| Mishra, B | 1 |
| Tarquinio, KM | 1 |
| Howell, JD | 1 |
| Montgomery, V | 1 |
| Turner, DA | 1 |
| Hsing, DD | 1 |
| Parker, MM | 1 |
| Brown, CA | 1 |
| Walls, RM | 2 |
| Kudchadkar, SR | 1 |
| Shaffner, DH | 1 |
| Lu, CH | 1 |
| Man, KM | 1 |
| Ou-Yang, HY | 1 |
| Chan, SM | 1 |
| Ho, ST | 1 |
| Wong, CS | 1 |
| Liaw, WJ | 1 |
| Choi, SR | 1 |
| Park, SW | 1 |
| Lee, JH | 1 |
| Lee, SC | 1 |
| Chung, CJ | 1 |
| Lee, KH | 1 |
| Nam, SH | 1 |
| Yoo, SY | 1 |
| Jung, CW | 1 |
| Bae, SS | 1 |
| Lee, JR | 1 |
| Ruschulte, H | 1 |
| Ward, TA | 1 |
| Miller, RD | 1 |
| Braehler, MR | 1 |
| Messieha, ZS | 1 |
| Guirguis, S | 1 |
| Hanna, S | 1 |
| Ochs, M | 2 |
| Davis, D | 1 |
| Hoyt, D | 1 |
| Bailey, D | 2 |
| Marshall, L | 1 |
| Rosen, P | 2 |
| Erhan, E | 1 |
| Ugur, G | 1 |
| Gunusen, I | 1 |
| Alper, I | 1 |
| Ozyar, B | 1 |
| Sagarin, MJ | 1 |
| Barton, ED | 1 |
| Sakles, JC | 1 |
| Vissers, RJ | 1 |
| Chiang, V | 1 |
| Davis, DP | 1 |
| Hoyt, DB | 1 |
| Marshall, LK | 1 |
| Fanneløp, T | 1 |
| Dahle, GO | 1 |
| Matre, K | 1 |
| Segadal, L | 1 |
| Grong, K | 1 |
| Baillard, C | 1 |
| Adnet, F | 1 |
| Borron, SW | 1 |
| Racine, SX | 1 |
| Ait Kaci, F | 1 |
| Fournier, JL | 1 |
| Larmignat, P | 1 |
| Cupa, M | 1 |
| Samama, CM | 1 |
| Farag, E | 1 |
| Chelune, GJ | 1 |
| Schubert, A | 1 |
| Mascha, EJ | 1 |
| van Twest, RM | 1 |
| Kirkegaard-Nielsen, H | 2 |
| Lindholm, P | 2 |
| Petersen, HS | 1 |
| Severinsen, IK | 2 |
| Ririe, DG | 1 |
| Shapiro, F | 1 |
| Sethna, NF | 1 |
| Ma, OJ | 1 |
| Atchley, RB | 1 |
| Hatley, T | 1 |
| Green, M | 1 |
| Young, J | 1 |
| Brady, W | 1 |
| Helbo-Hansen, HS | 1 |
| Pedersen, HS | 1 |
| Schmidt, MB | 1 |
| Asokumar, B | 1 |
| Cheng, D | 1 |
| Chung, F | 1 |
| Peniston, C | 1 |
| Sandler, A | 1 |
| Varin, F | 1 |
| Playfor, SD | 1 |
| Thomas, DA | 1 |
| Choonara, I | 2 |
| Jarvis, A | 1 |
| Playfor, S | 1 |
| Thomas, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pragmatic Investigation of Volume Targeted Ventilation-1 (PIVOT-1)[NCT03909854] | 139 participants (Actual) | Interventional | 2019-09-09 | Completed | |||
| Deep Sedation and General Anesthesia for Endoscopic Retrograde Cholangiopancreatography[NCT04087668] | 405 participants (Actual) | Interventional | 2019-09-01 | Completed | |||
| Comparison of Two Different Anesthetic Techniques on Incidence of Postoperative Delirium in Cancer Patients After Laparoscopic Surgery in Trendelenburg Position: A Prospective Randomized Clinical Trial[NCT03572517] | 65 participants (Actual) | Interventional | 2017-09-01 | Completed | |||
| Effect of Depth of Total Intravenous Anesthesia Using Propofol on Postoperative Cognitive Dysfunction : A Multi-Center Study[NCT01708837] | Phase 4 | 300 participants (Anticipated) | Interventional | 2012-10-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for midazolam and Neuromuscular Blockade
| Article | Year |
|---|---|
Sedation and analgesia to facilitate mechanical ventilation.
Topics: Analgesics; Analgesics, Opioid; Benzodiazepines; Clonidine; Humans; Hypnotics and Sedatives; Infant; | 2013 |
Association between tidal volume size, duration of ventilation, and sedation needs in patients without acute respiratory distress syndrome: an individual patient data meta-analysis.
Topics: Analgesics, Opioid; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Units; Length of Stay; | 2014 |
6 trials available for midazolam and Neuromuscular Blockade
| Article | Year |
|---|---|
Effect of different anesthetic agents on oculocardiac reflex in pediatric strabismus surgery.
Topics: Androstanols; Anesthesia; Anesthesia, General; Anesthetics; Anesthetics, Dissociative; Anesthetics, | 2009 |
Paramedic-performed rapid sequence intubation of patients with severe head injuries.
Topics: Adult; Allied Health Personnel; Craniocerebral Trauma; Emergency Medical Services; Humans; Hypnotics | 2002 |
Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Blood Pressure; Cough; Double-Blind | 2003 |
Is depth of anesthesia, as assessed by the Bispectral Index, related to postoperative cognitive dysfunction and recovery?
Topics: Adjuvants, Anesthesia; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Cognition; Female | 2006 |
Is depth of anesthesia, as assessed by the Bispectral Index, related to postoperative cognitive dysfunction and recovery?
Topics: Adjuvants, Anesthesia; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Cognition; Female | 2006 |
Is depth of anesthesia, as assessed by the Bispectral Index, related to postoperative cognitive dysfunction and recovery?
Topics: Adjuvants, Anesthesia; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Cognition; Female | 2006 |
Is depth of anesthesia, as assessed by the Bispectral Index, related to postoperative cognitive dysfunction and recovery?
Topics: Adjuvants, Anesthesia; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Cognition; Female | 2006 |
Bispectral index guided timing of intubation without neuromuscular blockade during sevoflurane induction of anaesthesia in adults.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Anesthesia, General; Anesthetics, Inhalation; Blood Pressu | 2006 |
Pharmacokinetics of doxacurium during normothermic and hypothermic cardiopulmonary bypass surgery.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Body Temperature; Cardiopulmonary Bypass; C | 1998 |
19 other studies available for midazolam and Neuromuscular Blockade
| Article | Year |
|---|---|
Prone positioning without neuromuscular blockade during extracorporeal membrane oxygenation in children.
Topics: Adolescent; Child; Child, Preschool; Chlorpromazine; Dexmedetomidine; Extracorporeal Membrane Oxygen | 2020 |
Premedication with neuromuscular blockade and sedation during neonatal intubation is associated with fewer adverse events.
Topics: Case-Control Studies; Fentanyl; Humans; Hypnotics and Sedatives; Infant, Newborn; Intensive Care Uni | 2019 |
Distal tracheoesophageal fistula in pediatric patient - an anesthetic challenge.
Topics: Accidental Falls; Adjuvants, Anesthesia; Airway Management; Androstanols; Anesthesia, Inhalation; An | 2014 |
Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study.
Topics: Adolescent; Child; Child, Preschool; Critical Illness; Female; Fentanyl; Hemodynamics; Humans; Hypno | 2015 |
Pharmacologic recipes for tracheal intubation in the PICU: what's on the menu?
Topics: Critical Illness; Female; Fentanyl; Humans; Intubation, Intratracheal; Ketamine; Male; Midazolam; Ne | 2015 |
Composite auditory evoked potential index versus bispectral index to estimate the level of sedation in paralyzed critically ill patients: a prospective observational study.
Topics: Analgesics, Opioid; Conscious Sedation; Critical Illness; Electroencephalography; Electromyography; | 2008 |
Vecuronium requirement during liver transplantation under sevoflurane anesthesia.
Topics: Aged; Analysis of Variance; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2010 |
Possible augmentation of neuromuscular blockade by propofol during recovery from rocuronium.
Topics: Adjuvants, Anesthesia; Adult; Androstanols; Anesthesia Recovery Period; Anesthesia, General; Anesthe | 2011 |
Bispectral index monitoring (BIS) as a guide for intubation without neuromuscular blockade in office-based pediatric general anesthesia: a retrospective evaluation.
Topics: Administration, Oral; Adolescent; Ambulatory Care; Anesthesia, Dental; Anesthesia, General; Anesthet | 2011 |
Underdosing of midazolam in emergency endotracheal intubation.
Topics: Adolescent; Adult; Child; Child, Preschool; Emergency Medicine; Emergency Service, Hospital; Etomida | 2003 |
Paramedic-administered neuromuscular blockade improves prehospital intubation success in severely head-injured patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allied Health Personnel; Androstanols; Case-Control Stud | 2003 |
An anaesthetic protocol in the young domestic pig allowing neuromuscular blockade for studies of cardiac function following cardioplegic arrest and cardiopulmonary bypass.
Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, Inhalation; Anesthetics, Intravenous; Animals; Cardio | 2004 |
Tracheal intubation in routine practice with and without muscular relaxation: an observational study.
Topics: Adult; Anesthetics, Intravenous; Atracurium; Female; Follow-Up Studies; Humans; Hydroxyzine; Hypnoti | 2005 |
Antagonism of atracurium-induced block in obese patients.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Atracurium; Body Mass Index; Body Weight; | 1998 |
The response of patients with Duchenne's muscular dystrophy to neuromuscular blockade with vecuronium.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Intravenous; Case-Control Studies; Child; Dose-Respo | 1998 |
Intubation success rates improve for an air medical program after implementing the use of neuromuscular blocking agents.
Topics: Adjuvants, Anesthesia; Adult; Air Ambulances; Anesthesia, Intravenous; Anesthetics, Local; Atropine; | 1998 |
New equipment for neuromuscular transmission monitoring: a comparison of the TOF-Guard with the Myograph 2000.
Topics: Acceleration; Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhal | 1998 |
Quality of sedation during mechanical ventilation.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Arousal; Child; Child, Preschool; Chloral Hydr | 2000 |
Recollection of children following intensive care.
Topics: Adolescent; Anti-Anxiety Agents; Attitude to Health; Child; Child, Preschool; Conscious Sedation; Cr | 2000 |