midazolam has been researched along with Neuroblastoma in 5 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human neuroblastoma cells were incubated with midazolam alone, as a pretreatment prior to incubation with TMZ or a coincubation of both." | 7.81 | Pretreatment but not subsequent coincubation with midazolam reduces the cytotoxicity of temozolomide in neuroblastoma cells. ( Bauer, I; Braun, S; Pannen, B; Werdehausen, R, 2015) |
| "Midazolam is a widely used short-acting benzodiazepine." | 5.72 | Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? ( Adamzik, M; Bazzi, M; Bazzi, Z; Bergmann, L; Holtkamp, C; Koos, B; Nowak, H; Orlowski, J; Rahmel, T; Rump, K; Thon, P; Unterberg, M, 2022) |
| "Human neuroblastoma cells were incubated with midazolam alone, as a pretreatment prior to incubation with TMZ or a coincubation of both." | 3.81 | Pretreatment but not subsequent coincubation with midazolam reduces the cytotoxicity of temozolomide in neuroblastoma cells. ( Bauer, I; Braun, S; Pannen, B; Werdehausen, R, 2015) |
| "Midazolam is a hypnotic-sedative drug with pleiotropic properties." | 1.91 | Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease. ( Chen, Y; Luan, H; Wang, P; Wu, Y, 2023) |
| "Midazolam is a widely used short-acting benzodiazepine." | 1.72 | Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? ( Adamzik, M; Bazzi, M; Bazzi, Z; Bergmann, L; Holtkamp, C; Koos, B; Nowak, H; Orlowski, J; Rahmel, T; Rump, K; Thon, P; Unterberg, M, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rump, K | 1 |
| Holtkamp, C | 1 |
| Bergmann, L | 1 |
| Nowak, H | 1 |
| Unterberg, M | 1 |
| Orlowski, J | 1 |
| Thon, P | 1 |
| Bazzi, Z | 1 |
| Bazzi, M | 1 |
| Adamzik, M | 1 |
| Koos, B | 1 |
| Rahmel, T | 1 |
| Wang, P | 6 |
| Luan, H | 3 |
| Wu, Y | 3 |
| Chen, Y | 3 |
| Braun, S | 1 |
| Bauer, I | 1 |
| Pannen, B | 1 |
| Werdehausen, R | 1 |
| Shiota, M | 1 |
| Oda, Y | 1 |
| Taniguchi, M | 1 |
| Hamabata, T | 1 |
| Mizumoto, H | 1 |
| Hata, D | 1 |
| Ishizawa, Y | 1 |
| Furuya, K | 1 |
| Yamagishi, S | 1 |
| Dohi, S | 1 |
5 other studies available for midazolam and Neuroblastoma
| Article | Year |
|---|---|
Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Delirium; Epigenesis, Geneti | 2022 |
Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cellular Senescence; Cyclooxygenase 2; H | 2023 |
Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cellular Senescence; Cyclooxygenase 2; H | 2023 |
Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cellular Senescence; Cyclooxygenase 2; H | 2023 |
Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cellular Senescence; Cyclooxygenase 2; H | 2023 |
Pretreatment but not subsequent coincubation with midazolam reduces the cytotoxicity of temozolomide in neuroblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; | 2015 |
Dexmedetomidine infusion for sedation in the intensive care setting in an infant with airway compromise due to congenital mediastinal neuroblastoma.
Topics: Airway Management; Airway Obstruction; Analgesics, Opioid; Antineoplastic Agents; Carboplatin; Criti | 2012 |
Non-GABAergic effects of midazolam, diazepam and flumazenil on voltage-dependent ion currents in NG108-15 cells.
Topics: Animals; Calcium Channels; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyri | 1997 |