midazolam has been researched along with Nervous System Diseases in 22 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a retrospective study to compare the outcome of intravenous midazolam infusion without electroencephalography or targeted temperature management and barbiturate coma therapy with electroencephalography and targeted temperature management for treating convulsive refractory febrile status epilepticus." | 7.80 | Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus. ( Fujita, K; Maruyama, A; Nagase, H; Nakagawa, T; Nishiyama, M; Saji, Y, 2014) |
| "Two cases of organophosphorus poisoning are reported." | 5.28 | Use of glycopyrrolate and atropine in acute organophosphorus poisoning. ( Gallagher, H; Tracey, JA, 1990) |
| " Each patient underwent baseline testing for motor function and aphasia, after which intravenous midazolam was delivered until mild drowsiness was detected." | 5.10 | Midazolam challenge reinduces neurological deficits after transient ischemic attack. ( Berman, MF; Fitzsimmons, BF; Lazar, RM; Marshall, RS; Mohr, JP, 2003) |
| "We conducted a retrospective study to compare the outcome of intravenous midazolam infusion without electroencephalography or targeted temperature management and barbiturate coma therapy with electroencephalography and targeted temperature management for treating convulsive refractory febrile status epilepticus." | 3.80 | Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus. ( Fujita, K; Maruyama, A; Nagase, H; Nakagawa, T; Nishiyama, M; Saji, Y, 2014) |
| "Forty consecutive patients with neurological disorders (encephalopathy, autism, and epilepsy) were referred to dental treatment, and 45 sedations were performed; all were sedated with Midazolam (intramuscular 0." | 3.76 | Special care dentistry: Midazolam conscious sedation for patients with neurological diseases. ( Capp, PL; Cillo, MT; de Faria, ME; de Siqueira, JT; Prado, EG; Siqueira, SR, 2010) |
| "Remimazolam is a novel ultrashort-acting benzodiazepine that produces sedation by acting as a positive allosteric modulator of the gamma-amino butyric acid-A receptor." | 3.54 | The Role of Remimazolam in Neurosurgery and in Patients With Neurological Diseases: A Narrative Review. ( Abcejo, AS; Brinkman, NJ; Pasternak, JJ; Teixeira, MT, 2024) |
| "Laryngospasm was observed in 6 patients without statistical difference between the 2 groups." | 2.77 | Ketamine with and without midazolam for gastrointestinal endoscopies in children. ( Brecelj, J; Orel, R; Trop, TK, 2012) |
| "Monitoring for pain, sedation, postoperative nausea/vomiting, dizziness, and pruritus was performed by anesthesiologists blinded to the study allocation." | 2.71 | Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine. ( Acharya, A; Kumar, P; Pan, AK; Rudra, A, 2005) |
| " These data are important for informing adult and pediatric dosing recommendations for NA-induced seizures." | 1.51 | Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats. ( Ardinger, C; Dunn, E; Haines, K; Lee-Stubbs, R; Matson, L; McCarren, H; McDonough, J; Miller-Smith, S; Whitten, K, 2019) |
| "Ketamine was used in most severe cases." | 1.42 | Preliminary results of the global audit of treatment of refractory status epilepticus. ( Ferlisi, M; Grade, M; Hocker, S; Shorvon, S; Trinka, E, 2015) |
| " In clinical practice, intrathecal midazolam (2 mg) did not increase adverse neurological symptoms compared with conventional therapies." | 1.32 | Intrathecal midazolam I: a cohort study investigating safety. ( Goodchild, CS; Lai, C; Nadeson, R; Tucker, AP, 2004) |
| "Tiagabine (Gabitril) is a unique anticonvulsant that is prescribed for a variety of psychiatric disorders." | 1.32 | Intentional overdose with tiagabine: an unusual clinical presentation. ( Cantrell, FL; Himes, E; Ritter, M, 2004) |
| "Two cases of organophosphorus poisoning are reported." | 1.28 | Use of glycopyrrolate and atropine in acute organophosphorus poisoning. ( Gallagher, H; Tracey, JA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Teixeira, MT | 1 |
| Brinkman, NJ | 1 |
| Pasternak, JJ | 1 |
| Abcejo, AS | 1 |
| Matson, L | 1 |
| Dunn, E | 1 |
| Haines, K | 1 |
| Miller-Smith, S | 1 |
| Lee-Stubbs, R | 1 |
| Whitten, K | 1 |
| Ardinger, C | 1 |
| McCarren, H | 1 |
| McDonough, J | 1 |
| Nagase, H | 1 |
| Nishiyama, M | 1 |
| Nakagawa, T | 1 |
| Fujita, K | 1 |
| Saji, Y | 1 |
| Maruyama, A | 1 |
| Ferlisi, M | 1 |
| Hocker, S | 1 |
| Grade, M | 1 |
| Trinka, E | 1 |
| Shorvon, S | 1 |
| Lin, N | 1 |
| Han, R | 1 |
| Zhou, J | 1 |
| Gelb, AW | 1 |
| Capp, PL | 1 |
| de Faria, ME | 1 |
| Siqueira, SR | 1 |
| Cillo, MT | 1 |
| Prado, EG | 1 |
| de Siqueira, JT | 1 |
| Brecelj, J | 1 |
| Trop, TK | 1 |
| Orel, R | 1 |
| Lazar, RM | 1 |
| Fitzsimmons, BF | 1 |
| Marshall, RS | 1 |
| Mohr, JP | 1 |
| Berman, MF | 1 |
| Tucker, AP | 1 |
| Lai, C | 1 |
| Nadeson, R | 1 |
| Goodchild, CS | 1 |
| Cantrell, FL | 1 |
| Ritter, M | 1 |
| Himes, E | 1 |
| McKenzie, CA | 1 |
| McKinnon, W | 1 |
| Naughton, DP | 1 |
| Treacher, D | 1 |
| Davies, G | 1 |
| Phillips, GJ | 1 |
| Hilton, PJ | 1 |
| Kumar, P | 1 |
| Rudra, A | 1 |
| Pan, AK | 1 |
| Acharya, A | 1 |
| Kountchev, J | 1 |
| Bellmann, R | 1 |
| Joannidis, M | 1 |
| Mehrotra, R | 1 |
| Smith, FJ | 1 |
| Bartel, PR | 1 |
| Hugo, JM | 1 |
| Becker, PJ | 1 |
| Cearnal, L | 1 |
| Chiaretti, A | 1 |
| Genovese, O | 1 |
| Antonelli, A | 1 |
| Tortorolo, L | 1 |
| Ruggiero, A | 1 |
| Focarelli, B | 1 |
| Di Rocco, C | 1 |
| Haberer, JP | 1 |
| Tassonyi, E | 1 |
| Fuchs, T | 1 |
| Forster, A | 1 |
| Tracey, JA | 1 |
| Gallagher, H | 1 |
| Williams, D | 1 |
| Dawson, P | 1 |
| Malinovsky, JM | 1 |
| Mussini, JM | 1 |
| Cozian, A | 1 |
| Lepage, JY | 1 |
| Cavaillé, P | 1 |
| Pinaud, M | 1 |
| de Dieuleveult, C | 1 |
| Souron, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227] | Phase 4 | 748 participants | Interventional | 2001-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midazolam and Nervous System Diseases
| Article | Year |
|---|---|
The Role of Remimazolam in Neurosurgery and in Patients With Neurological Diseases: A Narrative Review.
Topics: Benzodiazepines; Double-Blind Method; Humans; Hypnotics and Sedatives; Midazolam; Nervous System Dis | 2024 |
6 trials available for midazolam and Nervous System Diseases
| Article | Year |
|---|---|
Mild Sedation Exacerbates or Unmasks Focal Neurologic Dysfunction in Neurosurgical Patients with Supratentorial Brain Mass Lesions in a Drug-specific Manner.
Topics: Adult; Dexmedetomidine; Female; Fentanyl; Follow-Up Studies; Humans; Hypnotics and Sedatives; Male; | 2016 |
Ketamine with and without midazolam for gastrointestinal endoscopies in children.
Topics: Adolescent; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Drug Administrat | 2012 |
Midazolam challenge reinduces neurological deficits after transient ischemic attack.
Topics: Adult; Aged; Aphasia; Dysarthria; Female; GABA Agonists; GABA-A Receptor Agonists; Humans; Ischemic | 2003 |
Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine.
Topics: Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Intravenous; Anest | 2005 |
Anesthetic technique (sufentanil versus ketamine plus midazolam) and quantitative electroencephalographic changes after cardiac surgery.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Anesthetics, Combined; Anesthetics, Dissociative; An | 2006 |
Patient-controlled analgesia with fentanil and midazolam in children with postoperative neurosurgical pain.
Topics: Adolescent; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Blood Pressure; Child; Female; | 2008 |
15 other studies available for midazolam and Nervous System Diseases
| Article | Year |
|---|---|
Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Elect | 2019 |
Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus.
Topics: Aged, 80 and over; Brain; Child; Child, Preschool; Coma; Female; Follow-Up Studies; Humans; Hypnotic | 2014 |
Preliminary results of the global audit of treatment of refractory status epilepticus.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Dissociat | 2015 |
Special care dentistry: Midazolam conscious sedation for patients with neurological diseases.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthetics, Local; Autistic Disorder; Brain Damage, Chronic; | 2010 |
Intrathecal midazolam I: a cohort study investigating safety.
Topics: Aged; Chi-Square Distribution; Cohort Studies; Confidence Intervals; Female; Follow-Up Studies; Huma | 2004 |
Intentional overdose with tiagabine: an unusual clinical presentation.
Topics: Anticonvulsants; Drug Overdose; Female; Humans; Hypnotics and Sedatives; Midazolam; Middle Aged; Ner | 2004 |
Differentiating midazolam over-sedation from neurological damage in the intensive care unit.
Topics: Aged; APACHE; Hospital Mortality; Humans; Hypnotics and Sedatives; Intensive Care Units; Length of S | 2005 |
Between benzodiazepine over-sedation and neurological damage.
Topics: Dose-Response Relationship, Drug; Drug Tolerance; Humans; Hypnotics and Sedatives; Midazolam; Nervou | 2005 |
General anesthesia for a patient with alternating hemiplegia of childhood.
Topics: Abortion, Induced; Adjuvants, Anesthesia; Adult; Anesthesia, General; Anesthetics, Intravenous; Fema | 2005 |
The birth of the NETT: NIH-funded network will launch emergency neurological trials.
Topics: Anticonvulsants; Clinical Trials as Topic; Emergency Medical Services; Humans; Informed Consent; Lor | 2006 |
[Premedication and sedation complications during ophthalmic anesthesia].
Topics: Adjuvants, Anesthesia; Alfentanil; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anesthesi | 2000 |
[Role of benzodiazepines in neuroanesthesia].
Topics: Anesthesia, Intravenous; Barbiturates; Benzodiazepines; Cerebrovascular Circulation; Humans; Midazol | 1991 |
Use of glycopyrrolate and atropine in acute organophosphorus poisoning.
Topics: Adult; Atropine; Diazepam; Drug Therapy, Combination; Glycopyrrolate; Humans; Insecticides; Male; Mi | 1990 |
An unusual result with flumazenil.
Topics: Acute Kidney Injury; Critical Care; Female; Flumazenil; Humans; Midazolam; Middle Aged; Nervous Syst | 1989 |
[Neurotoxicity of ketamine and midazolam by intrathecal injection in the rabbit].
Topics: Animals; Injections, Spinal; Ketamine; Midazolam; Nervous System Diseases; Rabbits | 1989 |